Abstract：
PURPOSE:Sensitivity of contrast-enhanced ultrasound (CEUS) to microvascular flow modifications can be limited by intra-injection variability (injected dose, rate, volume). PROCEDURES:To evaluate the effect of injection variability on microvascular flow evaluation, CEUS was compared between controlled and manual injections where enhancement was assessed in vitro within a flow phantom, in normal murine kidney (N = 12) and in murine ectopic tumors (N = 10). RESULTS:For both in vitro and in vivo measurements in the renal cortex, controlled injections significantly improved reproducibility of functional parameter estimation. Their coefficient of variation (CV) in the renal cortex ranged from 4 to 19 % for controlled injection vs. 5 to 43 % for manual injections. For measurements in tumors, controlled injection only decreased the CV significantly for the mean transit time. In tumors, multiple injections of contrast agent with a 15-min delay between each were shown to strongly modify contrast uptake by facilitating penetration of microbubbles. CONCLUSION:Improved reproducibility of CEUS assessments in murine models should provide more robust quantification of flow parameters and more sensitive evaluation of tumor modifications in therapeutic models.
journal_name
Mol Imaging Bioljournal_title
Molecular imaging and biologyauthors
Dizeux A,Payen T,Barrois G,Le Guillou Buffello D,Bridal SLdoi
10.1007/s11307-016-0952-ysubject
Has Abstractpub_date
2016-10-01 00:00:00pages
651-8issue
5eissn
1536-1632issn
1860-2002pii
10.1007/s11307-016-0952-yjournal_volume
18pub_type
杂志文章abstract：PURPOSE:For targeted imaging and therapy of hepatocellular carcinoma (HCC), we established a chimeric promoter (EIIAPA) containing alpha-fetoprotein (AFP) promoter and hepatitis B virus enhancer II (EIIA) to control downstream expression of reporter and therapeutic genes. PROCEDURES:We combined AFP promoter and EIIA t...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-011-0509-z
更新日期：2012-08-01 00:00:00
abstract：PURPOSE:The aim of this study is to generate a four-class magnetic resonance imaging (MRI)-based attenuation map (μ-map) for attenuation correction of positron emission tomography (PET) data of the head area using a novel combination of short echo time (STE)/Dixon-MRI and a dedicated image segmentation method. PROCEDU...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-015-0849-1
更新日期：2015-12-01 00:00:00
abstract：PURPOSE:Synapse loss is a hallmark of Alzheimer's disease (AD) and correlates with cognitive decline. The validation of a noninvasive in vivo imaging approach to quantify synapse would greatly facilitate our understanding of AD pathogenesis and assist drug developments for AD. As animal models of neurodegenerative and ...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-020-01567-9
更新日期：2020-11-30 00:00:00
abstract：INTRODUCTION:Technetium (Tc) methylene diphosphonate (MDP) has been the standard method for bone scintigraphy for three decades. (18)F sodium fluoride ((18)F NaF) positron emission tomography (PET)/computed tomography (CT) has better resolution and is considered superior. The role of 2-deoxy-2-[(18)F]fluoro-D-glucose (...
journal_title：Molecular imaging and biology
pub_type： 临床试验,杂志文章
doi：10.1007/s11307-011-0486-2
更新日期：2012-04-01 00:00:00
abstract：:Amyloid plaques are highly heterogeneous in content, size, density, and macromolecular crowding, as they are composed of masses of fibrils and other cellular material. Given this target architecture, the aggregated microenvironment offers a unique imaging target for ligands and positron emission tomography (PET) molec...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-006-0037-4
更新日期：2006-05-01 00:00:00
abstract：PURPOSE:We aimed to elucidate trans-1-amino-3-[(18)F]fluorocyclobutanecarboxylic acid (anti-[(18)F]FACBC) uptake mechanisms in inflammatory and tumor cells, in comparison with those of L-[methyl-(11)C]methionine ([(11)C]Met) and 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG). PROCEDURES:Using carbon-14-labeled tracers...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-013-0693-0
更新日期：2014-06-01 00:00:00
abstract：:Atherosclerotic plaques can remain quiescent for years, but become life threatening upon rupture or disruption, initiating clot formation in the vessel lumen and causing acute myocardial infarction and ischemic stroke. Whether and how a plaque ruptures is determined by its macroscopic structure and microscopic composi...
journal_title：Molecular imaging and biology
pub_type： 杂志文章,评审
doi：10.1007/s11307-018-1264-1
更新日期：2018-12-01 00:00:00
abstract：PURPOSE:To assess a novel radiotracer aluminum [18F]fluoride-1,4,7-triazacyclononane-triacetic acid-pegylated dimeric RGD ([18F]ALF-NOTA-PRGD2, denoted as [18F]Alfatide) for positron emission tomography (PET)/X-ray computed tomography (CT) and explore the relationships between clinicopathological characteristics and ma...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-018-1216-9
更新日期：2019-02-01 00:00:00
abstract：PURPOSE:This study aims to determine a lumped constant (LC) value that can be applied to the 2-deoxy-2[18F]fluoro-D-glucose positron emission tomography (FDG-PET) study to yield a physiological value of cerebral metabolic rate of glucose (CMR(glc)) in normal brain. PROCEDURES:We developed a more robust method for dete...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1016/s1536-1632(02)00122-1
更新日期：2003-01-01 00:00:00
abstract：PURPOSE:To evaluate the utility of three-dimensional (3D) amide proton transfer-weighted (APTw) imaging for differentiation of endometrial adenocarcinoma and uterine benign lesions. PROCEDURES:This prospective study enrolled 22 normal volunteers and 113 patients with suspicious uterine lesions, including endometrial a...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-020-01565-x
更新日期：2020-11-13 00:00:00
abstract：PURPOSE:Recent researches have demonstrated the value of using 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) imaging to reveal the hypothyroidism-related damages in local brain regions. However, the influence of hypothyroidism on the entire brain network is barely studied. This study foc...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-018-1182-2
更新日期：2018-10-01 00:00:00
abstract：PURPOSE:Our objective was to determine the lowest diagnostically effective dose for E-selectin-targeted poly n-butyl cyanoacrylate (PBCA)-shelled microbubbles and to apply it to monitor antiangiogenic therapy effects. PROCEDURES:PBCA-shelled microbubbles (MBs) coupled to an E-selectin-specific peptide were applied in ...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-015-0894-9
更新日期：2016-04-01 00:00:00
abstract：PURPOSE:High-dose (HD) cytosine arabinoside (ara-C) is a major treatment in acute myeloblastic leukemia (AML) that can lead to cerebellar complications, although electroencephalogram, computed tomography, and magnetic resonance imaging remain normal. We conducted a prospective study to evaluate brain perfusion with sin...
journal_title：Molecular imaging and biology
pub_type： 临床试验,杂志文章
doi：10.1007/s11307-010-0409-7
更新日期：2011-08-01 00:00:00
abstract：:This article reviews positron emission tomography (PET) studies of labeled enantiomers of different PET-tracers from the early 1980s. Comparative studies on stereoselective behavior of the transport of tracers across the blood-brain barrier (BBB) are discussed. Tracers are transported through the BBB into the brain, v...
journal_title：Molecular imaging and biology
pub_type： 杂志文章,评审
doi：10.1016/j.mibio.2004.06.008
更新日期：2004-09-01 00:00:00
abstract：PURPOSE:Contrast-enhanced magnetic resonance imaging (MRI) has the potential to replace angiographic evaluation of atherosclerosis. While studies have investigated contrast agent (CA) uptake in atherosclerotic plaques, exact CA spatial distribution on a microscale is elusive. The purpose of this study was to investigat...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-020-01563-z
更新日期：2020-12-07 00:00:00
abstract：PURPOSE:Visualization of tumor necrosis can determine tumor response to therapy. Our previous study showed that the rhein-based magnetic resonance imaging (MRI) contrast agent with alkane linker (GdL2) could clearly image tumor necrosis. However, its water solubility and cell safety needed to be improved. Herein, three...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-020-01551-3
更新日期：2020-10-13 00:00:00
abstract：PURPOSE:Repetitive imaging with microPET of endogenous albumin gene expression by using transgenic mice in which the Herpes Simplex Virus Type 1 thymidine kinase (HSV1-tk) reporter gene is driven by the albumin promoter (AL-HSV1-tk). METHODS:Transgenic mice were imaged repeatedly on a microPET scanner with approximate...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1016/s1095-0397(01)00071-1
更新日期：2002-01-01 00:00:00
abstract：PURPOSE:The tyrosine kinase receptor Axl is overexpressed in various types of cancer and correlated with cancer malignancy. Selective Axl blockade reduces tumor growth and metastasis. The purpose of this study was to examine whether the humanized anti-Axl antibody humanized 173 (h173) labeled with near-infrared fluores...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-013-0714-z
更新日期：2014-08-01 00:00:00
abstract：PURPOSE:The present work was aimed at the development of prospective positron emission tomography (PET) agents for infection imaging. Towards this aim, ubiquicidin (UBI) fragments conjugated with the macrocyclic NODAGA chelator were radiolabeled with Ga-68 and evaluated. PROCEDURES:Conformations of custom synthesized ...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-016-0983-4
更新日期：2017-02-01 00:00:00
abstract：PURPOSE:Malignant cells exhibit increased rates of aerobic glycolysis. Here, we tested whether the accumulation of fluoro-deoxyglucose-6-phosphate (FDG6P) in ovarian cancers of differential malignancy reflects inversely correlated elevations of hexokinase (HK) and glucose-6-phosphatase (G6Pase) activities. PROCEDURES:...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-018-1247-2
更新日期：2019-04-01 00:00:00
abstract：PURPOSE:To evaluate bone blood flow and bone formation in patients after total hip revision surgery with impacted bone grafting using H2 15O and [18F]fluoride positron emission tomography (PET). PROCEDURES:To asses bone blood flow and bone metabolism in bone allograft after impaction grafting, four patients treated wi...
journal_title：Molecular imaging and biology
pub_type： 临床试验,杂志文章
doi：10.1007/s11307-008-0153-4
更新日期：2008-09-01 00:00:00
abstract：PURPOSE:Previously, some reports mentioned that magnetic resonance imaging (MRI) can predict histopathological features in primary CNS lymphoma (PCNSL). The reported data analyzed diffusion-weighted imaging findings. The aim of this study was to investigate possible associations between histopathological findings, such...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-017-1115-5
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:This study aimed to synthesize a necrosis-avid agent using rhein as a precursor and labeled with gallium-68 (Ga-68) for positron emission tomography/computed tomography (PET/CT) imaging, to evaluate response to anticancer treatment in a mouse model. PROCEDURES:1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaceti...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-019-01365-y
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:Prefrontal cortex (PFC) deep brain stimulation (DBS) has been proposed as a therapy for addiction and depression. This study investigates changes in rat cerebral glucose metabolism induced by different DBS frequencies using μPET. PROCEDURES:One hour DBS of the prelimbic area (PL) of the medial PFC (mPFC) (60 H...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-014-0757-9
更新日期：2014-12-01 00:00:00
abstract：PURPOSE:Using three publicly available small-animal atlases (Sprague-Dawley rat, MOBY, and Digimouse), we built three articulated atlases and present several applications in the scope of molecular imaging. PROCEDURES:Major bones/bone groups were manually segmented for each atlas skeleton. Then, a kinematic model for e...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-010-0386-x
更新日期：2011-10-01 00:00:00
abstract：PURPOSE:Dynamic positron emission tomography (PET) protocols allow for accurate quantification of [18F]flortaucipir-specific binding. However, dynamic acquisitions can be challenging given the long required scan duration of 130 min. The current study assessed the effect of shorter scan protocols for [18F]flortaucipir o...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-021-01581-5
更新日期：2021-01-26 00:00:00
abstract：PURPOSE:CXCR4 is overexpressed on tumor cells from many types of human cancers. A high level of CXCR4 expression often correlates with poor prognosis, chemotherapy resistance, and metastasis. The development of CXCR4-specific radiotracers for positron emission tomography (PET) imaging will allow in vivo evaluation of r...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-013-0640-0
更新日期：2013-12-01 00:00:00
abstract：PURPOSE:Human pluripotent stem cell (hPSC)-derived dopaminergic neuron progenitor cells (DAPCs) are a potential therapy for Parkinson's disease (PD). However, their intracranial administration raises safety concerns including uncontrolled proliferation, migration and inflammation. Here, we apply a bimodal imaging appro...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-020-01499-4
更新日期：2020-10-01 00:00:00
abstract：:We evaluated the clinical utility of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) on the precise localization of pathologic foci and exclusion of normal variants in the imaging evaluation of patients with esophageal carcinoma. Combined PET/CT scans were performed i...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-006-0036-5
更新日期：2006-05-01 00:00:00
abstract：PURPOSE:Conventional in vivo bioluminescence imaging using wild-type green-emitting luciferase is limited by absorption and scattering of the bioluminescent signal through tissues. Imaging methods using a red-shifted thermostable luciferase from Photinus pyralis were optimized to improve the sensitivity and image resol...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-009-0291-3
更新日期：2010-08-01 00:00:00
