当前位置： SCI文献检索 > MOLECULAR IMAGING AND BIOLOGY期刊下所有文献 > Predicting Response to Therapy for Autoimmune and Inflammatory Diseases Using a Folate Receptor-Targeted Near-Infrared Fluorescent Imaging Agent.

Predicting Response to Therapy for Autoimmune and Inflammatory Diseases Using a Folate Receptor-Targeted Near-Infrared Fluorescent Imaging Agent.

Abstract：

PURPOSE:Although current therapies for many inflammatory/autoimmune diseases are effective, a significant number of patients still exhibit only partial or negligible responses to therapeutic intervention. Since prolonged use of an inadequate therapy can result in both progressive tissue damage and unnecessary expense, methods to identify nonresponding patients are necessary. PROCEDURES:Four murine models of inflammatory disease (rheumatoid arthritis, ulcerative colitis, pulmonary fibrosis, and atherosclerosis) were induced, treated with anti-inflammatory agents, and evaluated for inflammatory response. The mice were also injected intraperitoneally with OTL0038, a folate receptor-targeted near-infrared dye that accumulates in activated macrophages at sites of inflammation. Uptake of OTL0038 in inflamed lesions was then correlated with clinical measurements of disease severity. RESULTS:OTL0038 accumulated at sites of inflammation in all four animal models. More importantly, changes in lesion-associated OTL0038 preceded changes in clinical symptoms in mice treated with all anti-inflammatory drugs examined. CONCLUSION:OTL0038 has the ability to predict responses to multiple therapies in four murine models of inflammation.

journal_name

Mol Imaging Biol

journal_title

Molecular imaging and biology

authors

Kelderhouse LE,Mahalingam S,Low PS

doi

10.1007/s11307-015-0876-y

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

201-8

issue

2

eissn

1536-1632

issn

1860-2002

pii

10.1007/s11307-015-0876-y

journal_volume

18

pub_type

杂志文章

相关文献

MOLECULAR IMAGING AND BIOLOGY文献大全
  • Imaging of cholinergic and monoaminergic neurochemical changes in neurodegenerative disorders.

    abstract：:Positron emission tomography (PET) or single photon emission computer tomography (SPECT) imaging provides the means to study neurochemical processes in vivo. These methods have been applied to examine monoaminergic and cholinergic changes in neurodegenerative disorders. These investigations have provided important ins...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章,评审

    doi：10.1007/s11307-007-0083-6

    authors： Bohnen NI,Frey KA

    更新日期：2007-07-01 00:00:00

  • Development of bimolecular fluorescence complementation using Dronpa for visualization of protein-protein interactions in cells.

    abstract：PURPOSE:We developed a bimolecular fluorescence complementation (BiFC) strategy using Dronpa, a new fluorescent protein with reversible photoswitching activity and fast responsibility to light, to monitor protein-protein interactions in cells. PROCEDURES:Dronpa was split at residue Glu164 in order to generate two Dron...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-010-0312-2

    authors： Lee YR,Park JH,Hahm SH,Kang LW,Chung JH,Nam KH,Hwang KY,Kwon IC,Han YS

    更新日期：2010-10-01 00:00:00

  • Validation of fluorescence molecular tomography/micro-CT multimodal imaging in vivo in rats.

    abstract：PURPOSE:Rats are important preclinical models for studying breast cancer metastasis and bone pathologies. In these research areas, fluorescence molecular tomography (FMT) is commonly applied for quantitative three-dimensional (3D) imaging in mice. However, uncertainties due to strong depth dependency of FMT signal and ...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-013-0698-8

    authors： Vonwil D,Christensen J,Fischer S,Ronneberger O,Shastri VP

    更新日期：2014-06-01 00:00:00

  • Transport across the blood-brain barrier: stereoselectivity and PET-tracers.

    abstract：:This article reviews positron emission tomography (PET) studies of labeled enantiomers of different PET-tracers from the early 1980s. Comparative studies on stereoselective behavior of the transport of tracers across the blood-brain barrier (BBB) are discussed. Tracers are transported through the BBB into the brain, v...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.mibio.2004.06.008

    authors： Luurtsema G,de Lange EC,Lammertsma AA,Franssen EJ

    更新日期：2004-09-01 00:00:00

  • Quantification of SV2A Binding in Rodent Brain Using [18F]SynVesT-1 and PET Imaging.

    abstract：PURPOSE:Synapse loss is a hallmark of Alzheimer's disease (AD) and correlates with cognitive decline. The validation of a noninvasive in vivo imaging approach to quantify synapse would greatly facilitate our understanding of AD pathogenesis and assist drug developments for AD. As animal models of neurodegenerative and ...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-020-01567-9

    authors： Sadasivam P,Fang XT,Toyonaga T,Lee S,Xu Y,Zheng MQ,Spurrier J,Huang Y,Strittmatter SM,Carson RE,Cai Z

    更新日期：2020-11-30 00:00:00

  • Global cerebral blood flow in relation to cognitive performance and reserve in subjects with mild memory deficits.

    abstract：PURPOSE:This study was undertaken to explore the mechanisms underlying cognitive reserve in subjects with mild memory deficits by using positron emission tomography (PET). METHODS:Global cerebral blood flow (gCBF) and cerebrovascular reserve (CVR) measurements were performed in 15 elders (5 men, 10 women, 62-84, 71.8 ...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-006-0066-z

    authors： Boles Ponto LL,Magnotta VA,Moser DJ,Duff KM,Schultz SK

    更新日期：2006-11-01 00:00:00

  • Distribution of Brown Adipose Tissue Radiodensity in Young Adults: Implications for Cold [18F]FDG-PET/CT Analyses.

    abstract：PURPOSE:Nowadays, 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET)/X-ray computed tomography (CT) is considered the best available technique to in vivo determination of human BAT volume. The most used Hounsfield unit (HU) threshold for BAT quantification is from - 250 to - 50 HU. Therefore,...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-019-01381-y

    authors： Martinez-Tellez B,Sanchez-Delgado G,Boon MR,Rensen PCN,Llamas-Elvira JM,Ruiz JR

    更新日期：2020-04-01 00:00:00

  • Development of antibody-carrying microbubbles based on clinically available ultrasound contrast agent for targeted molecular imaging: a preliminary chemical study.

    abstract：PURPOSE:The purpose of the study was to examine the feasibility of an antibody-carrying targeted-bubble preparation using clinically available phosphatidylserine (PS)-containing perfluorobutane-filled microbubbles for molecular ultrasound imaging. PROCEDURES:Firstly, we examined whether PS on the surface of perfluorob...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-010-0344-7

    authors： Otani K,Yamahara K

    更新日期：2011-04-01 00:00:00

  • MicroPET imaging of integrin αvβ3 expressing tumors using 89Zr-RGD peptides.

    abstract：PURPOSE:The dimeric transmembrane integrin, α(v)β(3), is a well-investigated target by different imaging modalities through suitably labeled arginine-glycine-aspartic acid (RGD) containing peptides. In this study, we labeled four cyclic RGD peptides with or without PEG functional groups: c(RGDfK) (denoted as FK), PEG(3...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-010-0458-y

    authors： Jacobson O,Zhu L,Niu G,Weiss ID,Szajek LP,Ma Y,Sun X,Yan Y,Kiesewetter DO,Liu S,Chen X

    更新日期：2011-12-01 00:00:00

  • 2-Deoxy-2-[18F]fluoro-D-glucose positron emission tomography uptake in a giant adrenal myelolipoma.

    abstract：:Incidental adrenal lesions found on anatomic imaging are not uncommon. 2-Deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET) imaging is highly accurate in the differentiation of benign from malignant adrenal lesions, both in patients with proven malignancy and with adrenal lesions detected incidentall...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1016/s1536-1632(02)00018-5

    authors： Ludwig V,Rice MH,Martin WH,Kelley MC,Delbeke D

    更新日期：2002-10-01 00:00:00

  • Current and Emerging Preclinical Approaches for Imaging-Based Characterization of Atherosclerosis.

    abstract：:Atherosclerotic plaques can remain quiescent for years, but become life threatening upon rupture or disruption, initiating clot formation in the vessel lumen and causing acute myocardial infarction and ischemic stroke. Whether and how a plaque ruptures is determined by its macroscopic structure and microscopic composi...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章,评审

    doi：10.1007/s11307-018-1264-1

    authors： Vigne J,Thackeray J,Essers J,Makowski M,Varasteh Z,Curaj A,Karlas A,Canet-Soulas E,Mulder W,Kiessling F,Schäfers M,Botnar R,Wildgruber M,Hyafil F,Cardiovascular study group of the European Society of Molecular Imaging.

    更新日期：2018-12-01 00:00:00

  • Comparison of (18)F-labeled CXCR4 antagonist peptides for PET imaging of CXCR4 expression.

    abstract：PURPOSE:CXCR4 is overexpressed on tumor cells from many types of human cancers. A high level of CXCR4 expression often correlates with poor prognosis, chemotherapy resistance, and metastasis. The development of CXCR4-specific radiotracers for positron emission tomography (PET) imaging will allow in vivo evaluation of r...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-013-0640-0

    authors： Zhang XX,Sun Z,Guo J,Wang Z,Wu C,Niu G,Ma Y,Kiesewetter DO,Chen X

    更新日期：2013-12-01 00:00:00

  • Use of positron emission tomography to target prostate cancer gene therapy by oncolytic herpes simplex virus.

    abstract：:Herpes simplex virus (HSV) oncolytic gene therapy is a promising treatment modality against cancer. We have demonstrated that androgen-induced cellular changes enhance oncolytic viral replication and improve efficacy in the treatment of androgen-dependent prostate cancer cell line. Imaging of changes in 2-deoxy-2-[F-1...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-005-0028-x

    authors： Mullerad M,Eisenberg DP,Akhurst TJ,Adusumilli PS,Riedl CC,Bhargava A,Gonen M,Finn R,Scardino PT,Fong Y

    更新日期：2006-01-01 00:00:00

  • Specific targeting of atherosclerotic plaques in ApoE(-/-) mice using a new Camelid sdAb binding the vulnerable plaque marker LOX-1.

    abstract：PURPOSE:Molecular imaging has the potential to provide quantitative information about specific biological aspects of developing atherosclerotic lesions. This requires the generation of reliable, highly specific plaque tracers. This study reports a new camelid single-domain antibody fragment (sdAb) targeting the Lectin-...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-014-0731-6

    authors： De Vos J,Mathijs I,Xavier C,Massa S,Wernery U,Bouwens L,Lahoutte T,Muyldermans S,Devoogdt N

    更新日期：2014-10-01 00:00:00

  • Source-Based Morphometry Multivariate Approach to Analyze [123I]FP-CIT SPECT Imaging.

    abstract：PURPOSE:[123I]FP-CIT (DaTSCAN®) single-photon emission computed tomography (SPECT) imaging is widely used to study neurodegenerative parkinsonism, by measuring presynaptic dopamine transporter (DAT) in striatal regions. Beyond DAT, [123I]FP-CIT may be considered for other monoaminergic systems, in particular the seroto...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-017-1052-3

    authors： Premi E,Calhoun VD,Garibotto V,Turrone R,Alberici A,Cottini E,Pilotto A,Gazzina S,Magoni M,Paghera B,Borroni B,Padovani A

    更新日期：2017-10-01 00:00:00

  • 2-deoxy-2-[F-18]fluoro-D-glucose-positron emission tomography/computed tomography imaging evaluation of esophageal cancer.

    abstract：:We evaluated the clinical utility of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) on the precise localization of pathologic foci and exclusion of normal variants in the imaging evaluation of patients with esophageal carcinoma. Combined PET/CT scans were performed i...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-006-0036-5

    authors： Jadvar H,Henderson RW,Conti PS

    更新日期：2006-05-01 00:00:00

  • A Novel Modality for Functional Imaging in Acute Intervertebral Disk Herniation via Tracking Leukocyte Infiltration.

    abstract：PURPOSE:Inflammation plays a key role in the progression of intervertebral disk (IVD) herniation and associated low back pain. However, real-time spatial diagnosis of inflammation associated with acute disk herniation has not been investigated. We sought to detect local neutrophil and macrophage infiltration near disk ...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-016-1038-6

    authors： Xiao L,Ding M,Zhang Y,Chordia M,Pan D,Shimer A,Shen F,Glover D,Jin L,Li X

    更新日期：2017-10-01 00:00:00

  • Reproducibility of non-invasive a1 adenosine receptor quantification in the rat brain using [(18)F]CPFPX and positron emission tomography.

    abstract：PURPOSE:The A1AR antagonist 8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine ([(18)F]CPFPX) has recently been shown to be a suitable radiotracer for quantitative in vivo imaging of the A1 adenosine receptor (A1AR) in rats. The present study evaluates the reproducibility of non-invasive longitudinal A1AR studies with [...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-014-0729-0

    authors： Kroll T,Elmenhorst D,Weisshaupt A,Beer S,Bauer A

    更新日期：2014-10-01 00:00:00

  • Radiomics Analysis of PET and CT Components of PET/CT Imaging Integrated with Clinical Parameters: Application to Prognosis for Nasopharyngeal Carcinoma.

    abstract：PURPOSE:To investigate the prognostic performance of radiomics features, as extracted from positron emission tomography (PET) and X-ray computed tomography (CT) components of baseline 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) PET/CT images and integrated with clinical parameters, in patients with nasopharyngeal carcin...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-018-01304-3

    authors： Lv W,Yuan Q,Wang Q,Ma J,Feng Q,Chen W,Rahmim A,Lu L

    更新日期：2019-10-01 00:00:00

  • Whole body biodistribution and radiation dosimetry in humans of a new PET ligand, [(18)F]-FEPPA, to image translocator protein (18 kDa).

    abstract：PURPOSE:[(18)F]-FEPPA is a translocator protein (18 kDa, TSPO) positron emission tomography (PET) radiotracer. Radiation dosimetry was estimated from the whole body biodistribution, taking into consideration TSPO rs6971 (Ala147Thr) polymorphism. PROCEDURES:[(18)F]-FEPPA whole body PET scans were acquired for six healt...

    journal_title：Molecular imaging and biology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11307-012-0589-4

    authors： Mizrahi R,Rusjan PM,Vitcu I,Ng A,Wilson AA,Houle S,Bloomfield PM

    更新日期：2013-06-01 00:00:00

  • Assessing Human Embryonic Stem Cell-Derived Dopaminergic Neuron Progenitor Transplants Using Non-invasive Imaging Techniques.

    abstract：PURPOSE:Human pluripotent stem cell (hPSC)-derived dopaminergic neuron progenitor cells (DAPCs) are a potential therapy for Parkinson's disease (PD). However, their intracranial administration raises safety concerns including uncontrolled proliferation, migration and inflammation. Here, we apply a bimodal imaging appro...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-020-01499-4

    authors： Mousavinejad M,Skidmore S,Barone FG,Tyers P,Pisupati V,Poptani H,Plagge A,Barker RA,Murray P,Taylor A,Hill CJ

    更新日期：2020-10-01 00:00:00

  • Lectin conjugates as biospecific contrast agents for MRI. Coupling of Lycopersicon esculentum agglutinin to linear water-soluble DTPA-loaded oligomers.

    abstract：:Magnetic resonance imaging (MRI) requires synthesis of contrast media bearing targeting groups and numerous gadolinium chelating groups generating high relaxivity. This paper explores the results of linking the gadolinium chelates to the targeting group, a protein molecule, via various types of linkers. Polycondensate...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-010-0358-1

    authors： Pashkunova-Martic I,Kremser C,Galanski M,Schluga P,Arion V,Debbage P,Jaschke W,Keppler B

    更新日期：2011-06-01 00:00:00

  • Anatomy, Functionality, and Neuronal Connectivity with Manganese Radiotracers for Positron Emission Tomography.

    abstract：PURPOSE:Manganese ion has been extensively used as a magnetic resonance imaging (MRI) contrast agent in preclinical studies to assess tissue anatomy, function, and neuronal connectivity. Unfortunately, its use in human studies has been limited by cellular toxicity and the need to use a very low dose. The much higher se...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-018-1162-6

    authors： Saar G,Millo CM,Szajek LP,Bacon J,Herscovitch P,Koretsky AP

    更新日期：2018-08-01 00:00:00

  • Standardized Uptake Values in 2-Deoxy-2-[18F]Fluoro-D-Glucose with Positron Emission Tomography. Clinical Significance of Iterative Reconstruction and Segmented Attenuation Compared with Conventional Filtered Back Projection and Measured Attenuation Corre

    abstract：PURPOSE:To evaluate the clinical significance of differences in 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET) lymph node standardized uptake values (SUV) in human immunodeficiency virus (HIV) infection using iterative reconstruction with segmented attenuation correction (IR SAC) compared to fil...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1016/s1536-1632(02)00014-8

    authors： Chin BB,Lyengar S,Sabundayo BP,Schwartz D

    更新日期：2002-07-01 00:00:00

  • Positron emission tomography imaging of endometrial cancer using engineered anti-EMP2 antibody fragments.

    abstract：PURPOSE:As imaging of the cell surface tetraspan protein epithelial membrane protein-2 (EMP2) expression in malignant tumors may provide important prognostic and predictive diagnostic information, the goal of this study is to determine if antibody fragments to EMP2 may be useful for imaging EMP2 positive tumors. PROCE...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-012-0558-y

    authors： Fu M,Brewer S,Olafsen T,Wu AM,Gordon LK,Said J,Braun J,Wadehra M

    更新日期：2013-02-01 00:00:00

  • Integrin α(v)β₃ as a PET imaging biomarker for osteoclast number in mouse models of negative and positive osteoclast regulation.

    abstract：PURPOSE:The goal of this study was to determine the specificity of ⁶⁴Cu-CB-TE2A-c(RGDyK) (⁶⁴Cu-RGD) for osteoclast-related diseases, such as Paget's disease or rheumatoid arthritis. PROCEDURES:C57BL/6 mice were treated systemically with osteoprotegerin (OPG) for 15 days or RANKL for 11 days to suppress and stimulate o...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-011-0512-4

    authors： Zheleznyak A,Wadas TJ,Sherman CD,Wilson JM,Kostenuik PJ,Weilbaecher KN,Anderson CJ

    更新日期：2012-08-01 00:00:00

  • Generation of a Four-Class Attenuation Map for MRI-Based Attenuation Correction of PET Data in the Head Area Using a Novel Combination of STE/Dixon-MRI and FCM Clustering.

    abstract：PURPOSE:The aim of this study is to generate a four-class magnetic resonance imaging (MRI)-based attenuation map (μ-map) for attenuation correction of positron emission tomography (PET) data of the head area using a novel combination of short echo time (STE)/Dixon-MRI and a dedicated image segmentation method. PROCEDU...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-015-0849-1

    authors： Khateri P,Saligheh Rad H,Jafari AH,Fathi Kazerooni A,Akbarzadeh A,Shojae Moghadam M,Aryan A,Ghafarian P,Ay MR

    更新日期：2015-12-01 00:00:00

  • Prospective evaluation of (99m)Tc MDP scintigraphy, (18)F NaF PET/CT, and (18)F FDG PET/CT for detection of skeletal metastases.

    abstract：INTRODUCTION:Technetium (Tc) methylene diphosphonate (MDP) has been the standard method for bone scintigraphy for three decades. (18)F sodium fluoride ((18)F NaF) positron emission tomography (PET)/computed tomography (CT) has better resolution and is considered superior. The role of 2-deoxy-2-[(18)F]fluoro-D-glucose (...

    journal_title：Molecular imaging and biology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s11307-011-0486-2

    authors： Iagaru A,Mittra E,Dick DW,Gambhir SS

    更新日期：2012-04-01 00:00:00

  • Correlation of Tumor Perfusion Between Carbon-13 Imaging with Hyperpolarized Pyruvate and Dynamic Susceptibility Contrast MRI in Pre-Clinical Model of Glioblastoma.

    abstract：PURPOSE:The purpose of this study was to compare C-13 imaging parameters with hyperpolarized [1-13C]pyruvate with conventional gadolinium (Gd)-based perfusion weighted imaging using an orthotopic xenograft model of human glioblastoma multiforme (GBM). PROCEDURES:C-13 3D magnetic resonance spectroscopic imaging (MRSI) ...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-018-1275-y

    authors： Park I,Lupo JM,Nelson SJ

    更新日期：2019-08-01 00:00:00

  • Molecular Imaging of PDE10A Knockout Mice with a Novel PET Radiotracer: [(11)C]T-773.

    abstract：PURPOSE:[(11)C]T-773 is a new radioligand for positron emission tomography (PET) targeting the phosphodiesterase 10A enzyme (PDE10A). PDE10A is highly expressed in the striatum by medium spiny neurons, and it has been demonstrated to be involved in the regulation of striatal signaling through the reduction of medium sp...

    journal_title：Molecular imaging and biology

    pub_type： 杂志文章

    doi：10.1007/s11307-015-0822-z

    authors： Tóth M,Häggkvist J,Stepanov V,Takano A,Nakao R,Amini N,Miura S,Kimura H,Taniguchi T,Gulyás B,Halldin C

    更新日期：2015-08-01 00:00:00