Abstract:
PURPOSE:The objective of this study is to evaluate the therapeutic response to a novel monoclonal antibody targeting human extracellular matrix metalloproteinase inducer (EMMPRIN) in combination with gemcitabine in a pancreatic-tumor xenograft murine model by sequential 2-deoxy-2-[18F]fluoro-D-glucose ((18)F-FDG) positron emission tomography/computed tomgraphy (PET/CT) imaging. PROCEDURES:Four groups of SCID mice bearing orthotopic pancreatic tumor xenografts were injected with phosphate-buffered saline, gemcitabine (120 mg/kg BW), anti-EMMPRIN antibody (0.2 mg), or combination, respectively, twice weekly for 2 weeks, while (18)F-FDG PET/CT imaging was performed weekly for 3 weeks. Changes in mean standardized uptake value (SUV(mean)) of (18)F-FDG and volume of tumors were determined. RESULTS:The tumor SUV(mean) change in the group receiving combination therapy was significantly lower than those of the other groups. Tumor-volume changes of groups treated with anti-EMMPRIN monotherapy or combined therapy were significantly lower than that of the control group. CONCLUSIONS:These data provide support for clinical studies of anti-EMMPRIN therapy with gemcitabine for pancreatic cancer treatment.
journal_name
Mol Imaging Bioljournal_title
Molecular imaging and biologyauthors
Shah N,Zhai G,Knowles JA,Stockard CR,Grizzle WE,Fineberg N,Zhou T,Zinn KR,Rosenthal EL,Kim Hdoi
10.1007/s11307-011-0491-5subject
Has Abstractpub_date
2012-04-01 00:00:00pages
237-44issue
2eissn
1536-1632issn
1860-2002journal_volume
14pub_type
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journal_title:Molecular imaging and biology
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journal_title:Molecular imaging and biology
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journal_title:Molecular imaging and biology
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更新日期:2005-01-01 00:00:00
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