当前位置： SCI文献检索 > MOLECULAR IMAGING AND BIOLOGY期刊下所有文献 > Impact of FDG-PET on prediction of clinical outcome after concurrent chemoradiotherapy in hypopharyngeal carcinoma.

Impact of FDG-PET on prediction of clinical outcome after concurrent chemoradiotherapy in hypopharyngeal carcinoma.

Abstract：

PURPOSE:To evaluate prognostic value of pretreatment and posttreatment 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET) in advanced hypopharyngeal carcinoma treated by chemoradiotherapy. PROCEDURES:Thirty-one patients underwent a baseline FDG-PET and then FDG-PET was repeated 7 weeks after chemoradiotherapy. Primary tumor uptake of FDG, measured as the maximal standardized uptake value (SUV(max)), was analyzed in relation to local control and survival. RESULTS:Neither local control nor cause-specific survival were associated with pretreatment SUV(max). In contrast, patients with a high posttreatment SUV(max) had significantly poorer local control (P = 0.002), as well as poorer cause-specific survival (P = 0.0075), compared to those with a low posttreatment SUV(max). This prognostic significance of posttreatment SUV(max) remained when only a subset of patients showing local complete response to chemoradiotherapy was analyzed. CONCLUSIONS:Posttreatment FDG uptake represents an independent prognostic factor for hypopharyngeal carcinoma treated by chemoradiotherapy. Patients with a high posttreatment FDG uptake may benefit from adjuvant chemotherapy.

journal_name

Mol Imaging Biol

journal_title

Molecular imaging and biology

authors

Inohara H,Enomoto K,Tomiyama Y,Higuchi I,Inoue T,Hatazawa J

doi

10.1007/s11307-009-0229-9

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

89-97

issue

1

eissn

1536-1632

issn

1860-2002

journal_volume

12

pub_type

临床试验,杂志文章

相关文献

MOLECULAR IMAGING AND BIOLOGY文献大全
  • Imaging of cholinergic and monoaminergic neurochemical changes in neurodegenerative disorders.

    abstract：:Positron emission tomography (PET) or single photon emission computer tomography (SPECT) imaging provides the means to study neurochemical processes in vivo. These methods have been applied to examine monoaminergic and cholinergic changes in neurodegenerative disorders. These investigations have provided important ins...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章,评审

    doi：10.1007/s11307-007-0083-6

    authors： Bohnen NI,Frey KA

    更新日期：2007-07-01 00:00:00

  • A Novel Modality for Functional Imaging in Acute Intervertebral Disk Herniation via Tracking Leukocyte Infiltration.

    abstract：PURPOSE:Inflammation plays a key role in the progression of intervertebral disk (IVD) herniation and associated low back pain. However, real-time spatial diagnosis of inflammation associated with acute disk herniation has not been investigated. We sought to detect local neutrophil and macrophage infiltration near disk ...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-016-1038-6

    authors： Xiao L,Ding M,Zhang Y,Chordia M,Pan D,Shimer A,Shen F,Glover D,Jin L,Li X

    更新日期：2017-10-01 00:00:00

  • Correction to: Metabolic Brain Network Analysis of Hypothyroidism Symptom Based on [18F]FDG-PET of Rats.

    abstract：:This article was updated to correct the spelling of Hongkai Wang's name: it is correct as displayed here. ...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章,已发布勘误

    doi：10.1007/s11307-018-1240-9

    authors： Wang H,Tan Z,Zheng Q,Yu J

    更新日期：2019-02-01 00:00:00

  • Comparison of [¹¹C]choline ([¹¹C]CHO) and S(+)-β-methyl-[¹¹C]choline ([¹¹C]SMC) as imaging probes for prostate cancer in a PC-3 prostate cancer xenograft model.

    abstract：PURPOSE:Carbon-11- and fluorine-18-labeled choline derivatives have been introduced as promising tracers for prostate cancer imaging. However, due to limited specificity and sensitivity, there is a need for new tracers with higher sensitivity and specificity for diagnosing prostate cancer to improve tracer uptake and e...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-014-0782-8

    authors： Schwarzenböck SM,Gertz J,Souvatzoglou M,Kurth J,Sachs D,Nawroth R,Treiber U,Schuster T,Senekowitsch-Schmidtke R,Schwaiger M,Ziegler SI,Henriksen G,Wester HJ,Krause BJ

    更新日期：2015-04-01 00:00:00

  • A comparison between time domain and spectral imaging systems for imaging quantum dots in small living animals.

    abstract：PURPOSE:We quantified the performance of time-domain imaging (TDI) and spectral imaging (SI) for fluorescence imaging of quantum dots (QDs) in three distinct imaging instruments: eXplore Optix (TDI, Advanced Research Technologies Inc.), Maestro (SI, CRi Inc.), and IVIS-Spectrum (SI, Caliper Life Sciences Inc.). PROCED...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-009-0290-4

    authors： de la Zerda A,Bodapati S,Teed R,Schipper ML,Keren S,Smith BR,Ng JS,Gambhir SS

    更新日期：2010-10-01 00:00:00

  • Deep brain stimulation of the prelimbic medial prefrontal cortex: quantification of the effect on glucose metabolism in the rat brain using [(18) F]FDG microPET.

    abstract：PURPOSE:Prefrontal cortex (PFC) deep brain stimulation (DBS) has been proposed as a therapy for addiction and depression. This study investigates changes in rat cerebral glucose metabolism induced by different DBS frequencies using μPET. PROCEDURES:One hour DBS of the prelimbic area (PL) of the medial PFC (mPFC) (60 H...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-014-0757-9

    authors： Parthoens J,Verhaeghe J,Stroobants S,Staelens S

    更新日期：2014-12-01 00:00:00

  • Radiolabeling and Preliminary Evaluation of Ga-68 Labeled NODAGA-Ubiquicidin Fragments for Prospective Infection Imaging.

    abstract：PURPOSE:The present work was aimed at the development of prospective positron emission tomography (PET) agents for infection imaging. Towards this aim, ubiquicidin (UBI) fragments conjugated with the macrocyclic NODAGA chelator were radiolabeled with Ga-68 and evaluated. PROCEDURES:Conformations of custom synthesized ...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-016-0983-4

    authors： Bhatt J,Mukherjee A,Korde A,Kumar M,Sarma HD,Dash A

    更新日期：2017-02-01 00:00:00

  • Whole body biodistribution and radiation dosimetry in humans of a new PET ligand, [(18)F]-FEPPA, to image translocator protein (18 kDa).

    abstract：PURPOSE:[(18)F]-FEPPA is a translocator protein (18 kDa, TSPO) positron emission tomography (PET) radiotracer. Radiation dosimetry was estimated from the whole body biodistribution, taking into consideration TSPO rs6971 (Ala147Thr) polymorphism. PROCEDURES:[(18)F]-FEPPA whole body PET scans were acquired for six healt...

    journal_title：Molecular imaging and biology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11307-012-0589-4

    authors： Mizrahi R,Rusjan PM,Vitcu I,Ng A,Wilson AA,Houle S,Bloomfield PM

    更新日期：2013-06-01 00:00:00

  • Axl-targeted cancer imaging with humanized antibody h173.

    abstract：PURPOSE:The tyrosine kinase receptor Axl is overexpressed in various types of cancer and correlated with cancer malignancy. Selective Axl blockade reduces tumor growth and metastasis. The purpose of this study was to examine whether the humanized anti-Axl antibody humanized 173 (h173) labeled with near-infrared fluores...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-013-0714-z

    authors： Li D,Liu S,Liu R,Park R,Yu H,Krasnoperov V,Gill PS,Li Z,Shan H,Conti PS

    更新日期：2014-08-01 00:00:00

  • Syntheses and radiosyntheses of two carbon-11 labeled potent and selective radioligands for imaging vesicular acetylcholine transporter.

    abstract：PURPOSE:The vesicular acetylcholine transporter (VAChT) is a specific biomarker for imaging presynaptic cholinergic neurons. The syntheses and C-11 labeling of two potent enantiopure VAChT inhibitors are reported here. PROCEDURES:Two VAChT inhibitors, (±)-2 and (±)-6, were successfully synthesized. A chiral HPLC colum...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-014-0748-x

    authors： Padakanti PK,Zhang X,Li J,Parsons SM,Perlmutter JS,Tu Z

    更新日期：2014-12-01 00:00:00

  • Exploring with [18F]UCB-H the in vivo Variations in SV2A Expression through the Kainic Acid Rat Model of Temporal Lobe Epilepsy.

    abstract：PURPOSE:The main purpose of this study was to understand how the positron emission tomography (PET) measure of the synaptic vesicle 2A (SV2A) protein varies in vivo during the development of temporal lobe epilepsy (TLE) in the kainic acid rat model. PROCEDURES:Twenty Sprague Dawley male rats were administered with mul...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-020-01488-7

    authors： Serrano ME,Bahri MA,Becker G,Seret A,Germonpré C,Lemaire C,Giacomelli F,Mievis F,Luxen A,Salmon E,Rogister B,Raedt R,Plenevaux A

    更新日期：2020-10-01 00:00:00

  • Distribution of Brown Adipose Tissue Radiodensity in Young Adults: Implications for Cold [18F]FDG-PET/CT Analyses.

    abstract：PURPOSE:Nowadays, 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET)/X-ray computed tomography (CT) is considered the best available technique to in vivo determination of human BAT volume. The most used Hounsfield unit (HU) threshold for BAT quantification is from - 250 to - 50 HU. Therefore,...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-019-01381-y

    authors： Martinez-Tellez B,Sanchez-Delgado G,Boon MR,Rensen PCN,Llamas-Elvira JM,Ruiz JR

    更新日期：2020-04-01 00:00:00

  • (18)F-FDG PET/CT imaging detects therapy efficacy of anti-EMMPRIN antibody and gemcitabine in orthotopic pancreatic tumor xenografts.

    abstract：PURPOSE:The objective of this study is to evaluate the therapeutic response to a novel monoclonal antibody targeting human extracellular matrix metalloproteinase inducer (EMMPRIN) in combination with gemcitabine in a pancreatic-tumor xenograft murine model by sequential 2-deoxy-2-[18F]fluoro-D-glucose ((18)F-FDG) posit...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-011-0491-5

    authors： Shah N,Zhai G,Knowles JA,Stockard CR,Grizzle WE,Fineberg N,Zhou T,Zinn KR,Rosenthal EL,Kim H

    更新日期：2012-04-01 00:00:00

  • Site-Specifically Labeled Immunoconjugates for Molecular Imaging--Part 1: Cysteine Residues and Glycans.

    abstract：:Due to their remarkable selectivity and specificity for cancer biomarkers, immunoconjugates have emerged as extremely promising vectors for the delivery of diagnostic radioisotopes and fluorophores to malignant tissues. Paradoxically, however, these tools for precision medicine are synthesized in a remarkably imprecis...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章,评审

    doi：10.1007/s11307-015-0919-4

    authors： Adumeau P,Sharma SK,Brent C,Zeglis BM

    更新日期：2016-02-01 00:00:00

  • Sodium [¹⁸F]fluoride PET/CT in myocardial infarction.

    abstract：PURPOSE:Sodium [(18)F]fluoride (Na[(18)F]F) positron emission tomography with integrated computed tomography (PET/CT) has not been used for imaging myocardial infarction (MI). Here, we aimed to investigate the Na[(18)F]F PET/CT features of MI in a rat model. PROCEDURES:MI was induced by coronary artery ligation in 8-w...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-014-0796-2

    authors： Han JH,Lim SY,Lee MS,Lee WW

    更新日期：2015-04-01 00:00:00

  • Use of positron emission tomography to target prostate cancer gene therapy by oncolytic herpes simplex virus.

    abstract：:Herpes simplex virus (HSV) oncolytic gene therapy is a promising treatment modality against cancer. We have demonstrated that androgen-induced cellular changes enhance oncolytic viral replication and improve efficacy in the treatment of androgen-dependent prostate cancer cell line. Imaging of changes in 2-deoxy-2-[F-1...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-005-0028-x

    authors： Mullerad M,Eisenberg DP,Akhurst TJ,Adusumilli PS,Riedl CC,Bhargava A,Gonen M,Finn R,Scardino PT,Fong Y

    更新日期：2006-01-01 00:00:00

  • Drugs and probes: the symbiotic relationship between pharmaceutical discovery and imaging science.

    abstract：:Pharmaceutical research and imaging science are becoming increasingly intertwined. Positron emission tomography (PET) is a molecular imaging technique with particularly broad application in drug discovery and development. At the same time, modern techniques of drug discovery are helping accelerate the development of n...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mibio.2003.09.008

    authors： Maclean D,Northrop JP,Padgett HC,Walsh JC

    更新日期：2003-09-01 00:00:00

  • Evaluation of arginine deiminase treatment in melanoma xenografts using (18)F-FLT PET.

    abstract：PURPOSE:This study aims to develop a molecular imaging strategy for response assessment of arginine deiminase (ADI) treatment in melanoma xenografts using 3'-[(18)F]fluoro-3'-deoxythymidine ([(18)F]-FLT) positron emission tomography (PET). PROCEDURES:F-FLT response to ADI therapy was studied in preclinical models of m...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-013-0655-6

    authors： Stelter L,Fuchs S,Jungbluth AA,Ritter G,Longo VA,Zanzonico P,Raschzok N,Sauer IM,Bomalaski JS,Larson SM

    更新日期：2013-12-01 00:00:00

  • Current and Emerging Preclinical Approaches for Imaging-Based Characterization of Atherosclerosis.

    abstract：:Atherosclerotic plaques can remain quiescent for years, but become life threatening upon rupture or disruption, initiating clot formation in the vessel lumen and causing acute myocardial infarction and ischemic stroke. Whether and how a plaque ruptures is determined by its macroscopic structure and microscopic composi...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章,评审

    doi：10.1007/s11307-018-1264-1

    authors： Vigne J,Thackeray J,Essers J,Makowski M,Varasteh Z,Curaj A,Karlas A,Canet-Soulas E,Mulder W,Kiessling F,Schäfers M,Botnar R,Wildgruber M,Hyafil F,Cardiovascular study group of the European Society of Molecular Imaging.

    更新日期：2018-12-01 00:00:00

  • Non-invasive Standardised Uptake Value for Verification of the Use of Previously Validated Reference Region for [18F]Flortaucipir and [18F]Florbetapir Brain PET Studies.

    abstract：PURPOSE:The simplified reference tissue model (SRTM) is commonly applied for the quantification of brain positron emission tomography (PET) studies, particularly because it avoids arterial cannulation. SRTM requires a validated reference region which is obtained by baseline-blocking or displacement studies. Once a refe...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-020-01572-y

    authors： de Vries BM,Timmers T,Wolters EE,Ossenkoppele R,Verfaillie SCJ,Schuit RC,Scheltens P,van der Flier WM,Windhorst AD,van Berckel BNM,Boellaard R,Golla SSV

    更新日期：2021-01-14 00:00:00

  • Quantitating antibody uptake in vivo: conditional dependence on antigen expression levels.

    abstract：PURPOSE:Antibodies form an important class of cancer therapeutics, and there is intense interest in using them for imaging applications in diagnosis and monitoring of cancer treatment. Despite the expanding body of knowledge describing pharmacokinetic and pharmacodynamic interactions of antibodies in vivo, discrepancie...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-010-0397-7

    authors： Thurber GM,Weissleder R

    更新日期：2011-08-01 00:00:00

  • Feasibility of Longitudinal Brain PET with Real-Time Arterial Input Function in Rats.

    abstract：PURPOSE:Preclinical dynamic brain PET studies remain hampered by the limitations related to the measurement of the arterial input function (AIF). In this regard, the use of an arterial-venous shunt is a promising method for the generation of real-time AIFs, but its application in longitudinal studies is still impeded b...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-020-01556-y

    authors： Rey-Bretal D,Moscoso A,Gómez-Lado N,Fernández-Ferreiro A,Silva-Rodríguez J,Ruibal Á,Aguiar P

    更新日期：2020-11-17 00:00:00

  • Source-Based Morphometry Multivariate Approach to Analyze [123I]FP-CIT SPECT Imaging.

    abstract：PURPOSE:[123I]FP-CIT (DaTSCAN®) single-photon emission computed tomography (SPECT) imaging is widely used to study neurodegenerative parkinsonism, by measuring presynaptic dopamine transporter (DAT) in striatal regions. Beyond DAT, [123I]FP-CIT may be considered for other monoaminergic systems, in particular the seroto...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-017-1052-3

    authors： Premi E,Calhoun VD,Garibotto V,Turrone R,Alberici A,Cottini E,Pilotto A,Gazzina S,Magoni M,Paghera B,Borroni B,Padovani A

    更新日期：2017-10-01 00:00:00

  • Early-Phase Luciferase Signals of Islet Grafts Predicts Successful Subcutaneous Site Transplantation in Rats.

    abstract：PURPOSE:The transplantation of pancreatic islets is a promising cell replacement therapy for type 1 diabetes. Subcutaneous islet transplantation is currently under investigation as a means to circumvent problems associated with standard intra-hepatic islet transplantation. As modifications are being developed to improv...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-020-01560-2

    authors： Komatsu H,Gonzalez N,Ortiz J,Rawson J,Omori K,Kandeel F,Mullen Y

    更新日期：2020-11-02 00:00:00

  • MicroPET imaging of integrin αvβ3 expressing tumors using 89Zr-RGD peptides.

    abstract：PURPOSE:The dimeric transmembrane integrin, α(v)β(3), is a well-investigated target by different imaging modalities through suitably labeled arginine-glycine-aspartic acid (RGD) containing peptides. In this study, we labeled four cyclic RGD peptides with or without PEG functional groups: c(RGDfK) (denoted as FK), PEG(3...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-010-0458-y

    authors： Jacobson O,Zhu L,Niu G,Weiss ID,Szajek LP,Ma Y,Sun X,Yan Y,Kiesewetter DO,Liu S,Chen X

    更新日期：2011-12-01 00:00:00

  • Assessment of Chemotherapy-Induced Organ Damage with Ga-68 Labeled Duramycin.

    abstract：PURPOSE:Evaluation of [68Ga]NODAGA-duramycin as a positron emission tomography (PET) tracer of cell death for whole-body detection of chemotherapy-induced organ toxicity. PROCEDURES:Tracer specificity of Ga-68 labeled NODAGA-duramycin was determined in vitro using competitive binding experiments. Organ uptake was anal...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-019-01417-3

    authors： Rix A,Drude NI,Mrugalla A,Baskaya F,Pak KY,Gray B,Kaiser HJ,Tolba RH,Fiegle E,Lederle W,Mottaghy FM,Kiessling F

    更新日期：2020-06-01 00:00:00

  • Imaging of Tumor Spheroids, Dual-Isotope SPECT, and Autoradiographic Analysis to Assess the Tumor Uptake and Distribution of Different Nanobodies.

    abstract：PURPOSE:Recent studies have shown rapid accumulation of nanobodies (NBs) in tumors and fast clearance of the unbound fraction, making NBs exceptional tracers for cancer imaging. In this study, we investigate the combination of in vitro imaging of tumor spheroids, in vivo dual-isotope single-photon emission computed tom...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-019-01320-x

    authors： Beltrán Hernández I,Rompen R,Rossin R,Xenaki KT,Katrukha EA,Nicolay K,van Bergen En Henegouwen P,Grüll H,Oliveira S

    更新日期：2019-12-01 00:00:00

  • Surface feature-guided mapping of cerebral metabolic changes in cognitively normal and mildly impaired elderly.

    abstract：PURPOSE:The aim of this study was to investigate the longitudinal positron emission tomography (PET) metabolic changes in the elderly. PROCEDURES:Nineteen nondemented subjects (mean Mini-Mental Status Examination 29.4 +/- 0.7 SD) underwent two detailed neuropsychological evaluations and resting 2-deoxy-2-[F-18]fluoro-...

    journal_title：Molecular imaging and biology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11307-009-0247-7

    authors： Apostolova LG,Thompson PM,Rogers SA,Dinov ID,Zoumalan C,Steiner CA,Siu E,Green AE,Small GW,Toga AW,Cummings JL,Phelps ME,Silverman DH

    更新日期：2010-04-01 00:00:00

  • ImmunoPET Imaging of αvβ6 Expression Using an Engineered Anti-αvβ6 Cys-diabody Site-Specifically Radiolabeled with Cu-64: Considerations for Optimal Imaging with Antibody Fragments.

    abstract：PURPOSE:Increased expression of the αvβ6 integrin correlates with advanced tumor grade and poor clinical outcome, identifying αvβ6 as a prognostic indicator and an attractive target for molecular imaging. This work investigated the ability of a disulfide-stabilized [64Cu]NOTA-αvβ6 cys-diabody to image αvβ6 expression i...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-017-1097-3

    authors： White JB,Hu LY,Boucher DL,Sutcliffe JL

    更新日期：2018-02-01 00:00:00

  • Transferrin-coated gadolinium nanoparticles as MRI contrast agent.

    abstract：PURPOSE:In this study, the contrasting properties of human serum albumin nanoparticles (HSA-NPs) loaded with gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and coated with transferrin in MRI in mice are evaluated. PROCEDURES:HSA-NPs were conjugated with Gd-DTPA (Gd-HSA-NPs) and coupled with transferrin (Gd-H...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-012-0579-6

    authors： Korkusuz H,Ulbrich K,Welzel K,Koeberle V,Watcharin W,Bahr U,Chernikov V,Knobloch T,Petersen S,Huebner F,Ackermann H,Gelperina S,Kromen W,Hammerstingl R,Haupenthal J,Gruenwald F,Fiehler J,Zeuzem S,Kreuter J,Vogl TJ,

    更新日期：2013-04-01 00:00:00