Coregistration of magnetic resonance and single photon emission computed tomography images for noninvasive localization of stem cells grafted in the infarcted rat myocardium.

abstract：PURPOSE:The dimeric transmembrane integrin, α(v)β(3), is a well-investigated target by different imaging modalities through suitably labeled arginine-glycine-aspartic acid (RGD) containing peptides. In this study, we labeled four cyclic RGD peptides with or without PEG functional groups: c(RGDfK) (denoted as FK), PEG(3...

journal_title：Molecular imaging and biology

authors： Jacobson O,Zhu L,Niu G,Weiss ID,Szajek LP,Ma Y,Sun X,Yan Y,Kiesewetter DO,Liu S,Chen X

更新日期：2011-12-01 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate the feasibility of dual magnetic resonance imaging (MRI) reporter genes, including ferritin heavy subunit (Fth) and transferrin receptor (TfR), which provide sufficient MRI contrast for in vivo MRI tracking, and the Deltex-1 (DTX1) gene, which promotes human mesenchy...

journal_title：Molecular imaging and biology

authors： Guo R,Li Q,Yang F,Hu X,Jiao J,Guo Y,Wang J,Zhang Y

更新日期：2018-06-01 00:00:00

abstract：PURPOSE:[(18)F]-FEPPA is a translocator protein (18 kDa, TSPO) positron emission tomography (PET) radiotracer. Radiation dosimetry was estimated from the whole body biodistribution, taking into consideration TSPO rs6971 (Ala147Thr) polymorphism. PROCEDURES:[(18)F]-FEPPA whole body PET scans were acquired for six healt...

journal_title：Molecular imaging and biology

authors： Mizrahi R,Rusjan PM,Vitcu I,Ng A,Wilson AA,Houle S,Bloomfield PM

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:We examine the feasibility of fluorescent imaging system for sentinel lymph node detection by using functionalized silica nanoparticles. MATERIALS AND METHODS:We developed a functionalized RITC-SiO(2) nanoparticles containing fluorescent dye, C(28)H(31)N(2)O(3)Cl (rhodamine B isothiocyanate) inside, and subseq...

journal_title：Molecular imaging and biology

authors： Jeon YH,Kim YH,Choi K,Piao JY,Quan B,Lee YS,Jeong JM,Chung JK,Lee DS,Lee MC,Lee J,Chung DS,Kang KW

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:Radioimmunotherapy uses tumor-specific antibodies to deliver therapeutic radionuclides, but hematological toxicity due to the long serum half-life of intact antibodies remains a challenge. We evaluated a smaller antibody fragment, the minibody, with faster kinetics and a potentially improved therapeutic index. ...

journal_title：Molecular imaging and biology

authors： Tsai WK,Zettlitz KA,Dahlbom M,Reiter RE,Wu AM

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:To evaluate bone blood flow and bone formation in patients after total hip revision surgery with impacted bone grafting using H2 15O and [18F]fluoride positron emission tomography (PET). PROCEDURES:To asses bone blood flow and bone metabolism in bone allograft after impaction grafting, four patients treated wi...

journal_title：Molecular imaging and biology

authors： Temmerman OP,Raijmakers PG,Heyligers IC,Comans EF,Lubberink M,Teule GJ,Lammertsma AA

更新日期：2008-09-01 00:00:00

abstract：INTRODUCTION:We have previously described the labeling of interleukin-2 (IL2) with (123)I and (99m)Tc-N(3)S. Both radiopharmaceuticals were successfully applied in humans to image several inflammatory lesions and autoimmune diseases characterized by tissue infiltrating lymphocytes expressing the IL2 receptor (CD25). Ho...

journal_title：Molecular imaging and biology

authors： D'Alessandria C,di Gialleonardo V,Chianelli M,Mather SJ,de Vries EF,Scopinaro F,Dierck RA,Signore A

更新日期：2010-10-01 00:00:00

abstract：INTRODUCTION:Advances in positron emission tomography (PET) imaging have provided opportunities to develop radiotracers specific for imaging insulin-producing pancreatic β-cells. However, a host of lingering questions should be addressed before these radiotracers are advocated for noninvasive quantification of β-cell m...

journal_title：Molecular imaging and biology

authors： Blomberg BA,Codreanu I,Cheng G,Werner TJ,Alavi A

更新日期：2013-04-01 00:00:00

abstract：PURPOSE:Widely used in clinical practice, the maximum standardized uptake value (SUVmax) is a statistical index highly prone to physical and biological variations, which can lead to unpredictable errors. This study has a methodological aim: to identify a more robust SUV-based index representing the tracer accumulation....

journal_title：Molecular imaging and biology

authors： Baiocco S,Matteucci F,Mezzenga E,Caroli P,Di Iorio V,Cittanti C,Bevilacqua A,Paganelli G,Sarnelli A

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:To evaluate the clinical significance of differences in 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (FDG-PET) lymph node standardized uptake values (SUV) in human immunodeficiency virus (HIV) infection using iterative reconstruction with segmented attenuation correction (IR SAC) compared to fil...

journal_title：Molecular imaging and biology

authors： Chin BB,Lyengar S,Sabundayo BP,Schwartz D

更新日期：2002-07-01 00:00:00

abstract：PURPOSE:The demand to optimize multidisciplinary treatment strategies in patients with benign and malignant diseases of the lung and other organs has led to the increased need of mechanistic proof-of-concept studies in preclinical small animal models using new non-invasive imaging methods. Therefore, we evaluated the r...

journal_title：Molecular imaging and biology

authors： Flechsig P,Kratochwil C,Warth A,Rath D,Eichwald V,Huber PE,Kauczor HU,Haberkorn U,Giesel FL

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Manganese ion has been extensively used as a magnetic resonance imaging (MRI) contrast agent in preclinical studies to assess tissue anatomy, function, and neuronal connectivity. Unfortunately, its use in human studies has been limited by cellular toxicity and the need to use a very low dose. The much higher se...

journal_title：Molecular imaging and biology

authors： Saar G,Millo CM,Szajek LP,Bacon J,Herscovitch P,Koretsky AP

更新日期：2018-08-01 00:00:00

abstract：PURPOSE:The increasing availability of fluorescent probes for in vivo optical imaging enables the interrogation of complex biological processes in small animals serving as models for human-like tissue function and disease. However, the validation of probe bio-distribution during their development or the study of differ...

journal_title：Molecular imaging and biology

authors： Sarantopoulos A,Themelis G,Ntziachristos V

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:The goal of this study was to determine the specificity of ⁶⁴Cu-CB-TE2A-c(RGDyK) (⁶⁴Cu-RGD) for osteoclast-related diseases, such as Paget's disease or rheumatoid arthritis. PROCEDURES:C57BL/6 mice were treated systemically with osteoprotegerin (OPG) for 15 days or RANKL for 11 days to suppress and stimulate o...

journal_title：Molecular imaging and biology

authors： Zheleznyak A,Wadas TJ,Sherman CD,Wilson JM,Kostenuik PJ,Weilbaecher KN,Anderson CJ

更新日期：2012-08-01 00:00:00

abstract：PURPOSE:Macrophage accumulation characterizes the development of atherosclerotic plaques, and the presence of certain macrophage subsets might be an indicator of plaque phenotype and (in)stability. The macrophage mannose receptor (MMR) is expressed on alternatively activated macrophages and found at sites of intraplaqu...

journal_title：Molecular imaging and biology

authors： Bala G,Baudhuin H,Remory I,Gillis K,Debie P,Krasniqi A,Lahoutte T,Raes G,Devoogdt N,Cosyns B,Hernot S

更新日期：2018-04-01 00:00:00

abstract：PURPOSE:Dynamic positron emission tomography (PET) protocols allow for accurate quantification of [18F]flortaucipir-specific binding. However, dynamic acquisitions can be challenging given the long required scan duration of 130 min. The current study assessed the effect of shorter scan protocols for [18F]flortaucipir o...

journal_title：Molecular imaging and biology

authors： Tuncel H,Visser D,Yaqub M,Timmers T,Wolters EE,Ossenkoppele R,van der Flier WM,van Berckel BNM,Boellaard R,Golla SSV

更新日期：2021-01-26 00:00:00

abstract：PURPOSE:The mTOR kinase inhibitor AZD8055 inhibits both mTORC1 and mTORC2 leading to disruption of glucose metabolism and proliferation pathways. This study assessed the impact of single and multiple doses of AZD8055 on the uptake of the glucose metabolism marker 2-deoxy-2-[(18) F]fluoro-D-glucose ([(18) F]FDG) and the...

journal_title：Molecular imaging and biology

authors： Keen HG,Ricketts SA,Maynard J,Logie A,Odedra R,Shannon AM,Wedge SR,Guichard SM

更新日期：2014-06-01 00:00:00

abstract：:This article was updated to correct the spelling of Hongkai Wang's name: it is correct as displayed here. ...

journal_title：Molecular imaging and biology

authors： Wang H,Tan Z,Zheng Q,Yu J

更新日期：2019-02-01 00:00:00

abstract：:In vivo imaging of the central nervous system (CNS) neuroreceptors in humans began was used in the early 1980s. Now, some twenty years later, the success of radiopharmaceutical imaging is still often one based on empiricism and serendipity. Nevertheless, a number of factors can be identified based on the robot experie...

journal_title：Molecular imaging and biology

authors： Wong DF,Pomper MG

更新日期：2003-11-01 00:00:00

abstract：PURPOSE:The purpose of this study is to evaluate if the differential exchange rates with bulk water between amine and amide protons can be exploited using chemical exchange saturation transfer magnetic resonance (CEST-MR) to monitor the release of glutamate induced by carboxypeptidase G2 (CPG2), an enzyme utilized in c...

journal_title：Molecular imaging and biology

authors： Jamin Y,Eykyn TR,Poon E,Springer CJ,Robinson SP

更新日期：2014-04-01 00:00:00

abstract：PURPOSE:Prefrontal cortex (PFC) deep brain stimulation (DBS) has been proposed as a therapy for addiction and depression. This study investigates changes in rat cerebral glucose metabolism induced by different DBS frequencies using μPET. PROCEDURES:One hour DBS of the prelimbic area (PL) of the medial PFC (mPFC) (60 H...

journal_title：Molecular imaging and biology

authors： Parthoens J,Verhaeghe J,Stroobants S,Staelens S

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:Angiogenesis is essential for physiological processes as well as for carcinogenesis. New approaches to cancer therapy include targeting angiogenesis. One target is VEGF-A and its receptor VEGFR2. In this study, we sought to investigate pancreatic cancer angiogenesis in a genetically modified VEGFR2-luc-KI mouse...

journal_title：Molecular imaging and biology

authors： Angst E,Chen M,Mojadidi M,Hines OJ,Reber HA,Eibl G

更新日期：2010-12-01 00:00:00

abstract：:Pharmaceutical research and imaging science are becoming increasingly intertwined. Positron emission tomography (PET) is a molecular imaging technique with particularly broad application in drug discovery and development. At the same time, modern techniques of drug discovery are helping accelerate the development of n...

journal_title：Molecular imaging and biology

authors： Maclean D,Northrop JP,Padgett HC,Walsh JC

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:The sigma-2 (σ(2)) receptor is a potential biomarker of proliferative status of solid tumors. Specific synthetic probes using N-substituted-9-azabicyclo [3.3.1]nonan-3α-yl carbamate analogs have been designed and implemented for experimental cancer diagnosis and therapy. PROCEDURES:We employed the fluorescentl...

journal_title：Molecular imaging and biology

authors： Haller JL,Panyutin I,Chaudhry A,Zeng C,Mach RH,Frank JA

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:Our objective was to determine the lowest diagnostically effective dose for E-selectin-targeted poly n-butyl cyanoacrylate (PBCA)-shelled microbubbles and to apply it to monitor antiangiogenic therapy effects. PROCEDURES:PBCA-shelled microbubbles (MBs) coupled to an E-selectin-specific peptide were applied in ...

journal_title：Molecular imaging and biology

authors： Spivak I,Rix A,Schmitz G,Fokong S,Iranzo O,Lederle W,Kiessling F

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:The objective of this study is to evaluate the therapeutic response to a novel monoclonal antibody targeting human extracellular matrix metalloproteinase inducer (EMMPRIN) in combination with gemcitabine in a pancreatic-tumor xenograft murine model by sequential 2-deoxy-2-[18F]fluoro-D-glucose ((18)F-FDG) posit...

journal_title：Molecular imaging and biology

authors： Shah N,Zhai G,Knowles JA,Stockard CR,Grizzle WE,Fineberg N,Zhou T,Zinn KR,Rosenthal EL,Kim H

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:Using three publicly available small-animal atlases (Sprague-Dawley rat, MOBY, and Digimouse), we built three articulated atlases and present several applications in the scope of molecular imaging. PROCEDURES:Major bones/bone groups were manually segmented for each atlas skeleton. Then, a kinematic model for e...

journal_title：Molecular imaging and biology

authors： Khmelinskii A,Baiker M,Kaijzel EL,Chen J,Reiber JH,Lelieveldt BP

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the longitudinal positron emission tomography (PET) metabolic changes in the elderly. PROCEDURES:Nineteen nondemented subjects (mean Mini-Mental Status Examination 29.4 +/- 0.7 SD) underwent two detailed neuropsychological evaluations and resting 2-deoxy-2-[F-18]fluoro-...

journal_title：Molecular imaging and biology

authors： Apostolova LG,Thompson PM,Rogers SA,Dinov ID,Zoumalan C,Steiner CA,Siu E,Green AE,Small GW,Toga AW,Cummings JL,Phelps ME,Silverman DH

更新日期：2010-04-01 00:00:00

abstract：PURPOSE:The purpose of the study was to examine the feasibility of an antibody-carrying targeted-bubble preparation using clinically available phosphatidylserine (PS)-containing perfluorobutane-filled microbubbles for molecular ultrasound imaging. PROCEDURES:Firstly, we examined whether PS on the surface of perfluorob...

journal_title：Molecular imaging and biology

authors： Otani K,Yamahara K

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:This study was designed to estimate the clinical significance of the contrast-enhanced computed tomography (CT) textural features for prediction of survival in colorectal cancer (CRC) patients receiving targeted therapy (bevacizumab and cetuximab). PROCEDURES:The LifeX software was used to extract the textural...

journal_title：Molecular imaging and biology

authors： Zhao Y,Yang J,Luo M,Yang Y,Guo X,Zhang T,Hao J,Yao Y,Ma X

更新日期：2020-10-27 00:00:00