Transplantation of Autologous Bone Marrow Mononuclear Cells Regulates Inflammation in a Rabbit Model of Carotid Artery Atherosclerosis.

abstract：:We tested the hypothesis that oxidized low-density lipoprotein (oxLDL)-induced inactivation of Akt within endothelial progenitor cells (EPCs) is mediated at the level of phosphoinositide 3-kinase (PI3K), specifically by nitrosylation of the p85 subunit of PI3K, and that this action is critical in provoking oxLDL-induc...

journal_title：Journal of vascular research

authors： Tie G,Yan J,Yang Y,Park BD,Messina JA,Raffai RL,Nowicki PT,Messina LM

更新日期：2010-01-01 00:00:00

abstract：:Actions of the novel Ca2+ antagonist, Ro 40-5967, which displays unusual efficacy against endothelin (ET)-induced contractions, were studied in isolated vascular muscle cells (VMCs) using the fluorescent protein kinase C (PKC) indicator, BODIPY 12 alpha-phorbol ester 13 beta-acetate (PBA-BODIPY). High-sensitivity (pho...

journal_title：Journal of vascular research

authors： Hermsmeyer K,Miyagawa K

更新日期：1996-01-01 00:00:00

abstract：:In coronary artery diseases, cigarette smoking is a risk factor and the endothelin system plays a key role in the pathogenesis. This study was to examine if dimethylsulfoxide-soluble smoke particles (DSP) upregulate endothelin type-B (ETB) receptors in the coronary artery and investigate the mechanism. The isolated ra...

journal_title：Journal of vascular research

authors： Huang LH,Zhang PA,He JY,Liu J,Cao YX

更新日期：2013-01-01 00:00:00

abstract：:Although most physiologically important processes are regulated through negative feedback loops and numerous factors regulating endothelial apoptosis are identified, little is known about negative feedback mechanisms for endothelial apoptosis. Here we describe the release of soluble anti-apoptotic activity by endothel...

journal_title：Journal of vascular research

authors： Bolitho C,Xu W,Zoellner H

更新日期：2008-01-01 00:00:00

abstract：:In the present study, we investigated the actions of calmodulin (CaM) and CaM-dependent protein kinase II (CaMK-II) on the L-type Ca2+ currents (ICa(L)) of cultured vascular smooth muscle (VSM) cells (A7r5 cell line), using the whole-cell voltage clamp method. The peak IBa (Ca2+ channel using 5 mM Ba2+ as charge carri...

journal_title：Journal of vascular research

authors： Sunagawa M,Yokoshiki H,Seki T,Sperelakis N

更新日期：1998-09-01 00:00:00

abstract：:Conduit arteries of hypertensive rats are thicker and stiffer than those of normotensive controls. The possible role played by collagen type I and II subtypes in the mechanism of arterial stiffness remains unknown. The carotid and aortic arterial wall of rats of Japanese (Wistar-Kyoto and spontaneously hypertensive ra...

journal_title：Journal of vascular research

authors： Chamiot Clerc P,Renaud JF,Blacher J,Legrand M,Samuel JL,Levy BI,Sassard J,Safar ME

更新日期：1999-03-01 00:00:00

abstract：:The Ig-like cell adhesion molecule ICAM-3 is mainly expressed on human leukocytes and is involved in cell-cell interactions. Its expression on endothelium is observed during disorders such as Crohn's disease and in solid tumors. We found low but detectable expression of ICAM-3 on VE-cadherin-expressing cells from prim...

journal_title：Journal of vascular research

authors： van Buul JD,Mul FP,van der Schoot CE,Hordijk PL

更新日期：2004-01-01 00:00:00

abstract：:It has been well established that wall shear stress is an important determinant of endothelial cell function and gene expression as well as of its structure. There is increasing evidence that low wall shear stress, as present in artery bifurcations opposite to the flow divider where atherosclerotic lesions preferentia...

journal_title：Journal of vascular research

authors： Reneman RS,Arts T,Hoeks AP

更新日期：2006-01-01 00:00:00

abstract：AIM:Vascular remodeling following injury substantially accounts for restenosis and adverse clinical outcomes. In this study, we investigated the role of the giant scaffold protein Ahnak1 in vascular healing after endothelial denudation of the murine femoral artery. METHODS:The spatiotemporal expression pattern of Ahna...

journal_title：Journal of vascular research

authors： Haase N,Rüder C,Haase H,Kamann S,Kouno M,Morano I,Dechend R,Zohlnhöfer D,Haase T

更新日期：2017-01-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating peptide (PACAP; 1-38 and 1-27) and vasoactive intestinal peptide (VIP) are related neuropeptides of the secretin/glucagon family. Overlapping signaling through G-protein-coupled receptors mediates their vasomotor activity. We previously showed that PACAP deficiency (PACAP-KO) shi...

journal_title：Journal of vascular research

authors： Ivic I,Solymar M,Fulop BD,Hashimoto H,Toth G,Tamas A,Juhasz T,Koller A,Reglodi D

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:It has been reported that smoking is one of the strongest positive risk factors for abdominal aortic aneurysms (AAAs). Although many studies have been directed to decipher the effect of smoking on AAA, its effect on macrophage activation has not yet been explored. OBJECTIVES:We have reported the importance ...

journal_title：Journal of vascular research

authors： Igari K,Kelly MJ,Yamanouchi D

更新日期：2019-01-01 00:00:00

abstract：:A radioligand binding assay and autoradiographic localisation of P2X-purinoceptors were carried out in several different blood vessels from rat, guinea-pig and rabbit by using [3H]alpha,beta-methylene ATP ([3H]alpha,beta-MeATP) as the radioligand. The radioligand binding assay on rabbit ear artery showed that the bind...

journal_title：Journal of vascular research

authors： Bo X,Burnstock G

更新日期：1993-03-01 00:00:00

abstract：:The role of leukocytes (WBCs) and platelets (PLTs) in the pulmonary circulation may be important in the development of monocrotaline (MCT)-induced pulmonary hypertension in rats. We investigated the suppressive effects of long-term prostaglandin E(1) (PGE(1)) aerosol on the changes in WBCs and PLTs in the peripheral b...

journal_title：Journal of vascular research

authors： Kato S,Kishiro I,Sugimura H,Machida S,Fuse D,Kaneko N

更新日期：2002-01-01 00:00:00

abstract：:The pH has marked effects on the blood flow in several vascular beds but the underlying mechanisms remain incompletely understood. It is still not agreed, for example, whether it is the fall in extracellular pH or intracellular pH that is responsible for changes in tone resulting from hypercapnic acidosis. The issue h...

journal_title：Journal of vascular research

authors： Aalkjaer C,Poston L

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Angiopoietin-like protein 3 (ANGPTL3) is a liver-derived plasma protein that modulates plasma triglyceride clearance, angiogenesis and atherosclerosis in experimental models. So far, no study has examined its role in atherosclerosis in human subjects. We evaluated the possible association between plasma ANGP...

journal_title：Journal of vascular research

authors： Hatsuda S,Shoji T,Shinohara K,Kimoto E,Mori K,Fukumoto S,Koyama H,Emoto M,Nishizawa Y

更新日期：2007-01-01 00:00:00

abstract：:Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) are cytoplasmic adaptor proteins of the TNF/interleukin (IL)-1/Toll-like receptor superfamily. Ligands of this family such as TNFα, CD40L, and IL-1β promote chronic inflammatory processes such as atherosclerosis and restenosis, the latter being a common a...

journal_title：Journal of vascular research

authors： Willecke F,Rupprecht B,Gissler MC,Pfeiffer K,Anto-Michel N,Stachon P,Wolf D,Hilgendorf I,Hoppe N,Bode C,Zirlik A

更新日期：2019-01-01 00:00:00

abstract：:This study utilised catecholamine fluorescence histochemistry, multiple-labelling immunohistochemistry and retrograde axonal transport to determine the distribution and neuropeptide content of sympathetic neurons innervating veins in the dorsal skin of the guinea pig pinna. There was a dense plexus of sympathetic axon...

journal_title：Journal of vascular research

authors： Morris JL

更新日期：1995-11-01 00:00:00

abstract：PURPOSE:Hypoxic conditions cause fibroblasts to differentiate into alpha smooth-muscle cell actin (α -SMA)-positive cells, i.e. myofibroblasts. This process is a hallmark of venous neointimal hyperplasia (VNH) associated with hemodialysis vascular access. The purpose of this study was to determine if blood outgrowth en...

journal_title：Journal of vascular research

authors： Nieves Torres EC,Yang B,Brahmbhatt A,Mukhopadhyay D,Misra S

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Vasomotion consists in cyclic oscillations of the arterial diameter induced by the synchronized activity of the smooth muscle cells. So far, contradictory results have emerged in the literature about the role of the endothelium in the onset and maintenance of vasomotion. Here our aim is to understan...

journal_title：Journal of vascular research

authors： Seppey D,Sauser R,Koenigsberger M,Bény JL,Meister JJ

更新日期：2008-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a principal stimulator of angiogenesis. However, the downstream targets of VEGF in endothelial cells (ECs) are not entirely clarified. Survey of downstream targets of VEGF in human ECs identified a number of genes, including Down syndrome candidate region 1 (DSCR1). Here, w...

journal_title：Journal of vascular research

authors： Iizuka M,Abe M,Shiiba K,Sasaki I,Sato Y

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVES:Hyperuricemia provokes endothelial dysfunction (ECD). Decreased endothelial nitric oxide synthase (eNOS) activity is an important source of ECD. Cationic amino acid transporter-1 (CAT-1) is the specific arginine transporter for eNOS. We hypothesize that hyperuricemia inhibits arginine uptake. METHODS:Experi...

journal_title：Journal of vascular research

authors： Schwartz IF,Grupper A,Chernichovski T,Grupper A,Hillel O,Engel A,Schwartz D

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND/AIMS:Endothelial colony-forming cells (ECFCs) have the potential to be used in regenerative medicine. Dysfunction of ECFCs is correlated with the onset of cardiovascular disorders, especially coronary artery disease (CAD). Binding of vascular endothelial growth factor A (VEGFA) to vascular endothelial growth...

journal_title：Journal of vascular research

authors： Su SH,Wu CH,Chiu YL,Chang SJ,Lo HH,Liao KH,Tsai CF,Tsai TN,Lin CH,Cheng SM,Cheng CC,Wang HW

更新日期：2017-01-01 00:00:00

abstract：:Therapies aimed at manipulating the microcirculation require the ability to control angiogenesis, defined as the sprouting of new capillaries from existing vessels. Blocking angiogenesis would be beneficial in many pathologies (e.g. cancer, retinopathies and rheumatoid arthritis). In others (e.g. myocardial infarction...

journal_title：Journal of vascular research

authors： Stapor PC,Sweat RS,Dashti DC,Betancourt AM,Murfee WL

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND/AIMS:Endothelial nitric oxide synthase (eNOS) is associated with caveolin-1 (Cav-1) in plasma membrane. We tested the hypothesis that eNOS activation by shear stress in resistance vessels depends on synchronized phosphorylation, dissociation from Cav-1 and translocation of the membrane-bound enzyme to Golgi ...

journal_title：Journal of vascular research

authors： Figueroa XF,González DR,Puebla M,Acevedo JP,Rojas-Libano D,Durán WN,Boric MP

更新日期：2013-01-01 00:00:00

abstract：:The release of cytokines and chemokines from activated immune-competent cells plays a crucial role in determining the pathology of the atherogenic progress. We investigated the effect of bacterial lipopolysaccharide (LPS) on cytokine/chemokine expression in carotid lesions and normal renal arteries. The lesions or ren...

journal_title：Journal of vascular research

authors： Jatta K,Wågsäter D,Norgren L,Stenberg B,Sirsjö A

更新日期：2005-05-01 00:00:00

abstract：UNLABELLED:Nitric oxide (NO) and cyclooxygenase (COX) derived prostaglandins (PGs) are involved in vascular homeostasis. Contradictory results have been obtained in previous studies on the putative 'cross-talk' between these two pathways. Our aim was to evaluate the interaction between NO and PG release in human microv...

journal_title：Journal of vascular research

authors： Vassalle C,Domenici C,Lubrano V,L'Abbate A

更新日期：2003-09-01 00:00:00

abstract：:The pathophysiology of Raynaud's phenomenon (RP) remains an enigma. Whatever theories proposed, the final event leading to the clinical symptoms is the occlusion of digital vessels. However, the possibility that the upstream large arterial vessels contribute to vasopasm has never been investigated. We used a high reso...

journal_title：Journal of vascular research

authors： Mourad JJ,Priollet P,Girerd X,Safar M,Lazareth I,Laurent S

更新日期：1997-07-01 00:00:00

abstract：:The purpose of this study was to determine the contribution of long-chain fatty acids relative to other mitochondrial substrates in active vascular smooth muscle (VSM). Hog carotid arteries were isometrically contracted in physiological saline solution containing 0.71 mM U-(13)C-oleic acid (bound to albumin at a ratio...

journal_title：Journal of vascular research

authors： Allen TJ,Hardin CD

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:Increased peripheral arterial resistances and decreased maximum vasodilation are characteristic features of chronic hypertension. However, little data are available in the literature regarding the possible alterations in the temporal patterns of vasodilatory responses elicited by various stimuli. DESIGN:This...

journal_title：Journal of vascular research

authors： Bertoldi D,Parzy E,Fromes Y,Wary C,Leroy-Willig A,Carlier PG

更新日期：2006-01-01 00:00:00

abstract：:Regulation of [Ca2+]i and modulation of the [Ca2+]i sensitivity of myosin phosphorylation in smooth muscles may involve phosphorylation of one or more proteins on tyrosine residues. We tested this hypothesis by measuring tyrosine phosphorylation of proteins extracted from swine carotid artery and separated by SDS gel ...

journal_title：Journal of vascular research

authors： Rembold CM,Weaver BA

更新日期：1997-01-01 00:00:00