In Vivo Evaluation of Magnetic Targeting in Mice Colon Tumors with Ultra-Magnetic Liposomes Monitored by MRI.

abstract：PURPOSE:[(18)F]-FEPPA is a translocator protein (18 kDa, TSPO) positron emission tomography (PET) radiotracer. Radiation dosimetry was estimated from the whole body biodistribution, taking into consideration TSPO rs6971 (Ala147Thr) polymorphism. PROCEDURES:[(18)F]-FEPPA whole body PET scans were acquired for six healt...

journal_title：Molecular imaging and biology

authors： Mizrahi R,Rusjan PM,Vitcu I,Ng A,Wilson AA,Houle S,Bloomfield PM

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:Radioimmunotherapy uses tumor-specific antibodies to deliver therapeutic radionuclides, but hematological toxicity due to the long serum half-life of intact antibodies remains a challenge. We evaluated a smaller antibody fragment, the minibody, with faster kinetics and a potentially improved therapeutic index. ...

journal_title：Molecular imaging and biology

authors： Tsai WK,Zettlitz KA,Dahlbom M,Reiter RE,Wu AM

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:We have previously described the labeling of interleukin-2 (IL2) with (123)I and (99m)Tc-N(3)S. Both radiopharmaceuticals were successfully applied in humans to image several inflammatory lesions and autoimmune diseases characterized by tissue infiltrating lymphocytes expressing the IL2 receptor (CD25). Ho...

journal_title：Molecular imaging and biology

authors： D'Alessandria C,di Gialleonardo V,Chianelli M,Mather SJ,de Vries EF,Scopinaro F,Dierck RA,Signore A

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:The purpose of this study was to assess the value of the spatial heterogeneity of somatostatin receptor (SSR) volume, quantified as asphericity (ASP), and to predict response to peptide receptor radionuclide therapy (PRRT) in patients with metastatic gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN). P...

journal_title：Molecular imaging and biology

authors： Wetz C,Apostolova I,Steffen IG,Hofheinz F,Furth C,Kupitz D,Ruf J,Venerito M,Klose S,Amthauer H

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:The purpose of this study was to determine the most useful parameter of dual-time-point 2-deoxy-2-[¹⁸F]fluoro-D: -glucose positron emission tomography/computed tomography (PET/CT) for detection of hepatic metastases in patients with colorectal cancer. PROCEDURES:Thirty-nine patients had undergone a dual-time-p...

journal_title：Molecular imaging and biology

authors： Lee JW,Kim SK,Lee SM,Moon SH,Kim TS

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate different non-invasive methods for generating (R)-1-((3-([11C]methyl)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) ([11C]UCB-J) parametric maps using white matter (centrum semi-ovale-SO) as reference tissue. PROCEDURES:Ten healthy volunteers (8 M/2F; age ...

journal_title：Molecular imaging and biology

authors： Mertens N,Maguire RP,Serdons K,Lacroix B,Mercier J,Sciberras D,Van Laere K,Koole M

更新日期：2020-04-01 00:00:00

abstract：:Due to their remarkable selectivity and specificity for cancer biomarkers, immunoconjugates have emerged as extremely promising vectors for the delivery of diagnostic radioisotopes and fluorophores to malignant tissues. Paradoxically, however, these tools for precision medicine are synthesized in a remarkably imprecis...

journal_title：Molecular imaging and biology

authors： Adumeau P,Sharma SK,Brent C,Zeglis BM

更新日期：2016-02-01 00:00:00

abstract：:This article reviews positron emission tomography (PET) studies of labeled enantiomers of different PET-tracers from the early 1980s. Comparative studies on stereoselective behavior of the transport of tracers across the blood-brain barrier (BBB) are discussed. Tracers are transported through the BBB into the brain, v...

journal_title：Molecular imaging and biology

authors： Luurtsema G,de Lange EC,Lammertsma AA,Franssen EJ

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:Widely used in clinical practice, the maximum standardized uptake value (SUVmax) is a statistical index highly prone to physical and biological variations, which can lead to unpredictable errors. This study has a methodological aim: to identify a more robust SUV-based index representing the tracer accumulation....

journal_title：Molecular imaging and biology

authors： Baiocco S,Matteucci F,Mezzenga E,Caroli P,Di Iorio V,Cittanti C,Bevilacqua A,Paganelli G,Sarnelli A

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:Dynamic positron emission tomography (PET) protocols allow for accurate quantification of [18F]flortaucipir-specific binding. However, dynamic acquisitions can be challenging given the long required scan duration of 130 min. The current study assessed the effect of shorter scan protocols for [18F]flortaucipir o...

journal_title：Molecular imaging and biology

authors： Tuncel H,Visser D,Yaqub M,Timmers T,Wolters EE,Ossenkoppele R,van der Flier WM,van Berckel BNM,Boellaard R,Golla SSV

更新日期：2021-01-26 00:00:00

abstract：PURPOSE:Manganese ion has been extensively used as a magnetic resonance imaging (MRI) contrast agent in preclinical studies to assess tissue anatomy, function, and neuronal connectivity. Unfortunately, its use in human studies has been limited by cellular toxicity and the need to use a very low dose. The much higher se...

journal_title：Molecular imaging and biology

authors： Saar G,Millo CM,Szajek LP,Bacon J,Herscovitch P,Koretsky AP

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:The purpose of this study was to compare C-13 imaging parameters with hyperpolarized [1-13C]pyruvate with conventional gadolinium (Gd)-based perfusion weighted imaging using an orthotopic xenograft model of human glioblastoma multiforme (GBM). PROCEDURES:C-13 3D magnetic resonance spectroscopic imaging (MRSI) ...

journal_title：Molecular imaging and biology

authors： Park I,Lupo JM,Nelson SJ

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:Magnetic resonance imaging (MRI) with targeted contrast agents provides a promising means for diagnosis and treatment monitoring after cerebrovascular injury. Our goal was to demonstrate the feasibility of this approach to detect the neuroinflammatory biomarker intercellular adhesion molecule-1 (ICAM-1) after s...

journal_title：Molecular imaging and biology

authors： Deddens LH,van Tilborg GA,van der Toorn A,van der Marel K,Paulis LE,van Bloois L,Storm G,Strijkers GJ,Mulder WJ,de Vries HE,Dijkhuizen RM

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:The aim of this work is to investigate the impact of tissue classification in magnetic resonance imaging (MRI)-guided positron emission tomography (PET) attenuation correction (AC) for whole-body (WB) Patlak net uptake rate constant (Ki) imaging in PET/MRI studies. PROCEDURES:WB dynamic PET/CT data were acquir...

journal_title：Molecular imaging and biology

authors： Zhuang M,Karakatsanis NA,Dierckx RAJO,Zaidi H

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:Noninvasive imaging of cell necrosis can provide an early evaluation of tumor response to treatments. Here, we aimed to design and synthesize a novel diindole-based magnetic resonance imaging (MRI) contrast agent (Gd-bis-DOTA-diindolylmethane, Gd-DIM) for assessment of tumor response to therapy at an early stag...

journal_title：Molecular imaging and biology

authors： Zhang L,Liu L,Zhang D,Jin Q,Gao M,Wu T,Feng Y,Ni Y,Yin Z,Zhang J

更新日期：2020-06-01 00:00:00

abstract：:Pharmaceutical research and imaging science are becoming increasingly intertwined. Positron emission tomography (PET) is a molecular imaging technique with particularly broad application in drug discovery and development. At the same time, modern techniques of drug discovery are helping accelerate the development of n...

journal_title：Molecular imaging and biology

authors： Maclean D,Northrop JP,Padgett HC,Walsh JC

更新日期：2003-09-01 00:00:00

abstract：:Incidental adrenal lesions found on anatomic imaging are not uncommon. 2-Deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET) imaging is highly accurate in the differentiation of benign from malignant adrenal lesions, both in patients with proven malignancy and with adrenal lesions detected incidentall...

journal_title：Molecular imaging and biology

authors： Ludwig V,Rice MH,Martin WH,Kelley MC,Delbeke D

更新日期：2002-10-01 00:00:00

abstract：PURPOSE:The sigma-2 (σ(2)) receptor is a potential biomarker of proliferative status of solid tumors. Specific synthetic probes using N-substituted-9-azabicyclo [3.3.1]nonan-3α-yl carbamate analogs have been designed and implemented for experimental cancer diagnosis and therapy. PROCEDURES:We employed the fluorescentl...

journal_title：Molecular imaging and biology

authors： Haller JL,Panyutin I,Chaudhry A,Zeng C,Mach RH,Frank JA

更新日期：2012-06-01 00:00:00

abstract：:We evaluated the clinical utility of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) on the precise localization of pathologic foci and exclusion of normal variants in the imaging evaluation of patients with esophageal carcinoma. Combined PET/CT scans were performed i...

journal_title：Molecular imaging and biology

authors： Jadvar H,Henderson RW,Conti PS

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:To develop a tool to measure the pH at the surfaces of individual cells. PROCEDURES:The SNARF pH-sensitive dye was conjugated to a pHLIP® peptide (pH-Low Insertion Peptide) that binds cellular membranes in tumor spheroids. A beam splitter allows simultaneous recording of two images (580 and 640 nm) by a CCD ca...

journal_title：Molecular imaging and biology

authors： Wei D,Engelman DM,Reshetnyak YK,Andreev OA

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:The demand to optimize multidisciplinary treatment strategies in patients with benign and malignant diseases of the lung and other organs has led to the increased need of mechanistic proof-of-concept studies in preclinical small animal models using new non-invasive imaging methods. Therefore, we evaluated the r...

journal_title：Molecular imaging and biology

authors： Flechsig P,Kratochwil C,Warth A,Rath D,Eichwald V,Huber PE,Kauczor HU,Haberkorn U,Giesel FL

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Negative surgical margins (NSMs) have favorable prognostic implications in breast tumor resection surgery. Fluorescence image-guided surgery (FIGS) has the ability to delineate surgical margins in real time, potentially improving the completeness of tumor resection. We have recently developed indocyanine green ...

journal_title：Molecular imaging and biology

authors： Wojtynek NE,Olson MT,Bielecki TA,An W,Bhat AM,Band H,Lauer SR,Silva-Lopez E,Mohs AM

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:Although current therapies for many inflammatory/autoimmune diseases are effective, a significant number of patients still exhibit only partial or negligible responses to therapeutic intervention. Since prolonged use of an inadequate therapy can result in both progressive tissue damage and unnecessary expense, ...

journal_title：Molecular imaging and biology

authors： Kelderhouse LE,Mahalingam S,Low PS

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:The purpose of the study is to synthesize and characterize near-infrared (NIR) fluorescence imaging probes targeted to gelatinases. PROCEDURES:A phage display-selected cyclic peptide containing the His-Try-Gly-Phe (HWGF) motif was used as the lead compound. Structure-activity relationship analysis was used to ...

journal_title：Molecular imaging and biology

authors： Wang W,Shao R,Wu Q,Ke S,McMurray J,Lang FF Jr,Charnsangavej C,Gelovani JG,Li C

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:Some patients cannot remain immobile for a long duration of 60 min, which is generally applied in the case of a 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) dynamic positron emission tomography (PET) scan. We investigated the change of the parametric values when the time duration of PET data was shortened. P...

journal_title：Molecular imaging and biology

authors： Monden T,Kudomi N,Sasakawa Y,Yamamoto Y,Kawai N,Nishiyama Y

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:Rats are important preclinical models for studying breast cancer metastasis and bone pathologies. In these research areas, fluorescence molecular tomography (FMT) is commonly applied for quantitative three-dimensional (3D) imaging in mice. However, uncertainties due to strong depth dependency of FMT signal and ...

journal_title：Molecular imaging and biology

authors： Vonwil D,Christensen J,Fischer S,Ronneberger O,Shastri VP

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:To demonstrate the efficacy of repeated, non-invasive optical imaging of reporter gene expression in monitoring the ability of bi-specific recombinant molecules (i) to "transductionally untarget" adenovirus from Coxsackie and Adenovirus Receptor (CAR)-dependent infection of normal tissue and (ii) to "transducti...

journal_title：Molecular imaging and biology

authors： Liang Q,Yamamoto M,Curiel DT,Herschman HR

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:Imaging using positron emission tomography (PET) in the field of nuclear medicine is becoming increasingly important. The aim of this study was to develop a method for labeling of affibody molecules with radiocobalt for PET applications. PROCEDURES:The human epidermal growth factor receptors type 2 (HER2) bind...

journal_title：Molecular imaging and biology

authors： Wållberg H,Ahlgren S,Widström C,Orlova A

更新日期：2010-01-01 00:00:00

abstract：:2'-deoxy-2'-[(18)F]fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil ([(18)F]FEAU) is a promising radiolabeled nucleoside designed to monitor Herpes Simplex Virus Type 1 thymidine kinase (HSV1-tk) reporter gene expression with positron emission tomography (PET). However, the challenging radiosynthesis creates problems fo...

journal_title：Molecular imaging and biology

authors： Chin FT,Namavari M,Levi J,Subbarayan M,Ray P,Chen X,Gambhir SS

更新日期：2008-03-01 00:00:00

abstract：:The Commercial Innovation of the Year Award went to Emile Beaulieu of Photon etc. for their work. ...

journal_title：Molecular imaging and biology

authors： Lewis JS,Membreno R

更新日期：2020-02-01 00:00:00