当前位置： SCI文献检索 > MOLECULAR IMAGING AND BIOLOGY期刊下所有文献 > Lectin conjugates as biospecific contrast agents for MRI. Coupling of Lycopersicon esculentum agglutinin to linear water-soluble DTPA-loaded oligomers.

Lectin conjugates as biospecific contrast agents for MRI. Coupling of Lycopersicon esculentum agglutinin to linear water-soluble DTPA-loaded oligomers.

Abstract：

:Magnetic resonance imaging (MRI) requires synthesis of contrast media bearing targeting groups and numerous gadolinium chelating groups generating high relaxivity. This paper explores the results of linking the gadolinium chelates to the targeting group, a protein molecule, via various types of linkers. Polycondensates of diethylenetriaminepentaacetic acid (DTPA) with either diols or diamines were synthesised and coupled to the targeting group, a lectin (Lycopersicon esculentum agglutinin, tomato lectin) which binds with high affinity to specific oligosaccharide configurations in the endothelial glycocalyx. The polycondensates bear up to four carboxylic groups per constitutive unit. Gd-chelate bonds are created through dative interactions with the unshared pair of electrons on each oxygen and nitrogen atom on DTPA. This is mandatory for complexation of Gd(III) and avoidance of the severe toxicity of free gadolinium ions. The polymer-DTPA compounds were characterised by (1)H NMR and mass spectrometry. The final lectin-DTPA-polycondensate conjugates were purified by fast protein liquid chromatography (FPLC). The capacity for specific binding was assessed, and the MRI properties were examined in order to evaluate the use of these oligomers as components of selective perfusional contrast agents.

journal_name

Mol Imaging Biol

journal_title

Molecular imaging and biology

authors

Pashkunova-Martic I,Kremser C,Galanski M,Schluga P,Arion V,Debbage P,Jaschke W,Keppler B

doi

10.1007/s11307-010-0358-1

subject

Has Abstract

pub_date

2011-06-01 00:00:00

pages

432-442

issue

3

eissn

1536-1632

issn

1860-2002

pii

10.1007/s11307-010-0358-1

journal_volume

13

pub_type

杂志文章

相关文献

MOLECULAR IMAGING AND BIOLOGY文献大全
  • Development of antibody-carrying microbubbles based on clinically available ultrasound contrast agent for targeted molecular imaging: a preliminary chemical study.

    abstract：PURPOSE:The purpose of the study was to examine the feasibility of an antibody-carrying targeted-bubble preparation using clinically available phosphatidylserine (PS)-containing perfluorobutane-filled microbubbles for molecular ultrasound imaging. PROCEDURES:Firstly, we examined whether PS on the surface of perfluorob...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-010-0344-7

    authors： Otani K,Yamahara K

    更新日期：2011-04-01 00:00:00

  • Relationship Between Clinicopathological Characteristics and PET/CT Uptake in Esophageal Squamous Cell Carcinoma: [18F]Alfatide versus [18F]FDG.

    abstract：PURPOSE:To assess a novel radiotracer aluminum [18F]fluoride-1,4,7-triazacyclononane-triacetic acid-pegylated dimeric RGD ([18F]ALF-NOTA-PRGD2, denoted as [18F]Alfatide) for positron emission tomography (PET)/X-ray computed tomography (CT) and explore the relationships between clinicopathological characteristics and ma...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-018-1216-9

    authors： Dong Y,Wei Y,Chen G,Huang Y,Song P,Liu S,Zheng J,Cheng M,Yuan S

    更新日期：2019-02-01 00:00:00

  • Cancer Patient-Derived Circulating Microparticles Enhance Lung Metastasis in a Rat Model: Dual-Source CT, Cellular, and Molecular Studies.

    abstract：PURPOSE:This study aimed to test the hypothesis that lung cancer patient-derived circulating microparticles (LCC-MPs) enhance metastatic lung tumors in a rat model. PROCEDURES:The controls (n = 6) and LCC-MP-treated rats (n = 6) with N1S1-induced pulmonary metastatic hepatocellular carcinoma (HCC) underwent dual-sourc...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-015-0923-8

    authors： Ko SF,Yip HK,Zhen YY,Lee CC,Li JH,Lee CC,Leu S,Huang CC,Ng SH,Lin JW

    更新日期：2016-08-01 00:00:00

  • MRI of ICAM-1 upregulation after stroke: the importance of choosing the appropriate target-specific particulate contrast agent.

    abstract：PURPOSE:Magnetic resonance imaging (MRI) with targeted contrast agents provides a promising means for diagnosis and treatment monitoring after cerebrovascular injury. Our goal was to demonstrate the feasibility of this approach to detect the neuroinflammatory biomarker intercellular adhesion molecule-1 (ICAM-1) after s...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-013-0617-z

    authors： Deddens LH,van Tilborg GA,van der Toorn A,van der Marel K,Paulis LE,van Bloois L,Storm G,Strijkers GJ,Mulder WJ,de Vries HE,Dijkhuizen RM

    更新日期：2013-08-01 00:00:00

  • (18)F-FDG PET/CT imaging detects therapy efficacy of anti-EMMPRIN antibody and gemcitabine in orthotopic pancreatic tumor xenografts.

    abstract：PURPOSE:The objective of this study is to evaluate the therapeutic response to a novel monoclonal antibody targeting human extracellular matrix metalloproteinase inducer (EMMPRIN) in combination with gemcitabine in a pancreatic-tumor xenograft murine model by sequential 2-deoxy-2-[18F]fluoro-D-glucose ((18)F-FDG) posit...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-011-0491-5

    authors： Shah N,Zhai G,Knowles JA,Stockard CR,Grizzle WE,Fineberg N,Zhou T,Zinn KR,Rosenthal EL,Kim H

    更新日期：2012-04-01 00:00:00

  • Whole body biodistribution and radiation dosimetry in humans of a new PET ligand, [(18)F]-FEPPA, to image translocator protein (18 kDa).

    abstract：PURPOSE:[(18)F]-FEPPA is a translocator protein (18 kDa, TSPO) positron emission tomography (PET) radiotracer. Radiation dosimetry was estimated from the whole body biodistribution, taking into consideration TSPO rs6971 (Ala147Thr) polymorphism. PROCEDURES:[(18)F]-FEPPA whole body PET scans were acquired for six healt...

    journal_title：Molecular imaging and biology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11307-012-0589-4

    authors： Mizrahi R,Rusjan PM,Vitcu I,Ng A,Wilson AA,Houle S,Bloomfield PM

    更新日期：2013-06-01 00:00:00

  • Exploring with [18F]UCB-H the in vivo Variations in SV2A Expression through the Kainic Acid Rat Model of Temporal Lobe Epilepsy.

    abstract：PURPOSE:The main purpose of this study was to understand how the positron emission tomography (PET) measure of the synaptic vesicle 2A (SV2A) protein varies in vivo during the development of temporal lobe epilepsy (TLE) in the kainic acid rat model. PROCEDURES:Twenty Sprague Dawley male rats were administered with mul...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-020-01488-7

    authors： Serrano ME,Bahri MA,Becker G,Seret A,Germonpré C,Lemaire C,Giacomelli F,Mievis F,Luxen A,Salmon E,Rogister B,Raedt R,Plenevaux A

    更新日期：2020-10-01 00:00:00

  • Reproducibility of Contrast-Enhanced Ultrasound in Mice with Controlled Injection.

    abstract：PURPOSE:Sensitivity of contrast-enhanced ultrasound (CEUS) to microvascular flow modifications can be limited by intra-injection variability (injected dose, rate, volume). PROCEDURES:To evaluate the effect of injection variability on microvascular flow evaluation, CEUS was compared between controlled and manual inject...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-016-0952-y

    authors： Dizeux A,Payen T,Barrois G,Le Guillou Buffello D,Bridal SL

    更新日期：2016-10-01 00:00:00

  • Lectin-Gd-loaded chitosan hydrogel nanoparticles: a new biospecific contrast agent for MRI.

    abstract：PURPOSE:Non-specific extracellular contrast agents have been on the market for more than 15 years. Here, we report on the synthesis of new selective lectin-gadolinium (Gd)-loaded chitosan nanoparticles with a prolonged clearance time and a much higher relaxivity in comparison to other preparations. PROCEDURES:Chitosan...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-010-0309-x

    authors： Pashkunova-Martic I,Kremser C,Galanski M,Arion V,Debbage P,Jaschke W,Keppler B

    更新日期：2011-02-01 00:00:00

  • Site-Specific Fluorescent Labeling of Antibodies and Diabodies Using SpyTag/SpyCatcher System for In Vivo Optical Imaging.

    abstract：PURPOSE:Construction of antibody-based, molecular-targeted optical imaging probes requires the labeling of an antibody with a fluorophore. The most common method for doing this involves non-specifically conjugating a fluorophore to an antibody, resulting in poorly defined, heterogeneous imaging probes that often have s...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-018-1222-y

    authors： Alam MK,El-Sayed A,Barreto K,Bernhard W,Fonge H,Geyer CR

    更新日期：2019-02-01 00:00:00

  • Assessment of Chemotherapy-Induced Organ Damage with Ga-68 Labeled Duramycin.

    abstract：PURPOSE:Evaluation of [68Ga]NODAGA-duramycin as a positron emission tomography (PET) tracer of cell death for whole-body detection of chemotherapy-induced organ toxicity. PROCEDURES:Tracer specificity of Ga-68 labeled NODAGA-duramycin was determined in vitro using competitive binding experiments. Organ uptake was anal...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-019-01417-3

    authors： Rix A,Drude NI,Mrugalla A,Baskaya F,Pak KY,Gray B,Kaiser HJ,Tolba RH,Fiegle E,Lederle W,Mottaghy FM,Kiessling F

    更新日期：2020-06-01 00:00:00

  • Sigma-2 receptor as potential indicator of stem cell differentiation.

    abstract：PURPOSE:The sigma-2 (σ(2)) receptor is a potential biomarker of proliferative status of solid tumors. Specific synthetic probes using N-substituted-9-azabicyclo [3.3.1]nonan-3α-yl carbamate analogs have been designed and implemented for experimental cancer diagnosis and therapy. PROCEDURES:We employed the fluorescentl...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-011-0493-3

    authors： Haller JL,Panyutin I,Chaudhry A,Zeng C,Mach RH,Frank JA

    更新日期：2012-06-01 00:00:00

  • Correction to: Pre-therapy Somatostatin Receptor-Based Heterogeneity Predicts Overall Survival in Pancreatic Neuroendocrine Tumor Patients Undergoing Peptide Receptor Radionuclide Therapy.

    abstract：:The article "Pre-therapy Somatostatin Receptor-Based Heterogeneity Predicts Overall Survival in Pancreatic Neuroendocrine Tumor Patients Undergoing Peptide Receptor Radionuclide Therapy," was originally published electronically on the publisher's internet portal without open access. ...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章,已发布勘误

    doi：10.1007/s11307-018-1261-4

    authors： Werner RA,Ilhan H,Lehner S,Papp L,Zsótér N,Schatka I,Muegge DO,Javadi MS,Higuchi T,Buck AK,Bartenstein P,Bengel F,Essler M,Lapa C,Bundschuh RA

    更新日期：2018-12-01 00:00:00

  • Evaluation of 89Zr-rituximab tracer by Cerenkov luminescence imaging and correlation with PET in a humanized transgenic mouse model to image NHL.

    abstract：PURPOSE:This research aimed to study the use of Cerenkov luminescence imaging (CLI) for non-Hodgkin's lymphoma (NHL) using 89Zr-rituximab positron emission tomography (PET) tracer with a humanized transgenic mouse model that expresses human CD20 and the correlation of CLI with PET. PROCEDURES:Zr-rituximab (2.6 MBq) wa...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-013-0624-0

    authors： Natarajan A,Habte F,Liu H,Sathirachinda A,Hu X,Cheng Z,Nagamine CM,Gambhir SS

    更新日期：2013-08-01 00:00:00

  • A study on the prognostic evaluation of carbon ion radiotherapy for head and neck adenocarcinoma with C-11 methionine PET.

    abstract：PURPOSE:Carbon ion radiotherapy (CIRT) has been developed, and a phase I/II CIRT trial has been conducted in patients with adenocarcinoma in the head and neck region. We evaluated whether the L-methyl [11C]-methionine (MET) uptake could be an early predictor for local recurrence, metastasis, and the prognosis in patien...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-010-0318-9

    authors： Hasebe M,Yoshikawa K,Ohashi S,Toubaru S,Kawaguchi K,Sato J,Mizoe J,Tsujii H

    更新日期：2010-10-01 00:00:00

  • Routine production of [(18)f]flumazenil from iodonium tosylate using a sample pretreatment method: a 2.5-year production report.

    abstract：PURPOSE:[(18)F]Flumazenil, which has the advantage of a longer half-life than [(11)C]flumazenil, is well known for determining of the central benzodiazepine receptor concentrations. However, [(18)F]flumazenil has not been widely used because fluctuating and relatively low yields render automatic production insufficient...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-014-0738-z

    authors： Moon BS,Park JH,Lee HJ,Lee BC,Kim SE

    更新日期：2014-10-01 00:00:00

  • Semiautomated radiosynthesis and biological evaluation of [18F]FEAU: a novel PET imaging agent for HSV1-tk/sr39tk reporter gene expression.

    abstract：:2'-deoxy-2'-[(18)F]fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil ([(18)F]FEAU) is a promising radiolabeled nucleoside designed to monitor Herpes Simplex Virus Type 1 thymidine kinase (HSV1-tk) reporter gene expression with positron emission tomography (PET). However, the challenging radiosynthesis creates problems fo...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-007-0122-3

    authors： Chin FT,Namavari M,Levi J,Subbarayan M,Ray P,Chen X,Gambhir SS

    更新日期：2008-03-01 00:00:00

  • Correction to: Differentiation of Malignant and Benign Head and Neck Tumors with Amide Proton Transfer-Weighted MR Imaging.

    abstract：:This article is about head and neck tumor MR imaging and is not within the scope of two National Institutes of Health grants (R0ICA166171, ROICA228188) erroneously listed. Thus, the authors would like to remove the reference to the NIH grants R01CA166171 and R01CA228188 in this article. ...

    journal_title：Molecular imaging and biology

    pub_type： 已发布勘误

    doi：10.1007/s11307-019-01459-7

    authors： Yu L,Li C,Luo X,Zhou J,Zhang C,Zhang Y,Chen M

    更新日期：2020-02-01 00:00:00

  • Specific targeting of atherosclerotic plaques in ApoE(-/-) mice using a new Camelid sdAb binding the vulnerable plaque marker LOX-1.

    abstract：PURPOSE:Molecular imaging has the potential to provide quantitative information about specific biological aspects of developing atherosclerotic lesions. This requires the generation of reliable, highly specific plaque tracers. This study reports a new camelid single-domain antibody fragment (sdAb) targeting the Lectin-...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-014-0731-6

    authors： De Vos J,Mathijs I,Xavier C,Massa S,Wernery U,Bouwens L,Lahoutte T,Muyldermans S,Devoogdt N

    更新日期：2014-10-01 00:00:00

  • To Explore a Representative Hypoxic Parameter to Predict the Treatment Response and Prognosis Obtained by [18F]FMISO-PET in Patients with Non-small Cell Lung Cancer.

    abstract：PURPOSE:To explore a representative hypoxic parameter to predict the treatment response and prognosis for [18F]fluoromisonidazole ([18F]FMISO) positron emission tomography (PET)/X-ray computed tomography (CT) in patients with non-small cell lung cancer (NSCLC). PROCEDURES:Twenty-nine patients with NSCLC underwent FMIS...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-018-1190-2

    authors： Li L,Wei Y,Huang Y,Yu Q,Liu W,Zhao S,Zheng J,Lu H,Yu J,Yuan S

    更新日期：2018-12-01 00:00:00

  • Noninvasive reporter gene imaging of human Oct4 (pluripotency) dynamics during the differentiation of embryonic stem cells in living subjects.

    abstract：PURPOSE:Human pluripotency gene networks (PGNs), controlled in part by Oct4, are central to understanding pluripotent stem cells, but current fluorescent reporter genes (RGs) preclude noninvasive assessment of Oct4 dynamics in living subjects. PROCEDURES:To assess Oc4 activity noninvasively, we engineered a mouse embr...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-014-0744-1

    authors： Ahn BC,Parashurama N,Patel M,Ziv K,Bhaumik S,Yaghoubi SS,Paulmurugan R,Gambhir SS

    更新日期：2014-12-01 00:00:00

  • Transferrin-coated gadolinium nanoparticles as MRI contrast agent.

    abstract：PURPOSE:In this study, the contrasting properties of human serum albumin nanoparticles (HSA-NPs) loaded with gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and coated with transferrin in MRI in mice are evaluated. PROCEDURES:HSA-NPs were conjugated with Gd-DTPA (Gd-HSA-NPs) and coupled with transferrin (Gd-H...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-012-0579-6

    authors： Korkusuz H,Ulbrich K,Welzel K,Koeberle V,Watcharin W,Bahr U,Chernikov V,Knobloch T,Petersen S,Huebner F,Ackermann H,Gelperina S,Kromen W,Hammerstingl R,Haupenthal J,Gruenwald F,Fiehler J,Zeuzem S,Kreuter J,Vogl TJ,

    更新日期：2013-04-01 00:00:00

  • Targeting gelatinases with a near-infrared fluorescent cyclic His-Try-Gly-Phe peptide.

    abstract：PURPOSE:The purpose of the study is to synthesize and characterize near-infrared (NIR) fluorescence imaging probes targeted to gelatinases. PROCEDURES:A phage display-selected cyclic peptide containing the His-Try-Gly-Phe (HWGF) motif was used as the lead compound. Structure-activity relationship analysis was used to ...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-009-0219-y

    authors： Wang W,Shao R,Wu Q,Ke S,McMurray J,Lang FF Jr,Charnsangavej C,Gelovani JG,Li C

    更新日期：2009-11-01 00:00:00

  • Current and Emerging Preclinical Approaches for Imaging-Based Characterization of Atherosclerosis.

    abstract：:Atherosclerotic plaques can remain quiescent for years, but become life threatening upon rupture or disruption, initiating clot formation in the vessel lumen and causing acute myocardial infarction and ischemic stroke. Whether and how a plaque ruptures is determined by its macroscopic structure and microscopic composi...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章,评审

    doi：10.1007/s11307-018-1264-1

    authors： Vigne J,Thackeray J,Essers J,Makowski M,Varasteh Z,Curaj A,Karlas A,Canet-Soulas E,Mulder W,Kiessling F,Schäfers M,Botnar R,Wildgruber M,Hyafil F,Cardiovascular study group of the European Society of Molecular Imaging.

    更新日期：2018-12-01 00:00:00

  • Impact of 2-deoxy-2[F-18]fluoro-D-glucose Positron Emission Tomography on the management of patients with advanced melanoma.

    abstract：OBJECTIVES:Accurate staging of patients with melanoma is vital to guide appropriate treatment. 2-Deoxy-2-[F-18]fluoro-D-glucose (FDG)-positron emission tomography (PET) has been reported to be a sensitive and specific technique for the staging of advanced melanoma, however, few studies provide information regarding its...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-005-0002-7

    authors： Harris MT,Berlangieri SU,Cebon JS,Davis ID,Scott AM

    更新日期：2005-07-01 00:00:00

  • Detection of hepatic metastases using dual-time-point FDG PET/CT scans in patients with colorectal cancer.

    abstract：PURPOSE:The purpose of this study was to determine the most useful parameter of dual-time-point 2-deoxy-2-[¹⁸F]fluoro-D: -glucose positron emission tomography/computed tomography (PET/CT) for detection of hepatic metastases in patients with colorectal cancer. PROCEDURES:Thirty-nine patients had undergone a dual-time-p...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-010-0394-x

    authors： Lee JW,Kim SK,Lee SM,Moon SH,Kim TS

    更新日期：2011-06-01 00:00:00

  • Positron emission tomography/computed tomography of a rare xanthogranulomatous process: Erdheim-Chester disease.

    abstract：:Erdheim-Chester disease (ECD) is a disseminated xanthogranulomatous infiltrative disease of unknown etiology due to infiltration of different organs and bones by foamy histiocytes. A 37-year-old male with cerebral and periorbital lesions was diagnosed with this rare disease and was evaluated with magnetic resonance im...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1016/j.mibio.2004.01.023

    authors： Pereira Neto CC,Roman C,Johnson M,Jagasia M,Martin WH,Delbeke D

    更新日期：2004-01-01 00:00:00

  • Design and Evaluation of Rhein-Based MRI Contrast Agents for Visualization of Tumor Necrosis Induced by Combretastatin A-4 Disodium Phosphate.

    abstract：PURPOSE:Visualization of tumor necrosis can determine tumor response to therapy. Our previous study showed that the rhein-based magnetic resonance imaging (MRI) contrast agent with alkane linker (GdL2) could clearly image tumor necrosis. However, its water solubility and cell safety needed to be improved. Herein, three...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-020-01551-3

    authors： Zhang L,Zhang D,Gao M,Jin Q,Jiang C,Wu T,Feng Y,Ni Y,Yin Z,Zhang J

    更新日期：2020-10-13 00:00:00

  • In Vivo Evaluation of Magnetic Targeting in Mice Colon Tumors with Ultra-Magnetic Liposomes Monitored by MRI.

    abstract：PURPOSE:The development of theranostic nanocarriers as an innovative therapy against cancer has been improved by targeting properties in order to optimize the drug delivery to safely achieve its desired therapeutic effect. The aim of this paper is to evaluate the magnetic targeting (MT) efficiency of ultra-magnetic lip...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-018-1238-3

    authors： Thébault CJ,Ramniceanu G,Michel A,Beauvineau C,Girard C,Seguin J,Mignet N,Ménager C,Doan BT

    更新日期：2019-04-01 00:00:00

  • The EIIAPA chimeric promoter for tumor specific gene therapy of hepatoma.

    abstract：PURPOSE:For targeted imaging and therapy of hepatocellular carcinoma (HCC), we established a chimeric promoter (EIIAPA) containing alpha-fetoprotein (AFP) promoter and hepatitis B virus enhancer II (EIIA) to control downstream expression of reporter and therapeutic genes. PROCEDURES:We combined AFP promoter and EIIA t...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-011-0509-z

    authors： Hsieh YJ,Chen FD,Ke CC,Wang HE,Huang CJ,Hou MF,Lin KP,Gelovani JG,Liu RS

    更新日期：2012-08-01 00:00:00