Abstract:
INTRODUCTION:Advances in positron emission tomography (PET) imaging have provided opportunities to develop radiotracers specific for imaging insulin-producing pancreatic β-cells. However, a host of lingering questions should be addressed before these radiotracers are advocated for noninvasive quantification of β-cell mass (BCM) in vivo in the native pancreas. METHOD:We provide an overview of tetrabenazine-based PET tracers developed to image and quantify BCM and discuss several theoretical, technical, and biological limitations of applying these tracers in clinical practice. DISCUSSION:VMAT2, a transporter protein expressed on pancreatic β-cells, has been advocated as a promising target for PET imaging tracers, such as dihydrotetrabenazine. However, the lack of radiotracer specificity for these proteins hampers their clinical application. Another important argument against their use is a striking discrepancy between radiotracer uptake and BCM in subjects with type I diabetes mellitus and healthy controls. Additionally, technical issues, such as the finite spatial resolution of PET, partial volume effects, and movement of the pancreas during respiration, impede PET imaging as a viable option for BCM quantification in the foreseeable future. CONCLUSION:The assertion that BCM can be accurately quantified by tetrabenazine derived β-cell-specific radiotracers as density per unit volume of pancreatic tissue is not justifiable at this time. The fallacy of these claims can be explained by technical as well as biological facts that have been disregarded and ignored in the literature.
journal_name
Mol Imaging Bioljournal_title
Molecular imaging and biologyauthors
Blomberg BA,Codreanu I,Cheng G,Werner TJ,Alavi Adoi
10.1007/s11307-013-0620-4subject
Has Abstractpub_date
2013-04-01 00:00:00pages
123-30issue
2eissn
1536-1632issn
1860-2002journal_volume
15pub_type
杂志文章,评审abstract:PURPOSE:Prefrontal cortex (PFC) deep brain stimulation (DBS) has been proposed as a therapy for addiction and depression. This study investigates changes in rat cerebral glucose metabolism induced by different DBS frequencies using μPET. PROCEDURES:One hour DBS of the prelimbic area (PL) of the medial PFC (mPFC) (60 H...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-014-0757-9
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
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journal_title:Molecular imaging and biology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-010-0372-3
更新日期:2011-06-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-019-01320-x
更新日期:2019-12-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-020-01551-3
更新日期:2020-10-13 00:00:00
abstract::Positron emission tomography (PET) with epidermal growth factor receptor (EGFR) kinase-specific radiolabeled tracers could provide the means for noninvasive and repetitive imaging of heterogeneity of EGFR expression and signaling activity in tumors in individual patients before and during therapy with EGFR signaling i...
journal_title:Molecular imaging and biology
pub_type: 杂志文章
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-019-01319-4
更新日期:2019-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1007/s11307-009-0227-y
更新日期:2009-11-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章
doi:10.1007/s11307-011-0493-3
更新日期:2012-06-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:Molecular imaging and biology
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更新日期:2011-08-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 临床试验,杂志文章
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更新日期:2012-04-01 00:00:00
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journal_title:Molecular imaging and biology
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2015-10-01 00:00:00
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更新日期:2018-04-01 00:00:00