Imaging the bio-distribution of fluorescent probes using multispectral epi-illumination cryoslicing imaging.

abstract：:Incidental adrenal lesions found on anatomic imaging are not uncommon. 2-Deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET) imaging is highly accurate in the differentiation of benign from malignant adrenal lesions, both in patients with proven malignancy and with adrenal lesions detected incidentall...

journal_title：Molecular imaging and biology

authors： Ludwig V,Rice MH,Martin WH,Kelley MC,Delbeke D

更新日期：2002-10-01 00:00:00

abstract：PURPOSE:Evaluation of [68Ga]NODAGA-duramycin as a positron emission tomography (PET) tracer of cell death for whole-body detection of chemotherapy-induced organ toxicity. PROCEDURES:Tracer specificity of Ga-68 labeled NODAGA-duramycin was determined in vitro using competitive binding experiments. Organ uptake was anal...

journal_title：Molecular imaging and biology

authors： Rix A,Drude NI,Mrugalla A,Baskaya F,Pak KY,Gray B,Kaiser HJ,Tolba RH,Fiegle E,Lederle W,Mottaghy FM,Kiessling F

更新日期：2020-06-01 00:00:00

abstract：:Positron emission tomography (PET) with epidermal growth factor receptor (EGFR) kinase-specific radiolabeled tracers could provide the means for noninvasive and repetitive imaging of heterogeneity of EGFR expression and signaling activity in tumors in individual patients before and during therapy with EGFR signaling i...

journal_title：Molecular imaging and biology

authors： Pal A,Glekas A,Doubrovin M,Balatoni J,Namavari M,Beresten T,Maxwell D,Soghomonyan S,Shavrin A,Ageyeva L,Finn R,Larson SM,Bornmann W,Gelovani JG

更新日期：2006-09-01 00:00:00

abstract：:Herpes simplex virus (HSV) oncolytic gene therapy is a promising treatment modality against cancer. We have demonstrated that androgen-induced cellular changes enhance oncolytic viral replication and improve efficacy in the treatment of androgen-dependent prostate cancer cell line. Imaging of changes in 2-deoxy-2-[F-1...

journal_title：Molecular imaging and biology

authors： Mullerad M,Eisenberg DP,Akhurst TJ,Adusumilli PS,Riedl CC,Bhargava A,Gonen M,Finn R,Scardino PT,Fong Y

更新日期：2006-01-01 00:00:00

abstract：:This article reviews positron emission tomography (PET) studies of labeled enantiomers of different PET-tracers from the early 1980s. Comparative studies on stereoselective behavior of the transport of tracers across the blood-brain barrier (BBB) are discussed. Tracers are transported through the BBB into the brain, v...

journal_title：Molecular imaging and biology

authors： Luurtsema G,de Lange EC,Lammertsma AA,Franssen EJ

更新日期：2004-09-01 00:00:00

abstract：PURPOSE:We developed a bimolecular fluorescence complementation (BiFC) strategy using Dronpa, a new fluorescent protein with reversible photoswitching activity and fast responsibility to light, to monitor protein-protein interactions in cells. PROCEDURES:Dronpa was split at residue Glu164 in order to generate two Dron...

journal_title：Molecular imaging and biology

authors： Lee YR,Park JH,Hahm SH,Kang LW,Chung JH,Nam KH,Hwang KY,Kwon IC,Han YS

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:The transplantation of pancreatic islets is a promising cell replacement therapy for type 1 diabetes. Subcutaneous islet transplantation is currently under investigation as a means to circumvent problems associated with standard intra-hepatic islet transplantation. As modifications are being developed to improv...

journal_title：Molecular imaging and biology

authors： Komatsu H,Gonzalez N,Ortiz J,Rawson J,Omori K,Kandeel F,Mullen Y

更新日期：2020-11-02 00:00:00

abstract：PURPOSE:Cellular receptor targeted imaging agents present the potential to target extracellular molecular expression in cancerous lesions; however, the image contrast in vivo does not reflect the magnitude of overexpression expected from in vitro data. Here, the in vivo delivery and binding kinetics of epidermal growth...

journal_title：Molecular imaging and biology

authors： Samkoe KS,Sexton K,Tichauer KM,Hextrum SK,Pardesi O,Davis SC,O'Hara JA,Hoopes PJ,Hasan T,Pogue BW

更新日期：2012-08-01 00:00:00

abstract：INTRODUCTION:Advances in positron emission tomography (PET) imaging have provided opportunities to develop radiotracers specific for imaging insulin-producing pancreatic β-cells. However, a host of lingering questions should be addressed before these radiotracers are advocated for noninvasive quantification of β-cell m...

journal_title：Molecular imaging and biology

authors： Blomberg BA,Codreanu I,Cheng G,Werner TJ,Alavi A

更新日期：2013-04-01 00:00:00

abstract：:Pharmaceutical research and imaging science are becoming increasingly intertwined. Positron emission tomography (PET) is a molecular imaging technique with particularly broad application in drug discovery and development. At the same time, modern techniques of drug discovery are helping accelerate the development of n...

journal_title：Molecular imaging and biology

authors： Maclean D,Northrop JP,Padgett HC,Walsh JC

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:Repetitive imaging with microPET of endogenous albumin gene expression by using transgenic mice in which the Herpes Simplex Virus Type 1 thymidine kinase (HSV1-tk) reporter gene is driven by the albumin promoter (AL-HSV1-tk). METHODS:Transgenic mice were imaged repeatedly on a microPET scanner with approximate...

journal_title：Molecular imaging and biology

authors： Green LA,Yap CS,Nguyen K,Barrio JR,Namavari M,Satyamurthy N,Phelps ME,Sandgren EP,Herschman HR,Gambhir SS

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:We aimed to elucidate trans-1-amino-3-[(18)F]fluorocyclobutanecarboxylic acid (anti-[(18)F]FACBC) uptake mechanisms in inflammatory and tumor cells, in comparison with those of L-[methyl-(11)C]methionine ([(11)C]Met) and 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG). PROCEDURES:Using carbon-14-labeled tracers...

journal_title：Molecular imaging and biology

authors： Oka S,Okudaira H,Ono M,Schuster DM,Goodman MM,Kawai K,Shirakami Y

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:This research aimed to study the use of Cerenkov luminescence imaging (CLI) for non-Hodgkin's lymphoma (NHL) using 89Zr-rituximab positron emission tomography (PET) tracer with a humanized transgenic mouse model that expresses human CD20 and the correlation of CLI with PET. PROCEDURES:Zr-rituximab (2.6 MBq) wa...

journal_title：Molecular imaging and biology

authors： Natarajan A,Habte F,Liu H,Sathirachinda A,Hu X,Cheng Z,Nagamine CM,Gambhir SS

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:The present work was aimed at the development of prospective positron emission tomography (PET) agents for infection imaging. Towards this aim, ubiquicidin (UBI) fragments conjugated with the macrocyclic NODAGA chelator were radiolabeled with Ga-68 and evaluated. PROCEDURES:Conformations of custom synthesized ...

journal_title：Molecular imaging and biology

authors： Bhatt J,Mukherjee A,Korde A,Kumar M,Sarma HD,Dash A

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:Conventional in vivo bioluminescence imaging using wild-type green-emitting luciferase is limited by absorption and scattering of the bioluminescent signal through tissues. Imaging methods using a red-shifted thermostable luciferase from Photinus pyralis were optimized to improve the sensitivity and image resol...

journal_title：Molecular imaging and biology

authors： Mezzanotte L,Fazzina R,Michelini E,Tonelli R,Pession A,Branchini B,Roda A

更新日期：2010-08-01 00:00:00

abstract：:In vivo imaging of the central nervous system (CNS) neuroreceptors in humans began was used in the early 1980s. Now, some twenty years later, the success of radiopharmaceutical imaging is still often one based on empiricism and serendipity. Nevertheless, a number of factors can be identified based on the robot experie...

journal_title：Molecular imaging and biology

authors： Wong DF,Pomper MG

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:The demand to optimize multidisciplinary treatment strategies in patients with benign and malignant diseases of the lung and other organs has led to the increased need of mechanistic proof-of-concept studies in preclinical small animal models using new non-invasive imaging methods. Therefore, we evaluated the r...

journal_title：Molecular imaging and biology

authors： Flechsig P,Kratochwil C,Warth A,Rath D,Eichwald V,Huber PE,Kauczor HU,Haberkorn U,Giesel FL

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Inflammation plays a key role in the progression of intervertebral disk (IVD) herniation and associated low back pain. However, real-time spatial diagnosis of inflammation associated with acute disk herniation has not been investigated. We sought to detect local neutrophil and macrophage infiltration near disk ...

journal_title：Molecular imaging and biology

authors： Xiao L,Ding M,Zhang Y,Chordia M,Pan D,Shimer A,Shen F,Glover D,Jin L,Li X

更新日期：2017-10-01 00:00:00

abstract：PURPOSE:This study was undertaken to determine if artifacts from misalignment of cardiac emission to transmission data is present in adenosine stress studies and if the artifact could be reproduced by intentional misalignment in normal exams. PROCEDURES:Seventy consecutive 82Rb myocardial perfusion studies were review...

journal_title：Molecular imaging and biology

authors： Schuster DM,Halkar RK,Esteves FP,Garcia EV,Cooke CD,Syed MA,Bowman FD,Votaw JR

更新日期：2008-07-01 00:00:00

abstract：:This article is about head and neck tumor MR imaging and is not within the scope of two National Institutes of Health grants (R0ICA166171, ROICA228188) erroneously listed. Thus, the authors would like to remove the reference to the NIH grants R01CA166171 and R01CA228188 in this article. ...

journal_title：Molecular imaging and biology

authors： Yu L,Li C,Luo X,Zhou J,Zhang C,Zhang Y,Chen M

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:Recent researches have demonstrated the value of using 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) imaging to reveal the hypothyroidism-related damages in local brain regions. However, the influence of hypothyroidism on the entire brain network is barely studied. This study foc...

journal_title：Molecular imaging and biology

authors： Wang H,Tan Z,Zheng Q,Yu J

更新日期：2018-10-01 00:00:00

abstract：PURPOSE:Previously, some reports mentioned that magnetic resonance imaging (MRI) can predict histopathological features in primary CNS lymphoma (PCNSL). The reported data analyzed diffusion-weighted imaging findings. The aim of this study was to investigate possible associations between histopathological findings, such...

journal_title：Molecular imaging and biology

authors： Meyer HJ,Schob S,Münch B,Frydrychowicz C,Garnov N,Quäschling U,Hoffmann KT,Surov A

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:CXCR4 is overexpressed on tumor cells from many types of human cancers. A high level of CXCR4 expression often correlates with poor prognosis, chemotherapy resistance, and metastasis. The development of CXCR4-specific radiotracers for positron emission tomography (PET) imaging will allow in vivo evaluation of r...

journal_title：Molecular imaging and biology

authors： Zhang XX,Sun Z,Guo J,Wang Z,Wu C,Niu G,Ma Y,Kiesewetter DO,Chen X

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:The vesicular acetylcholine transporter (VAChT) is a specific biomarker for imaging presynaptic cholinergic neurons. The syntheses and C-11 labeling of two potent enantiopure VAChT inhibitors are reported here. PROCEDURES:Two VAChT inhibitors, (±)-2 and (±)-6, were successfully synthesized. A chiral HPLC colum...

journal_title：Molecular imaging and biology

authors： Padakanti PK,Zhang X,Li J,Parsons SM,Perlmutter JS,Tu Z

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Human pluripotency gene networks (PGNs), controlled in part by Oct4, are central to understanding pluripotent stem cells, but current fluorescent reporter genes (RGs) preclude noninvasive assessment of Oct4 dynamics in living subjects. PROCEDURES:To assess Oc4 activity noninvasively, we engineered a mouse embr...

journal_title：Molecular imaging and biology

authors： Ahn BC,Parashurama N,Patel M,Ziv K,Bhaumik S,Yaghoubi SS,Paulmurugan R,Gambhir SS

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Increased expression of the αvβ6 integrin correlates with advanced tumor grade and poor clinical outcome, identifying αvβ6 as a prognostic indicator and an attractive target for molecular imaging. This work investigated the ability of a disulfide-stabilized [64Cu]NOTA-αvβ6 cys-diabody to image αvβ6 expression i...

journal_title：Molecular imaging and biology

authors： White JB,Hu LY,Boucher DL,Sutcliffe JL

更新日期：2018-02-01 00:00:00

abstract：:We evaluated the clinical utility of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG)-positron emission tomography (PET)/computed tomography (CT) on the precise localization of pathologic foci and exclusion of normal variants in the imaging evaluation of patients with esophageal carcinoma. Combined PET/CT scans were performed i...

journal_title：Molecular imaging and biology

authors： Jadvar H,Henderson RW,Conti PS

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:To demonstrate the efficacy of repeated, non-invasive optical imaging of reporter gene expression in monitoring the ability of bi-specific recombinant molecules (i) to "transductionally untarget" adenovirus from Coxsackie and Adenovirus Receptor (CAR)-dependent infection of normal tissue and (ii) to "transducti...

journal_title：Molecular imaging and biology

authors： Liang Q,Yamamoto M,Curiel DT,Herschman HR

更新日期：2004-11-01 00:00:00

abstract：PURPOSE:The aims of this study were to evaluate the binding and pharmacokinetics of novel 18F-labeled ethenyl-benzoxazole derivatives (i.e., [18F] fluorinated amyloid imaging compound of Tohoku university ([18F]FACT)) as amyloid positron emission tomography (PET) tracers and to assess [18F]FACT efficacy in imaging of A...

journal_title：Molecular imaging and biology

authors： Furumoto S,Okamura N,Furukawa K,Tashiro M,Ishikawa Y,Sugi K,Tomita N,Waragai M,Harada R,Tago T,Iwata R,Yanai K,Arai H,Kudo Y

更新日期：2013-08-01 00:00:00

abstract：PURPOSE:Non-specific extracellular contrast agents have been on the market for more than 15 years. Here, we report on the synthesis of new selective lectin-gadolinium (Gd)-loaded chitosan nanoparticles with a prolonged clearance time and a much higher relaxivity in comparison to other preparations. PROCEDURES:Chitosan...

journal_title：Molecular imaging and biology

authors： Pashkunova-Martic I,Kremser C,Galanski M,Arion V,Debbage P,Jaschke W,Keppler B

更新日期：2011-02-01 00:00:00