Impact of New Scatter Correction Strategies on High-Resolution Research Tomograph Brain PET Studies.

abstract：PURPOSE:The main purpose of this study was to understand how the positron emission tomography (PET) measure of the synaptic vesicle 2A (SV2A) protein varies in vivo during the development of temporal lobe epilepsy (TLE) in the kainic acid rat model. PROCEDURES:Twenty Sprague Dawley male rats were administered with mul...

journal_title：Molecular imaging and biology

authors： Serrano ME,Bahri MA,Becker G,Seret A,Germonpré C,Lemaire C,Giacomelli F,Mievis F,Luxen A,Salmon E,Rogister B,Raedt R,Plenevaux A

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:The purpose of this study is to evaluate if the differential exchange rates with bulk water between amine and amide protons can be exploited using chemical exchange saturation transfer magnetic resonance (CEST-MR) to monitor the release of glutamate induced by carboxypeptidase G2 (CPG2), an enzyme utilized in c...

journal_title：Molecular imaging and biology

authors： Jamin Y,Eykyn TR,Poon E,Springer CJ,Robinson SP

更新日期：2014-04-01 00:00:00

abstract：INTRODUCTION:We have previously described the labeling of interleukin-2 (IL2) with (123)I and (99m)Tc-N(3)S. Both radiopharmaceuticals were successfully applied in humans to image several inflammatory lesions and autoimmune diseases characterized by tissue infiltrating lymphocytes expressing the IL2 receptor (CD25). Ho...

journal_title：Molecular imaging and biology

authors： D'Alessandria C,di Gialleonardo V,Chianelli M,Mather SJ,de Vries EF,Scopinaro F,Dierck RA,Signore A

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:The A1AR antagonist 8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine ([(18)F]CPFPX) has recently been shown to be a suitable radiotracer for quantitative in vivo imaging of the A1 adenosine receptor (A1AR) in rats. The present study evaluates the reproducibility of non-invasive longitudinal A1AR studies with [...

journal_title：Molecular imaging and biology

authors： Kroll T,Elmenhorst D,Weisshaupt A,Beer S,Bauer A

更新日期：2014-10-01 00:00:00

abstract：:Atherosclerotic plaques can remain quiescent for years, but become life threatening upon rupture or disruption, initiating clot formation in the vessel lumen and causing acute myocardial infarction and ischemic stroke. Whether and how a plaque ruptures is determined by its macroscopic structure and microscopic composi...

journal_title：Molecular imaging and biology

authors： Vigne J,Thackeray J,Essers J,Makowski M,Varasteh Z,Curaj A,Karlas A,Canet-Soulas E,Mulder W,Kiessling F,Schäfers M,Botnar R,Wildgruber M,Hyafil F,Cardiovascular study group of the European Society of Molecular Imaging.

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:Carbon ion radiotherapy (CIRT) has been developed, and a phase I/II CIRT trial has been conducted in patients with adenocarcinoma in the head and neck region. We evaluated whether the L-methyl [11C]-methionine (MET) uptake could be an early predictor for local recurrence, metastasis, and the prognosis in patien...

journal_title：Molecular imaging and biology

authors： Hasebe M,Yoshikawa K,Ohashi S,Toubaru S,Kawaguchi K,Sato J,Mizoe J,Tsujii H

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:Magnetic resonance imaging (MRI) with targeted contrast agents provides a promising means for diagnosis and treatment monitoring after cerebrovascular injury. Our goal was to demonstrate the feasibility of this approach to detect the neuroinflammatory biomarker intercellular adhesion molecule-1 (ICAM-1) after s...

journal_title：Molecular imaging and biology

authors： Deddens LH,van Tilborg GA,van der Toorn A,van der Marel K,Paulis LE,van Bloois L,Storm G,Strijkers GJ,Mulder WJ,de Vries HE,Dijkhuizen RM

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:Previous studies has demonstrated the utility of human epidermal growth factor receptor type 2 (HER2) as an attractive target for cancer molecular imaging and therapy. An affibody protein with strong binding affinity for HER2, ZHER2:342, has been reported. Various methods of chelator conjugation for radiolabeli...

journal_title：Molecular imaging and biology

authors： Qi S,Hoppmann S,Xu Y,Cheng Z

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:The aim of this study is to generate a four-class magnetic resonance imaging (MRI)-based attenuation map (μ-map) for attenuation correction of positron emission tomography (PET) data of the head area using a novel combination of short echo time (STE)/Dixon-MRI and a dedicated image segmentation method. PROCEDU...

journal_title：Molecular imaging and biology

authors： Khateri P,Saligheh Rad H,Jafari AH,Fathi Kazerooni A,Akbarzadeh A,Shojae Moghadam M,Aryan A,Ghafarian P,Ay MR

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:We aimed to explore the feasibility of transfection methods for antisense imaging. PROCEDURES:Antisense oligonucleotides (ASON) targeted to the mRNA of hTERT gene were synthesized and labeled with Technetium-99m and fluorescein isothiocyanate (FITC), respectively. Then, ASON was combined with transfection reag...

journal_title：Molecular imaging and biology

authors： Liu CB,Xu JQ,Xu BX,Zhang JM,Chen YM,Wang RM,Tian JH

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:Carbon-11- and fluorine-18-labeled choline derivatives have been introduced as promising tracers for prostate cancer imaging. However, due to limited specificity and sensitivity, there is a need for new tracers with higher sensitivity and specificity for diagnosing prostate cancer to improve tracer uptake and e...

journal_title：Molecular imaging and biology

authors： Schwarzenböck SM,Gertz J,Souvatzoglou M,Kurth J,Sachs D,Nawroth R,Treiber U,Schuster T,Senekowitsch-Schmidtke R,Schwaiger M,Ziegler SI,Henriksen G,Wester HJ,Krause BJ

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:Our objective was to determine the lowest diagnostically effective dose for E-selectin-targeted poly n-butyl cyanoacrylate (PBCA)-shelled microbubbles and to apply it to monitor antiangiogenic therapy effects. PROCEDURES:PBCA-shelled microbubbles (MBs) coupled to an E-selectin-specific peptide were applied in ...

journal_title：Molecular imaging and biology

authors： Spivak I,Rix A,Schmitz G,Fokong S,Iranzo O,Lederle W,Kiessling F

更新日期：2016-04-01 00:00:00

abstract：:Morphological imaging techniques are typically used in the anti-cancer drug efficacy evaluation process. However, these techniques can evaluate the therapeutic efficacy only when the tumor shows anatomic changes-usually at later stages, when the therapeutic effects are poor. In contrast, molecular imaging allows nonin...

journal_title：Molecular imaging and biology

authors： Liang Q,Kong L,Zhu X,Du Y,Tian J

更新日期：2020-12-01 00:00:00

abstract：:Amyloid plaques are highly heterogeneous in content, size, density, and macromolecular crowding, as they are composed of masses of fibrils and other cellular material. Given this target architecture, the aggregated microenvironment offers a unique imaging target for ligands and positron emission tomography (PET) molec...

journal_title：Molecular imaging and biology

authors： Shoghi-Jadid K,Barrio JR,Kepe V,Huang SC

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:Macrophage accumulation characterizes the development of atherosclerotic plaques, and the presence of certain macrophage subsets might be an indicator of plaque phenotype and (in)stability. The macrophage mannose receptor (MMR) is expressed on alternatively activated macrophages and found at sites of intraplaqu...

journal_title：Molecular imaging and biology

authors： Bala G,Baudhuin H,Remory I,Gillis K,Debie P,Krasniqi A,Lahoutte T,Raes G,Devoogdt N,Cosyns B,Hernot S

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:Synapse loss is a hallmark of Alzheimer's disease (AD) and correlates with cognitive decline. The validation of a noninvasive in vivo imaging approach to quantify synapse would greatly facilitate our understanding of AD pathogenesis and assist drug developments for AD. As animal models of neurodegenerative and ...

journal_title：Molecular imaging and biology

authors： Sadasivam P,Fang XT,Toyonaga T,Lee S,Xu Y,Zheng MQ,Spurrier J,Huang Y,Strittmatter SM,Carson RE,Cai Z

更新日期：2020-11-30 00:00:00

abstract：:Erdheim-Chester disease (ECD) is a disseminated xanthogranulomatous infiltrative disease of unknown etiology due to infiltration of different organs and bones by foamy histiocytes. A 37-year-old male with cerebral and periorbital lesions was diagnosed with this rare disease and was evaluated with magnetic resonance im...

journal_title：Molecular imaging and biology

authors： Pereira Neto CC,Roman C,Johnson M,Jagasia M,Martin WH,Delbeke D

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:[123I]FP-CIT (DaTSCAN®) single-photon emission computed tomography (SPECT) imaging is widely used to study neurodegenerative parkinsonism, by measuring presynaptic dopamine transporter (DAT) in striatal regions. Beyond DAT, [123I]FP-CIT may be considered for other monoaminergic systems, in particular the seroto...

journal_title：Molecular imaging and biology

authors： Premi E,Calhoun VD,Garibotto V,Turrone R,Alberici A,Cottini E,Pilotto A,Gazzina S,Magoni M,Paghera B,Borroni B,Padovani A

更新日期：2017-10-01 00:00:00

abstract：:In vivo imaging of the central nervous system (CNS) neuroreceptors in humans began was used in the early 1980s. Now, some twenty years later, the success of radiopharmaceutical imaging is still often one based on empiricism and serendipity. Nevertheless, a number of factors can be identified based on the robot experie...

journal_title：Molecular imaging and biology

authors： Wong DF,Pomper MG

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:Molecular imaging has the potential to provide quantitative information about specific biological aspects of developing atherosclerotic lesions. This requires the generation of reliable, highly specific plaque tracers. This study reports a new camelid single-domain antibody fragment (sdAb) targeting the Lectin-...

journal_title：Molecular imaging and biology

authors： De Vos J,Mathijs I,Xavier C,Massa S,Wernery U,Bouwens L,Lahoutte T,Muyldermans S,Devoogdt N

更新日期：2014-10-01 00:00:00

abstract：PURPOSE:The present work was aimed at the formulation and evaluation of freeze-dried kits of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-peptides for the preparation of (68)Ga-labelled peptides for PET imaging of neuroendocrine tumours. The (68)GaCl3 was obtained from the locally produced nanoceria-...

journal_title：Molecular imaging and biology

authors： Mukherjee A,Pandey U,Chakravarty R,Sarma HD,Dash A

更新日期：2014-08-01 00:00:00

abstract：PURPOSE:Repetitive imaging with microPET of endogenous albumin gene expression by using transgenic mice in which the Herpes Simplex Virus Type 1 thymidine kinase (HSV1-tk) reporter gene is driven by the albumin promoter (AL-HSV1-tk). METHODS:Transgenic mice were imaged repeatedly on a microPET scanner with approximate...

journal_title：Molecular imaging and biology

authors： Green LA,Yap CS,Nguyen K,Barrio JR,Namavari M,Satyamurthy N,Phelps ME,Sandgren EP,Herschman HR,Gambhir SS

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:This study aims to explore whether 4-(2S,4R)-[18F]fluoroglutamine (4-[18F]FGln) positron emission tomography (PET) imaging is helpful in identifying and monitoring MYCN-amplified neuroblastoma by enhanced glutamine metabolism. PROCEDURES:Cell uptake studies and dynamic small-animal PET studies of 4-[18F]FGln a...

journal_title：Molecular imaging and biology

authors： Li C,Huang S,Guo J,Wang C,Huang Z,Huang R,Liu L,Liang S,Wang H

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:High-dose (HD) cytosine arabinoside (ara-C) is a major treatment in acute myeloblastic leukemia (AML) that can lead to cerebellar complications, although electroencephalogram, computed tomography, and magnetic resonance imaging remain normal. We conducted a prospective study to evaluate brain perfusion with sin...

journal_title：Molecular imaging and biology

authors： Modzelewski R,Lepretre S,Martinaud O,Hannequin D,Hitzel A,Habert MO,Tilly H,Vera P

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:Negative surgical margins (NSMs) have favorable prognostic implications in breast tumor resection surgery. Fluorescence image-guided surgery (FIGS) has the ability to delineate surgical margins in real time, potentially improving the completeness of tumor resection. We have recently developed indocyanine green ...

journal_title：Molecular imaging and biology

authors： Wojtynek NE,Olson MT,Bielecki TA,An W,Bhat AM,Band H,Lauer SR,Silva-Lopez E,Mohs AM

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:The tyrosine kinase receptor Axl is overexpressed in various types of cancer and correlated with cancer malignancy. Selective Axl blockade reduces tumor growth and metastasis. The purpose of this study was to examine whether the humanized anti-Axl antibody humanized 173 (h173) labeled with near-infrared fluores...

journal_title：Molecular imaging and biology

authors： Li D,Liu S,Liu R,Park R,Yu H,Krasnoperov V,Gill PS,Li Z,Shan H,Conti PS

更新日期：2014-08-01 00:00:00

abstract：PURPOSE:Some patients with temporal lobe epilepsy (TLE) lack evidence of hippocampal sclerosis (HS) on MRI (HS-ve). We hypothesized that this group would have a different pattern of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-positron emission tomography (PET) hypometabolism than typical mesial TLE/HS patients with evidence...

journal_title：Molecular imaging and biology

authors： Carne RP,Cook MJ,MacGregor LR,Kilpatrick CJ,Hicks RJ,O'Brien TJ

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:The aim of this work is to investigate the impact of tissue classification in magnetic resonance imaging (MRI)-guided positron emission tomography (PET) attenuation correction (AC) for whole-body (WB) Patlak net uptake rate constant (Ki) imaging in PET/MRI studies. PROCEDURES:WB dynamic PET/CT data were acquir...

journal_title：Molecular imaging and biology

authors： Zhuang M,Karakatsanis NA,Dierckx RAJO,Zaidi H

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:[(11)C]T-773 is a new radioligand for positron emission tomography (PET) targeting the phosphodiesterase 10A enzyme (PDE10A). PDE10A is highly expressed in the striatum by medium spiny neurons, and it has been demonstrated to be involved in the regulation of striatal signaling through the reduction of medium sp...

journal_title：Molecular imaging and biology

authors： Tóth M,Häggkvist J,Stepanov V,Takano A,Nakao R,Amini N,Miura S,Kimura H,Taniguchi T,Gulyás B,Halldin C

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:This study aims to develop a molecular imaging strategy for response assessment of arginine deiminase (ADI) treatment in melanoma xenografts using 3'-[(18)F]fluoro-3'-deoxythymidine ([(18)F]-FLT) positron emission tomography (PET). PROCEDURES:F-FLT response to ADI therapy was studied in preclinical models of m...

journal_title：Molecular imaging and biology

authors： Stelter L,Fuchs S,Jungbluth AA,Ritter G,Longo VA,Zanzonico P,Raschzok N,Sauer IM,Bomalaski JS,Larson SM

更新日期：2013-12-01 00:00:00