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Sigma-2 receptor as potential indicator of stem cell differentiation.

Abstract：

PURPOSE:The sigma-2 (σ(2)) receptor is a potential biomarker of proliferative status of solid tumors. Specific synthetic probes using N-substituted-9-azabicyclo [3.3.1]nonan-3α-yl carbamate analogs have been designed and implemented for experimental cancer diagnosis and therapy. PROCEDURES:We employed the fluorescently labeled σ(2) receptor probe, SW120, to evaluate σ(2) receptor expression in human stem cells (SC), including: bone marrow stromal, neural progenitor, amniotic fluid, hematopoetic, and embryonic stem cells. We concurrently evaluated the intensity of SW120 and 5-ethynyl-2'-deoxyuridine (EdU) relative to passage number and multi-potency. RESULTS:We substantiated significantly higher σ(2) receptor density among proliferating SC relative to lineage-restricted cell types. Additionally, cellular internalization of the σ(2) receptor in SC was consistent with receptor-mediated endocytosis and confocal microscopy indicated SW120 specific co-localization with a fluorescent marker of lysosomes in all SC imaged. CONCLUSION:These results suggest that σ(2) receptors may serve to monitor stem cell differentiation in future experimental studies.

journal_name

Mol Imaging Biol

journal_title

Molecular imaging and biology

authors

Haller JL,Panyutin I,Chaudhry A,Zeng C,Mach RH,Frank JA

doi

10.1007/s11307-011-0493-3

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

325-35

issue

3

eissn

1536-1632

issn

1860-2002

journal_volume

14

pub_type

杂志文章

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