Abstract:
INTRODUCTION:Technetium (Tc) methylene diphosphonate (MDP) has been the standard method for bone scintigraphy for three decades. (18)F sodium fluoride ((18)F NaF) positron emission tomography (PET)/computed tomography (CT) has better resolution and is considered superior. The role of 2-deoxy-2-[(18)F]fluoro-D-glucose ((18)F FDG) PET/CT is proven in a variety of cancers, for which it has changed the practice of oncology. There are few prospective studies comparing these three methods of detection of skeletal metastases. Thus, we were prompted to initiate this prospective pilot trial. METHODS:This is a prospective study (Sep 2007-Dec 2010) of 52 patients with proven malignancy referred for evaluation of skeletal metastases. There were 37 men and 15 women, 19-84 years old (average, 55.6 ± 15.9). Technetium-99m ((99m)Tc) MDP bone scintigraphy, (18)F NaF PET/CT, and (18)F FDG PET/CT were subsequently performed within 1 month. RESULTS:Skeletal lesions were detected by (99m)Tc MDP bone scintigraphy in 22 of 52 patients, by (18)F NaF PET/CT in 24 of 52 patients, and by (18)F FDG PET/CT in 16 of 52 patients. The image quality and evaluation of extent of disease were superior by (18)F NaF PET/CT over (99m)Tc MDP scintigraphy in all 22 patients with skeletal lesions on both scans and over (18)F FDG PET/CT in 11 of 16 patients with skeletal metastases on (18)F FDG PET/CT. In two patients, (18)F NaF PET/CT showed skeletal metastases not seen on either of the other two scans. Extraskeletal lesions were identified by (18)F FDG PET/CT in 28 of 52 subjects. CONCLUSION:Our prospective pilot-phase trial demonstrates superior image quality and evaluation of skeletal disease extent with (18)F NaF PET/CT over (99m)Tc MDP scintigraphy and (18)F FDG PET/CT. At the same time, (18)F FDG PET detects extraskeletal disease that can significantly change disease management. As such, a combination of (18)F FDG PET/CT and (18)F NaF PET/CT may be necessary for cancer detection. Additional evaluation with larger cohorts is required to confirm these preliminary findings.
journal_name
Mol Imaging Bioljournal_title
Molecular imaging and biologyauthors
Iagaru A,Mittra E,Dick DW,Gambhir SSdoi
10.1007/s11307-011-0486-2subject
Has Abstractpub_date
2012-04-01 00:00:00pages
252-9issue
2eissn
1536-1632issn
1860-2002journal_volume
14pub_type
临床试验,杂志文章abstract:PURPOSE:Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was utilized in postmortem imaging of gadolinium (Gd) spatial distribution in a mouse tumor model postadministration of PEGylated Gd liposomal nanoparticles. PROCEDURES:PEGylated liposomal nanoparticles were formulated using a paramagnetic...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-009-0282-4
更新日期:2010-08-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-019-01421-7
更新日期:2020-06-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-020-01488-7
更新日期:2020-10-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
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更新日期:2016-08-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-010-0309-x
更新日期:2011-02-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章,评审
doi:10.1016/j.mibio.2004.06.008
更新日期:2004-09-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-018-1216-9
更新日期:2019-02-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 临床试验,杂志文章
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更新日期:2011-08-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章,评审
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更新日期:2005-01-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1016/s1536-1632(02)00014-8
更新日期:2002-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s11307-019-01417-3
更新日期:2020-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s11307-014-0782-8
更新日期:2015-04-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-006-0037-4
更新日期:2006-05-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-013-0655-6
更新日期:2013-12-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-010-0394-x
更新日期:2011-06-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-013-0640-0
更新日期:2013-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-12-01 00:00:00
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更新日期:2020-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-06-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章,评审
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更新日期:2013-04-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-009-0237-9
更新日期:2010-01-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
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更新日期:2011-06-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-019-01399-2
更新日期:2020-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s11307-006-0042-7
更新日期:2006-07-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
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更新日期:2019-12-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-011-0509-z
更新日期:2012-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s11307-013-0714-z
更新日期:2014-08-01 00:00:00