Abstract：
PURPOSE:Some patients cannot remain immobile for a long duration of 60 min, which is generally applied in the case of a 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) dynamic positron emission tomography (PET) scan. We investigated the change of the parametric values when the time duration of PET data was shortened. PROCEDURES:Eight normal subjects and four subjects with brain glioma were studied. The rate values of K(1), k(2), k(3), and K(i) parametric images were computed by changing the time duration from 20 to 60 min, and changes of those parametric values were compared. RESULTS:The change was 20-30% and 3-5% for k(3) and K(i), respectively, when the scan time was shortened from 60 to 40 min. The ratios of normal and disease regions in k(3) and K(i) values were similar, and contrasts of those images were not changed when the scan time was shortened to 40 min. CONCLUSIONS:These results demonstrate that the short time duration of [(18)F]FDG PET examination can provide an acceptable estimation of parametric k(3) and K(i) images.
journal_name
Mol Imaging Bioljournal_title
Molecular imaging and biologyauthors
Monden T,Kudomi N,Sasakawa Y,Yamamoto Y,Kawai N,Nishiyama Ydoi
10.1007/s11307-010-0384-zsubject
Has Abstractpub_date
2011-08-01 00:00:00pages
754-8issue
4eissn
1536-1632issn
1860-2002journal_volume
13pub_type
临床试验,杂志文章abstract：PURPOSE:To demonstrate the efficacy of repeated, non-invasive optical imaging of reporter gene expression in monitoring the ability of bi-specific recombinant molecules (i) to "transductionally untarget" adenovirus from Coxsackie and Adenovirus Receptor (CAR)-dependent infection of normal tissue and (ii) to "transducti...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1016/j.mibio.2004.09.002
更新日期：2004-11-01 00:00:00
abstract：:This article was updated to correct the spelling of Hongkai Wang's name: it is correct as displayed here. ...
journal_title：Molecular imaging and biology
pub_type： 杂志文章,已发布勘误
doi：10.1007/s11307-018-1240-9
更新日期：2019-02-01 00:00:00
abstract：PURPOSE:This research aimed to study the use of Cerenkov luminescence imaging (CLI) for non-Hodgkin's lymphoma (NHL) using 89Zr-rituximab positron emission tomography (PET) tracer with a humanized transgenic mouse model that expresses human CD20 and the correlation of CLI with PET. PROCEDURES:Zr-rituximab (2.6 MBq) wa...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-013-0624-0
更新日期：2013-08-01 00:00:00
abstract：PURPOSE:Previous studies has demonstrated the utility of human epidermal growth factor receptor type 2 (HER2) as an attractive target for cancer molecular imaging and therapy. An affibody protein with strong binding affinity for HER2, ZHER2:342, has been reported. Various methods of chelator conjugation for radiolabeli...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-018-01310-5
更新日期：2019-10-01 00:00:00
abstract：PURPOSE:Previously, some reports mentioned that magnetic resonance imaging (MRI) can predict histopathological features in primary CNS lymphoma (PCNSL). The reported data analyzed diffusion-weighted imaging findings. The aim of this study was to investigate possible associations between histopathological findings, such...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-017-1115-5
更新日期：2018-04-01 00:00:00
abstract：PURPOSE:We evaluated the ability of 2-deoxy-2-(18)F-fluoro-D-glucose (FDG) positron emission tomography (PET) in the early assessment of therapeutic response in patients with small cell lung cancer (SCLC). PROCEDURES:FDG PET studies were performed before (baseline PET), after the first cycle of chemotherapy (early PET...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-009-0227-y
更新日期：2009-11-01 00:00:00
abstract：PURPOSE:Tc-99m methylene diphosphonate ([99mTc]MDP) is an in vivo bone imaging agent that also accumulates in injured skeletal muscle cells. The objective of this study was to investigate if [99mTc]MDP could be used to detect muscle injury in the mdx mouse model of Duchenne muscular dystrophy (DMD). PROCEDURES:Static ...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-019-01394-7
更新日期：2020-06-01 00:00:00
abstract：PURPOSE:Inflammation plays a key role in the progression of intervertebral disk (IVD) herniation and associated low back pain. However, real-time spatial diagnosis of inflammation associated with acute disk herniation has not been investigated. We sought to detect local neutrophil and macrophage infiltration near disk ...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-016-1038-6
更新日期：2017-10-01 00:00:00
abstract：:We evaluated the clinical utility of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) on the precise localization of pathologic foci and exclusion of normal variants in the imaging evaluation of patients with esophageal carcinoma. Combined PET/CT scans were performed i...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-006-0036-5
更新日期：2006-05-01 00:00:00
abstract：:Positron emission tomography (PET) or single photon emission computer tomography (SPECT) imaging provides the means to study neurochemical processes in vivo. These methods have been applied to examine monoaminergic and cholinergic changes in neurodegenerative disorders. These investigations have provided important ins...
journal_title：Molecular imaging and biology
pub_type： 杂志文章,评审
doi：10.1007/s11307-007-0083-6
更新日期：2007-07-01 00:00:00
abstract：PURPOSE:Transplantation of a regenerative cell population derived from human subcutaneous adipose tissue (hASCs) for cardiac regeneration represents a promising therapy due to the capacity of these cells for proliferation and differentiation. Understanding the fate of injected hASCs would help to understand how hASCs w...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-010-0392-z
更新日期：2011-08-01 00:00:00
abstract：PURPOSE:Negative surgical margins (NSMs) have favorable prognostic implications in breast tumor resection surgery. Fluorescence image-guided surgery (FIGS) has the ability to delineate surgical margins in real time, potentially improving the completeness of tumor resection. We have recently developed indocyanine green ...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-019-01462-y
更新日期：2020-08-01 00:00:00
abstract：PURPOSE:Rats are important preclinical models for studying breast cancer metastasis and bone pathologies. In these research areas, fluorescence molecular tomography (FMT) is commonly applied for quantitative three-dimensional (3D) imaging in mice. However, uncertainties due to strong depth dependency of FMT signal and ...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-013-0698-8
更新日期：2014-06-01 00:00:00
abstract：PURPOSE:Construction of antibody-based, molecular-targeted optical imaging probes requires the labeling of an antibody with a fluorophore. The most common method for doing this involves non-specifically conjugating a fluorophore to an antibody, resulting in poorly defined, heterogeneous imaging probes that often have s...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-018-1222-y
更新日期：2019-02-01 00:00:00
abstract：PURPOSE:This study aims to explore whether 4-(2S,4R)-[18F]fluoroglutamine (4-[18F]FGln) positron emission tomography (PET) imaging is helpful in identifying and monitoring MYCN-amplified neuroblastoma by enhanced glutamine metabolism. PROCEDURES:Cell uptake studies and dynamic small-animal PET studies of 4-[18F]FGln a...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-019-01330-9
更新日期：2019-12-01 00:00:00
abstract：PURPOSE:Vulnerable plaques are key factors for ischemic diseases. Thus, their precise detection is necessary for the diagnosis of such diseases. Immunoglobulin G (IgG)-based imaging probes have been developed for imaging biomolecules related to plaque formation for the diagnosis of atherosclerosis. However, IgG accumul...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-016-1036-8
更新日期：2017-08-01 00:00:00
abstract：PURPOSE:To develop a tool to measure the pH at the surfaces of individual cells. PROCEDURES:The SNARF pH-sensitive dye was conjugated to a pHLIP® peptide (pH-Low Insertion Peptide) that binds cellular membranes in tumor spheroids. A beam splitter allows simultaneous recording of two images (580 and 640 nm) by a CCD ca...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-019-01335-4
更新日期：2019-12-01 00:00:00
abstract：PURPOSE:Nowadays, 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET)/X-ray computed tomography (CT) is considered the best available technique to in vivo determination of human BAT volume. The most used Hounsfield unit (HU) threshold for BAT quantification is from - 250 to - 50 HU. Therefore,...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-019-01381-y
更新日期：2020-04-01 00:00:00
abstract：:This article reviews positron emission tomography (PET) studies of labeled enantiomers of different PET-tracers from the early 1980s. Comparative studies on stereoselective behavior of the transport of tracers across the blood-brain barrier (BBB) are discussed. Tracers are transported through the BBB into the brain, v...
journal_title：Molecular imaging and biology
pub_type： 杂志文章,评审
doi：10.1016/j.mibio.2004.06.008
更新日期：2004-09-01 00:00:00
abstract：PURPOSE:Many radioligands have been explored for imaging the 18-kDa translocator protein (TSPO), a diagnostic and therapeutic target for inflammation and cancer. Here, we investigated the TSPO radioligand [(18)F]DPA-714 for positron emission tomography (PET) imaging of cancer and inflammation. PROCEDURES:[(18)F]DPA-71...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-015-0877-x
更新日期：2016-02-01 00:00:00
abstract：PURPOSE:The present work was aimed at the formulation and evaluation of freeze-dried kits of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-peptides for the preparation of (68)Ga-labelled peptides for PET imaging of neuroendocrine tumours. The (68)GaCl3 was obtained from the locally produced nanoceria-...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-014-0719-2
更新日期：2014-08-01 00:00:00
abstract：PURPOSE:Non-specific extracellular contrast agents have been on the market for more than 15 years. Here, we report on the synthesis of new selective lectin-gadolinium (Gd)-loaded chitosan nanoparticles with a prolonged clearance time and a much higher relaxivity in comparison to other preparations. PROCEDURES:Chitosan...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-010-0309-x
更新日期：2011-02-01 00:00:00
abstract：PURPOSE:This study aimed to test the hypothesis that lung cancer patient-derived circulating microparticles (LCC-MPs) enhance metastatic lung tumors in a rat model. PROCEDURES:The controls (n = 6) and LCC-MP-treated rats (n = 6) with N1S1-induced pulmonary metastatic hepatocellular carcinoma (HCC) underwent dual-sourc...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-015-0923-8
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:The purpose of this study was to assess the value of the spatial heterogeneity of somatostatin receptor (SSR) volume, quantified as asphericity (ASP), and to predict response to peptide receptor radionuclide therapy (PRRT) in patients with metastatic gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN). P...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-016-1018-x
更新日期：2017-06-01 00:00:00
abstract：PURPOSE:Angiogenesis is essential for physiological processes as well as for carcinogenesis. New approaches to cancer therapy include targeting angiogenesis. One target is VEGF-A and its receptor VEGFR2. In this study, we sought to investigate pancreatic cancer angiogenesis in a genetically modified VEGFR2-luc-KI mouse...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-010-0310-4
更新日期：2010-12-01 00:00:00
abstract：PURPOSE:This study aimed to synthesize a necrosis-avid agent using rhein as a precursor and labeled with gallium-68 (Ga-68) for positron emission tomography/computed tomography (PET/CT) imaging, to evaluate response to anticancer treatment in a mouse model. PROCEDURES:1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraaceti...
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pub_type： 杂志文章
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更新日期：2020-06-01 00:00:00
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journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-009-0219-y
更新日期：2009-11-01 00:00:00
abstract：PURPOSE:Dynamic positron emission tomography (PET) protocols allow for accurate quantification of [18F]flortaucipir-specific binding. However, dynamic acquisitions can be challenging given the long required scan duration of 130 min. The current study assessed the effect of shorter scan protocols for [18F]flortaucipir o...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-021-01581-5
更新日期：2021-01-26 00:00:00
abstract：PURPOSE:For targeted imaging and therapy of hepatocellular carcinoma (HCC), we established a chimeric promoter (EIIAPA) containing alpha-fetoprotein (AFP) promoter and hepatitis B virus enhancer II (EIIA) to control downstream expression of reporter and therapeutic genes. PROCEDURES:We combined AFP promoter and EIIA t...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-011-0509-z
更新日期：2012-08-01 00:00:00
abstract：PURPOSE:The Cre-loxP system has become an important strategy for conditional gene deletion and conditional gene expression in genetically engineered mice. To evaluate Cre recombinase expression, we generated reporter mice that permit both noninvasive imaging in living animals and either ex vivo histochemical/immunohist...
journal_title：Molecular imaging and biology
pub_type： 杂志文章
doi：10.1007/s11307-010-0333-x
更新日期：2011-04-01 00:00:00
