Noninvasive reporter gene imaging of human Oct4 (pluripotency) dynamics during the differentiation of embryonic stem cells in living subjects.

abstract：PURPOSE:The tyrosine kinase receptor Axl is overexpressed in various types of cancer and correlated with cancer malignancy. Selective Axl blockade reduces tumor growth and metastasis. The purpose of this study was to examine whether the humanized anti-Axl antibody humanized 173 (h173) labeled with near-infrared fluores...

journal_title：Molecular imaging and biology

authors： Li D,Liu S,Liu R,Park R,Yu H,Krasnoperov V,Gill PS,Li Z,Shan H,Conti PS

更新日期：2014-08-01 00:00:00

abstract：PURPOSE:This study was undertaken to evaluate radiation dosimetry for the prostate-specific membrane antigen targeted [68Ga]Ga-P16-093 radiopharmaceutical, and to initially assess agent performance in positron emission tomography (PET) detection of the site of disease in prostate cancer patients presenting with biochem...

journal_title：Molecular imaging and biology

authors： Green MA,Hutchins GD,Bahler CD,Tann M,Mathias CJ,Territo W,Sims J,Polson H,Alexoff D,Eckelman WC,Kung HF,Fletcher JW

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:To assess a novel radiotracer aluminum [18F]fluoride-1,4,7-triazacyclononane-triacetic acid-pegylated dimeric RGD ([18F]ALF-NOTA-PRGD2, denoted as [18F]Alfatide) for positron emission tomography (PET)/X-ray computed tomography (CT) and explore the relationships between clinicopathological characteristics and ma...

journal_title：Molecular imaging and biology

authors： Dong Y,Wei Y,Chen G,Huang Y,Song P,Liu S,Zheng J,Cheng M,Yuan S

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:We evaluated the ability of 2-deoxy-2-(18)F-fluoro-D-glucose (FDG) positron emission tomography (PET) in the early assessment of therapeutic response in patients with small cell lung cancer (SCLC). PROCEDURES:FDG PET studies were performed before (baseline PET), after the first cycle of chemotherapy (early PET...

journal_title：Molecular imaging and biology

authors： Yamamoto Y,Kameyama R,Murota M,Bandoh S,Ishii T,Nishiyama Y

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:The aim of this study was to determine the effect of hyperinsulinemia on myocardial and hepatic distribution and metabolism of 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid ([18F]FTHA). PROCEDURES:Mitochondrial retention and intracellular lipid incorporation of [18F]FTHA were compared to that of [14C]-2-bromop...

journal_title：Molecular imaging and biology

authors： Ci X,Frisch F,Lavoie F,Germain P,Lecomte R,van Lier JE,Bénard F,Carpentier AC

更新日期：2006-07-01 00:00:00

abstract：:Erdheim-Chester disease (ECD) is a disseminated xanthogranulomatous infiltrative disease of unknown etiology due to infiltration of different organs and bones by foamy histiocytes. A 37-year-old male with cerebral and periorbital lesions was diagnosed with this rare disease and was evaluated with magnetic resonance im...

journal_title：Molecular imaging and biology

authors： Pereira Neto CC,Roman C,Johnson M,Jagasia M,Martin WH,Delbeke D

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:[123I]FP-CIT (DaTSCAN®) single-photon emission computed tomography (SPECT) imaging is widely used to study neurodegenerative parkinsonism, by measuring presynaptic dopamine transporter (DAT) in striatal regions. Beyond DAT, [123I]FP-CIT may be considered for other monoaminergic systems, in particular the seroto...

journal_title：Molecular imaging and biology

authors： Premi E,Calhoun VD,Garibotto V,Turrone R,Alberici A,Cottini E,Pilotto A,Gazzina S,Magoni M,Paghera B,Borroni B,Padovani A

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:Repetitive imaging with microPET of endogenous albumin gene expression by using transgenic mice in which the Herpes Simplex Virus Type 1 thymidine kinase (HSV1-tk) reporter gene is driven by the albumin promoter (AL-HSV1-tk). METHODS:Transgenic mice were imaged repeatedly on a microPET scanner with approximate...

journal_title：Molecular imaging and biology

authors： Green LA,Yap CS,Nguyen K,Barrio JR,Namavari M,Satyamurthy N,Phelps ME,Sandgren EP,Herschman HR,Gambhir SS

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:Contrast-enhanced magnetic resonance imaging (MRI) has the potential to replace angiographic evaluation of atherosclerosis. While studies have investigated contrast agent (CA) uptake in atherosclerotic plaques, exact CA spatial distribution on a microscale is elusive. The purpose of this study was to investigat...

journal_title：Molecular imaging and biology

authors： Uca YO,Hallmann D,Hesse B,Seim C,Stolzenburg N,Pietsch H,Schnorr J,Taupitz M

更新日期：2020-12-07 00:00:00

abstract：PURPOSE:The purpose of this study is to evaluate if the differential exchange rates with bulk water between amine and amide protons can be exploited using chemical exchange saturation transfer magnetic resonance (CEST-MR) to monitor the release of glutamate induced by carboxypeptidase G2 (CPG2), an enzyme utilized in c...

journal_title：Molecular imaging and biology

authors： Jamin Y,Eykyn TR,Poon E,Springer CJ,Robinson SP

更新日期：2014-04-01 00:00:00

abstract：PURPOSE:To evaluate the utility of three-dimensional (3D) amide proton transfer-weighted (APTw) imaging for differentiation of endometrial adenocarcinoma and uterine benign lesions. PROCEDURES:This prospective study enrolled 22 normal volunteers and 113 patients with suspicious uterine lesions, including endometrial a...

journal_title：Molecular imaging and biology

authors： Li Y,Lin CY,Qi YF,Wang XQ,Chen B,Zhou HL,Ren J,Yang JJ,Xiang Y,He YL,Xue HD,Jin ZY

更新日期：2020-11-13 00:00:00

abstract：:Positron emission tomography (PET) or single photon emission computer tomography (SPECT) imaging provides the means to study neurochemical processes in vivo. These methods have been applied to examine monoaminergic and cholinergic changes in neurodegenerative disorders. These investigations have provided important ins...

journal_title：Molecular imaging and biology

authors： Bohnen NI,Frey KA

更新日期：2007-07-01 00:00:00

abstract：PURPOSE:Transplantation of a regenerative cell population derived from human subcutaneous adipose tissue (hASCs) for cardiac regeneration represents a promising therapy due to the capacity of these cells for proliferation and differentiation. Understanding the fate of injected hASCs would help to understand how hASCs w...

journal_title：Molecular imaging and biology

authors： Bai X,Yan Y,Coleman M,Wu G,Rabinovich B,Seidensticker M,Alt E

更新日期：2011-08-01 00:00:00

abstract：:Morphological imaging techniques are typically used in the anti-cancer drug efficacy evaluation process. However, these techniques can evaluate the therapeutic efficacy only when the tumor shows anatomic changes-usually at later stages, when the therapeutic effects are poor. In contrast, molecular imaging allows nonin...

journal_title：Molecular imaging and biology

authors： Liang Q,Kong L,Zhu X,Du Y,Tian J

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:Negative surgical margins (NSMs) have favorable prognostic implications in breast tumor resection surgery. Fluorescence image-guided surgery (FIGS) has the ability to delineate surgical margins in real time, potentially improving the completeness of tumor resection. We have recently developed indocyanine green ...

journal_title：Molecular imaging and biology

authors： Wojtynek NE,Olson MT,Bielecki TA,An W,Bhat AM,Band H,Lauer SR,Silva-Lopez E,Mohs AM

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:Non-invasive in vivo positron emission tomography (PET) provides high detection sensitivity in the nano- to picomolar range and in addition to other advantages, the possibility to absolutely quantify the acquired data. The present study focuses on the comparison of transmission data acquired with an X-ray compu...

journal_title：Molecular imaging and biology

authors： Mannheim JG,Schmid AM,Pichler BJ

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:Some patients cannot remain immobile for a long duration of 60 min, which is generally applied in the case of a 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) dynamic positron emission tomography (PET) scan. We investigated the change of the parametric values when the time duration of PET data was shortened. P...

journal_title：Molecular imaging and biology

authors： Monden T,Kudomi N,Sasakawa Y,Yamamoto Y,Kawai N,Nishiyama Y

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:Manganese ion has been extensively used as a magnetic resonance imaging (MRI) contrast agent in preclinical studies to assess tissue anatomy, function, and neuronal connectivity. Unfortunately, its use in human studies has been limited by cellular toxicity and the need to use a very low dose. The much higher se...

journal_title：Molecular imaging and biology

authors： Saar G,Millo CM,Szajek LP,Bacon J,Herscovitch P,Koretsky AP

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:The sigma-2 (σ(2)) receptor is a potential biomarker of proliferative status of solid tumors. Specific synthetic probes using N-substituted-9-azabicyclo [3.3.1]nonan-3α-yl carbamate analogs have been designed and implemented for experimental cancer diagnosis and therapy. PROCEDURES:We employed the fluorescentl...

journal_title：Molecular imaging and biology

authors： Haller JL,Panyutin I,Chaudhry A,Zeng C,Mach RH,Frank JA

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:The A1AR antagonist 8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine ([(18)F]CPFPX) has recently been shown to be a suitable radiotracer for quantitative in vivo imaging of the A1 adenosine receptor (A1AR) in rats. The present study evaluates the reproducibility of non-invasive longitudinal A1AR studies with [...

journal_title：Molecular imaging and biology

authors： Kroll T,Elmenhorst D,Weisshaupt A,Beer S,Bauer A

更新日期：2014-10-01 00:00:00

abstract：:Fluorescence molecular imaging (MI) is an important concept in preclinical research that focuses on the visualization of cellular and biological function in a non-invasive fashion to better understand in vivo disease processes and treatment effects. MI differs fundamentally from traditional preclinical imaging strateg...

journal_title：Molecular imaging and biology

authors： Peterson JD

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:To explore a representative hypoxic parameter to predict the treatment response and prognosis for [18F]fluoromisonidazole ([18F]FMISO) positron emission tomography (PET)/X-ray computed tomography (CT) in patients with non-small cell lung cancer (NSCLC). PROCEDURES:Twenty-nine patients with NSCLC underwent FMIS...

journal_title：Molecular imaging and biology

authors： Li L,Wei Y,Huang Y,Yu Q,Liu W,Zhao S,Zheng J,Lu H,Yu J,Yuan S

更新日期：2018-12-01 00:00:00

abstract：:The article "Pre-therapy Somatostatin Receptor-Based Heterogeneity Predicts Overall Survival in Pancreatic Neuroendocrine Tumor Patients Undergoing Peptide Receptor Radionuclide Therapy," was originally published electronically on the publisher's internet portal without open access. ...

journal_title：Molecular imaging and biology

authors： Werner RA,Ilhan H,Lehner S,Papp L,Zsótér N,Schatka I,Muegge DO,Javadi MS,Higuchi T,Buck AK,Bartenstein P,Bengel F,Essler M,Lapa C,Bundschuh RA

更新日期：2018-12-01 00:00:00

abstract：:We evaluated the clinical utility of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) on the precise localization of pathologic foci and exclusion of normal variants in the imaging evaluation of patients with esophageal carcinoma. Combined PET/CT scans were performed i...

journal_title：Molecular imaging and biology

authors： Jadvar H,Henderson RW,Conti PS

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate different non-invasive methods for generating (R)-1-((3-([11C]methyl)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) ([11C]UCB-J) parametric maps using white matter (centrum semi-ovale-SO) as reference tissue. PROCEDURES:Ten healthy volunteers (8 M/2F; age ...

journal_title：Molecular imaging and biology

authors： Mertens N,Maguire RP,Serdons K,Lacroix B,Mercier J,Sciberras D,Van Laere K,Koole M

更新日期：2020-04-01 00:00:00

abstract：:This article reviews positron emission tomography (PET) studies of labeled enantiomers of different PET-tracers from the early 1980s. Comparative studies on stereoselective behavior of the transport of tracers across the blood-brain barrier (BBB) are discussed. Tracers are transported through the BBB into the brain, v...

journal_title：Molecular imaging and biology

authors： Luurtsema G,de Lange EC,Lammertsma AA,Franssen EJ

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:The purpose of the study was to examine the feasibility of an antibody-carrying targeted-bubble preparation using clinically available phosphatidylserine (PS)-containing perfluorobutane-filled microbubbles for molecular ultrasound imaging. PROCEDURES:Firstly, we examined whether PS on the surface of perfluorob...

journal_title：Molecular imaging and biology

authors： Otani K,Yamahara K

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:Radioimmunotherapy uses tumor-specific antibodies to deliver therapeutic radionuclides, but hematological toxicity due to the long serum half-life of intact antibodies remains a challenge. We evaluated a smaller antibody fragment, the minibody, with faster kinetics and a potentially improved therapeutic index. ...

journal_title：Molecular imaging and biology

authors： Tsai WK,Zettlitz KA,Dahlbom M,Reiter RE,Wu AM

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:The main purpose of this study was to understand how the positron emission tomography (PET) measure of the synaptic vesicle 2A (SV2A) protein varies in vivo during the development of temporal lobe epilepsy (TLE) in the kainic acid rat model. PROCEDURES:Twenty Sprague Dawley male rats were administered with mul...

journal_title：Molecular imaging and biology

authors： Serrano ME,Bahri MA,Becker G,Seret A,Germonpré C,Lemaire C,Giacomelli F,Mievis F,Luxen A,Salmon E,Rogister B,Raedt R,Plenevaux A

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:Many neurological diseases affect small structures in the brain and, as such, reliable visual evaluation and accurate quantification are required. Recent technological developments made the clinical use of hybrid positron emission tomography/magnetic resonance (PET/MR) systems possible, providing both functiona...

journal_title：Molecular imaging and biology

authors： Leemans EL,Kotasidis F,Wissmeyer M,Garibotto V,Zaidi H

更新日期：2015-10-01 00:00:00