Differences in transport mechanisms of trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid in inflammation, prostate cancer, and glioma cells: comparison with L-[methyl-11C]methionine and 2-deoxy-2-[18F]fluoro-D-glucose.

abstract：:Due to their remarkable selectivity and specificity for cancer biomarkers, immunoconjugates have emerged as extremely promising vectors for the delivery of diagnostic radioisotopes and fluorophores to malignant tissues. Paradoxically, however, these tools for precision medicine are synthesized in a remarkably imprecis...

journal_title：Molecular imaging and biology

authors： Adumeau P,Sharma SK,Brent C,Zeglis BM

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:The demand to optimize multidisciplinary treatment strategies in patients with benign and malignant diseases of the lung and other organs has led to the increased need of mechanistic proof-of-concept studies in preclinical small animal models using new non-invasive imaging methods. Therefore, we evaluated the r...

journal_title：Molecular imaging and biology

authors： Flechsig P,Kratochwil C,Warth A,Rath D,Eichwald V,Huber PE,Kauczor HU,Haberkorn U,Giesel FL

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:In this study, the contrasting properties of human serum albumin nanoparticles (HSA-NPs) loaded with gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) and coated with transferrin in MRI in mice are evaluated. PROCEDURES:HSA-NPs were conjugated with Gd-DTPA (Gd-HSA-NPs) and coupled with transferrin (Gd-H...

journal_title：Molecular imaging and biology

authors： Korkusuz H,Ulbrich K,Welzel K,Koeberle V,Watcharin W,Bahr U,Chernikov V,Knobloch T,Petersen S,Huebner F,Ackermann H,Gelperina S,Kromen W,Hammerstingl R,Haupenthal J,Gruenwald F,Fiehler J,Zeuzem S,Kreuter J,Vogl TJ,

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:Many radioligands have been explored for imaging the 18-kDa translocator protein (TSPO), a diagnostic and therapeutic target for inflammation and cancer. Here, we investigated the TSPO radioligand [(18)F]DPA-714 for positron emission tomography (PET) imaging of cancer and inflammation. PROCEDURES:[(18)F]DPA-71...

journal_title：Molecular imaging and biology

authors： Zheng J,Winkeler A,Peyronneau MA,Dollé F,Boisgard R

更新日期：2016-02-01 00:00:00

abstract：:The blood flow through normal liver parenchyma and a pathologically proven hepatic region of focal nodular hyperplasia (FNH) of the lateral lobe, was measured in a single patient in a quantitative manner using regional dynamic positron emission tomography (PET) imaging with O-15 carbon dioxide (steady state) and O-15 ...

journal_title：Molecular imaging and biology

authors： Kunishima S,Koh T,Fukuda K,Taniguchi H

更新日期：2002-05-01 00:00:00

abstract：PURPOSE:The simplified reference tissue model (SRTM) is commonly applied for the quantification of brain positron emission tomography (PET) studies, particularly because it avoids arterial cannulation. SRTM requires a validated reference region which is obtained by baseline-blocking or displacement studies. Once a refe...

journal_title：Molecular imaging and biology

authors： de Vries BM,Timmers T,Wolters EE,Ossenkoppele R,Verfaillie SCJ,Schuit RC,Scheltens P,van der Flier WM,Windhorst AD,van Berckel BNM,Boellaard R,Golla SSV

更新日期：2021-01-14 00:00:00

abstract：PURPOSE:Sodium [(18)F]fluoride (Na[(18)F]F) positron emission tomography with integrated computed tomography (PET/CT) has not been used for imaging myocardial infarction (MI). Here, we aimed to investigate the Na[(18)F]F PET/CT features of MI in a rat model. PROCEDURES:MI was induced by coronary artery ligation in 8-w...

journal_title：Molecular imaging and biology

authors： Han JH,Lim SY,Lee MS,Lee WW

更新日期：2015-04-01 00:00:00

abstract：PURPOSE:The A1AR antagonist 8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine ([(18)F]CPFPX) has recently been shown to be a suitable radiotracer for quantitative in vivo imaging of the A1 adenosine receptor (A1AR) in rats. The present study evaluates the reproducibility of non-invasive longitudinal A1AR studies with [...

journal_title：Molecular imaging and biology

authors： Kroll T,Elmenhorst D,Weisshaupt A,Beer S,Bauer A

更新日期：2014-10-01 00:00:00

abstract：PURPOSE:Molecular imaging has the potential to provide quantitative information about specific biological aspects of developing atherosclerotic lesions. This requires the generation of reliable, highly specific plaque tracers. This study reports a new camelid single-domain antibody fragment (sdAb) targeting the Lectin-...

journal_title：Molecular imaging and biology

authors： De Vos J,Mathijs I,Xavier C,Massa S,Wernery U,Bouwens L,Lahoutte T,Muyldermans S,Devoogdt N

更新日期：2014-10-01 00:00:00

abstract：PURPOSE:The increasing availability of fluorescent probes for in vivo optical imaging enables the interrogation of complex biological processes in small animals serving as models for human-like tissue function and disease. However, the validation of probe bio-distribution during their development or the study of differ...

journal_title：Molecular imaging and biology

authors： Sarantopoulos A,Themelis G,Ntziachristos V

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:Evaluation of [68Ga]NODAGA-duramycin as a positron emission tomography (PET) tracer of cell death for whole-body detection of chemotherapy-induced organ toxicity. PROCEDURES:Tracer specificity of Ga-68 labeled NODAGA-duramycin was determined in vitro using competitive binding experiments. Organ uptake was anal...

journal_title：Molecular imaging and biology

authors： Rix A,Drude NI,Mrugalla A,Baskaya F,Pak KY,Gray B,Kaiser HJ,Tolba RH,Fiegle E,Lederle W,Mottaghy FM,Kiessling F

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:Manganese ion has been extensively used as a magnetic resonance imaging (MRI) contrast agent in preclinical studies to assess tissue anatomy, function, and neuronal connectivity. Unfortunately, its use in human studies has been limited by cellular toxicity and the need to use a very low dose. The much higher se...

journal_title：Molecular imaging and biology

authors： Saar G,Millo CM,Szajek LP,Bacon J,Herscovitch P,Koretsky AP

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:This study was undertaken to explore the mechanisms underlying cognitive reserve in subjects with mild memory deficits by using positron emission tomography (PET). METHODS:Global cerebral blood flow (gCBF) and cerebrovascular reserve (CVR) measurements were performed in 15 elders (5 men, 10 women, 62-84, 71.8 ...

journal_title：Molecular imaging and biology

authors： Boles Ponto LL,Magnotta VA,Moser DJ,Duff KM,Schultz SK

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:Contrast-enhanced magnetic resonance imaging (MRI) has the potential to replace angiographic evaluation of atherosclerosis. While studies have investigated contrast agent (CA) uptake in atherosclerotic plaques, exact CA spatial distribution on a microscale is elusive. The purpose of this study was to investigat...

journal_title：Molecular imaging and biology

authors： Uca YO,Hallmann D,Hesse B,Seim C,Stolzenburg N,Pietsch H,Schnorr J,Taupitz M

更新日期：2020-12-07 00:00:00

abstract：PURPOSE:Non-specific extracellular contrast agents have been on the market for more than 15 years. Here, we report on the synthesis of new selective lectin-gadolinium (Gd)-loaded chitosan nanoparticles with a prolonged clearance time and a much higher relaxivity in comparison to other preparations. PROCEDURES:Chitosan...

journal_title：Molecular imaging and biology

authors： Pashkunova-Martic I,Kremser C,Galanski M,Arion V,Debbage P,Jaschke W,Keppler B

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:Tc-99m methylene diphosphonate ([99mTc]MDP) is an in vivo bone imaging agent that also accumulates in injured skeletal muscle cells. The objective of this study was to investigate if [99mTc]MDP could be used to detect muscle injury in the mdx mouse model of Duchenne muscular dystrophy (DMD). PROCEDURES:Static ...

journal_title：Molecular imaging and biology

authors： Gaut C,Sullivan JM,Biscaro B,Soares EJ,Nicholson K,Hoppin J,Verma A

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:To evaluate the clinical significance of differences in 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET) lymph node standardized uptake values (SUV) in human immunodeficiency virus (HIV) infection using iterative reconstruction with segmented attenuation correction (IR SAC) compared to fil...

journal_title：Molecular imaging and biology

authors： Chin BB,Lyengar S,Sabundayo BP,Schwartz D

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:[(18)F]Flumazenil, which has the advantage of a longer half-life than [(11)C]flumazenil, is well known for determining of the central benzodiazepine receptor concentrations. However, [(18)F]flumazenil has not been widely used because fluctuating and relatively low yields render automatic production insufficient...

journal_title：Molecular imaging and biology

authors： Moon BS,Park JH,Lee HJ,Lee BC,Kim SE

更新日期：2014-10-01 00:00:00

abstract：PURPOSE:The vesicular acetylcholine transporter (VAChT) is a specific biomarker for imaging presynaptic cholinergic neurons. The syntheses and C-11 labeling of two potent enantiopure VAChT inhibitors are reported here. PROCEDURES:Two VAChT inhibitors, (±)-2 and (±)-6, were successfully synthesized. A chiral HPLC colum...

journal_title：Molecular imaging and biology

authors： Padakanti PK,Zhang X,Li J,Parsons SM,Perlmutter JS,Tu Z

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to compare C-13 imaging parameters with hyperpolarized [1-13C]pyruvate with conventional gadolinium (Gd)-based perfusion weighted imaging using an orthotopic xenograft model of human glioblastoma multiforme (GBM). PROCEDURES:C-13 3D magnetic resonance spectroscopic imaging (MRSI) ...

journal_title：Molecular imaging and biology

authors： Park I,Lupo JM,Nelson SJ

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:Synapse loss is a hallmark of Alzheimer's disease (AD) and correlates with cognitive decline. The validation of a noninvasive in vivo imaging approach to quantify synapse would greatly facilitate our understanding of AD pathogenesis and assist drug developments for AD. As animal models of neurodegenerative and ...

journal_title：Molecular imaging and biology

authors： Sadasivam P,Fang XT,Toyonaga T,Lee S,Xu Y,Zheng MQ,Spurrier J,Huang Y,Strittmatter SM,Carson RE,Cai Z

更新日期：2020-11-30 00:00:00

abstract：:Erdheim-Chester disease (ECD) is a disseminated xanthogranulomatous infiltrative disease of unknown etiology due to infiltration of different organs and bones by foamy histiocytes. A 37-year-old male with cerebral and periorbital lesions was diagnosed with this rare disease and was evaluated with magnetic resonance im...

journal_title：Molecular imaging and biology

authors： Pereira Neto CC,Roman C,Johnson M,Jagasia M,Martin WH,Delbeke D

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:The main purpose of this study was to understand how the positron emission tomography (PET) measure of the synaptic vesicle 2A (SV2A) protein varies in vivo during the development of temporal lobe epilepsy (TLE) in the kainic acid rat model. PROCEDURES:Twenty Sprague Dawley male rats were administered with mul...

journal_title：Molecular imaging and biology

authors： Serrano ME,Bahri MA,Becker G,Seret A,Germonpré C,Lemaire C,Giacomelli F,Mievis F,Luxen A,Salmon E,Rogister B,Raedt R,Plenevaux A

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:For targeted imaging and therapy of hepatocellular carcinoma (HCC), we established a chimeric promoter (EIIAPA) containing alpha-fetoprotein (AFP) promoter and hepatitis B virus enhancer II (EIIA) to control downstream expression of reporter and therapeutic genes. PROCEDURES:We combined AFP promoter and EIIA t...

journal_title：Molecular imaging and biology

authors： Hsieh YJ,Chen FD,Ke CC,Wang HE,Huang CJ,Hou MF,Lin KP,Gelovani JG,Liu RS

更新日期：2012-08-01 00:00:00

abstract：PURPOSE:To develop a tool to measure the pH at the surfaces of individual cells. PROCEDURES:The SNARF pH-sensitive dye was conjugated to a pHLIP® peptide (pH-Low Insertion Peptide) that binds cellular membranes in tumor spheroids. A beam splitter allows simultaneous recording of two images (580 and 640 nm) by a CCD ca...

journal_title：Molecular imaging and biology

authors： Wei D,Engelman DM,Reshetnyak YK,Andreev OA

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:This study aims to explore whether 4-(2S,4R)-[18F]fluoroglutamine (4-[18F]FGln) positron emission tomography (PET) imaging is helpful in identifying and monitoring MYCN-amplified neuroblastoma by enhanced glutamine metabolism. PROCEDURES:Cell uptake studies and dynamic small-animal PET studies of 4-[18F]FGln a...

journal_title：Molecular imaging and biology

authors： Li C,Huang S,Guo J,Wang C,Huang Z,Huang R,Liu L,Liang S,Wang H

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:Prefrontal cortex (PFC) deep brain stimulation (DBS) has been proposed as a therapy for addiction and depression. This study investigates changes in rat cerebral glucose metabolism induced by different DBS frequencies using μPET. PROCEDURES:One hour DBS of the prelimbic area (PL) of the medial PFC (mPFC) (60 H...

journal_title：Molecular imaging and biology

authors： Parthoens J,Verhaeghe J,Stroobants S,Staelens S

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:To determine the prevalence of viable myocardium in patients with ischemic cardiomyopathy and, to evaluate the value of three-dimensional (3-D) fusion imaging of myocardial scintigraphic and angiographic data to assign coronary artery lesions to the corresponding viable and nonviable myocardial territory. PROC...

journal_title：Molecular imaging and biology

authors： Schindler TH,Nitzsche EU,Magosaki N,Mix M,Facta AD,Prior JO,Solzbach U,Schelbert HR,Just H

更新日期：2004-05-01 00:00:00

abstract：PURPOSE:Cellular receptor targeted imaging agents present the potential to target extracellular molecular expression in cancerous lesions; however, the image contrast in vivo does not reflect the magnitude of overexpression expected from in vitro data. Here, the in vivo delivery and binding kinetics of epidermal growth...

journal_title：Molecular imaging and biology

authors： Samkoe KS,Sexton K,Tichauer KM,Hextrum SK,Pardesi O,Davis SC,O'Hara JA,Hoopes PJ,Hasan T,Pogue BW

更新日期：2012-08-01 00:00:00

abstract：PURPOSE:Negative surgical margins (NSMs) have favorable prognostic implications in breast tumor resection surgery. Fluorescence image-guided surgery (FIGS) has the ability to delineate surgical margins in real time, potentially improving the completeness of tumor resection. We have recently developed indocyanine green ...

journal_title：Molecular imaging and biology

authors： Wojtynek NE,Olson MT,Bielecki TA,An W,Bhat AM,Band H,Lauer SR,Silva-Lopez E,Mohs AM

更新日期：2020-08-01 00:00:00