Molecular Imaging of PDE10A Knockout Mice with a Novel PET Radiotracer: [(11)C]T-773.

abstract：PURPOSE:The goal of this study was to determine the specificity of ⁶⁴Cu-CB-TE2A-c(RGDyK) (⁶⁴Cu-RGD) for osteoclast-related diseases, such as Paget's disease or rheumatoid arthritis. PROCEDURES:C57BL/6 mice were treated systemically with osteoprotegerin (OPG) for 15 days or RANKL for 11 days to suppress and stimulate o...

journal_title：Molecular imaging and biology

authors： Zheleznyak A,Wadas TJ,Sherman CD,Wilson JM,Kostenuik PJ,Weilbaecher KN,Anderson CJ

更新日期：2012-08-01 00:00:00

abstract：PURPOSE:Molecular imaging has the potential to provide quantitative information about specific biological aspects of developing atherosclerotic lesions. This requires the generation of reliable, highly specific plaque tracers. This study reports a new camelid single-domain antibody fragment (sdAb) targeting the Lectin-...

journal_title：Molecular imaging and biology

authors： De Vos J,Mathijs I,Xavier C,Massa S,Wernery U,Bouwens L,Lahoutte T,Muyldermans S,Devoogdt N

更新日期：2014-10-01 00:00:00

abstract：PURPOSE:Widely used in clinical practice, the maximum standardized uptake value (SUVmax) is a statistical index highly prone to physical and biological variations, which can lead to unpredictable errors. This study has a methodological aim: to identify a more robust SUV-based index representing the tracer accumulation....

journal_title：Molecular imaging and biology

authors： Baiocco S,Matteucci F,Mezzenga E,Caroli P,Di Iorio V,Cittanti C,Bevilacqua A,Paganelli G,Sarnelli A

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:Antibodies form an important class of cancer therapeutics, and there is intense interest in using them for imaging applications in diagnosis and monitoring of cancer treatment. Despite the expanding body of knowledge describing pharmacokinetic and pharmacodynamic interactions of antibodies in vivo, discrepancie...

journal_title：Molecular imaging and biology

authors： Thurber GM,Weissleder R

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:Increased expression of the αvβ6 integrin correlates with advanced tumor grade and poor clinical outcome, identifying αvβ6 as a prognostic indicator and an attractive target for molecular imaging. This work investigated the ability of a disulfide-stabilized [64Cu]NOTA-αvβ6 cys-diabody to image αvβ6 expression i...

journal_title：Molecular imaging and biology

authors： White JB,Hu LY,Boucher DL,Sutcliffe JL

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:Prostate-specific membrane antigen (PSMA) continues to be the hallmark biomarker for prostate cancer as it is expressed on nearly all prostatic tumors. In addition, increased PSMA expression correlates with castration resistance and progression to the metastatic stage of the disease. Recently, we combined both ...

journal_title：Molecular imaging and biology

authors： Ling X,Latoche JD,Choy CJ,Kurland BF,Laymon CM,Wu Y,Salamacha N,Shen D,Geruntho JJ,Rigatti LH,Windish HP,Langton-Webster B,Berkman CE,Anderson CJ

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:This study aims to explore whether 4-(2S,4R)-[18F]fluoroglutamine (4-[18F]FGln) positron emission tomography (PET) imaging is helpful in identifying and monitoring MYCN-amplified neuroblastoma by enhanced glutamine metabolism. PROCEDURES:Cell uptake studies and dynamic small-animal PET studies of 4-[18F]FGln a...

journal_title：Molecular imaging and biology

authors： Li C,Huang S,Guo J,Wang C,Huang Z,Huang R,Liu L,Liang S,Wang H

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:Construction of antibody-based, molecular-targeted optical imaging probes requires the labeling of an antibody with a fluorophore. The most common method for doing this involves non-specifically conjugating a fluorophore to an antibody, resulting in poorly defined, heterogeneous imaging probes that often have s...

journal_title：Molecular imaging and biology

authors： Alam MK,El-Sayed A,Barreto K,Bernhard W,Fonge H,Geyer CR

更新日期：2019-02-01 00:00:00

abstract：:Pharmaceutical research and imaging science are becoming increasingly intertwined. Positron emission tomography (PET) is a molecular imaging technique with particularly broad application in drug discovery and development. At the same time, modern techniques of drug discovery are helping accelerate the development of n...

journal_title：Molecular imaging and biology

authors： Maclean D,Northrop JP,Padgett HC,Walsh JC

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:Many neurological diseases affect small structures in the brain and, as such, reliable visual evaluation and accurate quantification are required. Recent technological developments made the clinical use of hybrid positron emission tomography/magnetic resonance (PET/MR) systems possible, providing both functiona...

journal_title：Molecular imaging and biology

authors： Leemans EL,Kotasidis F,Wissmeyer M,Garibotto V,Zaidi H

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:[123I]FP-CIT (DaTSCAN®) single-photon emission computed tomography (SPECT) imaging is widely used to study neurodegenerative parkinsonism, by measuring presynaptic dopamine transporter (DAT) in striatal regions. Beyond DAT, [123I]FP-CIT may be considered for other monoaminergic systems, in particular the seroto...

journal_title：Molecular imaging and biology

authors： Premi E,Calhoun VD,Garibotto V,Turrone R,Alberici A,Cottini E,Pilotto A,Gazzina S,Magoni M,Paghera B,Borroni B,Padovani A

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:Magnetic resonance imaging (MRI) with targeted contrast agents provides a promising means for diagnosis and treatment monitoring after cerebrovascular injury. Our goal was to demonstrate the feasibility of this approach to detect the neuroinflammatory biomarker intercellular adhesion molecule-1 (ICAM-1) after s...

journal_title：Molecular imaging and biology

authors： Deddens LH,van Tilborg GA,van der Toorn A,van der Marel K,Paulis LE,van Bloois L,Storm G,Strijkers GJ,Mulder WJ,de Vries HE,Dijkhuizen RM

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:Synapse loss is a hallmark of Alzheimer's disease (AD) and correlates with cognitive decline. The validation of a noninvasive in vivo imaging approach to quantify synapse would greatly facilitate our understanding of AD pathogenesis and assist drug developments for AD. As animal models of neurodegenerative and ...

journal_title：Molecular imaging and biology

authors： Sadasivam P,Fang XT,Toyonaga T,Lee S,Xu Y,Zheng MQ,Spurrier J,Huang Y,Strittmatter SM,Carson RE,Cai Z

更新日期：2020-11-30 00:00:00

abstract：PURPOSE:The Cre-loxP system has become an important strategy for conditional gene deletion and conditional gene expression in genetically engineered mice. To evaluate Cre recombinase expression, we generated reporter mice that permit both noninvasive imaging in living animals and either ex vivo histochemical/immunohist...

journal_title：Molecular imaging and biology

authors： Ishikawa TO,Herschman HR

更新日期：2011-04-01 00:00:00

abstract：:The blood flow through normal liver parenchyma and a pathologically proven hepatic region of focal nodular hyperplasia (FNH) of the lateral lobe, was measured in a single patient in a quantitative manner using regional dynamic positron emission tomography (PET) imaging with O-15 carbon dioxide (steady state) and O-15 ...

journal_title：Molecular imaging and biology

authors： Kunishima S,Koh T,Fukuda K,Taniguchi H

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:The dimeric transmembrane integrin, α(v)β(3), is a well-investigated target by different imaging modalities through suitably labeled arginine-glycine-aspartic acid (RGD) containing peptides. In this study, we labeled four cyclic RGD peptides with or without PEG functional groups: c(RGDfK) (denoted as FK), PEG(3...

journal_title：Molecular imaging and biology

authors： Jacobson O,Zhu L,Niu G,Weiss ID,Szajek LP,Ma Y,Sun X,Yan Y,Kiesewetter DO,Liu S,Chen X

更新日期：2011-12-01 00:00:00

abstract：:We evaluated the clinical utility of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) on the precise localization of pathologic foci and exclusion of normal variants in the imaging evaluation of patients with esophageal carcinoma. Combined PET/CT scans were performed i...

journal_title：Molecular imaging and biology

authors： Jadvar H,Henderson RW,Conti PS

更新日期：2006-05-01 00:00:00

abstract：INTRODUCTION:Advances in positron emission tomography (PET) imaging have provided opportunities to develop radiotracers specific for imaging insulin-producing pancreatic β-cells. However, a host of lingering questions should be addressed before these radiotracers are advocated for noninvasive quantification of β-cell m...

journal_title：Molecular imaging and biology

authors： Blomberg BA,Codreanu I,Cheng G,Werner TJ,Alavi A

更新日期：2013-04-01 00:00:00

abstract：:Positron emission tomography (PET) with epidermal growth factor receptor (EGFR) kinase-specific radiolabeled tracers could provide the means for noninvasive and repetitive imaging of heterogeneity of EGFR expression and signaling activity in tumors in individual patients before and during therapy with EGFR signaling i...

journal_title：Molecular imaging and biology

authors： Pal A,Glekas A,Doubrovin M,Balatoni J,Namavari M,Beresten T,Maxwell D,Soghomonyan S,Shavrin A,Ageyeva L,Finn R,Larson SM,Bornmann W,Gelovani JG

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:In this study, we aimed to quantitatively investigate the biodistribution of [18F]DCFPyL in patients with prostate cancer (PCa) and to determine whether uptake in normal organs correlates with an increase in tumor burden. PROCEDURES:Fifty patients who had been imaged with [18F]DCFPyL positron emission tomograp...

journal_title：Molecular imaging and biology

authors： Werner RA,Bundschuh RA,Bundschuh L,Lapa C,Yin Y,Javadi MS,Buck AK,Higuchi T,Pienta KJ,Pomper MG,Lodge MA,Gorin MA,Rowe SP

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:Many radioligands have been explored for imaging the 18-kDa translocator protein (TSPO), a diagnostic and therapeutic target for inflammation and cancer. Here, we investigated the TSPO radioligand [(18)F]DPA-714 for positron emission tomography (PET) imaging of cancer and inflammation. PROCEDURES:[(18)F]DPA-71...

journal_title：Molecular imaging and biology

authors： Zheng J,Winkeler A,Peyronneau MA,Dollé F,Boisgard R

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:Transplantation of a regenerative cell population derived from human subcutaneous adipose tissue (hASCs) for cardiac regeneration represents a promising therapy due to the capacity of these cells for proliferation and differentiation. Understanding the fate of injected hASCs would help to understand how hASCs w...

journal_title：Molecular imaging and biology

authors： Bai X,Yan Y,Coleman M,Wu G,Rabinovich B,Seidensticker M,Alt E

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:Although current therapies for many inflammatory/autoimmune diseases are effective, a significant number of patients still exhibit only partial or negligible responses to therapeutic intervention. Since prolonged use of an inadequate therapy can result in both progressive tissue damage and unnecessary expense, ...

journal_title：Molecular imaging and biology

authors： Kelderhouse LE,Mahalingam S,Low PS

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Using three publicly available small-animal atlases (Sprague-Dawley rat, MOBY, and Digimouse), we built three articulated atlases and present several applications in the scope of molecular imaging. PROCEDURES:Major bones/bone groups were manually segmented for each atlas skeleton. Then, a kinematic model for e...

journal_title：Molecular imaging and biology

authors： Khmelinskii A,Baiker M,Kaijzel EL,Chen J,Reiber JH,Lelieveldt BP

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:We developed a bimolecular fluorescence complementation (BiFC) strategy using Dronpa, a new fluorescent protein with reversible photoswitching activity and fast responsibility to light, to monitor protein-protein interactions in cells. PROCEDURES:Dronpa was split at residue Glu164 in order to generate two Dron...

journal_title：Molecular imaging and biology

authors： Lee YR,Park JH,Hahm SH,Kang LW,Chung JH,Nam KH,Hwang KY,Kwon IC,Han YS

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:The aim of this study is to generate a four-class magnetic resonance imaging (MRI)-based attenuation map (μ-map) for attenuation correction of positron emission tomography (PET) data of the head area using a novel combination of short echo time (STE)/Dixon-MRI and a dedicated image segmentation method. PROCEDU...

journal_title：Molecular imaging and biology

authors： Khateri P,Saligheh Rad H,Jafari AH,Fathi Kazerooni A,Akbarzadeh A,Shojae Moghadam M,Aryan A,Ghafarian P,Ay MR

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:We aimed to explore the feasibility of transfection methods for antisense imaging. PROCEDURES:Antisense oligonucleotides (ASON) targeted to the mRNA of hTERT gene were synthesized and labeled with Technetium-99m and fluorescein isothiocyanate (FITC), respectively. Then, ASON was combined with transfection reag...

journal_title：Molecular imaging and biology

authors： Liu CB,Xu JQ,Xu BX,Zhang JM,Chen YM,Wang RM,Tian JH

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:To determine the prevalence of viable myocardium in patients with ischemic cardiomyopathy and, to evaluate the value of three-dimensional (3-D) fusion imaging of myocardial scintigraphic and angiographic data to assign coronary artery lesions to the corresponding viable and nonviable myocardial territory. PROC...

journal_title：Molecular imaging and biology

authors： Schindler TH,Nitzsche EU,Magosaki N,Mix M,Facta AD,Prior JO,Solzbach U,Schelbert HR,Just H

更新日期：2004-05-01 00:00:00

abstract：PURPOSE:Carbon-11- and fluorine-18-labeled choline derivatives have been introduced as promising tracers for prostate cancer imaging. However, due to limited specificity and sensitivity, there is a need for new tracers with higher sensitivity and specificity for diagnosing prostate cancer to improve tracer uptake and e...

journal_title：Molecular imaging and biology

authors： Schwarzenböck SM,Gertz J,Souvatzoglou M,Kurth J,Sachs D,Nawroth R,Treiber U,Schuster T,Senekowitsch-Schmidtke R,Schwaiger M,Ziegler SI,Henriksen G,Wester HJ,Krause BJ

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:We recently reported that high thymidine phosphorylase (TP) expression is accompanied by low tumor thymidine concentration and high 3'-deoxy-3'-[18F]fluorothymidine ([18F]FLT) uptake in four untreated lung cancer xenografts. Here, we investigated whether this relationship also holds true for a broader range of ...

journal_title：Molecular imaging and biology

authors： Schelhaas S,Heinzmann K,Honess DJ,Smith DM,Keen H,Heskamp S,Witney TH,Besret L,Doblas S,Griffiths JR,Aboagye EO,Jacobs AH

更新日期：2018-04-01 00:00:00