Abstract:
:A monoclonal antibody (mAb) has been produced which reacts with human mitofilin, a mitochondrial inner membrane protein. This mAb immunocaptures its target protein in association with six other proteins, metaxins 1 and 2, SAM50, CHCHD3, CHCHD6 and DnaJC11, respectively. The first three are outer membrane proteins, CHCHD3 has been assigned to the matrix space, and the other two proteins have not been described in mitochondria previously. The functional role of this new complex is uncertain. However, a role in protein import related to maintenance of mitochondrial structure is suggested as mitofilin helps regulate mitochondrial morphology and at least four of the associated proteins (metaxins 1 and 2, SAM50 and CHCHD3) have been implicated in protein import, while DnaJC11 is a chaperone-like protein that may have a similar role.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Xie J,Marusich MF,Souda P,Whitelegge J,Capaldi RAdoi
10.1016/j.febslet.2007.06.052subject
Has Abstractpub_date
2007-07-24 00:00:00pages
3545-9issue
18eissn
0014-5793issn
1873-3468pii
S0014-5793(07)00709-0journal_volume
581pub_type
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