Transport across the blood-brain barrier: stereoselectivity and PET-tracers.

abstract：PURPOSE:Negative surgical margins (NSMs) have favorable prognostic implications in breast tumor resection surgery. Fluorescence image-guided surgery (FIGS) has the ability to delineate surgical margins in real time, potentially improving the completeness of tumor resection. We have recently developed indocyanine green ...

journal_title：Molecular imaging and biology

authors： Wojtynek NE,Olson MT,Bielecki TA,An W,Bhat AM,Band H,Lauer SR,Silva-Lopez E,Mohs AM

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:To provide reliable and reproducible heart/mediastinum (H/M) ratio cut-off values for parkinsonian disorders using two machine learning techniques, Support Vector Machines (SVM) and Random Forest (RF) classifier, applied to [123I]MIBG cardiac scintigraphy. PROCEDURES:We studied 85 subjects, 50 with idiopathic ...

journal_title：Molecular imaging and biology

authors： Nuvoli S,Spanu A,Fravolini ML,Bianconi F,Cascianelli S,Madeddu G,Palumbo B

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:Conventional in vivo bioluminescence imaging using wild-type green-emitting luciferase is limited by absorption and scattering of the bioluminescent signal through tissues. Imaging methods using a red-shifted thermostable luciferase from Photinus pyralis were optimized to improve the sensitivity and image resol...

journal_title：Molecular imaging and biology

authors： Mezzanotte L,Fazzina R,Michelini E,Tonelli R,Pession A,Branchini B,Roda A

更新日期：2010-08-01 00:00:00

abstract：:2'-deoxy-2'-[(18)F]fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil ([(18)F]FEAU) is a promising radiolabeled nucleoside designed to monitor Herpes Simplex Virus Type 1 thymidine kinase (HSV1-tk) reporter gene expression with positron emission tomography (PET). However, the challenging radiosynthesis creates problems fo...

journal_title：Molecular imaging and biology

authors： Chin FT,Namavari M,Levi J,Subbarayan M,Ray P,Chen X,Gambhir SS

更新日期：2008-03-01 00:00:00

abstract：:The cyclooxygenase-2 (COX-2) gene plays a role in a wide variety of normal physiologic pathways and is a major target of pharmacologic intervention in a large number of pathophysiologic contexts, including pain, fever, inflammation, and cancer. Expression of the COX-2 gene is induced in a wide range of cells, in respo...

journal_title：Molecular imaging and biology

authors： Nguyen JT,Machado H,Herschman HR

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:Many neurological diseases affect small structures in the brain and, as such, reliable visual evaluation and accurate quantification are required. Recent technological developments made the clinical use of hybrid positron emission tomography/magnetic resonance (PET/MR) systems possible, providing both functiona...

journal_title：Molecular imaging and biology

authors： Leemans EL,Kotasidis F,Wissmeyer M,Garibotto V,Zaidi H

更新日期：2015-10-01 00:00:00

abstract：PURPOSE:As imaging of the cell surface tetraspan protein epithelial membrane protein-2 (EMP2) expression in malignant tumors may provide important prognostic and predictive diagnostic information, the goal of this study is to determine if antibody fragments to EMP2 may be useful for imaging EMP2 positive tumors. PROCE...

journal_title：Molecular imaging and biology

authors： Fu M,Brewer S,Olafsen T,Wu AM,Gordon LK,Said J,Braun J,Wadehra M

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:Radioimmunotherapy uses tumor-specific antibodies to deliver therapeutic radionuclides, but hematological toxicity due to the long serum half-life of intact antibodies remains a challenge. We evaluated a smaller antibody fragment, the minibody, with faster kinetics and a potentially improved therapeutic index. ...

journal_title：Molecular imaging and biology

authors： Tsai WK,Zettlitz KA,Dahlbom M,Reiter RE,Wu AM

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:Malignant cells exhibit increased rates of aerobic glycolysis. Here, we tested whether the accumulation of fluoro-deoxyglucose-6-phosphate (FDG6P) in ovarian cancers of differential malignancy reflects inversely correlated elevations of hexokinase (HK) and glucose-6-phosphatase (G6Pase) activities. PROCEDURES:...

journal_title：Molecular imaging and biology

authors： Olsen BB,Gjedde A,Vilstrup MH,Johnsen IBG,Neumann G,Torigian DA,Alavi A,Høilund-Carlsen PF

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:To investigate the prognostic performance of radiomics features, as extracted from positron emission tomography (PET) and X-ray computed tomography (CT) components of baseline 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) PET/CT images and integrated with clinical parameters, in patients with nasopharyngeal carcin...

journal_title：Molecular imaging and biology

authors： Lv W,Yuan Q,Wang Q,Ma J,Feng Q,Chen W,Rahmim A,Lu L

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:The purpose of this study was to assess the value of the spatial heterogeneity of somatostatin receptor (SSR) volume, quantified as asphericity (ASP), and to predict response to peptide receptor radionuclide therapy (PRRT) in patients with metastatic gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN). P...

journal_title：Molecular imaging and biology

authors： Wetz C,Apostolova I,Steffen IG,Hofheinz F,Furth C,Kupitz D,Ruf J,Venerito M,Klose S,Amthauer H

更新日期：2017-06-01 00:00:00

abstract：:Morphological imaging techniques are typically used in the anti-cancer drug efficacy evaluation process. However, these techniques can evaluate the therapeutic efficacy only when the tumor shows anatomic changes-usually at later stages, when the therapeutic effects are poor. In contrast, molecular imaging allows nonin...

journal_title：Molecular imaging and biology

authors： Liang Q,Kong L,Zhu X,Du Y,Tian J

更新日期：2020-12-01 00:00:00

abstract：PURPOSE:Some patients with temporal lobe epilepsy (TLE) lack evidence of hippocampal sclerosis (HS) on MRI (HS-ve). We hypothesized that this group would have a different pattern of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-positron emission tomography (PET) hypometabolism than typical mesial TLE/HS patients with evidence...

journal_title：Molecular imaging and biology

authors： Carne RP,Cook MJ,MacGregor LR,Kilpatrick CJ,Hicks RJ,O'Brien TJ

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:This study was undertaken to explore the mechanisms underlying cognitive reserve in subjects with mild memory deficits by using positron emission tomography (PET). METHODS:Global cerebral blood flow (gCBF) and cerebrovascular reserve (CVR) measurements were performed in 15 elders (5 men, 10 women, 62-84, 71.8 ...

journal_title：Molecular imaging and biology

authors： Boles Ponto LL,Magnotta VA,Moser DJ,Duff KM,Schultz SK

更新日期：2006-11-01 00:00:00

abstract：PURPOSE:Our objective was to determine the lowest diagnostically effective dose for E-selectin-targeted poly n-butyl cyanoacrylate (PBCA)-shelled microbubbles and to apply it to monitor antiangiogenic therapy effects. PROCEDURES:PBCA-shelled microbubbles (MBs) coupled to an E-selectin-specific peptide were applied in ...

journal_title：Molecular imaging and biology

authors： Spivak I,Rix A,Schmitz G,Fokong S,Iranzo O,Lederle W,Kiessling F

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Non-specific extracellular contrast agents have been on the market for more than 15 years. Here, we report on the synthesis of new selective lectin-gadolinium (Gd)-loaded chitosan nanoparticles with a prolonged clearance time and a much higher relaxivity in comparison to other preparations. PROCEDURES:Chitosan...

journal_title：Molecular imaging and biology

authors： Pashkunova-Martic I,Kremser C,Galanski M,Arion V,Debbage P,Jaschke W,Keppler B

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:Recent studies have shown rapid accumulation of nanobodies (NBs) in tumors and fast clearance of the unbound fraction, making NBs exceptional tracers for cancer imaging. In this study, we investigate the combination of in vitro imaging of tumor spheroids, in vivo dual-isotope single-photon emission computed tom...

journal_title：Molecular imaging and biology

authors： Beltrán Hernández I,Rompen R,Rossin R,Xenaki KT,Katrukha EA,Nicolay K,van Bergen En Henegouwen P,Grüll H,Oliveira S

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:Although current therapies for many inflammatory/autoimmune diseases are effective, a significant number of patients still exhibit only partial or negligible responses to therapeutic intervention. Since prolonged use of an inadequate therapy can result in both progressive tissue damage and unnecessary expense, ...

journal_title：Molecular imaging and biology

authors： Kelderhouse LE,Mahalingam S,Low PS

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Some patients cannot remain immobile for a long duration of 60 min, which is generally applied in the case of a 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) dynamic positron emission tomography (PET) scan. We investigated the change of the parametric values when the time duration of PET data was shortened. P...

journal_title：Molecular imaging and biology

authors： Monden T,Kudomi N,Sasakawa Y,Yamamoto Y,Kawai N,Nishiyama Y

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:[18F]Mefway is a positron emission tomography (PET) radioligand for quantification of the brain serotonin 1A (5-HT1A) receptor density. The purpose of this study was to evaluate the radiation safety of [18F]Mefway in humans. PROCEDURES:Six healthy volunteers (three males and three females) were whole-body PET ...

journal_title：Molecular imaging and biology

authors： Choi JY,Lyoo CH,Kim JS,Kim KM,Lee M,Ryu YH

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:The aim of our study was to modify an aminosilane-coated superparamagnetic nanoparticle for cell labeling and subsequent multimodal imaging using magnetic resonance imaging (MRI), positron emission tomography (PET), and fluorescent imaging in vivo. PROCEDURES:We covalently bound the transfection agent HIV-1 ta...

journal_title：Molecular imaging and biology

authors： Stelter L,Pinkernelle JG,Michel R,Schwartländer R,Raschzok N,Morgul MH,Koch M,Denecke T,Ruf J,Bäumler H,Jordan A,Hamm B,Sauer IM,Teichgräber U

更新日期：2010-01-01 00:00:00

abstract：:Erdheim-Chester disease (ECD) is a disseminated xanthogranulomatous infiltrative disease of unknown etiology due to infiltration of different organs and bones by foamy histiocytes. A 37-year-old male with cerebral and periorbital lesions was diagnosed with this rare disease and was evaluated with magnetic resonance im...

journal_title：Molecular imaging and biology

authors： Pereira Neto CC,Roman C,Johnson M,Jagasia M,Martin WH,Delbeke D

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:To determine the prevalence of viable myocardium in patients with ischemic cardiomyopathy and, to evaluate the value of three-dimensional (3-D) fusion imaging of myocardial scintigraphic and angiographic data to assign coronary artery lesions to the corresponding viable and nonviable myocardial territory. PROC...

journal_title：Molecular imaging and biology

authors： Schindler TH,Nitzsche EU,Magosaki N,Mix M,Facta AD,Prior JO,Solzbach U,Schelbert HR,Just H

更新日期：2004-05-01 00:00:00

abstract：PURPOSE:Positron emission tomography (PET) with 2-deoxy-2-[18F]fluoro-D-glucose (FDG) has been used for various cancers, but reproducibility of common utilized semi-quantitative parameters, such as the maximal single pixel standardized uptake value (SUV) and effective glycolytic volume (EGV), remains unknown. Knowledge...

journal_title：Molecular imaging and biology

authors： Nakamoto Y,Zasadny KR,Minn H,Wahl RL

更新日期：2002-03-01 00:00:00

abstract：PURPOSE:Prefrontal cortex (PFC) deep brain stimulation (DBS) has been proposed as a therapy for addiction and depression. This study investigates changes in rat cerebral glucose metabolism induced by different DBS frequencies using μPET. PROCEDURES:One hour DBS of the prelimbic area (PL) of the medial PFC (mPFC) (60 H...

journal_title：Molecular imaging and biology

authors： Parthoens J,Verhaeghe J,Stroobants S,Staelens S

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:We quantified the performance of time-domain imaging (TDI) and spectral imaging (SI) for fluorescence imaging of quantum dots (QDs) in three distinct imaging instruments: eXplore Optix (TDI, Advanced Research Technologies Inc.), Maestro (SI, CRi Inc.), and IVIS-Spectrum (SI, Caliper Life Sciences Inc.). PROCED...

journal_title：Molecular imaging and biology

authors： de la Zerda A,Bodapati S,Teed R,Schipper ML,Keren S,Smith BR,Ng JS,Gambhir SS

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:Synapse loss is a hallmark of Alzheimer's disease (AD) and correlates with cognitive decline. The validation of a noninvasive in vivo imaging approach to quantify synapse would greatly facilitate our understanding of AD pathogenesis and assist drug developments for AD. As animal models of neurodegenerative and ...

journal_title：Molecular imaging and biology

authors： Sadasivam P,Fang XT,Toyonaga T,Lee S,Xu Y,Zheng MQ,Spurrier J,Huang Y,Strittmatter SM,Carson RE,Cai Z

更新日期：2020-11-30 00:00:00

abstract：PURPOSE:The purpose of the study is to synthesize and characterize near-infrared (NIR) fluorescence imaging probes targeted to gelatinases. PROCEDURES:A phage display-selected cyclic peptide containing the His-Try-Gly-Phe (HWGF) motif was used as the lead compound. Structure-activity relationship analysis was used to ...

journal_title：Molecular imaging and biology

authors： Wang W,Shao R,Wu Q,Ke S,McMurray J,Lang FF Jr,Charnsangavej C,Gelovani JG,Li C

更新日期：2009-11-01 00:00:00

abstract：PURPOSE:Manganese ion has been extensively used as a magnetic resonance imaging (MRI) contrast agent in preclinical studies to assess tissue anatomy, function, and neuronal connectivity. Unfortunately, its use in human studies has been limited by cellular toxicity and the need to use a very low dose. The much higher se...

journal_title：Molecular imaging and biology

authors： Saar G,Millo CM,Szajek LP,Bacon J,Herscovitch P,Koretsky AP

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:To evaluate bone blood flow and bone formation in patients after total hip revision surgery with impacted bone grafting using H2 15O and [18F]fluoride positron emission tomography (PET). PROCEDURES:To asses bone blood flow and bone metabolism in bone allograft after impaction grafting, four patients treated wi...

journal_title：Molecular imaging and biology

authors： Temmerman OP,Raijmakers PG,Heyligers IC,Comans EF,Lubberink M,Teule GJ,Lammertsma AA

更新日期：2008-09-01 00:00:00