当前位置： SCI文献检索 > MOLECULAR IMAGING AND BIOLOGY期刊下所有文献 > Measurement of the global lumped constant for 2-deoxy-2-[18F]fluoro-D-glucose in normal human brain using [15O]water and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography imaging. A method with validation based on multiple methodologies.

Measurement of the global lumped constant for 2-deoxy-2-[18F]fluoro-D-glucose in normal human brain using [15O]water and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography imaging. A method with validation based on multiple methodologies.

Abstract：

PURPOSE:This study aims to determine a lumped constant (LC) value that can be applied to the 2-deoxy-2[18F]fluoro-D-glucose positron emission tomography (FDG-PET) study to yield a physiological value of cerebral metabolic rate of glucose (CMR(glc)) in normal brain. PROCEDURES:We developed a more robust method for determining the global FDG LC. Dynamic FDG and H(2)(15)O PET studied were acquired in 18 normal subjects. Arterial-venous difference of blood glucose level was measured. RESULTS:A global LC of 0.65 +/- 0.15 was obtained if a 3-microparameter FDG model (k*(4)=0)was assumed. Assumption of a 4-microparameter FDG model (k*(4) not equal 0) in analyzing the FDG data resulted in a higher LC value of 0.81 +/- 0.18. CONCLUSION:The value of LC used for quantitating CMR(glc) should match the assumption inherent to the method of data analysis. The LC results in this study agree well with recent findings in the literature.

journal_name

Mol Imaging Biol

journal_title

Molecular imaging and biology

authors

Wu HM,Bergsneider M,Glenn TC,Yeh E,Hovda DA,Phelps ME,Huang SC

doi

10.1016/s1536-1632(02)00122-1

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

32-41

issue

1

eissn

1536-1632

issn

1860-2002

pii

S1536163202001221

journal_volume

5

pub_type

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