Microdistribution of Magnetic Resonance Imaging Contrast Agents in Atherosclerotic Plaques Determined by LA-ICP-MS and SR-μXRF Imaging.

abstract：PURPOSE:The mTOR kinase inhibitor AZD8055 inhibits both mTORC1 and mTORC2 leading to disruption of glucose metabolism and proliferation pathways. This study assessed the impact of single and multiple doses of AZD8055 on the uptake of the glucose metabolism marker 2-deoxy-2-[(18) F]fluoro-D-glucose ([(18) F]FDG) and the...

journal_title：Molecular imaging and biology

authors： Keen HG,Ricketts SA,Maynard J,Logie A,Odedra R,Shannon AM,Wedge SR,Guichard SM

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:[123I]FP-CIT (DaTSCAN®) single-photon emission computed tomography (SPECT) imaging is widely used to study neurodegenerative parkinsonism, by measuring presynaptic dopamine transporter (DAT) in striatal regions. Beyond DAT, [123I]FP-CIT may be considered for other monoaminergic systems, in particular the seroto...

journal_title：Molecular imaging and biology

authors： Premi E,Calhoun VD,Garibotto V,Turrone R,Alberici A,Cottini E,Pilotto A,Gazzina S,Magoni M,Paghera B,Borroni B,Padovani A

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:Construction of antibody-based, molecular-targeted optical imaging probes requires the labeling of an antibody with a fluorophore. The most common method for doing this involves non-specifically conjugating a fluorophore to an antibody, resulting in poorly defined, heterogeneous imaging probes that often have s...

journal_title：Molecular imaging and biology

authors： Alam MK,El-Sayed A,Barreto K,Bernhard W,Fonge H,Geyer CR

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:Recent researches have demonstrated the value of using 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) imaging to reveal the hypothyroidism-related damages in local brain regions. However, the influence of hypothyroidism on the entire brain network is barely studied. This study foc...

journal_title：Molecular imaging and biology

authors： Wang H,Tan Z,Zheng Q,Yu J

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:Positron emission tomography (PET) with 2-deoxy-2-[18F]fluoro-D-glucose (FDG) has been used for various cancers, but reproducibility of common utilized semi-quantitative parameters, such as the maximal single pixel standardized uptake value (SUV) and effective glycolytic volume (EGV), remains unknown. Knowledge...

journal_title：Molecular imaging and biology

authors： Nakamoto Y,Zasadny KR,Minn H,Wahl RL

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:The purpose of this study was to assess the value of the spatial heterogeneity of somatostatin receptor (SSR) volume, quantified as asphericity (ASP), and to predict response to peptide receptor radionuclide therapy (PRRT) in patients with metastatic gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN). P...

journal_title：Molecular imaging and biology

authors： Wetz C,Apostolova I,Steffen IG,Hofheinz F,Furth C,Kupitz D,Ruf J,Venerito M,Klose S,Amthauer H

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:To evaluate the utility of three-dimensional (3D) amide proton transfer-weighted (APTw) imaging for differentiation of endometrial adenocarcinoma and uterine benign lesions. PROCEDURES:This prospective study enrolled 22 normal volunteers and 113 patients with suspicious uterine lesions, including endometrial a...

journal_title：Molecular imaging and biology

authors： Li Y,Lin CY,Qi YF,Wang XQ,Chen B,Zhou HL,Ren J,Yang JJ,Xiang Y,He YL,Xue HD,Jin ZY

更新日期：2020-11-13 00:00:00

abstract：PURPOSE:The increasing availability of fluorescent probes for in vivo optical imaging enables the interrogation of complex biological processes in small animals serving as models for human-like tissue function and disease. However, the validation of probe bio-distribution during their development or the study of differ...

journal_title：Molecular imaging and biology

authors： Sarantopoulos A,Themelis G,Ntziachristos V

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:Some patients cannot remain immobile for a long duration of 60 min, which is generally applied in the case of a 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) dynamic positron emission tomography (PET) scan. We investigated the change of the parametric values when the time duration of PET data was shortened. P...

journal_title：Molecular imaging and biology

authors： Monden T,Kudomi N,Sasakawa Y,Yamamoto Y,Kawai N,Nishiyama Y

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:Many radioligands have been explored for imaging the 18-kDa translocator protein (TSPO), a diagnostic and therapeutic target for inflammation and cancer. Here, we investigated the TSPO radioligand [(18)F]DPA-714 for positron emission tomography (PET) imaging of cancer and inflammation. PROCEDURES:[(18)F]DPA-71...

journal_title：Molecular imaging and biology

authors： Zheng J,Winkeler A,Peyronneau MA,Dollé F,Boisgard R

更新日期：2016-02-01 00:00:00

abstract：:The blood flow through normal liver parenchyma and a pathologically proven hepatic region of focal nodular hyperplasia (FNH) of the lateral lobe, was measured in a single patient in a quantitative manner using regional dynamic positron emission tomography (PET) imaging with O-15 carbon dioxide (steady state) and O-15 ...

journal_title：Molecular imaging and biology

authors： Kunishima S,Koh T,Fukuda K,Taniguchi H

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:To provide reliable and reproducible heart/mediastinum (H/M) ratio cut-off values for parkinsonian disorders using two machine learning techniques, Support Vector Machines (SVM) and Random Forest (RF) classifier, applied to [123I]MIBG cardiac scintigraphy. PROCEDURES:We studied 85 subjects, 50 with idiopathic ...

journal_title：Molecular imaging and biology

authors： Nuvoli S,Spanu A,Fravolini ML,Bianconi F,Cascianelli S,Madeddu G,Palumbo B

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:The sigma-2 (σ(2)) receptor is a potential biomarker of proliferative status of solid tumors. Specific synthetic probes using N-substituted-9-azabicyclo [3.3.1]nonan-3α-yl carbamate analogs have been designed and implemented for experimental cancer diagnosis and therapy. PROCEDURES:We employed the fluorescentl...

journal_title：Molecular imaging and biology

authors： Haller JL,Panyutin I,Chaudhry A,Zeng C,Mach RH,Frank JA

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:The aim of this work is to investigate the impact of tissue classification in magnetic resonance imaging (MRI)-guided positron emission tomography (PET) attenuation correction (AC) for whole-body (WB) Patlak net uptake rate constant (Ki) imaging in PET/MRI studies. PROCEDURES:WB dynamic PET/CT data were acquir...

journal_title：Molecular imaging and biology

authors： Zhuang M,Karakatsanis NA,Dierckx RAJO,Zaidi H

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:In this study, we aimed to quantitatively investigate the biodistribution of [18F]DCFPyL in patients with prostate cancer (PCa) and to determine whether uptake in normal organs correlates with an increase in tumor burden. PROCEDURES:Fifty patients who had been imaged with [18F]DCFPyL positron emission tomograp...

journal_title：Molecular imaging and biology

authors： Werner RA,Bundschuh RA,Bundschuh L,Lapa C,Yin Y,Javadi MS,Buck AK,Higuchi T,Pienta KJ,Pomper MG,Lodge MA,Gorin MA,Rowe SP

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:Radioimmunotherapy uses tumor-specific antibodies to deliver therapeutic radionuclides, but hematological toxicity due to the long serum half-life of intact antibodies remains a challenge. We evaluated a smaller antibody fragment, the minibody, with faster kinetics and a potentially improved therapeutic index. ...

journal_title：Molecular imaging and biology

authors： Tsai WK,Zettlitz KA,Dahlbom M,Reiter RE,Wu AM

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:Many neurological diseases affect small structures in the brain and, as such, reliable visual evaluation and accurate quantification are required. Recent technological developments made the clinical use of hybrid positron emission tomography/magnetic resonance (PET/MR) systems possible, providing both functiona...

journal_title：Molecular imaging and biology

authors： Leemans EL,Kotasidis F,Wissmeyer M,Garibotto V,Zaidi H

更新日期：2015-10-01 00:00:00

abstract：:We evaluated the clinical utility of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) on the precise localization of pathologic foci and exclusion of normal variants in the imaging evaluation of patients with esophageal carcinoma. Combined PET/CT scans were performed i...

journal_title：Molecular imaging and biology

authors： Jadvar H,Henderson RW,Conti PS

更新日期：2006-05-01 00:00:00

abstract：:Noninvasive conventional imaging methods are established technologies in modern drug discovery and development providing valuable morphological, physiological, and metabolic information to characterize disease phenotypes, to evaluate the efficacy of therapy and to identify and develop potential biomarkers for clinical...

journal_title：Molecular imaging and biology

authors： Rudin M,Rausch M,Stoeckli M

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Visualization of tumor necrosis can determine tumor response to therapy. Our previous study showed that the rhein-based magnetic resonance imaging (MRI) contrast agent with alkane linker (GdL2) could clearly image tumor necrosis. However, its water solubility and cell safety needed to be improved. Herein, three...

journal_title：Molecular imaging and biology

authors： Zhang L,Zhang D,Gao M,Jin Q,Jiang C,Wu T,Feng Y,Ni Y,Yin Z,Zhang J

更新日期：2020-10-13 00:00:00

abstract：PURPOSE:Previous studies has demonstrated the utility of human epidermal growth factor receptor type 2 (HER2) as an attractive target for cancer molecular imaging and therapy. An affibody protein with strong binding affinity for HER2, ZHER2:342, has been reported. Various methods of chelator conjugation for radiolabeli...

journal_title：Molecular imaging and biology

authors： Qi S,Hoppmann S,Xu Y,Cheng Z

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:Human pluripotent stem cell (hPSC)-derived dopaminergic neuron progenitor cells (DAPCs) are a potential therapy for Parkinson's disease (PD). However, their intracranial administration raises safety concerns including uncontrolled proliferation, migration and inflammation. Here, we apply a bimodal imaging appro...

journal_title：Molecular imaging and biology

authors： Mousavinejad M,Skidmore S,Barone FG,Tyers P,Pisupati V,Poptani H,Plagge A,Barker RA,Murray P,Taylor A,Hill CJ

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:2-Deoxy-2-[F-18]fluoro-D-glucose positron emission tomography (FDG-PET) has an established role in restaging of various cancers, including papillary and undifferentiated thyroid carcinoma, but detection rates are variable in the published literature. We were therefore prompted to review our experience with FD...

journal_title：Molecular imaging and biology

authors： Iagaru A,Masamed R,Singer PA,Conti PS

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:Non-invasive in vivo positron emission tomography (PET) provides high detection sensitivity in the nano- to picomolar range and in addition to other advantages, the possibility to absolutely quantify the acquired data. The present study focuses on the comparison of transmission data acquired with an X-ray compu...

journal_title：Molecular imaging and biology

authors： Mannheim JG,Schmid AM,Pichler BJ

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate different non-invasive methods for generating (R)-1-((3-([11C]methyl)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) ([11C]UCB-J) parametric maps using white matter (centrum semi-ovale-SO) as reference tissue. PROCEDURES:Ten healthy volunteers (8 M/2F; age ...

journal_title：Molecular imaging and biology

authors： Mertens N,Maguire RP,Serdons K,Lacroix B,Mercier J,Sciberras D,Van Laere K,Koole M

更新日期：2020-04-01 00:00:00

abstract：:This paper demonstrates the application of mutual information based coregistration of radionuclide and magnetic resonance imaging (MRI) in an effort to use multimodality imaging for noninvasive localization of stem cells grafted in the infarcted myocardium in rats. Radionuclide imaging such as single photon emission c...

journal_title：Molecular imaging and biology

authors： Shen D,Liu D,Cao Z,Acton PD,Zhou R

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION:We have previously described the labeling of interleukin-2 (IL2) with (123)I and (99m)Tc-N(3)S. Both radiopharmaceuticals were successfully applied in humans to image several inflammatory lesions and autoimmune diseases characterized by tissue infiltrating lymphocytes expressing the IL2 receptor (CD25). Ho...

journal_title：Molecular imaging and biology

authors： D'Alessandria C,di Gialleonardo V,Chianelli M,Mather SJ,de Vries EF,Scopinaro F,Dierck RA,Signore A

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:Tc-99m methylene diphosphonate ([99mTc]MDP) is an in vivo bone imaging agent that also accumulates in injured skeletal muscle cells. The objective of this study was to investigate if [99mTc]MDP could be used to detect muscle injury in the mdx mouse model of Duchenne muscular dystrophy (DMD). PROCEDURES:Static ...

journal_title：Molecular imaging and biology

authors： Gaut C,Sullivan JM,Biscaro B,Soares EJ,Nicholson K,Hoppin J,Verma A

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:Imaging using positron emission tomography (PET) in the field of nuclear medicine is becoming increasingly important. The aim of this study was to develop a method for labeling of affibody molecules with radiocobalt for PET applications. PROCEDURES:The human epidermal growth factor receptors type 2 (HER2) bind...

journal_title：Molecular imaging and biology

authors： Wållberg H,Ahlgren S,Widström C,Orlova A

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:The present work was aimed at the development of prospective positron emission tomography (PET) agents for infection imaging. Towards this aim, ubiquicidin (UBI) fragments conjugated with the macrocyclic NODAGA chelator were radiolabeled with Ga-68 and evaluated. PROCEDURES:Conformations of custom synthesized ...

journal_title：Molecular imaging and biology

authors： Bhatt J,Mukherjee A,Korde A,Kumar M,Sarma HD,Dash A

更新日期：2017-02-01 00:00:00