The anti-apoptotic activity of albumin for endothelium is mediated by a partially cryptic protein domain and reduced by inhibitors of G-coupled protein and PI-3 kinase, but is independent of radical scavenging or bound lipid.

abstract：:This work compares the expression of adrenoceptors (ARs) and G-protein-coupled receptor kinase (GRK) 2 (RT-PCR and immunoblotting) and functional responses in conductance (aorta) and resistance vessels (mesenteric resistance arteries; MRA) in two different models of rat hypertension: hypertension induced by chronic tr...

journal_title：Journal of vascular research

authors： Oliver E,Flacco N,Arce C,Ivorra MD,D'Ocon MP,Noguera MA

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Extracellular matrix deposition is the main factor inducing stenotic lesions in arterial grafts. Lysyl oxidases (LOX) play a key role in stabilizing collagen and elastin. OBJECTIVE:To examine the repair response to arterial allografts in terms of LOX expression and collagen/elastin deposition using LOX inhi...

journal_title：Journal of vascular research

authors： Rodríguez M,Pascual G,Cifuentes A,Perez-Köhler B,Bellón JM,Buján J

更新日期：2011-01-01 00:00:00

abstract：:Studies on the possible causal relationship between the Ca2+ channel current density in the vascular muscle cell (VMC) and increases in blood pressure were extended by a comparison of stroke-prone spontaneously hypertensive rats (SP-SHR) with N/nih outbred normotensive rats. Maximal amplitudes of both L-type and T-typ...

journal_title：Journal of vascular research

authors： Self DA,Bian K,Mishra SK,Hermsmeyer K

更新日期：1994-11-01 00:00:00

abstract：AIMS:The effects of ischemia and hypercholesterolemia on the function and morphological adaptation of the rabbit hindlimb were assessed. METHODS:In rabbits on normal or cholesterol diet, experiments were performed on days 0-28 following bilateral femoral artery ligation. Calf blood pressure (C(BP)), exercise tolerance...

journal_title：Journal of vascular research

authors： Wafai R,Angus JA,Wright CE

更新日期：2008-01-01 00:00:00

abstract：:The pH has marked effects on the blood flow in several vascular beds but the underlying mechanisms remain incompletely understood. It is still not agreed, for example, whether it is the fall in extracellular pH or intracellular pH that is responsible for changes in tone resulting from hypercapnic acidosis. The issue h...

journal_title：Journal of vascular research

authors： Aalkjaer C,Poston L

更新日期：1996-09-01 00:00:00

abstract：:The aim of this study was to use periarterial manipulation to produce an atheroma-like neo-intima in rabbits and study resting blood flow and vascular responsiveness in vivo. One common carotid artery was enclosed in a silastic collar to induce a neo-intima similar to that of human early atherosclerosis, and carotid b...

journal_title：Journal of vascular research

authors： Arthur JF,Dusting GJ,Woodman OL

更新日期：1994-07-01 00:00:00

abstract：:Thrombospondin-1 (TSP1) is a potent natural inhibitor of angiogenesis. Although TSP1 has been reported to induce endothelial cell apoptosis in vitro and to downregulate neovascularization in vivo, the molecular mechanisms that link these two processes have yet to be established. Here we report that TSP1 mediates endot...

journal_title：Journal of vascular research

authors： Nör JE,Mitra RS,Sutorik MM,Mooney DJ,Castle VP,Polverini PJ

更新日期：2000-05-01 00:00:00

abstract：:Neointima formation participates in the pathophysiology of atherosclerosis and restenosis. Proliferation and migration of vascular smooth muscle cells (VSMC) are initial responses to vascular injury. The aim of the present study was to assess the effect of gliotoxin, an inhibitor of nuclear factor (NF)-kappaB, on migr...

journal_title：Journal of vascular research

authors： Pozo M,Izquierdo MC,de Nicolás R,Egido J,Ortiz A,González-Cabrero J

更新日期：2009-01-01 00:00:00

abstract：:The effect of insulin on the vasoconstriction induced by norepinephrine is presently controversial. Therefore, the aims of our study were: (1) to evaluate the effect of low- and high-dose insulin on the concentration-response curve to norepinephrine in small resistance arteries of spontaneously hypertensive rats (SHR)...

journal_title：Journal of vascular research

authors： Rizzoni D,Porteri E,Piccoli A,Castellano M,Pasini G,Guelfi D,Muiesan ML,Rosei EA

更新日期：1999-09-01 00:00:00

abstract：AIMS:We investigated the role of superoxide O(2)(-) during the initiation of vascular endothelial growth factor (VEGF)- and placental growth factor (PlGF)-mediated signal transduction in bone marrow-derived endothelial cells. METHODS:BMhTERT cells were treated with VEGF or PlGF in the presence or absence of antioxidan...

journal_title：Journal of vascular research

authors： Dhar-Mascareno M,Mascareno E,Golde DW

更新日期：2009-01-01 00:00:00

abstract：:In the present study, we investigated the actions of calmodulin (CaM) and CaM-dependent protein kinase II (CaMK-II) on the L-type Ca2+ currents (ICa(L)) of cultured vascular smooth muscle (VSM) cells (A7r5 cell line), using the whole-cell voltage clamp method. The peak IBa (Ca2+ channel using 5 mM Ba2+ as charge carri...

journal_title：Journal of vascular research

authors： Sunagawa M,Yokoshiki H,Seki T,Sperelakis N

更新日期：1998-09-01 00:00:00

abstract：:Although most physiologically important processes are regulated through negative feedback loops and numerous factors regulating endothelial apoptosis are identified, little is known about negative feedback mechanisms for endothelial apoptosis. Here we describe the release of soluble anti-apoptotic activity by endothel...

journal_title：Journal of vascular research

authors： Bolitho C,Xu W,Zoellner H

更新日期：2008-01-01 00:00:00

abstract：:The localization of dopamine receptor subtypes in the rabbit pulmonary circulation was investigated by using combined radioligand binding and light microscope autoradiography techniques. Dopamine D1-like receptors, probably belonging to the dopamine D1 receptor subtype, were demonstrated in sections of rabbit lung usi...

journal_title：Journal of vascular research

authors： Kobayashi Y,Ricci A,Amenta F,Cavallotti C,Hattori K

更新日期：1995-05-01 00:00:00

abstract：:Proper development of the vascular system as one of the earliest and most critical steps during vertebrate embryogenesis is ensured by the exact spatial and temporal control of gene expression in cells forming the vessel network. Whereas the regulation of vascular system development is well elucidated on the level of ...

journal_title：Journal of vascular research

authors： Bruderer M,Alini M,Stoddart MJ

更新日期：2013-01-01 00:00:00

abstract：:Atherosclerosis underlies late occlusion of human saphenous vein (HSV) coronary artery bypass grafts. Monocyte infiltration is implicated, but its mechanisms are unclear given that HSV normally expresses the ICAM-1 but not the VCAM-1 adhesion molecule. To define the mechanisms underlying monocyte adhesion, samples of ...

journal_title：Journal of vascular research

authors： Crook MF,Southgate KM,Newby AC

更新日期：2002-05-01 00:00:00

abstract：:We tested the hypothesis that oxidized low-density lipoprotein (oxLDL)-induced inactivation of Akt within endothelial progenitor cells (EPCs) is mediated at the level of phosphoinositide 3-kinase (PI3K), specifically by nitrosylation of the p85 subunit of PI3K, and that this action is critical in provoking oxLDL-induc...

journal_title：Journal of vascular research

authors： Tie G,Yan J,Yang Y,Park BD,Messina JA,Raffai RL,Nowicki PT,Messina LM

更新日期：2010-01-01 00:00:00

abstract：:This study utilised catecholamine fluorescence histochemistry, multiple-labelling immunohistochemistry and retrograde axonal transport to determine the distribution and neuropeptide content of sympathetic neurons innervating veins in the dorsal skin of the guinea pig pinna. There was a dense plexus of sympathetic axon...

journal_title：Journal of vascular research

authors： Morris JL

更新日期：1995-11-01 00:00:00

abstract：:This study examines the ultrastructural features of diffuse intimal thickenings of human coronary arteries and correlates structural heterogeneity along the radial axis with the distribution and known actions of transforming growth factor beta 1 (TGF-beta 1). Morphometric and immunohistochemical data were collected fr...

journal_title：Journal of vascular research

authors： Merrilees MJ,Beaumont B

更新日期：1993-09-01 00:00:00

abstract：:Recent research in ultrasound technology has led to the development of a high-resolution echo-tracking device. The present study was performed to evaluate the accuracy in the measurement of human radial artery intima-media thickness with this new device. We determined the correlation between histological and ultrasoni...

journal_title：Journal of vascular research

authors： Girerd X,Mourad JJ,Acar C,Heudes D,Chiche S,Bruneval P,Mignot JP,Billaud E,Safar M,Laurent S

更新日期：1994-03-01 00:00:00

abstract：:Regulation of [Ca2+]i and modulation of the [Ca2+]i sensitivity of myosin phosphorylation in smooth muscles may involve phosphorylation of one or more proteins on tyrosine residues. We tested this hypothesis by measuring tyrosine phosphorylation of proteins extracted from swine carotid artery and separated by SDS gel ...

journal_title：Journal of vascular research

authors： Rembold CM,Weaver BA

更新日期：1997-01-01 00:00:00

abstract：:It has been well established that wall shear stress is an important determinant of endothelial cell function and gene expression as well as of its structure. There is increasing evidence that low wall shear stress, as present in artery bifurcations opposite to the flow divider where atherosclerotic lesions preferentia...

journal_title：Journal of vascular research

authors： Reneman RS,Arts T,Hoeks AP

更新日期：2006-01-01 00:00:00

abstract：AIM:Vascular remodeling following injury substantially accounts for restenosis and adverse clinical outcomes. In this study, we investigated the role of the giant scaffold protein Ahnak1 in vascular healing after endothelial denudation of the murine femoral artery. METHODS:The spatiotemporal expression pattern of Ahna...

journal_title：Journal of vascular research

authors： Haase N,Rüder C,Haase H,Kamann S,Kouno M,Morano I,Dechend R,Zohlnhöfer D,Haase T

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:Laser Doppler flowmetry (LDF) was used to determine the influence of acute myocardial infarction (AMI) and of successful reperfusion treatment on basal skin blood flow and its oscillatory components. METHODS:Skin LDF was performed on all extremities in 58 patients 4-9 days after AMI (Killip class I), a...

journal_title：Journal of vascular research

authors： Azman-Juvan K,Bernjak A,Urbancic-Rovan V,Stefanovska A,Stajer D

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:It is well known that inflammation plays key roles in the development of atherosclerosis and that the transplantation of bone marrow mononuclear cells (BMMNCs) can suppress inflammation in rodent models of ischemic diseases. Here, we explored whether transplantation of autologous BMMNCs could prevent the prog...

journal_title：Journal of vascular research

authors： Cui K,Wang M,Yu L,Ren X,Cui H,Yu XF,Hou S,Fu C,Wang J

更新日期：2016-01-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating peptide (PACAP; 1-38 and 1-27) and vasoactive intestinal peptide (VIP) are related neuropeptides of the secretin/glucagon family. Overlapping signaling through G-protein-coupled receptors mediates their vasomotor activity. We previously showed that PACAP deficiency (PACAP-KO) shi...

journal_title：Journal of vascular research

authors： Ivic I,Solymar M,Fulop BD,Hashimoto H,Toth G,Tamas A,Juhasz T,Koller A,Reglodi D

更新日期：2017-01-01 00:00:00

abstract：:The effect of shear stress at the endothelium in the attenuation of the noradrenaline-induced constriction of the femoral vascular bed perfused at a constant blood flow was investigated in 16 anesthetized cats. It is known that the adrenergic vasoconstriction of the femoral vascular bed is considerably greater at a co...

journal_title：Journal of vascular research

authors： Kartamyshev SP,Balashov SA,Melkumyants AM

更新日期：2007-01-01 00:00:00

abstract：:The pathophysiology of Raynaud's phenomenon (RP) remains an enigma. Whatever theories proposed, the final event leading to the clinical symptoms is the occlusion of digital vessels. However, the possibility that the upstream large arterial vessels contribute to vasopasm has never been investigated. We used a high reso...

journal_title：Journal of vascular research

authors： Mourad JJ,Priollet P,Girerd X,Safar M,Lazareth I,Laurent S

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Transfer of molecular signals from veins to adjacent arteries is an established mechanism of vascular communication in the uterine circulation, which ultimately depends on venous permeability. This study tests the hypotheses that: (1) uterine veins are permeable to intravenous solutes, using a 3-kDa dextran ...

journal_title：Journal of vascular research

authors： Celia G,Osol G

更新日期：2005-01-01 00:00:00

abstract：OBJECTIVES:Hyperuricemia provokes endothelial dysfunction (ECD). Decreased endothelial nitric oxide synthase (eNOS) activity is an important source of ECD. Cationic amino acid transporter-1 (CAT-1) is the specific arginine transporter for eNOS. We hypothesize that hyperuricemia inhibits arginine uptake. METHODS:Experi...

journal_title：Journal of vascular research

authors： Schwartz IF,Grupper A,Chernichovski T,Grupper A,Hillel O,Engel A,Schwartz D

更新日期：2011-01-01 00:00:00

abstract：:The mechanosensitive nonselective cation channel (NSC(MS)) is a key player in vascular myogenic contraction. The functional channel density and pressure sensitivity of NSC(MS) in vascular myocytes were compared between pulmonary and systemic arteries (coronary, mesenteric and cerebral arteries) in the rabbit. In cell-...

journal_title：Journal of vascular research

authors： Park KS,Lee HA,Earm KH,Ko JH,Earm YE,Kim SJ

更新日期：2006-01-01 00:00:00