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Transferrin-coated gadolinium nanoparticles as MRI contrast agent.

Abstract：

PURPOSE:In this study, the contrasting properties of human serum albumin nanoparticles (HSA-NPs) loaded with gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and coated with transferrin in MRI in mice are evaluated. PROCEDURES:HSA-NPs were conjugated with Gd-DTPA (Gd-HSA-NPs) and coupled with transferrin (Gd-HSA-NP-Tf). Mice underwent MRI before or after injection of Gd-DTPA, Gd-HSA-NP, or Gd-HSA-NP-Tf. RESULTS:All the studied contrast agents provided a contrast enhancement (CE) in the blood, heart muscle, and liver. Compared to Gd-DTPA, CE with HSA-NP was achieved at lower Gd doses. Gd-HSA-NP-Tf yielded significantly higher CE than Gd-HSA-NP in the skeletal muscle, blood, cardiac muscle, and liver (p < 0.05). Gd-HSA-NP-Tf achieved a significantly higher CE than Gd-HSA-NP and Gd-DTPA in the blood, cardiac muscle, and liver (p < 0.05). In the brain, only Gd-HSA-NP-Tf was found to cause a significant CE (p < 0.05). CONCLUSIONS:The Gd-HSA nanoparticles have potential as MRI contrast agents. In particular, Gd-HSA-NP-Tf has a potential as a specific contrast agent for the brain, while the blood-brain barrier is still intact, as well as in the heart, liver, and skeletal muscle.

journal_name

Mol Imaging Biol

journal_title

Molecular imaging and biology

authors

Korkusuz H,Ulbrich K,Welzel K,Koeberle V,Watcharin W,Bahr U,Chernikov V,Knobloch T,Petersen S,Huebner F,Ackermann H,Gelperina S,Kromen W,Hammerstingl R,Haupenthal J,Gruenwald F,Fiehler J,Zeuzem S,Kreuter J,Vogl TJ,

doi

10.1007/s11307-012-0579-6

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

148-54

issue

2

eissn

1536-1632

issn

1860-2002

journal_volume

15

pub_type

杂志文章

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