Abstract：
PURPOSE:[18F]Mefway is a positron emission tomography (PET) radioligand for quantification of the brain serotonin 1A (5-HT1A) receptor density. The purpose of this study was to evaluate the radiation safety of [18F]Mefway in humans. PROCEDURES:Six healthy volunteers (three males and three females) were whole-body PET scanned for 114 min after injection of [18F]Mefway (226 ± 35 MBq). Estimated radiation doses were determined by the OLINDA/EXM software. RESULTS:[18F]Mefway was safe and well tolerated by all subjects. Residence time ranges from 0 (gallbladder) to 0.822 h (urinary bladder wall). While the estimated radiation doses in the reproductive and blood-forming organs were below 13.35-22.87 μSv/MBq, radiation dose in the urinary bladder wall was 471 μSv/MBq. The mean effective dose was 40.23 ± 6.63 μSv/MBq. CONCLUSION:For a typical single injection of 185 MBq (5 mCi), the dose will result in 87.1 mSv for the urinary bladder wall. To reduce radiation burden, the bladder voiding can be used before [18F]Mefway PET scan.
journal_name
Mol Imaging Bioljournal_title
Molecular imaging and biologyauthors
Choi JY,Lyoo CH,Kim JS,Kim KM,Lee M,Ryu YHdoi
10.1007/s11307-016-0955-8subject
Has Abstractpub_date
2016-12-01 00:00:00pages
803-806issue
6eissn
1536-1632issn
1860-2002pii
10.1007/s11307-016-0955-8journal_volume
18pub_type
临床试验,杂志文章abstract：PURPOSE:Antibodies form an important class of cancer therapeutics, and there is intense interest in using them for imaging applications in diagnosis and monitoring of cancer treatment. Despite the expanding body of knowledge describing pharmacokinetic and pharmacodynamic interactions of antibodies in vivo, discrepancie...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-010-0397-7
更新日期：2011-08-01 00:00:00
abstract：:Erdheim-Chester disease (ECD) is a disseminated xanthogranulomatous infiltrative disease of unknown etiology due to infiltration of different organs and bones by foamy histiocytes. A 37-year-old male with cerebral and periorbital lesions was diagnosed with this rare disease and was evaluated with magnetic resonance im...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1016/j.mibio.2004.01.023
更新日期：2004-01-01 00:00:00
abstract：INTRODUCTION:We have previously described the labeling of interleukin-2 (IL2) with (123)I and (99m)Tc-N(3)S. Both radiopharmaceuticals were successfully applied in humans to image several inflammatory lesions and autoimmune diseases characterized by tissue infiltrating lymphocytes expressing the IL2 receptor (CD25). Ho...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-009-0285-1
更新日期：2010-10-01 00:00:00
abstract：:The blood flow through normal liver parenchyma and a pathologically proven hepatic region of focal nodular hyperplasia (FNH) of the lateral lobe, was measured in a single patient in a quantitative manner using regional dynamic positron emission tomography (PET) imaging with O-15 carbon dioxide (steady state) and O-15 ...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1016/s1536-1632(01)00002-6
更新日期：2002-05-01 00:00:00
abstract：PURPOSE:Recent studies have shown rapid accumulation of nanobodies (NBs) in tumors and fast clearance of the unbound fraction, making NBs exceptional tracers for cancer imaging. In this study, we investigate the combination of in vitro imaging of tumor spheroids, in vivo dual-isotope single-photon emission computed tom...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-019-01320-x
更新日期：2019-12-01 00:00:00
abstract：PURPOSE:The purpose of this paper is to validate a rapid and cost-effective ex vivo technique, microCT-based virtual histology, as an alternative to MRI imaging for assessing the therapeutic response in genetically engineered mouse models of cancer. PROCEDURES:All animal procedures were conducted in accordance with th...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-010-0372-3
更新日期：2011-06-01 00:00:00
abstract：PURPOSE:We aimed to elucidate trans-1-amino-3-[(18)F]fluorocyclobutanecarboxylic acid (anti-[(18)F]FACBC) uptake mechanisms in inflammatory and tumor cells, in comparison with those of L-[methyl-(11)C]methionine ([(11)C]Met) and 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG). PROCEDURES:Using carbon-14-labeled tracers...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-013-0693-0
更新日期：2014-06-01 00:00:00
abstract：PURPOSE:[(18)F]-FEPPA is a translocator protein (18 kDa, TSPO) positron emission tomography (PET) radiotracer. Radiation dosimetry was estimated from the whole body biodistribution, taking into consideration TSPO rs6971 (Ala147Thr) polymorphism. PROCEDURES:[(18)F]-FEPPA whole body PET scans were acquired for six healt...
journal_title：Molecular imaging and biology
pub_type： 临床试验,杂志文章
doi：10.1007/s11307-012-0589-4
更新日期：2013-06-01 00:00:00
abstract：:This article reviews positron emission tomography (PET) studies of labeled enantiomers of different PET-tracers from the early 1980s. Comparative studies on stereoselective behavior of the transport of tracers across the blood-brain barrier (BBB) are discussed. Tracers are transported through the BBB into the brain, v...
journal_title：Molecular imaging and biology
pub_type： 杂志文章,评审
doi：10.1016/j.mibio.2004.06.008
更新日期：2004-09-01 00:00:00
abstract：:This paper demonstrates the application of mutual information based coregistration of radionuclide and magnetic resonance imaging (MRI) in an effort to use multimodality imaging for noninvasive localization of stem cells grafted in the infarcted myocardium in rats. Radionuclide imaging such as single photon emission c...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-006-0062-3
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:Cellular receptor targeted imaging agents present the potential to target extracellular molecular expression in cancerous lesions; however, the image contrast in vivo does not reflect the magnitude of overexpression expected from in vitro data. Here, the in vivo delivery and binding kinetics of epidermal growth...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-011-0503-5
更新日期：2012-08-01 00:00:00
abstract：PURPOSE:This study was undertaken to determine if artifacts from misalignment of cardiac emission to transmission data is present in adenosine stress studies and if the artifact could be reproduced by intentional misalignment in normal exams. PROCEDURES:Seventy consecutive 82Rb myocardial perfusion studies were review...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-008-0139-2
更新日期：2008-07-01 00:00:00
abstract：PURPOSE:The present work was aimed at the development of prospective positron emission tomography (PET) agents for infection imaging. Towards this aim, ubiquicidin (UBI) fragments conjugated with the macrocyclic NODAGA chelator were radiolabeled with Ga-68 and evaluated. PROCEDURES:Conformations of custom synthesized ...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-016-0983-4
更新日期：2017-02-01 00:00:00
abstract：PURPOSE:The aim of this study was to investigate the longitudinal positron emission tomography (PET) metabolic changes in the elderly. PROCEDURES:Nineteen nondemented subjects (mean Mini-Mental Status Examination 29.4 +/- 0.7 SD) underwent two detailed neuropsychological evaluations and resting 2-deoxy-2-[F-18]fluoro-...
journal_title：Molecular imaging and biology
pub_type： 临床试验,杂志文章
doi：10.1007/s11307-009-0247-7
更新日期：2010-04-01 00:00:00
abstract：PURPOSE:[123I]FP-CIT (DaTSCAN®) single-photon emission computed tomography (SPECT) imaging is widely used to study neurodegenerative parkinsonism, by measuring presynaptic dopamine transporter (DAT) in striatal regions. Beyond DAT, [123I]FP-CIT may be considered for other monoaminergic systems, in particular the seroto...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-017-1052-3
更新日期：2017-10-01 00:00:00
abstract：PURPOSE:This study aimed to test the hypothesis that lung cancer patient-derived circulating microparticles (LCC-MPs) enhance metastatic lung tumors in a rat model. PROCEDURES:The controls (n = 6) and LCC-MP-treated rats (n = 6) with N1S1-induced pulmonary metastatic hepatocellular carcinoma (HCC) underwent dual-sourc...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-015-0923-8
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:To assess a novel radiotracer aluminum [18F]fluoride-1,4,7-triazacyclononane-triacetic acid-pegylated dimeric RGD ([18F]ALF-NOTA-PRGD2, denoted as [18F]Alfatide) for positron emission tomography (PET)/X-ray computed tomography (CT) and explore the relationships between clinicopathological characteristics and ma...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-018-1216-9
更新日期：2019-02-01 00:00:00
abstract：PURPOSE:Carbon ion radiotherapy (CIRT) has been developed, and a phase I/II CIRT trial has been conducted in patients with adenocarcinoma in the head and neck region. We evaluated whether the L-methyl [11C]-methionine (MET) uptake could be an early predictor for local recurrence, metastasis, and the prognosis in patien...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-010-0318-9
更新日期：2010-10-01 00:00:00
abstract：PURPOSE:We evaluated the ability of 2-deoxy-2-(18)F-fluoro-D-glucose (FDG) positron emission tomography (PET) in the early assessment of therapeutic response in patients with small cell lung cancer (SCLC). PROCEDURES:FDG PET studies were performed before (baseline PET), after the first cycle of chemotherapy (early PET...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-009-0227-y
更新日期：2009-11-01 00:00:00
abstract：PURPOSE:Contrast-enhanced magnetic resonance imaging (MRI) has the potential to replace angiographic evaluation of atherosclerosis. While studies have investigated contrast agent (CA) uptake in atherosclerotic plaques, exact CA spatial distribution on a microscale is elusive. The purpose of this study was to investigat...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-020-01563-z
更新日期：2020-12-07 00:00:00
abstract：PURPOSE:Imaging using positron emission tomography (PET) in the field of nuclear medicine is becoming increasingly important. The aim of this study was to develop a method for labeling of affibody molecules with radiocobalt for PET applications. PROCEDURES:The human epidermal growth factor receptors type 2 (HER2) bind...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-009-0238-8
更新日期：2010-01-01 00:00:00
abstract：PURPOSE:Macrophage accumulation characterizes the development of atherosclerotic plaques, and the presence of certain macrophage subsets might be an indicator of plaque phenotype and (in)stability. The macrophage mannose receptor (MMR) is expressed on alternatively activated macrophages and found at sites of intraplaqu...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-017-1117-3
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:The present work was aimed at the formulation and evaluation of freeze-dried kits of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-peptides for the preparation of (68)Ga-labelled peptides for PET imaging of neuroendocrine tumours. The (68)GaCl3 was obtained from the locally produced nanoceria-...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-014-0719-2
更新日期：2014-08-01 00:00:00
abstract：PURPOSE:The aim of this study is to evaluate the impact of different scatter correction strategies on quantification of high-resolution research tomograph (HRRT) data for three tracers covering a wide range in kinetic profiles. PROCEDURES:Healthy subjects received dynamic HRRT scans using either (R)-[(11)C]verapamil (...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-015-0921-x
更新日期：2016-08-01 00:00:00
abstract：:In vivo imaging of the central nervous system (CNS) neuroreceptors in humans began was used in the early 1980s. Now, some twenty years later, the success of radiopharmaceutical imaging is still often one based on empiricism and serendipity. Nevertheless, a number of factors can be identified based on the robot experie...
journal_title：Molecular imaging and biology
pub_type： 杂志文章,评审
doi：10.1016/j.mibio.2003.09.011
更新日期：2003-11-01 00:00:00
abstract：OBJECTIVE:2-Deoxy-2-[F-18]fluoro-D-glucose positron emission tomography (FDG-PET) has an established role in restaging of various cancers, including papillary and undifferentiated thyroid carcinoma, but detection rates are variable in the published literature. We were therefore prompted to review our experience with FD...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-006-0046-3
更新日期：2006-09-01 00:00:00
abstract：PURPOSE:To investigate the prognostic performance of radiomics features, as extracted from positron emission tomography (PET) and X-ray computed tomography (CT) components of baseline 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) PET/CT images and integrated with clinical parameters, in patients with nasopharyngeal carcin...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-018-01304-3
更新日期：2019-10-01 00:00:00
abstract：PURPOSE:The vesicular acetylcholine transporter (VAChT) is a specific biomarker for imaging presynaptic cholinergic neurons. The syntheses and C-11 labeling of two potent enantiopure VAChT inhibitors are reported here. PROCEDURES:Two VAChT inhibitors, (±)-2 and (±)-6, were successfully synthesized. A chiral HPLC colum...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-014-0748-x
更新日期：2014-12-01 00:00:00
abstract：PURPOSE:In this study, the contrasting properties of human serum albumin nanoparticles (HSA-NPs) loaded with gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and coated with transferrin in MRI in mice are evaluated. PROCEDURES:HSA-NPs were conjugated with Gd-DTPA (Gd-HSA-NPs) and coupled with transferrin (Gd-H...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-012-0579-6
更新日期：2013-04-01 00:00:00
abstract：PURPOSE:The main purpose of this study was to understand how the positron emission tomography (PET) measure of the synaptic vesicle 2A (SV2A) protein varies in vivo during the development of temporal lobe epilepsy (TLE) in the kainic acid rat model. PROCEDURES:Twenty Sprague Dawley male rats were administered with mul...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-020-01488-7
更新日期：2020-10-01 00:00:00
