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Use of positron emission tomography to target prostate cancer gene therapy by oncolytic herpes simplex virus.

Abstract：

:Herpes simplex virus (HSV) oncolytic gene therapy is a promising treatment modality against cancer. We have demonstrated that androgen-induced cellular changes enhance oncolytic viral replication and improve efficacy in the treatment of androgen-dependent prostate cancer cell line. Imaging of changes in 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) uptake by positron emission tomography (PET) is a sensitive method of detecting altered cellular metabolism involved in cancer therapy. We therefore hypothesized that FDG-PET can predict tumor response to oncolytic HSV therapy. In this study, androgen increased cell kill (74%) in vitro and enhanced viral yield (2.4-fold) in vivo following HSV therapy. This enhanced efficacy was predicted by high FDG accumulation in intact animals compared to low FDG uptake following orchiectomy (p = 0.002). This proof-of-concept study provides the mechanistic basis for selecting patients for targeted oncolytic viral therapy by means of a noninvasive molecular imaging method in the treatment of prostate cancer.

journal_name

Mol Imaging Biol

journal_title

Molecular imaging and biology

authors

Mullerad M,Eisenberg DP,Akhurst TJ,Adusumilli PS,Riedl CC,Bhargava A,Gonen M,Finn R,Scardino PT,Fong Y

doi

10.1007/s11307-005-0028-x

keywords:

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

30-5

issue

1

eissn

1536-1632

issn

1860-2002

journal_volume

8

pub_type

杂志文章

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