Abstract:
PURPOSE:Prefrontal cortex (PFC) deep brain stimulation (DBS) has been proposed as a therapy for addiction and depression. This study investigates changes in rat cerebral glucose metabolism induced by different DBS frequencies using μPET. PROCEDURES:One hour DBS of the prelimbic area (PL) of the medial PFC (mPFC) (60 Hz, 130 Hz or sham) in rats (n = 9) was followed by 2-deoxy-2-[(18) F] fluoro-D-glucose ([(18) F]FDG) μPET. RESULTS:Sixty Hz DBS elicited significant hypermetabolism in the ipsilateral PL ([(18) F]FDG uptake +5.2 ± 2.3 %, p < 0.05). At 130 Hz, hypometabolism was induced in the ipsilateral PL (-2.5 ± 2.6 %, non-significant). Statistical parametric mapping revealed hypo and hypermetabolism clusters for both 60 and 130 Hz versus sham and show a certain state of alertness (increased activity in sensory and motor-related regions) mainly for 60 Hz. CONCLUSIONS:This study suggests the potential of 60 Hz PL mPFC DBS for the treatment of disorders associated with prefrontal hypofunction.
journal_name
Mol Imaging Bioljournal_title
Molecular imaging and biologyauthors
Parthoens J,Verhaeghe J,Stroobants S,Staelens Sdoi
10.1007/s11307-014-0757-9subject
Has Abstractpub_date
2014-12-01 00:00:00pages
838-45issue
6eissn
1536-1632issn
1860-2002journal_volume
16pub_type
杂志文章abstract:PURPOSE:Magnetic resonance imaging (MRI) with targeted contrast agents provides a promising means for diagnosis and treatment monitoring after cerebrovascular injury. Our goal was to demonstrate the feasibility of this approach to detect the neuroinflammatory biomarker intercellular adhesion molecule-1 (ICAM-1) after s...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-013-0617-z
更新日期:2013-08-01 00:00:00
abstract::Herpes simplex virus (HSV) oncolytic gene therapy is a promising treatment modality against cancer. We have demonstrated that androgen-induced cellular changes enhance oncolytic viral replication and improve efficacy in the treatment of androgen-dependent prostate cancer cell line. Imaging of changes in 2-deoxy-2-[F-1...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-005-0028-x
更新日期:2006-01-01 00:00:00
abstract::The blood flow through normal liver parenchyma and a pathologically proven hepatic region of focal nodular hyperplasia (FNH) of the lateral lobe, was measured in a single patient in a quantitative manner using regional dynamic positron emission tomography (PET) imaging with O-15 carbon dioxide (steady state) and O-15 ...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1016/s1536-1632(01)00002-6
更新日期:2002-05-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 临床试验,杂志文章
doi:10.1007/s11307-009-0247-7
更新日期:2010-04-01 00:00:00
abstract:PURPOSE:To evaluate prognostic value of pretreatment and posttreatment 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET) in advanced hypopharyngeal carcinoma treated by chemoradiotherapy. PROCEDURES:Thirty-one patients underwent a baseline FDG-PET and then FDG-PET was repeated 7 weeks after chemor...
journal_title:Molecular imaging and biology
pub_type: 临床试验,杂志文章
doi:10.1007/s11307-009-0229-9
更新日期:2010-01-01 00:00:00
abstract::This article reviews positron emission tomography (PET) studies of labeled enantiomers of different PET-tracers from the early 1980s. Comparative studies on stereoselective behavior of the transport of tracers across the blood-brain barrier (BBB) are discussed. Tracers are transported through the BBB into the brain, v...
journal_title:Molecular imaging and biology
pub_type: 杂志文章,评审
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更新日期:2004-09-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-013-0680-5
更新日期:2014-04-01 00:00:00
abstract:PURPOSE:Rats are important preclinical models for studying breast cancer metastasis and bone pathologies. In these research areas, fluorescence molecular tomography (FMT) is commonly applied for quantitative three-dimensional (3D) imaging in mice. However, uncertainties due to strong depth dependency of FMT signal and ...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-013-0698-8
更新日期:2014-06-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-018-1247-2
更新日期:2019-04-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-019-01417-3
更新日期:2020-06-01 00:00:00
abstract:PURPOSE:Preclinical dynamic brain PET studies remain hampered by the limitations related to the measurement of the arterial input function (AIF). In this regard, the use of an arterial-venous shunt is a promising method for the generation of real-time AIFs, but its application in longitudinal studies is still impeded b...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-020-01556-y
更新日期:2020-11-17 00:00:00
abstract:PURPOSE:The demand to optimize multidisciplinary treatment strategies in patients with benign and malignant diseases of the lung and other organs has led to the increased need of mechanistic proof-of-concept studies in preclinical small animal models using new non-invasive imaging methods. Therefore, we evaluated the r...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-015-0890-0
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:The aim of this study was to determine the effect of hyperinsulinemia on myocardial and hepatic distribution and metabolism of 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid ([18F]FTHA). PROCEDURES:Mitochondrial retention and intracellular lipid incorporation of [18F]FTHA were compared to that of [14C]-2-bromop...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-006-0042-7
更新日期:2006-07-01 00:00:00
abstract:PURPOSE:The transplantation of pancreatic islets is a promising cell replacement therapy for type 1 diabetes. Subcutaneous islet transplantation is currently under investigation as a means to circumvent problems associated with standard intra-hepatic islet transplantation. As modifications are being developed to improv...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-020-01560-2
更新日期:2020-11-02 00:00:00
abstract:PURPOSE:The objective of this study is to evaluate the therapeutic response to a novel monoclonal antibody targeting human extracellular matrix metalloproteinase inducer (EMMPRIN) in combination with gemcitabine in a pancreatic-tumor xenograft murine model by sequential 2-deoxy-2-[18F]fluoro-D-glucose ((18)F-FDG) posit...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-011-0491-5
更新日期:2012-04-01 00:00:00
abstract:PURPOSE:Our objective was to determine the lowest diagnostically effective dose for E-selectin-targeted poly n-butyl cyanoacrylate (PBCA)-shelled microbubbles and to apply it to monitor antiangiogenic therapy effects. PROCEDURES:PBCA-shelled microbubbles (MBs) coupled to an E-selectin-specific peptide were applied in ...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-015-0894-9
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:Non-invasive in vivo positron emission tomography (PET) provides high detection sensitivity in the nano- to picomolar range and in addition to other advantages, the possibility to absolutely quantify the acquired data. The present study focuses on the comparison of transmission data acquired with an X-ray compu...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-017-1074-x
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:Some patients with temporal lobe epilepsy (TLE) lack evidence of hippocampal sclerosis (HS) on MRI (HS-ve). We hypothesized that this group would have a different pattern of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-positron emission tomography (PET) hypometabolism than typical mesial TLE/HS patients with evidence...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-006-0073-0
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:Antibodies form an important class of cancer therapeutics, and there is intense interest in using them for imaging applications in diagnosis and monitoring of cancer treatment. Despite the expanding body of knowledge describing pharmacokinetic and pharmacodynamic interactions of antibodies in vivo, discrepancie...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-010-0397-7
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:The aim of this study was to examine strain differences in the uptake of Fenestra liver contrast agent (LC) in Nude, C57, and severe-combined immunodeficient (SCID) mice. In addition, we aimed to determine optimum dosing and to determine if there are positron emission tomography (PET)-attenuation effects on 2-d...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-007-0128-x
更新日期:2008-03-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 临床试验,杂志文章
doi:10.1007/s11307-012-0589-4
更新日期:2013-06-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-020-01572-y
更新日期:2021-01-14 00:00:00
abstract:PURPOSE:To investigate the prognostic performance of radiomics features, as extracted from positron emission tomography (PET) and X-ray computed tomography (CT) components of baseline 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) PET/CT images and integrated with clinical parameters, in patients with nasopharyngeal carcin...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-018-01304-3
更新日期:2019-10-01 00:00:00
abstract::2'-deoxy-2'-[(18)F]fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil ([(18)F]FEAU) is a promising radiolabeled nucleoside designed to monitor Herpes Simplex Virus Type 1 thymidine kinase (HSV1-tk) reporter gene expression with positron emission tomography (PET). However, the challenging radiosynthesis creates problems fo...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-007-0122-3
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:This study was undertaken to determine if artifacts from misalignment of cardiac emission to transmission data is present in adenosine stress studies and if the artifact could be reproduced by intentional misalignment in normal exams. PROCEDURES:Seventy consecutive 82Rb myocardial perfusion studies were review...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-008-0139-2
更新日期:2008-07-01 00:00:00
abstract::We evaluated the clinical utility of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) on the precise localization of pathologic foci and exclusion of normal variants in the imaging evaluation of patients with esophageal carcinoma. Combined PET/CT scans were performed i...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-006-0036-5
更新日期:2006-05-01 00:00:00
abstract:PURPOSE:Previously, some reports mentioned that magnetic resonance imaging (MRI) can predict histopathological features in primary CNS lymphoma (PCNSL). The reported data analyzed diffusion-weighted imaging findings. The aim of this study was to investigate possible associations between histopathological findings, such...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-017-1115-5
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:Visualization of tumor necrosis can determine tumor response to therapy. Our previous study showed that the rhein-based magnetic resonance imaging (MRI) contrast agent with alkane linker (GdL2) could clearly image tumor necrosis. However, its water solubility and cell safety needed to be improved. Herein, three...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-020-01551-3
更新日期:2020-10-13 00:00:00
abstract:PURPOSE:Repetitive imaging with microPET of endogenous albumin gene expression by using transgenic mice in which the Herpes Simplex Virus Type 1 thymidine kinase (HSV1-tk) reporter gene is driven by the albumin promoter (AL-HSV1-tk). METHODS:Transgenic mice were imaged repeatedly on a microPET scanner with approximate...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1016/s1095-0397(01)00071-1
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:This study was undertaken to explore the mechanisms underlying cognitive reserve in subjects with mild memory deficits by using positron emission tomography (PET). METHODS:Global cerebral blood flow (gCBF) and cerebrovascular reserve (CVR) measurements were performed in 15 elders (5 men, 10 women, 62-84, 71.8 ...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-006-0066-z
更新日期:2006-11-01 00:00:00