Examining changes in [18 F]FDG and [18 F]FLT uptake in U87-MG glioma xenografts as early response biomarkers to treatment with the dual mTOR1/2 inhibitor AZD8055.

abstract：PURPOSE:To demonstrate the efficacy of repeated, non-invasive optical imaging of reporter gene expression in monitoring the ability of bi-specific recombinant molecules (i) to "transductionally untarget" adenovirus from Coxsackie and Adenovirus Receptor (CAR)-dependent infection of normal tissue and (ii) to "transducti...

journal_title：Molecular imaging and biology

authors： Liang Q,Yamamoto M,Curiel DT,Herschman HR

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:[123I]FP-CIT (DaTSCAN®) single-photon emission computed tomography (SPECT) imaging is widely used to study neurodegenerative parkinsonism, by measuring presynaptic dopamine transporter (DAT) in striatal regions. Beyond DAT, [123I]FP-CIT may be considered for other monoaminergic systems, in particular the seroto...

journal_title：Molecular imaging and biology

authors： Premi E,Calhoun VD,Garibotto V,Turrone R,Alberici A,Cottini E,Pilotto A,Gazzina S,Magoni M,Paghera B,Borroni B,Padovani A

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:Non-specific extracellular contrast agents have been on the market for more than 15 years. Here, we report on the synthesis of new selective lectin-gadolinium (Gd)-loaded chitosan nanoparticles with a prolonged clearance time and a much higher relaxivity in comparison to other preparations. PROCEDURES:Chitosan...

journal_title：Molecular imaging and biology

authors： Pashkunova-Martic I,Kremser C,Galanski M,Arion V,Debbage P,Jaschke W,Keppler B

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:We recently reported that high thymidine phosphorylase (TP) expression is accompanied by low tumor thymidine concentration and high 3'-deoxy-3'-[18F]fluorothymidine ([18F]FLT) uptake in four untreated lung cancer xenografts. Here, we investigated whether this relationship also holds true for a broader range of ...

journal_title：Molecular imaging and biology

authors： Schelhaas S,Heinzmann K,Honess DJ,Smith DM,Keen H,Heskamp S,Witney TH,Besret L,Doblas S,Griffiths JR,Aboagye EO,Jacobs AH

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:Evaluation of [68Ga]NODAGA-duramycin as a positron emission tomography (PET) tracer of cell death for whole-body detection of chemotherapy-induced organ toxicity. PROCEDURES:Tracer specificity of Ga-68 labeled NODAGA-duramycin was determined in vitro using competitive binding experiments. Organ uptake was anal...

journal_title：Molecular imaging and biology

authors： Rix A,Drude NI,Mrugalla A,Baskaya F,Pak KY,Gray B,Kaiser HJ,Tolba RH,Fiegle E,Lederle W,Mottaghy FM,Kiessling F

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:Technetium (Tc) methylene diphosphonate (MDP) has been the standard method for bone scintigraphy for three decades. (18)F sodium fluoride ((18)F NaF) positron emission tomography (PET)/computed tomography (CT) has better resolution and is considered superior. The role of 2-deoxy-2-[(18)F]fluoro-D-glucose (...

journal_title：Molecular imaging and biology

authors： Iagaru A,Mittra E,Dick DW,Gambhir SS

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:To provide reliable and reproducible heart/mediastinum (H/M) ratio cut-off values for parkinsonian disorders using two machine learning techniques, Support Vector Machines (SVM) and Random Forest (RF) classifier, applied to [123I]MIBG cardiac scintigraphy. PROCEDURES:We studied 85 subjects, 50 with idiopathic ...

journal_title：Molecular imaging and biology

authors： Nuvoli S,Spanu A,Fravolini ML,Bianconi F,Cascianelli S,Madeddu G,Palumbo B

更新日期：2020-06-01 00:00:00

abstract：:In vivo imaging of the central nervous system (CNS) neuroreceptors in humans began was used in the early 1980s. Now, some twenty years later, the success of radiopharmaceutical imaging is still often one based on empiricism and serendipity. Nevertheless, a number of factors can be identified based on the robot experie...

journal_title：Molecular imaging and biology

authors： Wong DF,Pomper MG

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:Carbon ion radiotherapy (CIRT) has been developed, and a phase I/II CIRT trial has been conducted in patients with adenocarcinoma in the head and neck region. We evaluated whether the L-methyl [11C]-methionine (MET) uptake could be an early predictor for local recurrence, metastasis, and the prognosis in patien...

journal_title：Molecular imaging and biology

authors： Hasebe M,Yoshikawa K,Ohashi S,Toubaru S,Kawaguchi K,Sato J,Mizoe J,Tsujii H

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:The present work was aimed at the development of prospective positron emission tomography (PET) agents for infection imaging. Towards this aim, ubiquicidin (UBI) fragments conjugated with the macrocyclic NODAGA chelator were radiolabeled with Ga-68 and evaluated. PROCEDURES:Conformations of custom synthesized ...

journal_title：Molecular imaging and biology

authors： Bhatt J,Mukherjee A,Korde A,Kumar M,Sarma HD,Dash A

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:The aim of our study was to modify an aminosilane-coated superparamagnetic nanoparticle for cell labeling and subsequent multimodal imaging using magnetic resonance imaging (MRI), positron emission tomography (PET), and fluorescent imaging in vivo. PROCEDURES:We covalently bound the transfection agent HIV-1 ta...

journal_title：Molecular imaging and biology

authors： Stelter L,Pinkernelle JG,Michel R,Schwartländer R,Raschzok N,Morgul MH,Koch M,Denecke T,Ruf J,Bäumler H,Jordan A,Hamm B,Sauer IM,Teichgräber U

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:Previous reports confirmed that (2S,4R)-4-[18F]Fluoroglutamine ([18F]GLN) accumulated in bone and bone marrow. This study investigates the potential of using [18F]GLN positron emission tomography (PET) to monitor changes of bone marrow activity after chemotherapy (myelosuppression). PROCEDURES:Bone marrow inhi...

journal_title：Molecular imaging and biology

authors： Zhu H,Liu F,Zhang Y,Yang J,Xu X,Guo X,Liu T,Li N,Zhu L,Kung HF,Yang Z

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:To evaluate the utility of three-dimensional (3D) amide proton transfer-weighted (APTw) imaging for differentiation of endometrial adenocarcinoma and uterine benign lesions. PROCEDURES:This prospective study enrolled 22 normal volunteers and 113 patients with suspicious uterine lesions, including endometrial a...

journal_title：Molecular imaging and biology

authors： Li Y,Lin CY,Qi YF,Wang XQ,Chen B,Zhou HL,Ren J,Yang JJ,Xiang Y,He YL,Xue HD,Jin ZY

更新日期：2020-11-13 00:00:00

abstract：PURPOSE:To determine the prevalence of viable myocardium in patients with ischemic cardiomyopathy and, to evaluate the value of three-dimensional (3-D) fusion imaging of myocardial scintigraphic and angiographic data to assign coronary artery lesions to the corresponding viable and nonviable myocardial territory. PROC...

journal_title：Molecular imaging and biology

authors： Schindler TH,Nitzsche EU,Magosaki N,Mix M,Facta AD,Prior JO,Solzbach U,Schelbert HR,Just H

更新日期：2004-05-01 00:00:00

abstract：PURPOSE:Widely used in clinical practice, the maximum standardized uptake value (SUVmax) is a statistical index highly prone to physical and biological variations, which can lead to unpredictable errors. This study has a methodological aim: to identify a more robust SUV-based index representing the tracer accumulation....

journal_title：Molecular imaging and biology

authors： Baiocco S,Matteucci F,Mezzenga E,Caroli P,Di Iorio V,Cittanti C,Bevilacqua A,Paganelli G,Sarnelli A

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:Recent researches have demonstrated the value of using 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) imaging to reveal the hypothyroidism-related damages in local brain regions. However, the influence of hypothyroidism on the entire brain network is barely studied. This study foc...

journal_title：Molecular imaging and biology

authors： Wang H,Tan Z,Zheng Q,Yu J

更新日期：2018-10-01 00:00:00

abstract：:This article is about head and neck tumor MR imaging and is not within the scope of two National Institutes of Health grants (R0ICA166171, ROICA228188) erroneously listed. Thus, the authors would like to remove the reference to the NIH grants R01CA166171 and R01CA228188 in this article. ...

journal_title：Molecular imaging and biology

authors： Yu L,Li C,Luo X,Zhou J,Zhang C,Zhang Y,Chen M

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:[18F]Mefway is a positron emission tomography (PET) radioligand for quantification of the brain serotonin 1A (5-HT1A) receptor density. The purpose of this study was to evaluate the radiation safety of [18F]Mefway in humans. PROCEDURES:Six healthy volunteers (three males and three females) were whole-body PET ...

journal_title：Molecular imaging and biology

authors： Choi JY,Lyoo CH,Kim JS,Kim KM,Lee M,Ryu YH

更新日期：2016-12-01 00:00:00

abstract：:This article was updated to correct the spelling of Hongkai Wang's name: it is correct as displayed here. ...

journal_title：Molecular imaging and biology

authors： Wang H,Tan Z,Zheng Q,Yu J

更新日期：2019-02-01 00:00:00

abstract：PURPOSE:Malignant cells exhibit increased rates of aerobic glycolysis. Here, we tested whether the accumulation of fluoro-deoxyglucose-6-phosphate (FDG6P) in ovarian cancers of differential malignancy reflects inversely correlated elevations of hexokinase (HK) and glucose-6-phosphatase (G6Pase) activities. PROCEDURES:...

journal_title：Molecular imaging and biology

authors： Olsen BB,Gjedde A,Vilstrup MH,Johnsen IBG,Neumann G,Torigian DA,Alavi A,Høilund-Carlsen PF

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate different non-invasive methods for generating (R)-1-((3-([11C]methyl)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) ([11C]UCB-J) parametric maps using white matter (centrum semi-ovale-SO) as reference tissue. PROCEDURES:Ten healthy volunteers (8 M/2F; age ...

journal_title：Molecular imaging and biology

authors： Mertens N,Maguire RP,Serdons K,Lacroix B,Mercier J,Sciberras D,Van Laere K,Koole M

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:As imaging of the cell surface tetraspan protein epithelial membrane protein-2 (EMP2) expression in malignant tumors may provide important prognostic and predictive diagnostic information, the goal of this study is to determine if antibody fragments to EMP2 may be useful for imaging EMP2 positive tumors. PROCE...

journal_title：Molecular imaging and biology

authors： Fu M,Brewer S,Olafsen T,Wu AM,Gordon LK,Said J,Braun J,Wadehra M

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:Dynamic positron emission tomography (PET) protocols allow for accurate quantification of [18F]flortaucipir-specific binding. However, dynamic acquisitions can be challenging given the long required scan duration of 130 min. The current study assessed the effect of shorter scan protocols for [18F]flortaucipir o...

journal_title：Molecular imaging and biology

authors： Tuncel H,Visser D,Yaqub M,Timmers T,Wolters EE,Ossenkoppele R,van der Flier WM,van Berckel BNM,Boellaard R,Golla SSV

更新日期：2021-01-26 00:00:00

abstract：PURPOSE:Transplantation of a regenerative cell population derived from human subcutaneous adipose tissue (hASCs) for cardiac regeneration represents a promising therapy due to the capacity of these cells for proliferation and differentiation. Understanding the fate of injected hASCs would help to understand how hASCs w...

journal_title：Molecular imaging and biology

authors： Bai X,Yan Y,Coleman M,Wu G,Rabinovich B,Seidensticker M,Alt E

更新日期：2011-08-01 00:00:00

abstract：INTRODUCTION:We have previously described the labeling of interleukin-2 (IL2) with (123)I and (99m)Tc-N(3)S. Both radiopharmaceuticals were successfully applied in humans to image several inflammatory lesions and autoimmune diseases characterized by tissue infiltrating lymphocytes expressing the IL2 receptor (CD25). Ho...

journal_title：Molecular imaging and biology

authors： D'Alessandria C,di Gialleonardo V,Chianelli M,Mather SJ,de Vries EF,Scopinaro F,Dierck RA,Signore A

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:Construction of antibody-based, molecular-targeted optical imaging probes requires the labeling of an antibody with a fluorophore. The most common method for doing this involves non-specifically conjugating a fluorophore to an antibody, resulting in poorly defined, heterogeneous imaging probes that often have s...

journal_title：Molecular imaging and biology

authors： Alam MK,El-Sayed A,Barreto K,Bernhard W,Fonge H,Geyer CR

更新日期：2019-02-01 00:00:00

abstract：:The article "Pre-therapy Somatostatin Receptor-Based Heterogeneity Predicts Overall Survival in Pancreatic Neuroendocrine Tumor Patients Undergoing Peptide Receptor Radionuclide Therapy," was originally published electronically on the publisher's internet portal without open access. ...

journal_title：Molecular imaging and biology

authors： Werner RA,Ilhan H,Lehner S,Papp L,Zsótér N,Schatka I,Muegge DO,Javadi MS,Higuchi T,Buck AK,Bartenstein P,Bengel F,Essler M,Lapa C,Bundschuh RA

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:Human pluripotency gene networks (PGNs), controlled in part by Oct4, are central to understanding pluripotent stem cells, but current fluorescent reporter genes (RGs) preclude noninvasive assessment of Oct4 dynamics in living subjects. PROCEDURES:To assess Oc4 activity noninvasively, we engineered a mouse embr...

journal_title：Molecular imaging and biology

authors： Ahn BC,Parashurama N,Patel M,Ziv K,Bhaumik S,Yaghoubi SS,Paulmurugan R,Gambhir SS

更新日期：2014-12-01 00:00:00

abstract：:Herpes simplex virus (HSV) oncolytic gene therapy is a promising treatment modality against cancer. We have demonstrated that androgen-induced cellular changes enhance oncolytic viral replication and improve efficacy in the treatment of androgen-dependent prostate cancer cell line. Imaging of changes in 2-deoxy-2-[F-1...

journal_title：Molecular imaging and biology

authors： Mullerad M,Eisenberg DP,Akhurst TJ,Adusumilli PS,Riedl CC,Bhargava A,Gonen M,Finn R,Scardino PT,Fong Y

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:The Cre-loxP system has become an important strategy for conditional gene deletion and conditional gene expression in genetically engineered mice. To evaluate Cre recombinase expression, we generated reporter mice that permit both noninvasive imaging in living animals and either ex vivo histochemical/immunohist...

journal_title：Molecular imaging and biology

authors： Ishikawa TO,Herschman HR

更新日期：2011-04-01 00:00:00