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Bioluminescence imaging of angiogenesis in a murine orthotopic pancreatic cancer model.

Abstract：

PURPOSE:Angiogenesis is essential for physiological processes as well as for carcinogenesis. New approaches to cancer therapy include targeting angiogenesis. One target is VEGF-A and its receptor VEGFR2. In this study, we sought to investigate pancreatic cancer angiogenesis in a genetically modified VEGFR2-luc-KI mouse. PROCEDURES:Live in vivo bioluminescence imaging of angiogenesis was performed continuously until sacrifice in subcutaneous tumors as well as in orthotopically transplanted tumors. Tumor tissue was immunostained for CD-31 and VEGFR2. RESULTS:Peritumoral angiogenesis measured by light emission was detected beginning at week 3 following subcutaneous injection. In the orthotopic model, light emission began at day 4, which likely corresponds to wound healing, and continued throughout the experimental period during tumor growth. Peritumoral CD-31 vessel- and VEGFR2-staining were positive. CONCLUSIONS:The VEGFR2-luc-KI mouse is a valuable tool to demonstrate tumor angiogenesis and seems to be suitable to evaluate anti-angiogenic approaches in pancreatic cancer.

journal_name

Mol Imaging Biol

journal_title

Molecular imaging and biology

authors

Angst E,Chen M,Mojadidi M,Hines OJ,Reber HA,Eibl G

doi

10.1007/s11307-010-0310-4

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

570-5

issue

6

eissn

1536-1632

issn

1860-2002

journal_volume

12

pub_type

杂志文章

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