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Global cerebral blood flow in relation to cognitive performance and reserve in subjects with mild memory deficits.

Abstract：

PURPOSE:This study was undertaken to explore the mechanisms underlying cognitive reserve in subjects with mild memory deficits by using positron emission tomography (PET). METHODS:Global cerebral blood flow (gCBF) and cerebrovascular reserve (CVR) measurements were performed in 15 elders (5 men, 10 women, 62-84, 71.8 +/- 6.2 years) meeting criteria for mild cognitive impairment (MCI). PET consisted of quantitative [(15)O]water determinations of CBF, two at baseline and one postadministration of acetazolamide (ACZ). RESULTS:Mean gCBF were 44.9 +/- 5.5 during counting, 44.5 +/- 6.7 for the memory task, and 60.2 +/- 4.8 ml/min/100 g for post-ACZ (CVR of 33.9 +/- 13.2%). Task-related gCBF change was significantly related to memory score, performance on the Trail Making Test B (Trails-B), premorbid IQ, and education, and differed significantly between the learning-based groups. CONCLUSIONS:Cognitive reserve appears analogous to cardiac reserve. The ability to alter gCBF paralleled performance on general cognitive measures, was enhanced in higher levels of cognitive reserve, and was impaired in individuals who no longer appear to benefit from repeated exposure to testing.

journal_name

Mol Imaging Biol

journal_title

Molecular imaging and biology

authors

Boles Ponto LL,Magnotta VA,Moser DJ,Duff KM,Schultz SK

doi

10.1007/s11307-006-0066-z

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

363-72

issue

6

eissn

1536-1632

issn

1860-2002

journal_volume

8

pub_type

杂志文章

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