Correction to: Pre-therapy Somatostatin Receptor-Based Heterogeneity Predicts Overall Survival in Pancreatic Neuroendocrine Tumor Patients Undergoing Peptide Receptor Radionuclide Therapy.

abstract：PURPOSE:This study was undertaken to evaluate radiation dosimetry for the prostate-specific membrane antigen targeted [68Ga]Ga-P16-093 radiopharmaceutical, and to initially assess agent performance in positron emission tomography (PET) detection of the site of disease in prostate cancer patients presenting with biochem...

journal_title：Molecular imaging and biology

authors： Green MA,Hutchins GD,Bahler CD,Tann M,Mathias CJ,Territo W,Sims J,Polson H,Alexoff D,Eckelman WC,Kung HF,Fletcher JW

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:The aim of this work is to investigate the impact of tissue classification in magnetic resonance imaging (MRI)-guided positron emission tomography (PET) attenuation correction (AC) for whole-body (WB) Patlak net uptake rate constant (Ki) imaging in PET/MRI studies. PROCEDURES:WB dynamic PET/CT data were acquir...

journal_title：Molecular imaging and biology

authors： Zhuang M,Karakatsanis NA,Dierckx RAJO,Zaidi H

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:Non-specific extracellular contrast agents have been on the market for more than 15 years. Here, we report on the synthesis of new selective lectin-gadolinium (Gd)-loaded chitosan nanoparticles with a prolonged clearance time and a much higher relaxivity in comparison to other preparations. PROCEDURES:Chitosan...

journal_title：Molecular imaging and biology

authors： Pashkunova-Martic I,Kremser C,Galanski M,Arion V,Debbage P,Jaschke W,Keppler B

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:Conventional in vivo bioluminescence imaging using wild-type green-emitting luciferase is limited by absorption and scattering of the bioluminescent signal through tissues. Imaging methods using a red-shifted thermostable luciferase from Photinus pyralis were optimized to improve the sensitivity and image resol...

journal_title：Molecular imaging and biology

authors： Mezzanotte L,Fazzina R,Michelini E,Tonelli R,Pession A,Branchini B,Roda A

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:The Cre-loxP system has become an important strategy for conditional gene deletion and conditional gene expression in genetically engineered mice. To evaluate Cre recombinase expression, we generated reporter mice that permit both noninvasive imaging in living animals and either ex vivo histochemical/immunohist...

journal_title：Molecular imaging and biology

authors： Ishikawa TO,Herschman HR

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:Dynamic positron emission tomography (PET) protocols allow for accurate quantification of [18F]flortaucipir-specific binding. However, dynamic acquisitions can be challenging given the long required scan duration of 130 min. The current study assessed the effect of shorter scan protocols for [18F]flortaucipir o...

journal_title：Molecular imaging and biology

authors： Tuncel H,Visser D,Yaqub M,Timmers T,Wolters EE,Ossenkoppele R,van der Flier WM,van Berckel BNM,Boellaard R,Golla SSV

更新日期：2021-01-26 00:00:00

abstract：PURPOSE:Noninvasive imaging of cell necrosis can provide an early evaluation of tumor response to treatments. Here, we aimed to design and synthesize a novel diindole-based magnetic resonance imaging (MRI) contrast agent (Gd-bis-DOTA-diindolylmethane, Gd-DIM) for assessment of tumor response to therapy at an early stag...

journal_title：Molecular imaging and biology

authors： Zhang L,Liu L,Zhang D,Jin Q,Gao M,Wu T,Feng Y,Ni Y,Yin Z,Zhang J

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:Cellular receptor targeted imaging agents present the potential to target extracellular molecular expression in cancerous lesions; however, the image contrast in vivo does not reflect the magnitude of overexpression expected from in vitro data. Here, the in vivo delivery and binding kinetics of epidermal growth...

journal_title：Molecular imaging and biology

authors： Samkoe KS,Sexton K,Tichauer KM,Hextrum SK,Pardesi O,Davis SC,O'Hara JA,Hoopes PJ,Hasan T,Pogue BW

更新日期：2012-08-01 00:00:00

abstract：PURPOSE:CXCR4 is overexpressed on tumor cells from many types of human cancers. A high level of CXCR4 expression often correlates with poor prognosis, chemotherapy resistance, and metastasis. The development of CXCR4-specific radiotracers for positron emission tomography (PET) imaging will allow in vivo evaluation of r...

journal_title：Molecular imaging and biology

authors： Zhang XX,Sun Z,Guo J,Wang Z,Wu C,Niu G,Ma Y,Kiesewetter DO,Chen X

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:The main purpose of this study was to understand how the positron emission tomography (PET) measure of the synaptic vesicle 2A (SV2A) protein varies in vivo during the development of temporal lobe epilepsy (TLE) in the kainic acid rat model. PROCEDURES:Twenty Sprague Dawley male rats were administered with mul...

journal_title：Molecular imaging and biology

authors： Serrano ME,Bahri MA,Becker G,Seret A,Germonpré C,Lemaire C,Giacomelli F,Mievis F,Luxen A,Salmon E,Rogister B,Raedt R,Plenevaux A

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:Preclinical dynamic brain PET studies remain hampered by the limitations related to the measurement of the arterial input function (AIF). In this regard, the use of an arterial-venous shunt is a promising method for the generation of real-time AIFs, but its application in longitudinal studies is still impeded b...

journal_title：Molecular imaging and biology

authors： Rey-Bretal D,Moscoso A,Gómez-Lado N,Fernández-Ferreiro A,Silva-Rodríguez J,Ruibal Á,Aguiar P

更新日期：2020-11-17 00:00:00

abstract：PURPOSE:Malignant cells exhibit increased rates of aerobic glycolysis. Here, we tested whether the accumulation of fluoro-deoxyglucose-6-phosphate (FDG6P) in ovarian cancers of differential malignancy reflects inversely correlated elevations of hexokinase (HK) and glucose-6-phosphatase (G6Pase) activities. PROCEDURES:...

journal_title：Molecular imaging and biology

authors： Olsen BB,Gjedde A,Vilstrup MH,Johnsen IBG,Neumann G,Torigian DA,Alavi A,Høilund-Carlsen PF

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:This study was undertaken to explore the mechanisms underlying cognitive reserve in subjects with mild memory deficits by using positron emission tomography (PET). METHODS:Global cerebral blood flow (gCBF) and cerebrovascular reserve (CVR) measurements were performed in 15 elders (5 men, 10 women, 62-84, 71.8 ...

journal_title：Molecular imaging and biology

authors： Boles Ponto LL,Magnotta VA,Moser DJ,Duff KM,Schultz SK

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:The tyrosine kinase receptor Axl is overexpressed in various types of cancer and correlated with cancer malignancy. Selective Axl blockade reduces tumor growth and metastasis. The purpose of this study was to examine whether the humanized anti-Axl antibody humanized 173 (h173) labeled with near-infrared fluores...

journal_title：Molecular imaging and biology

authors： Li D,Liu S,Liu R,Park R,Yu H,Krasnoperov V,Gill PS,Li Z,Shan H,Conti PS

更新日期：2014-08-01 00:00:00

abstract：PURPOSE:To assess a novel radiotracer aluminum [18F]fluoride-1,4,7-triazacyclononane-triacetic acid-pegylated dimeric RGD ([18F]ALF-NOTA-PRGD2, denoted as [18F]Alfatide) for positron emission tomography (PET)/X-ray computed tomography (CT) and explore the relationships between clinicopathological characteristics and ma...

journal_title：Molecular imaging and biology

authors： Dong Y,Wei Y,Chen G,Huang Y,Song P,Liu S,Zheng J,Cheng M,Yuan S

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:To develop a tool to measure the pH at the surfaces of individual cells. PROCEDURES:The SNARF pH-sensitive dye was conjugated to a pHLIP® peptide (pH-Low Insertion Peptide) that binds cellular membranes in tumor spheroids. A beam splitter allows simultaneous recording of two images (580 and 640 nm) by a CCD ca...

journal_title：Molecular imaging and biology

authors： Wei D,Engelman DM,Reshetnyak YK,Andreev OA

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:The mTOR kinase inhibitor AZD8055 inhibits both mTORC1 and mTORC2 leading to disruption of glucose metabolism and proliferation pathways. This study assessed the impact of single and multiple doses of AZD8055 on the uptake of the glucose metabolism marker 2-deoxy-2-[(18) F]fluoro-D-glucose ([(18) F]FDG) and the...

journal_title：Molecular imaging and biology

authors： Keen HG,Ricketts SA,Maynard J,Logie A,Odedra R,Shannon AM,Wedge SR,Guichard SM

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:To evaluate prognostic value of pretreatment and posttreatment 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET) in advanced hypopharyngeal carcinoma treated by chemoradiotherapy. PROCEDURES:Thirty-one patients underwent a baseline FDG-PET and then FDG-PET was repeated 7 weeks after chemor...

journal_title：Molecular imaging and biology

authors： Inohara H,Enomoto K,Tomiyama Y,Higuchi I,Inoue T,Hatazawa J

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:We evaluated the ability of 2-deoxy-2-(18)F-fluoro-D-glucose (FDG) positron emission tomography (PET) in the early assessment of therapeutic response in patients with small cell lung cancer (SCLC). PROCEDURES:FDG PET studies were performed before (baseline PET), after the first cycle of chemotherapy (early PET...

journal_title：Molecular imaging and biology

authors： Yamamoto Y,Kameyama R,Murota M,Bandoh S,Ishii T,Nishiyama Y

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:The purpose of this study was to assess the value of the spatial heterogeneity of somatostatin receptor (SSR) volume, quantified as asphericity (ASP), and to predict response to peptide receptor radionuclide therapy (PRRT) in patients with metastatic gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN). P...

journal_title：Molecular imaging and biology

authors： Wetz C,Apostolova I,Steffen IG,Hofheinz F,Furth C,Kupitz D,Ruf J,Venerito M,Klose S,Amthauer H

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:The simplified reference tissue model (SRTM) is commonly applied for the quantification of brain positron emission tomography (PET) studies, particularly because it avoids arterial cannulation. SRTM requires a validated reference region which is obtained by baseline-blocking or displacement studies. Once a refe...

journal_title：Molecular imaging and biology

authors： de Vries BM,Timmers T,Wolters EE,Ossenkoppele R,Verfaillie SCJ,Schuit RC,Scheltens P,van der Flier WM,Windhorst AD,van Berckel BNM,Boellaard R,Golla SSV

更新日期：2021-01-14 00:00:00

abstract：PURPOSE:Rats are important preclinical models for studying breast cancer metastasis and bone pathologies. In these research areas, fluorescence molecular tomography (FMT) is commonly applied for quantitative three-dimensional (3D) imaging in mice. However, uncertainties due to strong depth dependency of FMT signal and ...

journal_title：Molecular imaging and biology

authors： Vonwil D,Christensen J,Fischer S,Ronneberger O,Shastri VP

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:The purpose of the study was to examine the feasibility of an antibody-carrying targeted-bubble preparation using clinically available phosphatidylserine (PS)-containing perfluorobutane-filled microbubbles for molecular ultrasound imaging. PROCEDURES:Firstly, we examined whether PS on the surface of perfluorob...

journal_title：Molecular imaging and biology

authors： Otani K,Yamahara K

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:The present work was aimed at the formulation and evaluation of freeze-dried kits of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-peptides for the preparation of (68)Ga-labelled peptides for PET imaging of neuroendocrine tumours. The (68)GaCl3 was obtained from the locally produced nanoceria-...

journal_title：Molecular imaging and biology

authors： Mukherjee A,Pandey U,Chakravarty R,Sarma HD,Dash A

更新日期：2014-08-01 00:00:00

abstract：PURPOSE:Sodium [(18)F]fluoride (Na[(18)F]F) positron emission tomography with integrated computed tomography (PET/CT) has not been used for imaging myocardial infarction (MI). Here, we aimed to investigate the Na[(18)F]F PET/CT features of MI in a rat model. PROCEDURES:MI was induced by coronary artery ligation in 8-w...

journal_title：Molecular imaging and biology

authors： Han JH,Lim SY,Lee MS,Lee WW

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:Radioimmunotherapy uses tumor-specific antibodies to deliver therapeutic radionuclides, but hematological toxicity due to the long serum half-life of intact antibodies remains a challenge. We evaluated a smaller antibody fragment, the minibody, with faster kinetics and a potentially improved therapeutic index. ...

journal_title：Molecular imaging and biology

authors： Tsai WK,Zettlitz KA,Dahlbom M,Reiter RE,Wu AM

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:Ga-68-labeled prostate-specific membrane antigen (PSMA) ligands have been used clinically for positron emission tomography (PET) imaging of prostate cancer. However, F-18-labeled compounds offer several advantages, including the potential for delayed imaging, high starting activities enabling multidose preparat...

journal_title：Molecular imaging and biology

authors： Malik N,Baur B,Winter G,Reske SN,Beer AJ,Solbach C

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:We developed a bimolecular fluorescence complementation (BiFC) strategy using Dronpa, a new fluorescent protein with reversible photoswitching activity and fast responsibility to light, to monitor protein-protein interactions in cells. PROCEDURES:Dronpa was split at residue Glu164 in order to generate two Dron...

journal_title：Molecular imaging and biology

authors： Lee YR,Park JH,Hahm SH,Kang LW,Chung JH,Nam KH,Hwang KY,Kwon IC,Han YS

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:For targeted imaging and therapy of hepatocellular carcinoma (HCC), we established a chimeric promoter (EIIAPA) containing alpha-fetoprotein (AFP) promoter and hepatitis B virus enhancer II (EIIA) to control downstream expression of reporter and therapeutic genes. PROCEDURES:We combined AFP promoter and EIIA t...

journal_title：Molecular imaging and biology

authors： Hsieh YJ,Chen FD,Ke CC,Wang HE,Huang CJ,Hou MF,Lin KP,Gelovani JG,Liu RS

更新日期：2012-08-01 00:00:00

abstract：PURPOSE:High-dose (HD) cytosine arabinoside (ara-C) is a major treatment in acute myeloblastic leukemia (AML) that can lead to cerebellar complications, although electroencephalogram, computed tomography, and magnetic resonance imaging remain normal. We conducted a prospective study to evaluate brain perfusion with sin...

journal_title：Molecular imaging and biology

authors： Modzelewski R,Lepretre S,Martinaud O,Hannequin D,Hitzel A,Habert MO,Tilly H,Vera P

更新日期：2011-08-01 00:00:00