Mechanism of VEGF-induced uterine venous hyperpermeability.

abstract：BACKGROUND AND AIMS:Vasomotion consists in cyclic oscillations of the arterial diameter induced by the synchronized activity of the smooth muscle cells. So far, contradictory results have emerged in the literature about the role of the endothelium in the onset and maintenance of vasomotion. Here our aim is to understan...

journal_title：Journal of vascular research

authors： Seppey D,Sauser R,Koenigsberger M,Bény JL,Meister JJ

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:A new method was evaluated where local changes in oxygen tension were induced in a tissue while being studied under a microscope in vivo. We tested whether hypoxic vasodilation and hyperoxic vasoconstriction in arterioles in striated muscle are being propagated upstream, and whether the endothelium and smoot...

journal_title：Journal of vascular research

authors： Riemann M,Rai A,Ngo AT,Dziegiel MH,Holstein-Rathlou NH,Torp-Pedersen C

更新日期：2011-01-01 00:00:00

abstract：:A radioligand binding assay and autoradiographic localisation of P2X-purinoceptors were carried out in several different blood vessels from rat, guinea-pig and rabbit by using [3H]alpha,beta-methylene ATP ([3H]alpha,beta-MeATP) as the radioligand. The radioligand binding assay on rabbit ear artery showed that the bind...

journal_title：Journal of vascular research

authors： Bo X,Burnstock G

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND/AIMS:Dysfunction of endothelial progenitor cell (EPCs) contributes to diabetic vascular disease. We reported that downregulated miR-126 in diabetic patients causes EPC dysfunction. The study was designed to investigate how high glucose (HG) and advanced glycation end products (AGEs) regulate miR-126 expressi...

journal_title：Journal of vascular research

authors： Li Y,Zhou Q,Pei C,Liu B,Li M,Fang L,Sun Y,Li Y,Meng S

更新日期：2016-01-01 00:00:00

abstract：AIMS:The effects of ischemia and hypercholesterolemia on the function and morphological adaptation of the rabbit hindlimb were assessed. METHODS:In rabbits on normal or cholesterol diet, experiments were performed on days 0-28 following bilateral femoral artery ligation. Calf blood pressure (C(BP)), exercise tolerance...

journal_title：Journal of vascular research

authors： Wafai R,Angus JA,Wright CE

更新日期：2008-01-01 00:00:00

abstract：AIMS:We investigated the role of superoxide O(2)(-) during the initiation of vascular endothelial growth factor (VEGF)- and placental growth factor (PlGF)-mediated signal transduction in bone marrow-derived endothelial cells. METHODS:BMhTERT cells were treated with VEGF or PlGF in the presence or absence of antioxidan...

journal_title：Journal of vascular research

authors： Dhar-Mascareno M,Mascareno E,Golde DW

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:Exercise elicits early adaptation of coronary vessels enabling the coronary circulation to respond adequately to higher flow demands. We hypothesized that short-term daily exercise induces biomechanical and functional remodeling of the coronary resistance arteries related to pressure. METHODS:Male rats were su...

journal_title：Journal of vascular research

authors： Szekeres M,Nádasy GL,Dörnyei G,Szénási A,Koller A

更新日期：2018-01-01 00:00:00

abstract：:Although most physiologically important processes are regulated through negative feedback loops and numerous factors regulating endothelial apoptosis are identified, little is known about negative feedback mechanisms for endothelial apoptosis. Here we describe the release of soluble anti-apoptotic activity by endothel...

journal_title：Journal of vascular research

authors： Bolitho C,Xu W,Zoellner H

更新日期：2008-01-01 00:00:00

abstract：:During the early stage of angiogenesis, neovascular sprouts are composed primarily of endothelial cells. As they mature, microvessels acquire a coating of mural cells, which are critical for the development and maintenance of a functional vasculature. Though growth factor regulation of mural cell recruitment has been ...

journal_title：Journal of vascular research

authors： Zhu WH,Han J,Nicosia RF

更新日期：2003-03-01 00:00:00

abstract：:Inflammation is a highly regulated process with common but also specific characteristics in each tissue affected. Recruitment of leukocytes from the blood to the injured tissue is an important early step in the inflammatory cascade. This review highlights the role of connexins (Cxs) in the regulation of both acute and...

journal_title：Journal of vascular research

authors： Scheckenbach KE,Crespin S,Kwak BR,Chanson M

更新日期：2011-01-01 00:00:00

abstract：:This study was designed to establish the in vitro pharmacological responses of rat middle cerebral arteries (MCA), and also their susceptibility to overnight cold storage at 4 degrees C. MCAs were harvested from rats and pharmacological responses were studied using a Mulvany myograph. Responses to prostaglandin F2 alp...

journal_title：Journal of vascular research

authors： Laing RJ,Jakubowski J,Morice AH

更新日期：1995-07-01 00:00:00

abstract：:Topical application of elastase to induce arterial aneurysm formation is an emerging murine model of vascular disease. In the context of aortic abdominal aneurysm (AAA), angiotensin II infusion and porcine pancreatic elastase perfusion models are commonly used today. This study, therefore, compares matrix remodeling, ...

journal_title：Journal of vascular research

authors： Busch A,Holm A,Wagner N,Ergün S,Rosenfeld M,Otto C,Baur J,Kellersmann R,Lorenz U

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND/AIMS:The present report examines a new pig model for progressive induction of high-grade stenosis, for the study of chronic myocardial ischemia and the dynamics of collateral vessel growth. METHODS:Thirty-nine Landrace pigs were instrumented with a novel experimental stent (GVD stent) in the left anterior d...

journal_title：Journal of vascular research

authors： Horstick G,Bierbach B,Abegunewardene N,Both S,Kuhn S,Manefeld D,Reinecke HJ,Vosseler M,Helisch A,Becker D,Lauterbach M,Kempski O,Lehr HA

更新日期：2009-01-01 00:00:00

abstract：:This study examines the ultrastructural features of diffuse intimal thickenings of human coronary arteries and correlates structural heterogeneity along the radial axis with the distribution and known actions of transforming growth factor beta 1 (TGF-beta 1). Morphometric and immunohistochemical data were collected fr...

journal_title：Journal of vascular research

authors： Merrilees MJ,Beaumont B

更新日期：1993-09-01 00:00:00

abstract：:Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) are cytoplasmic adaptor proteins of the TNF/interleukin (IL)-1/Toll-like receptor superfamily. Ligands of this family such as TNFα, CD40L, and IL-1β promote chronic inflammatory processes such as atherosclerosis and restenosis, the latter being a common a...

journal_title：Journal of vascular research

authors： Willecke F,Rupprecht B,Gissler MC,Pfeiffer K,Anto-Michel N,Stachon P,Wolf D,Hilgendorf I,Hoppe N,Bode C,Zirlik A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to evaluate different signaling pathways by which exercise training would interfere in endothelial function in obesity. Therefore, we examined adipocytokine levels and their receptors in the corpus cavernosum and femoral artery from trained rats on a high-fat diet. METHODS:F...

journal_title：Journal of vascular research

authors： Sponton AC,Silva FH,Araujo HN,Valgas da Silva CP,de Moraes C,Antunes E,Zanesco A,Delbin MA

更新日期：2017-01-01 00:00:00

abstract：AIMS:Percutaneous coronary intervention is routinely performed to treat occlusive coronary artery disease. Coronary perforation is a potential complication and can be treated with a stent graft. Current stent grafts are associated with high restenosis rates. We tested the safety and feasibility of biodegradable stent g...

journal_title：Journal of vascular research

authors： Taavitsainen J,Tarvainen S,Kuivanen A,Mangiardi EK,Guelcher M,Martin J,Mathur A,Hytönen JP,Ylä-Herttuala S

更新日期：2020-01-01 00:00:00

abstract：UNLABELLED:Diabetic patients have an increased risk of restenosis and late stent thrombosis after angioplasty, i.e. complications that are related to a defective re-endothelialization. Exendin-4, a stable glucagon-like peptide (GLP)-1 receptor agonist, has been suggested to influence the formation of intimal hyperplasi...

journal_title：Journal of vascular research

authors： Eriksson L,Saxelin R,Röhl S,Roy J,Caidahl K,Nyström T,Hedin U,Razuvaev A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Controversial reports on prolactin receptors (PRL-R), the long and short form, on endothelial cells (EC) may be explained by the choice of EC derived from the micro- and macrovascular bed of either endocrine and non-endocrine organs. METHODS:We studied here PRL-R expression in organs [bovine corpus luteum (...

journal_title：Journal of vascular research

authors： Ricken AM,Traenkner A,Merkwitz C,Hummitzsch K,Grosche J,Spanel-Borowski K

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:It has been reported that smoking is one of the strongest positive risk factors for abdominal aortic aneurysms (AAAs). Although many studies have been directed to decipher the effect of smoking on AAA, its effect on macrophage activation has not yet been explored. OBJECTIVES:We have reported the importance ...

journal_title：Journal of vascular research

authors： Igari K,Kelly MJ,Yamanouchi D

更新日期：2019-01-01 00:00:00

abstract：:The localization of dopamine receptor subtypes in the rabbit pulmonary circulation was investigated by using combined radioligand binding and light microscope autoradiography techniques. Dopamine D1-like receptors, probably belonging to the dopamine D1 receptor subtype, were demonstrated in sections of rabbit lung usi...

journal_title：Journal of vascular research

authors： Kobayashi Y,Ricci A,Amenta F,Cavallotti C,Hattori K

更新日期：1995-05-01 00:00:00

abstract：:It has been well established that wall shear stress is an important determinant of endothelial cell function and gene expression as well as of its structure. There is increasing evidence that low wall shear stress, as present in artery bifurcations opposite to the flow divider where atherosclerotic lesions preferentia...

journal_title：Journal of vascular research

authors： Reneman RS,Arts T,Hoeks AP

更新日期：2006-01-01 00:00:00

abstract：:Actions of the novel Ca2+ antagonist, Ro 40-5967, which displays unusual efficacy against endothelin (ET)-induced contractions, were studied in isolated vascular muscle cells (VMCs) using the fluorescent protein kinase C (PKC) indicator, BODIPY 12 alpha-phorbol ester 13 beta-acetate (PBA-BODIPY). High-sensitivity (pho...

journal_title：Journal of vascular research

authors： Hermsmeyer K,Miyagawa K

更新日期：1996-01-01 00:00:00

abstract：:This work compares the expression of adrenoceptors (ARs) and G-protein-coupled receptor kinase (GRK) 2 (RT-PCR and immunoblotting) and functional responses in conductance (aorta) and resistance vessels (mesenteric resistance arteries; MRA) in two different models of rat hypertension: hypertension induced by chronic tr...

journal_title：Journal of vascular research

authors： Oliver E,Flacco N,Arce C,Ivorra MD,D'Ocon MP,Noguera MA

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Increased peripheral arterial resistances and decreased maximum vasodilation are characteristic features of chronic hypertension. However, little data are available in the literature regarding the possible alterations in the temporal patterns of vasodilatory responses elicited by various stimuli. DESIGN:This...

journal_title：Journal of vascular research

authors： Bertoldi D,Parzy E,Fromes Y,Wary C,Leroy-Willig A,Carlier PG

更新日期：2006-01-01 00:00:00

abstract：:The assembly of the vessel wall from its cellular and extracellular matrix components is a critical process in the development and maturation of the cardiovascular system. However, fundamental questions concerning the origin of vessel wall cells and the mechanisms that regulate their development and differentiation re...

journal_title：Journal of vascular research

authors： Hungerford JE,Little CD

更新日期：1999-01-01 00:00:00

abstract：:Peripheral vascular resistance is increased in essential hypertension. This involves structural changes of resistance arteries and stiffening of the arterial wall, including remodeling of the extracellular matrix. We hypothesized that biopsies of the human parietal pericardium, obtained during coronary artery bypass g...

journal_title：Journal of vascular research

authors： Bloksgaard M,Leurgans TM,Nissen I,Jensen PS,Hansen ML,Brewer JR,Bagatolli LA,Marcussen N,Irmukhamedov A,Rasmussen LM,De Mey JG

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Low birth weight (LBW) is associated with increased risk of type 2 diabetes and cardiovascular disease. We studied endothelial function and insulin sensitivity in young men with LBW (n = 22) and controls (n = 22). METHODS:Insulin sensitivity and endothelial function was studied with venous occlusion plethys...

journal_title：Journal of vascular research

authors： Sonne MP,Højbjerre L,Alibegovic AC,Vaag A,Stallknecht B,Dela F

更新日期：2010-01-01 00:00:00

abstract：:Insulin was reported to decrease Na(+)/H(+) exchange activity in murine vascular smooth muscle (VSM) tissue. In most other cells, insulin increases activity. We tested the effects of insulin on Na(+)/H(+) exchange activity in primary cultured canine VSM cells. Intracellular pH (pH(i)) was measured with 2',7'-bis(2-car...

journal_title：Journal of vascular research

authors： Kahn AM,Yang M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Infusion of exogenous vascular endothelial growth factor (VEGF) into adult brain at doses above 60 ng/day induces dramatic angiogenesis accompanied by vascular leak and inflammation. Blood vessels formed by this treatment are dilated and tortuous, exhibiting a pathological morphology. Pathological VEGF-induc...

journal_title：Journal of vascular research

authors： Kasselman LJ,Kintner J,Sideris A,Pasnikowski E,Krellman JW,Shah S,Rudge JS,Yancopoulos GD,Wiegand SJ,Croll SD

更新日期：2007-01-01 00:00:00