Assessment of Chemotherapy-Induced Organ Damage with Ga-68 Labeled Duramycin.

abstract：:This article reviews positron emission tomography (PET) studies of labeled enantiomers of different PET-tracers from the early 1980s. Comparative studies on stereoselective behavior of the transport of tracers across the blood-brain barrier (BBB) are discussed. Tracers are transported through the BBB into the brain, v...

journal_title：Molecular imaging and biology

authors： Luurtsema G,de Lange EC,Lammertsma AA,Franssen EJ

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:Cellular receptor targeted imaging agents present the potential to target extracellular molecular expression in cancerous lesions; however, the image contrast in vivo does not reflect the magnitude of overexpression expected from in vitro data. Here, the in vivo delivery and binding kinetics of epidermal growth...

journal_title：Molecular imaging and biology

authors： Samkoe KS,Sexton K,Tichauer KM,Hextrum SK,Pardesi O,Davis SC,O'Hara JA,Hoopes PJ,Hasan T,Pogue BW

更新日期：2012-08-01 00:00:00

abstract：PURPOSE:To develop a tool to measure the pH at the surfaces of individual cells. PROCEDURES:The SNARF pH-sensitive dye was conjugated to a pHLIP® peptide (pH-Low Insertion Peptide) that binds cellular membranes in tumor spheroids. A beam splitter allows simultaneous recording of two images (580 and 640 nm) by a CCD ca...

journal_title：Molecular imaging and biology

authors： Wei D,Engelman DM,Reshetnyak YK,Andreev OA

更新日期：2019-12-01 00:00:00

abstract：:The article "Pre-therapy Somatostatin Receptor-Based Heterogeneity Predicts Overall Survival in Pancreatic Neuroendocrine Tumor Patients Undergoing Peptide Receptor Radionuclide Therapy," was originally published electronically on the publisher's internet portal without open access. ...

journal_title：Molecular imaging and biology

authors： Werner RA,Ilhan H,Lehner S,Papp L,Zsótér N,Schatka I,Muegge DO,Javadi MS,Higuchi T,Buck AK,Bartenstein P,Bengel F,Essler M,Lapa C,Bundschuh RA

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:This research aimed to study the use of Cerenkov luminescence imaging (CLI) for non-Hodgkin's lymphoma (NHL) using 89Zr-rituximab positron emission tomography (PET) tracer with a humanized transgenic mouse model that expresses human CD20 and the correlation of CLI with PET. PROCEDURES:Zr-rituximab (2.6 MBq) wa...

journal_title：Molecular imaging and biology

authors： Natarajan A,Habte F,Liu H,Sathirachinda A,Hu X,Cheng Z,Nagamine CM,Gambhir SS

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:To determine the prevalence of viable myocardium in patients with ischemic cardiomyopathy and, to evaluate the value of three-dimensional (3-D) fusion imaging of myocardial scintigraphic and angiographic data to assign coronary artery lesions to the corresponding viable and nonviable myocardial territory. PROC...

journal_title：Molecular imaging and biology

authors： Schindler TH,Nitzsche EU,Magosaki N,Mix M,Facta AD,Prior JO,Solzbach U,Schelbert HR,Just H

更新日期：2004-05-01 00:00:00

abstract：PURPOSE:Imaging using positron emission tomography (PET) in the field of nuclear medicine is becoming increasingly important. The aim of this study was to develop a method for labeling of affibody molecules with radiocobalt for PET applications. PROCEDURES:The human epidermal growth factor receptors type 2 (HER2) bind...

journal_title：Molecular imaging and biology

authors： Wållberg H,Ahlgren S,Widström C,Orlova A

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to determine the effect of hyperinsulinemia on myocardial and hepatic distribution and metabolism of 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid ([18F]FTHA). PROCEDURES:Mitochondrial retention and intracellular lipid incorporation of [18F]FTHA were compared to that of [14C]-2-bromop...

journal_title：Molecular imaging and biology

authors： Ci X,Frisch F,Lavoie F,Germain P,Lecomte R,van Lier JE,Bénard F,Carpentier AC

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:To evaluate prognostic value of pretreatment and posttreatment 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET) in advanced hypopharyngeal carcinoma treated by chemoradiotherapy. PROCEDURES:Thirty-one patients underwent a baseline FDG-PET and then FDG-PET was repeated 7 weeks after chemor...

journal_title：Molecular imaging and biology

authors： Inohara H,Enomoto K,Tomiyama Y,Higuchi I,Inoue T,Hatazawa J

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:Carbon ion radiotherapy (CIRT) has been developed, and a phase I/II CIRT trial has been conducted in patients with adenocarcinoma in the head and neck region. We evaluated whether the L-methyl [11C]-methionine (MET) uptake could be an early predictor for local recurrence, metastasis, and the prognosis in patien...

journal_title：Molecular imaging and biology

authors： Hasebe M,Yoshikawa K,Ohashi S,Toubaru S,Kawaguchi K,Sato J,Mizoe J,Tsujii H

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:The aim of this study is to generate a four-class magnetic resonance imaging (MRI)-based attenuation map (μ-map) for attenuation correction of positron emission tomography (PET) data of the head area using a novel combination of short echo time (STE)/Dixon-MRI and a dedicated image segmentation method. PROCEDU...

journal_title：Molecular imaging and biology

authors： Khateri P,Saligheh Rad H,Jafari AH,Fathi Kazerooni A,Akbarzadeh A,Shojae Moghadam M,Aryan A,Ghafarian P,Ay MR

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:This study was undertaken to explore the mechanisms underlying cognitive reserve in subjects with mild memory deficits by using positron emission tomography (PET). METHODS:Global cerebral blood flow (gCBF) and cerebrovascular reserve (CVR) measurements were performed in 15 elders (5 men, 10 women, 62-84, 71.8 ...

journal_title：Molecular imaging and biology

authors： Boles Ponto LL,Magnotta VA,Moser DJ,Duff KM,Schultz SK

更新日期：2006-11-01 00:00:00

abstract：:Positron emission tomography (PET) or single photon emission computer tomography (SPECT) imaging provides the means to study neurochemical processes in vivo. These methods have been applied to examine monoaminergic and cholinergic changes in neurodegenerative disorders. These investigations have provided important ins...

journal_title：Molecular imaging and biology

authors： Bohnen NI,Frey KA

更新日期：2007-07-01 00:00:00

abstract：PURPOSE:The mTOR kinase inhibitor AZD8055 inhibits both mTORC1 and mTORC2 leading to disruption of glucose metabolism and proliferation pathways. This study assessed the impact of single and multiple doses of AZD8055 on the uptake of the glucose metabolism marker 2-deoxy-2-[(18) F]fluoro-D-glucose ([(18) F]FDG) and the...

journal_title：Molecular imaging and biology

authors： Keen HG,Ricketts SA,Maynard J,Logie A,Odedra R,Shannon AM,Wedge SR,Guichard SM

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:Repetitive imaging with microPET of endogenous albumin gene expression by using transgenic mice in which the Herpes Simplex Virus Type 1 thymidine kinase (HSV1-tk) reporter gene is driven by the albumin promoter (AL-HSV1-tk). METHODS:Transgenic mice were imaged repeatedly on a microPET scanner with approximate...

journal_title：Molecular imaging and biology

authors： Green LA,Yap CS,Nguyen K,Barrio JR,Namavari M,Satyamurthy N,Phelps ME,Sandgren EP,Herschman HR,Gambhir SS

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:Previous reports confirmed that (2S,4R)-4-[18F]Fluoroglutamine ([18F]GLN) accumulated in bone and bone marrow. This study investigates the potential of using [18F]GLN positron emission tomography (PET) to monitor changes of bone marrow activity after chemotherapy (myelosuppression). PROCEDURES:Bone marrow inhi...

journal_title：Molecular imaging and biology

authors： Zhu H,Liu F,Zhang Y,Yang J,Xu X,Guo X,Liu T,Li N,Zhu L,Kung HF,Yang Z

更新日期：2019-10-01 00:00:00

abstract：:This paper demonstrates the application of mutual information based coregistration of radionuclide and magnetic resonance imaging (MRI) in an effort to use multimodality imaging for noninvasive localization of stem cells grafted in the infarcted myocardium in rats. Radionuclide imaging such as single photon emission c...

journal_title：Molecular imaging and biology

authors： Shen D,Liu D,Cao Z,Acton PD,Zhou R

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Widely used in clinical practice, the maximum standardized uptake value (SUVmax) is a statistical index highly prone to physical and biological variations, which can lead to unpredictable errors. This study has a methodological aim: to identify a more robust SUV-based index representing the tracer accumulation....

journal_title：Molecular imaging and biology

authors： Baiocco S,Matteucci F,Mezzenga E,Caroli P,Di Iorio V,Cittanti C,Bevilacqua A,Paganelli G,Sarnelli A

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:We examine the feasibility of fluorescent imaging system for sentinel lymph node detection by using functionalized silica nanoparticles. MATERIALS AND METHODS:We developed a functionalized RITC-SiO(2) nanoparticles containing fluorescent dye, C(28)H(31)N(2)O(3)Cl (rhodamine B isothiocyanate) inside, and subseq...

journal_title：Molecular imaging and biology

authors： Jeon YH,Kim YH,Choi K,Piao JY,Quan B,Lee YS,Jeong JM,Chung JK,Lee DS,Lee MC,Lee J,Chung DS,Kang KW

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:This study was designed to estimate the clinical significance of the contrast-enhanced computed tomography (CT) textural features for prediction of survival in colorectal cancer (CRC) patients receiving targeted therapy (bevacizumab and cetuximab). PROCEDURES:The LifeX software was used to extract the textural...

journal_title：Molecular imaging and biology

authors： Zhao Y,Yang J,Luo M,Yang Y,Guo X,Zhang T,Hao J,Yao Y,Ma X

更新日期：2020-10-27 00:00:00

abstract：PURPOSE:Antibodies form an important class of cancer therapeutics, and there is intense interest in using them for imaging applications in diagnosis and monitoring of cancer treatment. Despite the expanding body of knowledge describing pharmacokinetic and pharmacodynamic interactions of antibodies in vivo, discrepancie...

journal_title：Molecular imaging and biology

authors： Thurber GM,Weissleder R

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:Radioimmunotherapy uses tumor-specific antibodies to deliver therapeutic radionuclides, but hematological toxicity due to the long serum half-life of intact antibodies remains a challenge. We evaluated a smaller antibody fragment, the minibody, with faster kinetics and a potentially improved therapeutic index. ...

journal_title：Molecular imaging and biology

authors： Tsai WK,Zettlitz KA,Dahlbom M,Reiter RE,Wu AM

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:Using three publicly available small-animal atlases (Sprague-Dawley rat, MOBY, and Digimouse), we built three articulated atlases and present several applications in the scope of molecular imaging. PROCEDURES:Major bones/bone groups were manually segmented for each atlas skeleton. Then, a kinematic model for e...

journal_title：Molecular imaging and biology

authors： Khmelinskii A,Baiker M,Kaijzel EL,Chen J,Reiber JH,Lelieveldt BP

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:For targeted imaging and therapy of hepatocellular carcinoma (HCC), we established a chimeric promoter (EIIAPA) containing alpha-fetoprotein (AFP) promoter and hepatitis B virus enhancer II (EIIA) to control downstream expression of reporter and therapeutic genes. PROCEDURES:We combined AFP promoter and EIIA t...

journal_title：Molecular imaging and biology

authors： Hsieh YJ,Chen FD,Ke CC,Wang HE,Huang CJ,Hou MF,Lin KP,Gelovani JG,Liu RS

更新日期：2012-08-01 00:00:00

abstract：PURPOSE:The vesicular acetylcholine transporter (VAChT) is a specific biomarker for imaging presynaptic cholinergic neurons. The syntheses and C-11 labeling of two potent enantiopure VAChT inhibitors are reported here. PROCEDURES:Two VAChT inhibitors, (±)-2 and (±)-6, were successfully synthesized. A chiral HPLC colum...

journal_title：Molecular imaging and biology

authors： Padakanti PK,Zhang X,Li J,Parsons SM,Perlmutter JS,Tu Z

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:The demand to optimize multidisciplinary treatment strategies in patients with benign and malignant diseases of the lung and other organs has led to the increased need of mechanistic proof-of-concept studies in preclinical small animal models using new non-invasive imaging methods. Therefore, we evaluated the r...

journal_title：Molecular imaging and biology

authors： Flechsig P,Kratochwil C,Warth A,Rath D,Eichwald V,Huber PE,Kauczor HU,Haberkorn U,Giesel FL

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:The objective of this study is to evaluate the therapeutic response to a novel monoclonal antibody targeting human extracellular matrix metalloproteinase inducer (EMMPRIN) in combination with gemcitabine in a pancreatic-tumor xenograft murine model by sequential 2-deoxy-2-[18F]fluoro-D-glucose ((18)F-FDG) posit...

journal_title：Molecular imaging and biology

authors： Shah N,Zhai G,Knowles JA,Stockard CR,Grizzle WE,Fineberg N,Zhou T,Zinn KR,Rosenthal EL,Kim H

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:Sodium [(18)F]fluoride (Na[(18)F]F) positron emission tomography with integrated computed tomography (PET/CT) has not been used for imaging myocardial infarction (MI). Here, we aimed to investigate the Na[(18)F]F PET/CT features of MI in a rat model. PROCEDURES:MI was induced by coronary artery ligation in 8-w...

journal_title：Molecular imaging and biology

authors： Han JH,Lim SY,Lee MS,Lee WW

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:Our objective was to determine the lowest diagnostically effective dose for E-selectin-targeted poly n-butyl cyanoacrylate (PBCA)-shelled microbubbles and to apply it to monitor antiangiogenic therapy effects. PROCEDURES:PBCA-shelled microbubbles (MBs) coupled to an E-selectin-specific peptide were applied in ...

journal_title：Molecular imaging and biology

authors： Spivak I,Rix A,Schmitz G,Fokong S,Iranzo O,Lederle W,Kiessling F

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:High-dose (HD) cytosine arabinoside (ara-C) is a major treatment in acute myeloblastic leukemia (AML) that can lead to cerebellar complications, although electroencephalogram, computed tomography, and magnetic resonance imaging remain normal. We conducted a prospective study to evaluate brain perfusion with sin...

journal_title：Molecular imaging and biology

authors： Modzelewski R,Lepretre S,Martinaud O,Hannequin D,Hitzel A,Habert MO,Tilly H,Vera P

更新日期：2011-08-01 00:00:00