In vivo imaging of sentinel nodes using fluorescent silica nanoparticles in living mice.

abstract：:The cyclooxygenase-2 (COX-2) gene plays a role in a wide variety of normal physiologic pathways and is a major target of pharmacologic intervention in a large number of pathophysiologic contexts, including pain, fever, inflammation, and cancer. Expression of the COX-2 gene is induced in a wide range of cells, in respo...

journal_title：Molecular imaging and biology

authors： Nguyen JT,Machado H,Herschman HR

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:Some patients with temporal lobe epilepsy (TLE) lack evidence of hippocampal sclerosis (HS) on MRI (HS-ve). We hypothesized that this group would have a different pattern of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-positron emission tomography (PET) hypometabolism than typical mesial TLE/HS patients with evidence...

journal_title：Molecular imaging and biology

authors： Carne RP,Cook MJ,MacGregor LR,Kilpatrick CJ,Hicks RJ,O'Brien TJ

更新日期：2007-01-01 00:00:00

abstract：:This article reviews positron emission tomography (PET) studies of labeled enantiomers of different PET-tracers from the early 1980s. Comparative studies on stereoselective behavior of the transport of tracers across the blood-brain barrier (BBB) are discussed. Tracers are transported through the BBB into the brain, v...

journal_title：Molecular imaging and biology

authors： Luurtsema G,de Lange EC,Lammertsma AA,Franssen EJ

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:The aim of this study was to determine the effect of hyperinsulinemia on myocardial and hepatic distribution and metabolism of 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid ([18F]FTHA). PROCEDURES:Mitochondrial retention and intracellular lipid incorporation of [18F]FTHA were compared to that of [14C]-2-bromop...

journal_title：Molecular imaging and biology

authors： Ci X,Frisch F,Lavoie F,Germain P,Lecomte R,van Lier JE,Bénard F,Carpentier AC

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:To evaluate the utility of three-dimensional (3D) amide proton transfer-weighted (APTw) imaging for differentiation of endometrial adenocarcinoma and uterine benign lesions. PROCEDURES:This prospective study enrolled 22 normal volunteers and 113 patients with suspicious uterine lesions, including endometrial a...

journal_title：Molecular imaging and biology

authors： Li Y,Lin CY,Qi YF,Wang XQ,Chen B,Zhou HL,Ren J,Yang JJ,Xiang Y,He YL,Xue HD,Jin ZY

更新日期：2020-11-13 00:00:00

abstract：:Due to their remarkable selectivity and specificity for cancer biomarkers, immunoconjugates have emerged as extremely promising vectors for the delivery of diagnostic radioisotopes and fluorophores to malignant tissues. Paradoxically, however, these tools for precision medicine are synthesized in a remarkably imprecis...

journal_title：Molecular imaging and biology

authors： Adumeau P,Sharma SK,Brent C,Zeglis BM

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:Prostate-specific membrane antigen (PSMA) continues to be the hallmark biomarker for prostate cancer as it is expressed on nearly all prostatic tumors. In addition, increased PSMA expression correlates with castration resistance and progression to the metastatic stage of the disease. Recently, we combined both ...

journal_title：Molecular imaging and biology

authors： Ling X,Latoche JD,Choy CJ,Kurland BF,Laymon CM,Wu Y,Salamacha N,Shen D,Geruntho JJ,Rigatti LH,Windish HP,Langton-Webster B,Berkman CE,Anderson CJ

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:The purpose of this study is to evaluate if the differential exchange rates with bulk water between amine and amide protons can be exploited using chemical exchange saturation transfer magnetic resonance (CEST-MR) to monitor the release of glutamate induced by carboxypeptidase G2 (CPG2), an enzyme utilized in c...

journal_title：Molecular imaging and biology

authors： Jamin Y,Eykyn TR,Poon E,Springer CJ,Robinson SP

更新日期：2014-04-01 00:00:00

abstract：PURPOSE:To evaluate prognostic value of pretreatment and posttreatment 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET) in advanced hypopharyngeal carcinoma treated by chemoradiotherapy. PROCEDURES:Thirty-one patients underwent a baseline FDG-PET and then FDG-PET was repeated 7 weeks after chemor...

journal_title：Molecular imaging and biology

authors： Inohara H,Enomoto K,Tomiyama Y,Higuchi I,Inoue T,Hatazawa J

更新日期：2010-01-01 00:00:00

abstract：:Positron emission tomography (PET) or single photon emission computer tomography (SPECT) imaging provides the means to study neurochemical processes in vivo. These methods have been applied to examine monoaminergic and cholinergic changes in neurodegenerative disorders. These investigations have provided important ins...

journal_title：Molecular imaging and biology

authors： Bohnen NI,Frey KA

更新日期：2007-07-01 00:00:00

abstract：PURPOSE:The transplantation of pancreatic islets is a promising cell replacement therapy for type 1 diabetes. Subcutaneous islet transplantation is currently under investigation as a means to circumvent problems associated with standard intra-hepatic islet transplantation. As modifications are being developed to improv...

journal_title：Molecular imaging and biology

authors： Komatsu H,Gonzalez N,Ortiz J,Rawson J,Omori K,Kandeel F,Mullen Y

更新日期：2020-11-02 00:00:00

abstract：:Noninvasive conventional imaging methods are established technologies in modern drug discovery and development providing valuable morphological, physiological, and metabolic information to characterize disease phenotypes, to evaluate the efficacy of therapy and to identify and develop potential biomarkers for clinical...

journal_title：Molecular imaging and biology

authors： Rudin M,Rausch M,Stoeckli M

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:The demand to optimize multidisciplinary treatment strategies in patients with benign and malignant diseases of the lung and other organs has led to the increased need of mechanistic proof-of-concept studies in preclinical small animal models using new non-invasive imaging methods. Therefore, we evaluated the r...

journal_title：Molecular imaging and biology

authors： Flechsig P,Kratochwil C,Warth A,Rath D,Eichwald V,Huber PE,Kauczor HU,Haberkorn U,Giesel FL

更新日期：2016-04-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) requires synthesis of contrast media bearing targeting groups and numerous gadolinium chelating groups generating high relaxivity. This paper explores the results of linking the gadolinium chelates to the targeting group, a protein molecule, via various types of linkers. Polycondensate...

journal_title：Molecular imaging and biology

authors： Pashkunova-Martic I,Kremser C,Galanski M,Schluga P,Arion V,Debbage P,Jaschke W,Keppler B

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:To evaluate the clinical significance of differences in 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET) lymph node standardized uptake values (SUV) in human immunodeficiency virus (HIV) infection using iterative reconstruction with segmented attenuation correction (IR SAC) compared to fil...

journal_title：Molecular imaging and biology

authors： Chin BB,Lyengar S,Sabundayo BP,Schwartz D

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:The aim of our study was to modify an aminosilane-coated superparamagnetic nanoparticle for cell labeling and subsequent multimodal imaging using magnetic resonance imaging (MRI), positron emission tomography (PET), and fluorescent imaging in vivo. PROCEDURES:We covalently bound the transfection agent HIV-1 ta...

journal_title：Molecular imaging and biology

authors： Stelter L,Pinkernelle JG,Michel R,Schwartländer R,Raschzok N,Morgul MH,Koch M,Denecke T,Ruf J,Bäumler H,Jordan A,Hamm B,Sauer IM,Teichgräber U

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:The A1AR antagonist 8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine ([(18)F]CPFPX) has recently been shown to be a suitable radiotracer for quantitative in vivo imaging of the A1 adenosine receptor (A1AR) in rats. The present study evaluates the reproducibility of non-invasive longitudinal A1AR studies with [...

journal_title：Molecular imaging and biology

authors： Kroll T,Elmenhorst D,Weisshaupt A,Beer S,Bauer A

更新日期：2014-10-01 00:00:00

abstract：PURPOSE:Inflammation plays a key role in the progression of intervertebral disk (IVD) herniation and associated low back pain. However, real-time spatial diagnosis of inflammation associated with acute disk herniation has not been investigated. We sought to detect local neutrophil and macrophage infiltration near disk ...

journal_title：Molecular imaging and biology

authors： Xiao L,Ding M,Zhang Y,Chordia M,Pan D,Shimer A,Shen F,Glover D,Jin L,Li X

更新日期：2017-10-01 00:00:00

abstract：:Amyloid plaques are highly heterogeneous in content, size, density, and macromolecular crowding, as they are composed of masses of fibrils and other cellular material. Given this target architecture, the aggregated microenvironment offers a unique imaging target for ligands and positron emission tomography (PET) molec...

journal_title：Molecular imaging and biology

authors： Shoghi-Jadid K,Barrio JR,Kepe V,Huang SC

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:Recent researches have demonstrated the value of using 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) imaging to reveal the hypothyroidism-related damages in local brain regions. However, the influence of hypothyroidism on the entire brain network is barely studied. This study foc...

journal_title：Molecular imaging and biology

authors： Wang H,Tan Z,Zheng Q,Yu J

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:The tyrosine kinase receptor Axl is overexpressed in various types of cancer and correlated with cancer malignancy. Selective Axl blockade reduces tumor growth and metastasis. The purpose of this study was to examine whether the humanized anti-Axl antibody humanized 173 (h173) labeled with near-infrared fluores...

journal_title：Molecular imaging and biology

authors： Li D,Liu S,Liu R,Park R,Yu H,Krasnoperov V,Gill PS,Li Z,Shan H,Conti PS

更新日期：2014-08-01 00:00:00

abstract：:This article was updated to correct the spelling of Hongkai Wang's name: it is correct as displayed here. ...

journal_title：Molecular imaging and biology

authors： Wang H,Tan Z,Zheng Q,Yu J

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:This research aimed to study the use of Cerenkov luminescence imaging (CLI) for non-Hodgkin's lymphoma (NHL) using 89Zr-rituximab positron emission tomography (PET) tracer with a humanized transgenic mouse model that expresses human CD20 and the correlation of CLI with PET. PROCEDURES:Zr-rituximab (2.6 MBq) wa...

journal_title：Molecular imaging and biology

authors： Natarajan A,Habte F,Liu H,Sathirachinda A,Hu X,Cheng Z,Nagamine CM,Gambhir SS

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:This study was designed to estimate the clinical significance of the contrast-enhanced computed tomography (CT) textural features for prediction of survival in colorectal cancer (CRC) patients receiving targeted therapy (bevacizumab and cetuximab). PROCEDURES:The LifeX software was used to extract the textural...

journal_title：Molecular imaging and biology

authors： Zhao Y,Yang J,Luo M,Yang Y,Guo X,Zhang T,Hao J,Yao Y,Ma X

更新日期：2020-10-27 00:00:00

abstract：PURPOSE:Manganese ion has been extensively used as a magnetic resonance imaging (MRI) contrast agent in preclinical studies to assess tissue anatomy, function, and neuronal connectivity. Unfortunately, its use in human studies has been limited by cellular toxicity and the need to use a very low dose. The much higher se...

journal_title：Molecular imaging and biology

authors： Saar G,Millo CM,Szajek LP,Bacon J,Herscovitch P,Koretsky AP

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:To provide reliable and reproducible heart/mediastinum (H/M) ratio cut-off values for parkinsonian disorders using two machine learning techniques, Support Vector Machines (SVM) and Random Forest (RF) classifier, applied to [123I]MIBG cardiac scintigraphy. PROCEDURES:We studied 85 subjects, 50 with idiopathic ...

journal_title：Molecular imaging and biology

authors： Nuvoli S,Spanu A,Fravolini ML,Bianconi F,Cascianelli S,Madeddu G,Palumbo B

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:Antibodies form an important class of cancer therapeutics, and there is intense interest in using them for imaging applications in diagnosis and monitoring of cancer treatment. Despite the expanding body of knowledge describing pharmacokinetic and pharmacodynamic interactions of antibodies in vivo, discrepancie...

journal_title：Molecular imaging and biology

authors： Thurber GM,Weissleder R

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:Carbon ion radiotherapy (CIRT) has been developed, and a phase I/II CIRT trial has been conducted in patients with adenocarcinoma in the head and neck region. We evaluated whether the L-methyl [11C]-methionine (MET) uptake could be an early predictor for local recurrence, metastasis, and the prognosis in patien...

journal_title：Molecular imaging and biology

authors： Hasebe M,Yoshikawa K,Ohashi S,Toubaru S,Kawaguchi K,Sato J,Mizoe J,Tsujii H

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:Nowadays, 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET)/X-ray computed tomography (CT) is considered the best available technique to in vivo determination of human BAT volume. The most used Hounsfield unit (HU) threshold for BAT quantification is from - 250 to - 50 HU. Therefore,...

journal_title：Molecular imaging and biology

authors： Martinez-Tellez B,Sanchez-Delgado G,Boon MR,Rensen PCN,Llamas-Elvira JM,Ruiz JR

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:Dynamic positron emission tomography (PET) protocols allow for accurate quantification of [18F]flortaucipir-specific binding. However, dynamic acquisitions can be challenging given the long required scan duration of 130 min. The current study assessed the effect of shorter scan protocols for [18F]flortaucipir o...

journal_title：Molecular imaging and biology

authors： Tuncel H,Visser D,Yaqub M,Timmers T,Wolters EE,Ossenkoppele R,van der Flier WM,van Berckel BNM,Boellaard R,Golla SSV

更新日期：2021-01-26 00:00:00