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Using glow stick chemistry for biological imaging.

Abstract：

PURPOSE:This study describes an imaging strategy based on glow stick chemistry to non-invasively image oxidative stress and reactive oxygen species (ROS) production in living animals. PROCEDURES:Upon stimulation, phagocytes produce toxic levels of ROS to kill engulfed microorganisms. The mitochondrial respiratory chain continually generates low levels of superoxide (O2·(-)) that serve as a source for generation of downstream ROS, which function as regulatory signaling intermediaries. A ROS-reacting substrate, 2-methyl-6-[4-methoxyphenyl]-3,7-dihydroimidazo[1,2-a]pyrazin-3-one hydrochloride, was used as the chemical energy donor for generating energy transfer luminescence in phagosomes and mitochondria. RESULTS:Using targeted photoluminescent dyes with specific subcellular localization that serve as chemical energy recipients, our imaging data demonstrate proof-of-concept for using glow stick chemistry to visualize ROS production associated with phagocytosis and mitochondrial respiration in living mice. CONCLUSIONS:Glow stick imaging is a complementary hybrid of chemiluminescence and photoluminescence imaging, capable of generating red or far-red emission for deep tissue imaging.

journal_name

Mol Imaging Biol

journal_title

Molecular imaging and biology

authors

Tseng JC,Bailey D,Tupper T,Kung AL

doi

10.1007/s11307-014-0721-8

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

478-87

issue

4

eissn

1536-1632

issn

1860-2002

journal_volume

16

pub_type

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