Distribution of Brown Adipose Tissue Radiodensity in Young Adults: Implications for Cold [18F]FDG-PET/CT Analyses.

abstract：PURPOSE:To demonstrate the efficacy of repeated, non-invasive optical imaging of reporter gene expression in monitoring the ability of bi-specific recombinant molecules (i) to "transductionally untarget" adenovirus from Coxsackie and Adenovirus Receptor (CAR)-dependent infection of normal tissue and (ii) to "transducti...

journal_title：Molecular imaging and biology

authors： Liang Q,Yamamoto M,Curiel DT,Herschman HR

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:The tyrosine kinase receptor Axl is overexpressed in various types of cancer and correlated with cancer malignancy. Selective Axl blockade reduces tumor growth and metastasis. The purpose of this study was to examine whether the humanized anti-Axl antibody humanized 173 (h173) labeled with near-infrared fluores...

journal_title：Molecular imaging and biology

authors： Li D,Liu S,Liu R,Park R,Yu H,Krasnoperov V,Gill PS,Li Z,Shan H,Conti PS

更新日期：2014-08-01 00:00:00

abstract：PURPOSE:To evaluate the utility of three-dimensional (3D) amide proton transfer-weighted (APTw) imaging for differentiation of endometrial adenocarcinoma and uterine benign lesions. PROCEDURES:This prospective study enrolled 22 normal volunteers and 113 patients with suspicious uterine lesions, including endometrial a...

journal_title：Molecular imaging and biology

authors： Li Y,Lin CY,Qi YF,Wang XQ,Chen B,Zhou HL,Ren J,Yang JJ,Xiang Y,He YL,Xue HD,Jin ZY

更新日期：2020-11-13 00:00:00

abstract：:In vivo imaging of the central nervous system (CNS) neuroreceptors in humans began was used in the early 1980s. Now, some twenty years later, the success of radiopharmaceutical imaging is still often one based on empiricism and serendipity. Nevertheless, a number of factors can be identified based on the robot experie...

journal_title：Molecular imaging and biology

authors： Wong DF,Pomper MG

更新日期：2003-11-01 00:00:00

abstract：:The cyclooxygenase-2 (COX-2) gene plays a role in a wide variety of normal physiologic pathways and is a major target of pharmacologic intervention in a large number of pathophysiologic contexts, including pain, fever, inflammation, and cancer. Expression of the COX-2 gene is induced in a wide range of cells, in respo...

journal_title：Molecular imaging and biology

authors： Nguyen JT,Machado H,Herschman HR

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:Previous studies has demonstrated the utility of human epidermal growth factor receptor type 2 (HER2) as an attractive target for cancer molecular imaging and therapy. An affibody protein with strong binding affinity for HER2, ZHER2:342, has been reported. Various methods of chelator conjugation for radiolabeli...

journal_title：Molecular imaging and biology

authors： Qi S,Hoppmann S,Xu Y,Cheng Z

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:We developed a bimolecular fluorescence complementation (BiFC) strategy using Dronpa, a new fluorescent protein with reversible photoswitching activity and fast responsibility to light, to monitor protein-protein interactions in cells. PROCEDURES:Dronpa was split at residue Glu164 in order to generate two Dron...

journal_title：Molecular imaging and biology

authors： Lee YR,Park JH,Hahm SH,Kang LW,Chung JH,Nam KH,Hwang KY,Kwon IC,Han YS

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:Non-invasive in vivo positron emission tomography (PET) provides high detection sensitivity in the nano- to picomolar range and in addition to other advantages, the possibility to absolutely quantify the acquired data. The present study focuses on the comparison of transmission data acquired with an X-ray compu...

journal_title：Molecular imaging and biology

authors： Mannheim JG,Schmid AM,Pichler BJ

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:Manganese ion has been extensively used as a magnetic resonance imaging (MRI) contrast agent in preclinical studies to assess tissue anatomy, function, and neuronal connectivity. Unfortunately, its use in human studies has been limited by cellular toxicity and the need to use a very low dose. The much higher se...

journal_title：Molecular imaging and biology

authors： Saar G,Millo CM,Szajek LP,Bacon J,Herscovitch P,Koretsky AP

更新日期：2018-08-01 00:00:00

abstract：:Morphological imaging techniques are typically used in the anti-cancer drug efficacy evaluation process. However, these techniques can evaluate the therapeutic efficacy only when the tumor shows anatomic changes-usually at later stages, when the therapeutic effects are poor. In contrast, molecular imaging allows nonin...

journal_title：Molecular imaging and biology

authors： Liang Q,Kong L,Zhu X,Du Y,Tian J

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:To investigate the prognostic performance of radiomics features, as extracted from positron emission tomography (PET) and X-ray computed tomography (CT) components of baseline 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) PET/CT images and integrated with clinical parameters, in patients with nasopharyngeal carcin...

journal_title：Molecular imaging and biology

authors： Lv W,Yuan Q,Wang Q,Ma J,Feng Q,Chen W,Rahmim A,Lu L

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:The aim of this study is to evaluate the impact of different scatter correction strategies on quantification of high-resolution research tomograph (HRRT) data for three tracers covering a wide range in kinetic profiles. PROCEDURES:Healthy subjects received dynamic HRRT scans using either (R)-[(11)C]verapamil (...

journal_title：Molecular imaging and biology

authors： Mansor S,Boellaard R,Huisman MC,van Berckel BN,Schuit RC,Windhorst AD,Lammertsma AA,van Velden FH

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:Positron emission tomography (PET) with 2-deoxy-2-[18F]fluoro-D-glucose (FDG) has been used for various cancers, but reproducibility of common utilized semi-quantitative parameters, such as the maximal single pixel standardized uptake value (SUV) and effective glycolytic volume (EGV), remains unknown. Knowledge...

journal_title：Molecular imaging and biology

authors： Nakamoto Y,Zasadny KR,Minn H,Wahl RL

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:This study aims to determine a lumped constant (LC) value that can be applied to the 2-deoxy-2[18F]fluoro-D-glucose positron emission tomography (FDG-PET) study to yield a physiological value of cerebral metabolic rate of glucose (CMR(glc)) in normal brain. PROCEDURES:We developed a more robust method for dete...

journal_title：Molecular imaging and biology

authors： Wu HM,Bergsneider M,Glenn TC,Yeh E,Hovda DA,Phelps ME,Huang SC

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:Repetitive imaging with microPET of endogenous albumin gene expression by using transgenic mice in which the Herpes Simplex Virus Type 1 thymidine kinase (HSV1-tk) reporter gene is driven by the albumin promoter (AL-HSV1-tk). METHODS:Transgenic mice were imaged repeatedly on a microPET scanner with approximate...

journal_title：Molecular imaging and biology

authors： Green LA,Yap CS,Nguyen K,Barrio JR,Namavari M,Satyamurthy N,Phelps ME,Sandgren EP,Herschman HR,Gambhir SS

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:To assess a novel radiotracer aluminum [18F]fluoride-1,4,7-triazacyclononane-triacetic acid-pegylated dimeric RGD ([18F]ALF-NOTA-PRGD2, denoted as [18F]Alfatide) for positron emission tomography (PET)/X-ray computed tomography (CT) and explore the relationships between clinicopathological characteristics and ma...

journal_title：Molecular imaging and biology

authors： Dong Y,Wei Y,Chen G,Huang Y,Song P,Liu S,Zheng J,Cheng M,Yuan S

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:The simplified reference tissue model (SRTM) is commonly applied for the quantification of brain positron emission tomography (PET) studies, particularly because it avoids arterial cannulation. SRTM requires a validated reference region which is obtained by baseline-blocking or displacement studies. Once a refe...

journal_title：Molecular imaging and biology

authors： de Vries BM,Timmers T,Wolters EE,Ossenkoppele R,Verfaillie SCJ,Schuit RC,Scheltens P,van der Flier WM,Windhorst AD,van Berckel BNM,Boellaard R,Golla SSV

更新日期：2021-01-14 00:00:00

abstract：PURPOSE:We recently reported that high thymidine phosphorylase (TP) expression is accompanied by low tumor thymidine concentration and high 3'-deoxy-3'-[18F]fluorothymidine ([18F]FLT) uptake in four untreated lung cancer xenografts. Here, we investigated whether this relationship also holds true for a broader range of ...

journal_title：Molecular imaging and biology

authors： Schelhaas S,Heinzmann K,Honess DJ,Smith DM,Keen H,Heskamp S,Witney TH,Besret L,Doblas S,Griffiths JR,Aboagye EO,Jacobs AH

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was utilized in postmortem imaging of gadolinium (Gd) spatial distribution in a mouse tumor model postadministration of PEGylated Gd liposomal nanoparticles. PROCEDURES:PEGylated liposomal nanoparticles were formulated using a paramagnetic...

journal_title：Molecular imaging and biology

authors： Kamaly N,Pugh JA,Kalber TL,Bunch J,Miller AD,McLeod CW,Bell JD

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:Antibodies form an important class of cancer therapeutics, and there is intense interest in using them for imaging applications in diagnosis and monitoring of cancer treatment. Despite the expanding body of knowledge describing pharmacokinetic and pharmacodynamic interactions of antibodies in vivo, discrepancie...

journal_title：Molecular imaging and biology

authors： Thurber GM,Weissleder R

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:The aim of this work is to investigate the impact of tissue classification in magnetic resonance imaging (MRI)-guided positron emission tomography (PET) attenuation correction (AC) for whole-body (WB) Patlak net uptake rate constant (Ki) imaging in PET/MRI studies. PROCEDURES:WB dynamic PET/CT data were acquir...

journal_title：Molecular imaging and biology

authors： Zhuang M,Karakatsanis NA,Dierckx RAJO,Zaidi H

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to assess the value of the spatial heterogeneity of somatostatin receptor (SSR) volume, quantified as asphericity (ASP), and to predict response to peptide receptor radionuclide therapy (PRRT) in patients with metastatic gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN). P...

journal_title：Molecular imaging and biology

authors： Wetz C,Apostolova I,Steffen IG,Hofheinz F,Furth C,Kupitz D,Ruf J,Venerito M,Klose S,Amthauer H

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:In this study, the contrasting properties of human serum albumin nanoparticles (HSA-NPs) loaded with gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and coated with transferrin in MRI in mice are evaluated. PROCEDURES:HSA-NPs were conjugated with Gd-DTPA (Gd-HSA-NPs) and coupled with transferrin (Gd-H...

journal_title：Molecular imaging and biology

authors： Korkusuz H,Ulbrich K,Welzel K,Koeberle V,Watcharin W,Bahr U,Chernikov V,Knobloch T,Petersen S,Huebner F,Ackermann H,Gelperina S,Kromen W,Hammerstingl R,Haupenthal J,Gruenwald F,Fiehler J,Zeuzem S,Kreuter J,Vogl TJ,

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:Vulnerable plaques are key factors for ischemic diseases. Thus, their precise detection is necessary for the diagnosis of such diseases. Immunoglobulin G (IgG)-based imaging probes have been developed for imaging biomolecules related to plaque formation for the diagnosis of atherosclerosis. However, IgG accumul...

journal_title：Molecular imaging and biology

authors： Shimizu Y,Hanzawa H,Zhao Y,Fukura S,Nishijima KI,Sakamoto T,Zhao S,Tamaki N,Ogawa M,Kuge Y

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:The sigma-2 (σ(2)) receptor is a potential biomarker of proliferative status of solid tumors. Specific synthetic probes using N-substituted-9-azabicyclo [3.3.1]nonan-3α-yl carbamate analogs have been designed and implemented for experimental cancer diagnosis and therapy. PROCEDURES:We employed the fluorescentl...

journal_title：Molecular imaging and biology

authors： Haller JL,Panyutin I,Chaudhry A,Zeng C,Mach RH,Frank JA

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:Tc-99m methylene diphosphonate ([99mTc]MDP) is an in vivo bone imaging agent that also accumulates in injured skeletal muscle cells. The objective of this study was to investigate if [99mTc]MDP could be used to detect muscle injury in the mdx mouse model of Duchenne muscular dystrophy (DMD). PROCEDURES:Static ...

journal_title：Molecular imaging and biology

authors： Gaut C,Sullivan JM,Biscaro B,Soares EJ,Nicholson K,Hoppin J,Verma A

更新日期：2020-06-01 00:00:00

abstract：:The Commercial Innovation of the Year Award went to Emile Beaulieu of Photon etc. for their work. ...

journal_title：Molecular imaging and biology

authors： Lewis JS,Membreno R

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:The A1AR antagonist 8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine ([(18)F]CPFPX) has recently been shown to be a suitable radiotracer for quantitative in vivo imaging of the A1 adenosine receptor (A1AR) in rats. The present study evaluates the reproducibility of non-invasive longitudinal A1AR studies with [...

journal_title：Molecular imaging and biology

authors： Kroll T,Elmenhorst D,Weisshaupt A,Beer S,Bauer A

更新日期：2014-10-01 00:00:00

abstract：PURPOSE:The demand to optimize multidisciplinary treatment strategies in patients with benign and malignant diseases of the lung and other organs has led to the increased need of mechanistic proof-of-concept studies in preclinical small animal models using new non-invasive imaging methods. Therefore, we evaluated the r...

journal_title：Molecular imaging and biology

authors： Flechsig P,Kratochwil C,Warth A,Rath D,Eichwald V,Huber PE,Kauczor HU,Haberkorn U,Giesel FL

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:The aim of our study was to modify an aminosilane-coated superparamagnetic nanoparticle for cell labeling and subsequent multimodal imaging using magnetic resonance imaging (MRI), positron emission tomography (PET), and fluorescent imaging in vivo. PROCEDURES:We covalently bound the transfection agent HIV-1 ta...

journal_title：Molecular imaging and biology

authors： Stelter L,Pinkernelle JG,Michel R,Schwartländer R,Raschzok N,Morgul MH,Koch M,Denecke T,Ruf J,Bäumler H,Jordan A,Hamm B,Sauer IM,Teichgräber U

更新日期：2010-01-01 00:00:00