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Nanoparticle Formulation of Indocyanine Green Improves Image-Guided Surgery in a Murine Model of Breast Cancer.

Abstract：

PURPOSE:Negative surgical margins (NSMs) have favorable prognostic implications in breast tumor resection surgery. Fluorescence image-guided surgery (FIGS) has the ability to delineate surgical margins in real time, potentially improving the completeness of tumor resection. We have recently developed indocyanine green (ICG)-loaded self-assembled hyaluronic acid (HA) nanoparticles (NanoICG) for solid tumor imaging, which were shown to enhance intraoperative contrast. PROCEDURES:This study sought to assess the efficacy of NanoICG on completeness of breast tumor resection and post-surgical survival. BALB/c mice bearing iRFP+/luciferase+ 4T1 syngeneic breast tumors were administered NanoICG or ICG, underwent FIGS, and were compared to bright light surgery (BLS) and sham controls. RESULTS:NanoICG increased the number of complete resections and improved tumor-free survival. This was a product of improved intraoperative contrast enhancement and the identification of a greater number of small, occult lesions than ICG and BLS. Additionally, NanoICG identified chest wall invasion and predicted recurrence in a model of late-stage breast cancer. CONCLUSIONS:NanoICG is an efficacious intraoperative contrast agent and could potentially improve surgical outcomes in breast cancer.

journal_name

Mol Imaging Biol

journal_title

Molecular imaging and biology

authors

Wojtynek NE,Olson MT,Bielecki TA,An W,Bhat AM,Band H,Lauer SR,Silva-Lopez E,Mohs AM

doi

10.1007/s11307-019-01462-y

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

891-903

issue

4

eissn

1536-1632

issn

1860-2002

pii

10.1007/s11307-019-01462-y

journal_volume

22

pub_type

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