Lectin-Gd-loaded chitosan hydrogel nanoparticles: a new biospecific contrast agent for MRI.

abstract：PURPOSE:To evaluate bone blood flow and bone formation in patients after total hip revision surgery with impacted bone grafting using H2 15O and [18F]fluoride positron emission tomography (PET). PROCEDURES:To asses bone blood flow and bone metabolism in bone allograft after impaction grafting, four patients treated wi...

journal_title：Molecular imaging and biology

authors： Temmerman OP,Raijmakers PG,Heyligers IC,Comans EF,Lubberink M,Teule GJ,Lammertsma AA

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:We developed a bimolecular fluorescence complementation (BiFC) strategy using Dronpa, a new fluorescent protein with reversible photoswitching activity and fast responsibility to light, to monitor protein-protein interactions in cells. PROCEDURES:Dronpa was split at residue Glu164 in order to generate two Dron...

journal_title：Molecular imaging and biology

authors： Lee YR,Park JH,Hahm SH,Kang LW,Chung JH,Nam KH,Hwang KY,Kwon IC,Han YS

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:This study aimed to synthesize a necrosis-avid agent using rhein as a precursor and labeled with gallium-68 (Ga-68) for positron emission tomography/computed tomography (PET/CT) imaging, to evaluate response to anticancer treatment in a mouse model. PROCEDURES:1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaceti...

journal_title：Molecular imaging and biology

authors： Zhang A,Wu T,Bian L,Li P,Liu Q,Zhang D,Jin Q,Zhang J,Huang G,Song S

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:Angiogenesis is essential for physiological processes as well as for carcinogenesis. New approaches to cancer therapy include targeting angiogenesis. One target is VEGF-A and its receptor VEGFR2. In this study, we sought to investigate pancreatic cancer angiogenesis in a genetically modified VEGFR2-luc-KI mouse...

journal_title：Molecular imaging and biology

authors： Angst E,Chen M,Mojadidi M,Hines OJ,Reber HA,Eibl G

更新日期：2010-12-01 00:00:00

abstract：INTRODUCTION:Technetium (Tc) methylene diphosphonate (MDP) has been the standard method for bone scintigraphy for three decades. (18)F sodium fluoride ((18)F NaF) positron emission tomography (PET)/computed tomography (CT) has better resolution and is considered superior. The role of 2-deoxy-2-[(18)F]fluoro-D-glucose (...

journal_title：Molecular imaging and biology

authors： Iagaru A,Mittra E,Dick DW,Gambhir SS

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:Increased expression of the αvβ6 integrin correlates with advanced tumor grade and poor clinical outcome, identifying αvβ6 as a prognostic indicator and an attractive target for molecular imaging. This work investigated the ability of a disulfide-stabilized [64Cu]NOTA-αvβ6 cys-diabody to image αvβ6 expression i...

journal_title：Molecular imaging and biology

authors： White JB,Hu LY,Boucher DL,Sutcliffe JL

更新日期：2018-02-01 00:00:00

abstract：PURPOSE:Sodium [(18)F]fluoride (Na[(18)F]F) positron emission tomography with integrated computed tomography (PET/CT) has not been used for imaging myocardial infarction (MI). Here, we aimed to investigate the Na[(18)F]F PET/CT features of MI in a rat model. PROCEDURES:MI was induced by coronary artery ligation in 8-w...

journal_title：Molecular imaging and biology

authors： Han JH,Lim SY,Lee MS,Lee WW

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:Tc-99m methylene diphosphonate ([99mTc]MDP) is an in vivo bone imaging agent that also accumulates in injured skeletal muscle cells. The objective of this study was to investigate if [99mTc]MDP could be used to detect muscle injury in the mdx mouse model of Duchenne muscular dystrophy (DMD). PROCEDURES:Static ...

journal_title：Molecular imaging and biology

authors： Gaut C,Sullivan JM,Biscaro B,Soares EJ,Nicholson K,Hoppin J,Verma A

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:This study describes an imaging strategy based on glow stick chemistry to non-invasively image oxidative stress and reactive oxygen species (ROS) production in living animals. PROCEDURES:Upon stimulation, phagocytes produce toxic levels of ROS to kill engulfed microorganisms. The mitochondrial respiratory chai...

journal_title：Molecular imaging and biology

authors： Tseng JC,Bailey D,Tupper T,Kung AL

更新日期：2014-08-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) requires synthesis of contrast media bearing targeting groups and numerous gadolinium chelating groups generating high relaxivity. This paper explores the results of linking the gadolinium chelates to the targeting group, a protein molecule, via various types of linkers. Polycondensate...

journal_title：Molecular imaging and biology

authors： Pashkunova-Martic I,Kremser C,Galanski M,Schluga P,Arion V,Debbage P,Jaschke W,Keppler B

更新日期：2011-06-01 00:00:00

abstract：:This article was updated to correct the spelling of Hongkai Wang's name: it is correct as displayed here. ...

journal_title：Molecular imaging and biology

authors： Wang H,Tan Z,Zheng Q,Yu J

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:Many radioligands have been explored for imaging the 18-kDa translocator protein (TSPO), a diagnostic and therapeutic target for inflammation and cancer. Here, we investigated the TSPO radioligand [(18)F]DPA-714 for positron emission tomography (PET) imaging of cancer and inflammation. PROCEDURES:[(18)F]DPA-71...

journal_title：Molecular imaging and biology

authors： Zheng J,Winkeler A,Peyronneau MA,Dollé F,Boisgard R

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:The Cre-loxP system has become an important strategy for conditional gene deletion and conditional gene expression in genetically engineered mice. To evaluate Cre recombinase expression, we generated reporter mice that permit both noninvasive imaging in living animals and either ex vivo histochemical/immunohist...

journal_title：Molecular imaging and biology

authors： Ishikawa TO,Herschman HR

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:Rats are important preclinical models for studying breast cancer metastasis and bone pathologies. In these research areas, fluorescence molecular tomography (FMT) is commonly applied for quantitative three-dimensional (3D) imaging in mice. However, uncertainties due to strong depth dependency of FMT signal and ...

journal_title：Molecular imaging and biology

authors： Vonwil D,Christensen J,Fischer S,Ronneberger O,Shastri VP

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:Some patients with temporal lobe epilepsy (TLE) lack evidence of hippocampal sclerosis (HS) on MRI (HS-ve). We hypothesized that this group would have a different pattern of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-positron emission tomography (PET) hypometabolism than typical mesial TLE/HS patients with evidence...

journal_title：Molecular imaging and biology

authors： Carne RP,Cook MJ,MacGregor LR,Kilpatrick CJ,Hicks RJ,O'Brien TJ

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:Transplantation of a regenerative cell population derived from human subcutaneous adipose tissue (hASCs) for cardiac regeneration represents a promising therapy due to the capacity of these cells for proliferation and differentiation. Understanding the fate of injected hASCs would help to understand how hASCs w...

journal_title：Molecular imaging and biology

authors： Bai X,Yan Y,Coleman M,Wu G,Rabinovich B,Seidensticker M,Alt E

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:Previous reports confirmed that (2S,4R)-4-[18F]Fluoroglutamine ([18F]GLN) accumulated in bone and bone marrow. This study investigates the potential of using [18F]GLN positron emission tomography (PET) to monitor changes of bone marrow activity after chemotherapy (myelosuppression). PROCEDURES:Bone marrow inhi...

journal_title：Molecular imaging and biology

authors： Zhu H,Liu F,Zhang Y,Yang J,Xu X,Guo X,Liu T,Li N,Zhu L,Kung HF,Yang Z

更新日期：2019-10-01 00:00:00

abstract：:Due to their remarkable selectivity and specificity for cancer biomarkers, immunoconjugates have emerged as extremely promising vectors for the delivery of diagnostic radioisotopes and fluorophores to malignant tissues. Paradoxically, however, these tools for precision medicine are synthesized in a remarkably imprecis...

journal_title：Molecular imaging and biology

authors： Adumeau P,Sharma SK,Brent C,Zeglis BM

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:Contrast-enhanced magnetic resonance imaging (MRI) has the potential to replace angiographic evaluation of atherosclerosis. While studies have investigated contrast agent (CA) uptake in atherosclerotic plaques, exact CA spatial distribution on a microscale is elusive. The purpose of this study was to investigat...

journal_title：Molecular imaging and biology

authors： Uca YO,Hallmann D,Hesse B,Seim C,Stolzenburg N,Pietsch H,Schnorr J,Taupitz M

更新日期：2020-12-07 00:00:00

abstract：PURPOSE:This study aims to explore whether 4-(2S,4R)-[18F]fluoroglutamine (4-[18F]FGln) positron emission tomography (PET) imaging is helpful in identifying and monitoring MYCN-amplified neuroblastoma by enhanced glutamine metabolism. PROCEDURES:Cell uptake studies and dynamic small-animal PET studies of 4-[18F]FGln a...

journal_title：Molecular imaging and biology

authors： Li C,Huang S,Guo J,Wang C,Huang Z,Huang R,Liu L,Liang S,Wang H

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:Visualization of tumor necrosis can determine tumor response to therapy. Our previous study showed that the rhein-based magnetic resonance imaging (MRI) contrast agent with alkane linker (GdL2) could clearly image tumor necrosis. However, its water solubility and cell safety needed to be improved. Herein, three...

journal_title：Molecular imaging and biology

authors： Zhang L,Zhang D,Gao M,Jin Q,Jiang C,Wu T,Feng Y,Ni Y,Yin Z,Zhang J

更新日期：2020-10-13 00:00:00

abstract：PURPOSE:Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was utilized in postmortem imaging of gadolinium (Gd) spatial distribution in a mouse tumor model postadministration of PEGylated Gd liposomal nanoparticles. PROCEDURES:PEGylated liposomal nanoparticles were formulated using a paramagnetic...

journal_title：Molecular imaging and biology

authors： Kamaly N,Pugh JA,Kalber TL,Bunch J,Miller AD,McLeod CW,Bell JD

更新日期：2010-08-01 00:00:00

abstract：PURPOSE:Many neurological diseases affect small structures in the brain and, as such, reliable visual evaluation and accurate quantification are required. Recent technological developments made the clinical use of hybrid positron emission tomography/magnetic resonance (PET/MR) systems possible, providing both functiona...

journal_title：Molecular imaging and biology

authors： Leemans EL,Kotasidis F,Wissmeyer M,Garibotto V,Zaidi H

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:The purpose of this study is to evaluate if the differential exchange rates with bulk water between amine and amide protons can be exploited using chemical exchange saturation transfer magnetic resonance (CEST-MR) to monitor the release of glutamate induced by carboxypeptidase G2 (CPG2), an enzyme utilized in c...

journal_title：Molecular imaging and biology

authors： Jamin Y,Eykyn TR,Poon E,Springer CJ,Robinson SP

更新日期：2014-04-01 00:00:00

abstract：:Atherosclerotic plaques can remain quiescent for years, but become life threatening upon rupture or disruption, initiating clot formation in the vessel lumen and causing acute myocardial infarction and ischemic stroke. Whether and how a plaque ruptures is determined by its macroscopic structure and microscopic composi...

journal_title：Molecular imaging and biology

authors： Vigne J,Thackeray J,Essers J,Makowski M,Varasteh Z,Curaj A,Karlas A,Canet-Soulas E,Mulder W,Kiessling F,Schäfers M,Botnar R,Wildgruber M,Hyafil F,Cardiovascular study group of the European Society of Molecular Imaging.

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:[(18)F]-FEPPA is a translocator protein (18 kDa, TSPO) positron emission tomography (PET) radiotracer. Radiation dosimetry was estimated from the whole body biodistribution, taking into consideration TSPO rs6971 (Ala147Thr) polymorphism. PROCEDURES:[(18)F]-FEPPA whole body PET scans were acquired for six healt...

journal_title：Molecular imaging and biology

authors： Mizrahi R,Rusjan PM,Vitcu I,Ng A,Wilson AA,Houle S,Bloomfield PM

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:Human pluripotency gene networks (PGNs), controlled in part by Oct4, are central to understanding pluripotent stem cells, but current fluorescent reporter genes (RGs) preclude noninvasive assessment of Oct4 dynamics in living subjects. PROCEDURES:To assess Oc4 activity noninvasively, we engineered a mouse embr...

journal_title：Molecular imaging and biology

authors： Ahn BC,Parashurama N,Patel M,Ziv K,Bhaumik S,Yaghoubi SS,Paulmurugan R,Gambhir SS

更新日期：2014-12-01 00:00:00

abstract：:In vivo imaging of the central nervous system (CNS) neuroreceptors in humans began was used in the early 1980s. Now, some twenty years later, the success of radiopharmaceutical imaging is still often one based on empiricism and serendipity. Nevertheless, a number of factors can be identified based on the robot experie...

journal_title：Molecular imaging and biology

authors： Wong DF,Pomper MG

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:Using three publicly available small-animal atlases (Sprague-Dawley rat, MOBY, and Digimouse), we built three articulated atlases and present several applications in the scope of molecular imaging. PROCEDURES:Major bones/bone groups were manually segmented for each atlas skeleton. Then, a kinematic model for e...

journal_title：Molecular imaging and biology

authors： Khmelinskii A,Baiker M,Kaijzel EL,Chen J,Reiber JH,Lelieveldt BP

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate the feasibility of dual magnetic resonance imaging (MRI) reporter genes, including ferritin heavy subunit (Fth) and transferrin receptor (TfR), which provide sufficient MRI contrast for in vivo MRI tracking, and the Deltex-1 (DTX1) gene, which promotes human mesenchy...

journal_title：Molecular imaging and biology

authors： Guo R,Li Q,Yang F,Hu X,Jiao J,Guo Y,Wang J,Zhang Y

更新日期：2018-06-01 00:00:00