Cigarette Smoke Extract Activates Tartrate-Resistant Acid Phosphatase-Positive Macrophage.

Abstract:

BACKGROUND:It has been reported that smoking is one of the strongest positive risk factors for abdominal aortic aneurysms (AAAs). Although many studies have been directed to decipher the effect of smoking on AAA, its effect on macrophage activation has not yet been explored. OBJECTIVES:We have reported the importance of osteoclastogenesis (OCG) in aneurysm formation. Therefore, we examined the effect of cigarette smoking on OCG and arterial aneurysmal formation by using cigarette smoke extract (CSE) in this study. METHODS:Macrophage cell lines were stimulated with CSE, and their activation and differentiation were examined in vitro. Since macrophages activated through the OCG pathway are identified by tartrate-resistant acid phosphatase (TRAP) expression, these cells are referred to as TRAP-positive macrophages (TPMs) in this study. We also applied CSE-contained PBS in the calcium chloride-induced mouse carotid aneurysm model in vivo. RESULTS:Macrophages stimulated with CSE expressed significantly higher levels of nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), TRAP, cathepsin K, matrix metalloproteinase-9 and membrane-type metalloproteinase (MT1-MMP). CSE-treated mouse aneurysms showed increased aneurysm size with increased TPM infiltration and protease expression compared to non-CSE-treated mouse aneurysms. CONCLUSIONS:These results suggest that CSE intensifies OCG in macrophages and promotes arterial aneurysmal progression.

journal_name

J Vasc Res

authors

Igari K,Kelly MJ,Yamanouchi D

doi

10.1159/000498893

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

139-151

issue

3

eissn

1018-1172

issn

1423-0135

pii

000498893

journal_volume

56

pub_type

杂志文章
  • Skin blood flow and its oscillatory components in patients with acute myocardial infarction.

    abstract:BACKGROUND/AIMS:Laser Doppler flowmetry (LDF) was used to determine the influence of acute myocardial infarction (AMI) and of successful reperfusion treatment on basal skin blood flow and its oscillatory components. METHODS:Skin LDF was performed on all extremities in 58 patients 4-9 days after AMI (Killip class I), a...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000110208

    authors: Azman-Juvan K,Bernjak A,Urbancic-Rovan V,Stefanovska A,Stajer D

    更新日期:2008-01-01 00:00:00

  • Stroke-prone SHR vascular muscle Ca2+ current amplitudes correlate with lethal increases in blood pressure.

    abstract::Studies on the possible causal relationship between the Ca2+ channel current density in the vascular muscle cell (VMC) and increases in blood pressure were extended by a comparison of stroke-prone spontaneously hypertensive rats (SP-SHR) with N/nih outbred normotensive rats. Maximal amplitudes of both L-type and T-typ...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000159064

    authors: Self DA,Bian K,Mishra SK,Hermsmeyer K

    更新日期:1994-11-01 00:00:00

  • Hyperglycemia and Advanced Glycation End Products Regulate miR-126 Expression in Endothelial Progenitor Cells.

    abstract:BACKGROUND/AIMS:Dysfunction of endothelial progenitor cell (EPCs) contributes to diabetic vascular disease. We reported that downregulated miR-126 in diabetic patients causes EPC dysfunction. The study was designed to investigate how high glucose (HG) and advanced glycation end products (AGEs) regulate miR-126 expressi...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000448713

    authors: Li Y,Zhou Q,Pei C,Liu B,Li M,Fang L,Sun Y,Li Y,Meng S

    更新日期:2016-01-01 00:00:00

  • Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway.

    abstract::We tested the hypothesis that oxidized low-density lipoprotein (oxLDL)-induced inactivation of Akt within endothelial progenitor cells (EPCs) is mediated at the level of phosphoinositide 3-kinase (PI3K), specifically by nitrosylation of the p85 subunit of PI3K, and that this action is critical in provoking oxLDL-induc...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000313879

    authors: Tie G,Yan J,Yang Y,Park BD,Messina JA,Raffai RL,Nowicki PT,Messina LM

    更新日期:2010-01-01 00:00:00

  • Human vascular reactivity and polymorphisms of the angiotensin-converting enzyme and the angiotensin type 1 receptor genes.

    abstract::The D allele of the insertion (I)/deletion (D) polymorphism in the angiotensin-converting enzyme (ACE) gene and the C allele of the A1166-C polymorphism in the angiotensin II type 1 receptor (AGT1R) gene have been associated with altered vascular structure and with an increased risk of myocardial infarction. The aim o...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000025687

    authors: Steeds RP,Toole LO,Channer KS,Morice AH

    更新日期:1999-11-01 00:00:00

  • Wall remodeling after wall shear rate normalization in rat mesenteric arterial collaterals.

    abstract::Previous studies have demonstrated endothelial and smooth muscle hyperplasia occur during arterial luminal expansion associated with elevation of arterial wall shear rates. The current study investigated whether remodeling induced by elevated wall shear would ultimately result in a vessel with intimal and medial cell ...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000025592

    authors: Fath SW,Burkhart HM,Miller SC,Dalsing MC,Unthank JL

    更新日期:1998-07-01 00:00:00

  • Pial microvascular responses to transient bilateral common carotid artery occlusion: effects of hypertonic glycerol.

    abstract:OBJECTIVE:The aim of the study was to assess the rat pial microvessel alterations due to transient bilateral common carotid artery occlusion (BCCAO) and to investigate the mechanism of 10% hypertonic glycerol neuroprotection. Our suggestion was that 10% glycerol solution infusion could dilate pial arterioles through ni...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000109818

    authors: Lapi D,Marchiafava PL,Colantuoni A

    更新日期:2008-01-01 00:00:00

  • Mechanism of VEGF-induced uterine venous hyperpermeability.

    abstract:BACKGROUND:Transfer of molecular signals from veins to adjacent arteries is an established mechanism of vascular communication in the uterine circulation, which ultimately depends on venous permeability. This study tests the hypotheses that: (1) uterine veins are permeable to intravenous solutes, using a 3-kDa dextran ...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000082976

    authors: Celia G,Osol G

    更新日期:2005-01-01 00:00:00

  • Changes of sequestered leukocytes and platelets by inhalation prostaglandin E(1) in the pulmonary microvasculature of rats with monocrotaline-induced pulmonary hypertension.

    abstract::The role of leukocytes (WBCs) and platelets (PLTs) in the pulmonary circulation may be important in the development of monocrotaline (MCT)-induced pulmonary hypertension in rats. We investigated the suppressive effects of long-term prostaglandin E(1) (PGE(1)) aerosol on the changes in WBCs and PLTs in the peripheral b...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000048996

    authors: Kato S,Kishiro I,Sugimura H,Machida S,Fuse D,Kaneko N

    更新日期:2002-01-01 00:00:00

  • Interaction between nitric oxide and cyclooxygenase pathways in endothelial cells.

    abstract:UNLABELLED:Nitric oxide (NO) and cyclooxygenase (COX) derived prostaglandins (PGs) are involved in vascular homeostasis. Contradictory results have been obtained in previous studies on the putative 'cross-talk' between these two pathways. Our aim was to evaluate the interaction between NO and PG release in human microv...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000074550

    authors: Vassalle C,Domenici C,Lubrano V,L'Abbate A

    更新日期:2003-09-01 00:00:00

  • Protein kinase C mechanism enhances vascular muscle relaxation by the Ca2+ antagonist, Ro 40-5967.

    abstract::Actions of the novel Ca2+ antagonist, Ro 40-5967, which displays unusual efficacy against endothelin (ET)-induced contractions, were studied in isolated vascular muscle cells (VMCs) using the fluorescent protein kinase C (PKC) indicator, BODIPY 12 alpha-phorbol ester 13 beta-acetate (PBA-BODIPY). High-sensitivity (pho...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000159134

    authors: Hermsmeyer K,Miyagawa K

    更新日期:1996-01-01 00:00:00

  • Requisite role of p38 MAPK in mural cell recruitment during angiogenesis in the rat aorta model.

    abstract::During the early stage of angiogenesis, neovascular sprouts are composed primarily of endothelial cells. As they mature, microvessels acquire a coating of mural cells, which are critical for the development and maintenance of a functional vasculature. Though growth factor regulation of mural cell recruitment has been ...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000070711

    authors: Zhu WH,Han J,Nicosia RF

    更新日期:2003-03-01 00:00:00

  • No role of ATP-sensitive potassium channels in the vasoconstriction produced by vasopressin.

    abstract::The contribution of ATP-sensitive potassium channel (KATP channel) blockade in the vasoconstriction produced by vasopressin was studied. All experiments were performed using rat thoracic aorta cut in 4-mm rings, denuded from their endothelium and mounted into 20-ml organ baths. Glibenclamide (0.01-10 microM), a KATP c...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000159088

    authors: Dumont E,Lamontagne D

    更新日期:1995-03-01 00:00:00

  • Calcium-release-activated calcium influx in endothelium.

    abstract::Signaling pathways activated by the tachykinin substance P (SP) were investigated in pig coronary artery endothelial cells (PCAECs). Single cells were obtained after enzymatic digestion of coronary arteries. Intracellular Ca2+ ([Ca2+]i) was measured from fura-2 fluorescence while membrane potential or ionic current wa...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000159222

    authors: Davis MJ,Sharma NR

    更新日期:1997-05-01 00:00:00

  • Changes in adrenoceptors and G-protein-coupled receptor kinase 2 in L-NAME-induced hypertension compared to spontaneous hypertension in rats.

    abstract::This work compares the expression of adrenoceptors (ARs) and G-protein-coupled receptor kinase (GRK) 2 (RT-PCR and immunoblotting) and functional responses in conductance (aorta) and resistance vessels (mesenteric resistance arteries; MRA) in two different models of rat hypertension: hypertension induced by chronic tr...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000360400

    authors: Oliver E,Flacco N,Arce C,Ivorra MD,D'Ocon MP,Noguera MA

    更新日期:2014-01-01 00:00:00

  • Aging-Induced Modulation of Pituitary Adenylate Cyclase-Activating Peptide- and Vasoactive Intestinal Peptide-Induced Vasomotor Responses in the Arteries of Mice.

    abstract::Pituitary adenylate cyclase-activating peptide (PACAP; 1-38 and 1-27) and vasoactive intestinal peptide (VIP) are related neuropeptides of the secretin/glucagon family. Overlapping signaling through G-protein-coupled receptors mediates their vasomotor activity. We previously showed that PACAP deficiency (PACAP-KO) shi...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000481781

    authors: Ivic I,Solymar M,Fulop BD,Hashimoto H,Toth G,Tamas A,Juhasz T,Koller A,Reglodi D

    更新日期:2017-01-01 00:00:00

  • Pericyte dynamics during angiogenesis: new insights from new identities.

    abstract::Therapies aimed at manipulating the microcirculation require the ability to control angiogenesis, defined as the sprouting of new capillaries from existing vessels. Blocking angiogenesis would be beneficial in many pathologies (e.g. cancer, retinopathies and rheumatoid arthritis). In others (e.g. myocardial infarction...

    journal_title:Journal of vascular research

    pub_type: 杂志文章,评审

    doi:10.1159/000362276

    authors: Stapor PC,Sweat RS,Dashti DC,Betancourt AM,Murfee WL

    更新日期:2014-01-01 00:00:00

  • Inhibition of vascular smooth muscle cell migration by intact endothelium is nitric oxide-mediated: interference by oxidised low density lipoproteins.

    abstract::Migration of vascular smooth muscle cells (SMCs) leading to neointimal hyperplasia is an early and cardinal feature of atherogenesis. Migration of rat aortic SMCs from an upper chamber towards a lower one has been studied in a microchemotaxis (Boyden) chamber. Spontaneous migration of SMCs was practically prevented by...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000025580

    authors: Gorog P,Kovacs IB

    更新日期:1998-05-01 00:00:00

  • Chemokine receptors and their role in vascular biology.

    abstract::Chemokines play an important role in the process of leukocyte recruitment and activation at sites of inflammation. Until recently, the actions of chemokines and the expression of their receptors have only been described on different leukocyte populations. However, increasing evidence has suggested that non-haematopoie...

    journal_title:Journal of vascular research

    pub_type: 杂志文章,评审

    doi:10.1159/000025707

    authors: Murdoch C,Finn A

    更新日期:2000-01-01 00:00:00

  • Visualization of activated platelets by targeted magnetic resonance imaging utilizing conformation-specific antibodies against glycoprotein IIb/IIIa.

    abstract::Ruptured atherosclerotic plaques, lined with activated platelets, constitute an attractive target for magnetic resonance imaging (MRI). This study evaluated whether microparticles of iron oxide (MPIO) targeting ligand-induced binding sites (LIBS) on the activated conformation of glycoprotein IIb/IIIa could be used to ...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000135660

    authors: von zur Muhlen C,Peter K,Ali ZA,Schneider JE,McAteer MA,Neubauer S,Channon KM,Bode C,Choudhury RP

    更新日期:2009-01-01 00:00:00

  • Remodeling of Wall Mechanics and the Myogenic Mechanism of Rat Intramural Coronary Arterioles in Response to a Short-Term Daily Exercise Program: Role of Endothelial Factors.

    abstract:PURPOSE:Exercise elicits early adaptation of coronary vessels enabling the coronary circulation to respond adequately to higher flow demands. We hypothesized that short-term daily exercise induces biomechanical and functional remodeling of the coronary resistance arteries related to pressure. METHODS:Male rats were su...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000486571

    authors: Szekeres M,Nádasy GL,Dörnyei G,Szénási A,Koller A

    更新日期:2018-01-01 00:00:00

  • The Effects of a Simulated Workday of Prolonged Sitting on Seated versus Supine Blood Pressure and Pulse Wave Velocity in Adults with Overweight/Obesity and Elevated Blood Pressure.

    abstract::We evaluated the effects of a simulated workday of prolonged sitting on blood pressure (BP) and pulse wave velocity (PWV) and examined whether posture (seated vs. supine) affected responses. Participants (n = 25) were adults, with overweight/obesity and elevated BP, and performed seated desk work for 7.5 h. BP and PWV...

    journal_title:Journal of vascular research

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000510294

    authors: Alansare AB,Kowalsky RJ,Jones MA,Perdomo SJ,Stoner L,Gibbs BB

    更新日期:2020-01-01 00:00:00

  • Epigallocatechin-3-Gallate Ameliorates Angiotensin II-Induced Oxidative Stress and Apoptosis in Human Umbilical Vein Endothelial Cells through the Activation of Nrf2/Caspase-3 Signaling.

    abstract:INTRODUCTION:This study aimed to investigate whether epigallocatechin-3-gallate (EGCG) shows antioxidant activity against angiotensin II (Ang II)-induced human umbilical vein endothelial cell (HUVEC) apoptosis. MATERIALS AND METHODS:The viability of HUVECs was revealed by MTT and LDH assay. The cell apoptosis was dete...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000479873

    authors: Zhou X,Liang L,Zhao Y,Zhang H

    更新日期:2017-01-01 00:00:00

  • Regulation of arachidonic acid release by calcium influx in human endothelial cells.

    abstract::In response to stimuli, endothelial cells release arachidonic acid, a lipid precursor of various vasoactive substances. We have investigated the relationships between cytosolic Ca2+ movements and arachidonic acid release in human umbilical vein endothelial cells. Histamine, a receptor-dependent agonist, and thapsigarg...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000025647

    authors: Millanvoye-Van Brussel E,David-Dufilho M,Pham TD,Iouzalen L,Aude Devynck M

    更新日期:1999-05-01 00:00:00

  • The wall to lumen ratio of the radial artery in patients with Raynaud's phenomenon.

    abstract::The pathophysiology of Raynaud's phenomenon (RP) remains an enigma. Whatever theories proposed, the final event leading to the clinical symptoms is the occlusion of digital vessels. However, the possibility that the upstream large arterial vessels contribute to vasopasm has never been investigated. We used a high reso...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000159237

    authors: Mourad JJ,Priollet P,Girerd X,Safar M,Lazareth I,Laurent S

    更新日期:1997-07-01 00:00:00

  • Lipoxin A4 mediates aortic contraction via RHOA/RHO kinase, endothelial dysfunction and reactive oxygen species.

    abstract:BACKGROUND:Lipoxin A4 (LXA4) is a biologically active product generated from arachidonic acid by lipoxygenase action. The production of lipoxins is enhanced by aspirin through acetylation of cyclooxygenase-2, via a mechanism known as 'aspirin-triggered lipoxin'. LXA4 has both anti-inflammatory and proinflammatory actio...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000371490

    authors: Wenceslau CF,McCarthy CG,Szasz T,Webb RC

    更新日期:2014-01-01 00:00:00

  • The short prolactin receptor predominates in endothelial cells of micro- and macrovascular origin.

    abstract:BACKGROUND:Controversial reports on prolactin receptors (PRL-R), the long and short form, on endothelial cells (EC) may be explained by the choice of EC derived from the micro- and macrovascular bed of either endocrine and non-endocrine organs. METHODS:We studied here PRL-R expression in organs [bovine corpus luteum (...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000097892

    authors: Ricken AM,Traenkner A,Merkwitz C,Hummitzsch K,Grosche J,Spanel-Borowski K

    更新日期:2007-01-01 00:00:00

  • An in vitro study of the pharmacological responses of rat middle cerebral artery: effects of overnight storage.

    abstract::This study was designed to establish the in vitro pharmacological responses of rat middle cerebral arteries (MCA), and also their susceptibility to overnight cold storage at 4 degrees C. MCAs were harvested from rats and pharmacological responses were studied using a Mulvany myograph. Responses to prostaglandin F2 alp...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000159097

    authors: Laing RJ,Jakubowski J,Morice AH

    更新日期:1995-07-01 00:00:00

  • Critical single proximal left arterial descending coronary artery stenosis to mimic chronic myocardial ischemia: a new model induced by minimal invasive technology.

    abstract:BACKGROUND/AIMS:The present report examines a new pig model for progressive induction of high-grade stenosis, for the study of chronic myocardial ischemia and the dynamics of collateral vessel growth. METHODS:Thirty-nine Landrace pigs were instrumented with a novel experimental stent (GVD stent) in the left anterior d...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000181545

    authors: Horstick G,Bierbach B,Abegunewardene N,Both S,Kuhn S,Manefeld D,Reinecke HJ,Vosseler M,Helisch A,Becker D,Lauterbach M,Kempski O,Lehr HA

    更新日期:2009-01-01 00:00:00

  • Actions of platelet-activating factor on isolated rabbit basilar artery: modulation by activated polymorphonuclear leukocytes.

    abstract::In segments of rabbit basilar artery (BA) platelet-activating factor (PAF) initiated a concentration-dependent transitory contraction which was unaffected by indomethacin or nordihydroguaiaretic acid (NDGA). N omega-nitro-L-arginine (NLA) did not change the magnitude of PAF-induced contraction, but in the presence of ...

    journal_title:Journal of vascular research

    pub_type: 杂志文章

    doi:10.1159/000159077

    authors: Akopov SE,Sercombe R,Seylaz J

    更新日期:1995-01-01 00:00:00