Imaging of cholinergic and monoaminergic neurochemical changes in neurodegenerative disorders.

abstract：PURPOSE:The present work was aimed at the development of prospective positron emission tomography (PET) agents for infection imaging. Towards this aim, ubiquicidin (UBI) fragments conjugated with the macrocyclic NODAGA chelator were radiolabeled with Ga-68 and evaluated. PROCEDURES:Conformations of custom synthesized ...

journal_title：Molecular imaging and biology

authors： Bhatt J,Mukherjee A,Korde A,Kumar M,Sarma HD,Dash A

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:Inflammation plays a key role in the progression of intervertebral disk (IVD) herniation and associated low back pain. However, real-time spatial diagnosis of inflammation associated with acute disk herniation has not been investigated. We sought to detect local neutrophil and macrophage infiltration near disk ...

journal_title：Molecular imaging and biology

authors： Xiao L,Ding M,Zhang Y,Chordia M,Pan D,Shimer A,Shen F,Glover D,Jin L,Li X

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:The aim of this work is to investigate the impact of tissue classification in magnetic resonance imaging (MRI)-guided positron emission tomography (PET) attenuation correction (AC) for whole-body (WB) Patlak net uptake rate constant (Ki) imaging in PET/MRI studies. PROCEDURES:WB dynamic PET/CT data were acquir...

journal_title：Molecular imaging and biology

authors： Zhuang M,Karakatsanis NA,Dierckx RAJO,Zaidi H

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:The main purpose of this study was to understand how the positron emission tomography (PET) measure of the synaptic vesicle 2A (SV2A) protein varies in vivo during the development of temporal lobe epilepsy (TLE) in the kainic acid rat model. PROCEDURES:Twenty Sprague Dawley male rats were administered with mul...

journal_title：Molecular imaging and biology

authors： Serrano ME,Bahri MA,Becker G,Seret A,Germonpré C,Lemaire C,Giacomelli F,Mievis F,Luxen A,Salmon E,Rogister B,Raedt R,Plenevaux A

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:Preclinical dynamic brain PET studies remain hampered by the limitations related to the measurement of the arterial input function (AIF). In this regard, the use of an arterial-venous shunt is a promising method for the generation of real-time AIFs, but its application in longitudinal studies is still impeded b...

journal_title：Molecular imaging and biology

authors： Rey-Bretal D,Moscoso A,Gómez-Lado N,Fernández-Ferreiro A,Silva-Rodríguez J,Ruibal Á,Aguiar P

更新日期：2020-11-17 00:00:00

abstract：PURPOSE:The present work was aimed at the formulation and evaluation of freeze-dried kits of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-peptides for the preparation of (68)Ga-labelled peptides for PET imaging of neuroendocrine tumours. The (68)GaCl3 was obtained from the locally produced nanoceria-...

journal_title：Molecular imaging and biology

authors： Mukherjee A,Pandey U,Chakravarty R,Sarma HD,Dash A

更新日期：2014-08-01 00:00:00

abstract：PURPOSE:Recent researches have demonstrated the value of using 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) imaging to reveal the hypothyroidism-related damages in local brain regions. However, the influence of hypothyroidism on the entire brain network is barely studied. This study foc...

journal_title：Molecular imaging and biology

authors： Wang H,Tan Z,Zheng Q,Yu J

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:Recent studies have shown rapid accumulation of nanobodies (NBs) in tumors and fast clearance of the unbound fraction, making NBs exceptional tracers for cancer imaging. In this study, we investigate the combination of in vitro imaging of tumor spheroids, in vivo dual-isotope single-photon emission computed tom...

journal_title：Molecular imaging and biology

authors： Beltrán Hernández I,Rompen R,Rossin R,Xenaki KT,Katrukha EA,Nicolay K,van Bergen En Henegouwen P,Grüll H,Oliveira S

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:The Cre-loxP system has become an important strategy for conditional gene deletion and conditional gene expression in genetically engineered mice. To evaluate Cre recombinase expression, we generated reporter mice that permit both noninvasive imaging in living animals and either ex vivo histochemical/immunohist...

journal_title：Molecular imaging and biology

authors： Ishikawa TO,Herschman HR

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:The purpose of this paper is to validate a rapid and cost-effective ex vivo technique, microCT-based virtual histology, as an alternative to MRI imaging for assessing the therapeutic response in genetically engineered mouse models of cancer. PROCEDURES:All animal procedures were conducted in accordance with th...

journal_title：Molecular imaging and biology

authors： Prajapati SI,Kilcoyne A,Samano AK,Green DP,McCarthy SD,Blackman BA,Brady MM,Zarzabal LA,Tatiparthi AK,Sledz TJ,Duong T,Ohshima-Hosoyama S,Giles FJ,Michalek JE,Rubin BP,Keller C

更新日期：2011-06-01 00:00:00

abstract：:In vivo imaging of the central nervous system (CNS) neuroreceptors in humans began was used in the early 1980s. Now, some twenty years later, the success of radiopharmaceutical imaging is still often one based on empiricism and serendipity. Nevertheless, a number of factors can be identified based on the robot experie...

journal_title：Molecular imaging and biology

authors： Wong DF,Pomper MG

更新日期：2003-11-01 00:00:00

abstract：:Atherosclerotic plaques can remain quiescent for years, but become life threatening upon rupture or disruption, initiating clot formation in the vessel lumen and causing acute myocardial infarction and ischemic stroke. Whether and how a plaque ruptures is determined by its macroscopic structure and microscopic composi...

journal_title：Molecular imaging and biology

authors： Vigne J,Thackeray J,Essers J,Makowski M,Varasteh Z,Curaj A,Karlas A,Canet-Soulas E,Mulder W,Kiessling F,Schäfers M,Botnar R,Wildgruber M,Hyafil F,Cardiovascular study group of the European Society of Molecular Imaging.

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:Dynamic positron emission tomography (PET) protocols allow for accurate quantification of [18F]flortaucipir-specific binding. However, dynamic acquisitions can be challenging given the long required scan duration of 130 min. The current study assessed the effect of shorter scan protocols for [18F]flortaucipir o...

journal_title：Molecular imaging and biology

authors： Tuncel H,Visser D,Yaqub M,Timmers T,Wolters EE,Ossenkoppele R,van der Flier WM,van Berckel BNM,Boellaard R,Golla SSV

更新日期：2021-01-26 00:00:00

abstract：PURPOSE:Nowadays, 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET)/X-ray computed tomography (CT) is considered the best available technique to in vivo determination of human BAT volume. The most used Hounsfield unit (HU) threshold for BAT quantification is from - 250 to - 50 HU. Therefore,...

journal_title：Molecular imaging and biology

authors： Martinez-Tellez B,Sanchez-Delgado G,Boon MR,Rensen PCN,Llamas-Elvira JM,Ruiz JR

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:The dimeric transmembrane integrin, α(v)β(3), is a well-investigated target by different imaging modalities through suitably labeled arginine-glycine-aspartic acid (RGD) containing peptides. In this study, we labeled four cyclic RGD peptides with or without PEG functional groups: c(RGDfK) (denoted as FK), PEG(3...

journal_title：Molecular imaging and biology

authors： Jacobson O,Zhu L,Niu G,Weiss ID,Szajek LP,Ma Y,Sun X,Yan Y,Kiesewetter DO,Liu S,Chen X

更新日期：2011-12-01 00:00:00

abstract：PURPOSE:Evaluation of [68Ga]NODAGA-duramycin as a positron emission tomography (PET) tracer of cell death for whole-body detection of chemotherapy-induced organ toxicity. PROCEDURES:Tracer specificity of Ga-68 labeled NODAGA-duramycin was determined in vitro using competitive binding experiments. Organ uptake was anal...

journal_title：Molecular imaging and biology

authors： Rix A,Drude NI,Mrugalla A,Baskaya F,Pak KY,Gray B,Kaiser HJ,Tolba RH,Fiegle E,Lederle W,Mottaghy FM,Kiessling F

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:The aim of this study is to evaluate the impact of different scatter correction strategies on quantification of high-resolution research tomograph (HRRT) data for three tracers covering a wide range in kinetic profiles. PROCEDURES:Healthy subjects received dynamic HRRT scans using either (R)-[(11)C]verapamil (...

journal_title：Molecular imaging and biology

authors： Mansor S,Boellaard R,Huisman MC,van Berckel BN,Schuit RC,Windhorst AD,Lammertsma AA,van Velden FH

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:To evaluate bone blood flow and bone formation in patients after total hip revision surgery with impacted bone grafting using H2 15O and [18F]fluoride positron emission tomography (PET). PROCEDURES:To asses bone blood flow and bone metabolism in bone allograft after impaction grafting, four patients treated wi...

journal_title：Molecular imaging and biology

authors： Temmerman OP,Raijmakers PG,Heyligers IC,Comans EF,Lubberink M,Teule GJ,Lammertsma AA

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:[18F]Mefway is a positron emission tomography (PET) radioligand for quantification of the brain serotonin 1A (5-HT1A) receptor density. The purpose of this study was to evaluate the radiation safety of [18F]Mefway in humans. PROCEDURES:Six healthy volunteers (three males and three females) were whole-body PET ...

journal_title：Molecular imaging and biology

authors： Choi JY,Lyoo CH,Kim JS,Kim KM,Lee M,Ryu YH

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:To evaluate the clinical significance of differences in 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET) lymph node standardized uptake values (SUV) in human immunodeficiency virus (HIV) infection using iterative reconstruction with segmented attenuation correction (IR SAC) compared to fil...

journal_title：Molecular imaging and biology

authors： Chin BB,Lyengar S,Sabundayo BP,Schwartz D

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:We recently reported that high thymidine phosphorylase (TP) expression is accompanied by low tumor thymidine concentration and high 3'-deoxy-3'-[18F]fluorothymidine ([18F]FLT) uptake in four untreated lung cancer xenografts. Here, we investigated whether this relationship also holds true for a broader range of ...

journal_title：Molecular imaging and biology

authors： Schelhaas S,Heinzmann K,Honess DJ,Smith DM,Keen H,Heskamp S,Witney TH,Besret L,Doblas S,Griffiths JR,Aboagye EO,Jacobs AH

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate the feasibility of dual magnetic resonance imaging (MRI) reporter genes, including ferritin heavy subunit (Fth) and transferrin receptor (TfR), which provide sufficient MRI contrast for in vivo MRI tracking, and the Deltex-1 (DTX1) gene, which promotes human mesenchy...

journal_title：Molecular imaging and biology

authors： Guo R,Li Q,Yang F,Hu X,Jiao J,Guo Y,Wang J,Zhang Y

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:Malignant cells exhibit increased rates of aerobic glycolysis. Here, we tested whether the accumulation of fluoro-deoxyglucose-6-phosphate (FDG6P) in ovarian cancers of differential malignancy reflects inversely correlated elevations of hexokinase (HK) and glucose-6-phosphatase (G6Pase) activities. PROCEDURES:...

journal_title：Molecular imaging and biology

authors： Olsen BB,Gjedde A,Vilstrup MH,Johnsen IBG,Neumann G,Torigian DA,Alavi A,Høilund-Carlsen PF

更新日期：2019-04-01 00:00:00

abstract：:This article was updated to correct the spelling of Hongkai Wang's name: it is correct as displayed here. ...

journal_title：Molecular imaging and biology

authors： Wang H,Tan Z,Zheng Q,Yu J

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:The development of theranostic nanocarriers as an innovative therapy against cancer has been improved by targeting properties in order to optimize the drug delivery to safely achieve its desired therapeutic effect. The aim of this paper is to evaluate the magnetic targeting (MT) efficiency of ultra-magnetic lip...

journal_title：Molecular imaging and biology

authors： Thébault CJ,Ramniceanu G,Michel A,Beauvineau C,Girard C,Seguin J,Mignet N,Ménager C,Doan BT

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:We developed a bimolecular fluorescence complementation (BiFC) strategy using Dronpa, a new fluorescent protein with reversible photoswitching activity and fast responsibility to light, to monitor protein-protein interactions in cells. PROCEDURES:Dronpa was split at residue Glu164 in order to generate two Dron...

journal_title：Molecular imaging and biology

authors： Lee YR,Park JH,Hahm SH,Kang LW,Chung JH,Nam KH,Hwang KY,Kwon IC,Han YS

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:Synapse loss is a hallmark of Alzheimer's disease (AD) and correlates with cognitive decline. The validation of a noninvasive in vivo imaging approach to quantify synapse would greatly facilitate our understanding of AD pathogenesis and assist drug developments for AD. As animal models of neurodegenerative and ...

journal_title：Molecular imaging and biology

authors： Sadasivam P,Fang XT,Toyonaga T,Lee S,Xu Y,Zheng MQ,Spurrier J,Huang Y,Strittmatter SM,Carson RE,Cai Z

更新日期：2020-11-30 00:00:00

abstract：PURPOSE:[123I]FP-CIT (DaTSCAN®) single-photon emission computed tomography (SPECT) imaging is widely used to study neurodegenerative parkinsonism, by measuring presynaptic dopamine transporter (DAT) in striatal regions. Beyond DAT, [123I]FP-CIT may be considered for other monoaminergic systems, in particular the seroto...

journal_title：Molecular imaging and biology

authors： Premi E,Calhoun VD,Garibotto V,Turrone R,Alberici A,Cottini E,Pilotto A,Gazzina S,Magoni M,Paghera B,Borroni B,Padovani A

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:This study aims to develop a molecular imaging strategy for response assessment of arginine deiminase (ADI) treatment in melanoma xenografts using 3'-[(18)F]fluoro-3'-deoxythymidine ([(18)F]-FLT) positron emission tomography (PET). PROCEDURES:F-FLT response to ADI therapy was studied in preclinical models of m...

journal_title：Molecular imaging and biology

authors： Stelter L,Fuchs S,Jungbluth AA,Ritter G,Longo VA,Zanzonico P,Raschzok N,Sauer IM,Bomalaski JS,Larson SM

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:Repetitive imaging with microPET of endogenous albumin gene expression by using transgenic mice in which the Herpes Simplex Virus Type 1 thymidine kinase (HSV1-tk) reporter gene is driven by the albumin promoter (AL-HSV1-tk). METHODS:Transgenic mice were imaged repeatedly on a microPET scanner with approximate...

journal_title：Molecular imaging and biology

authors： Green LA,Yap CS,Nguyen K,Barrio JR,Namavari M,Satyamurthy N,Phelps ME,Sandgren EP,Herschman HR,Gambhir SS

更新日期：2002-01-01 00:00:00