Abstract：
AIMS:The effects of ischemia and hypercholesterolemia on the function and morphological adaptation of the rabbit hindlimb were assessed. METHODS:In rabbits on normal or cholesterol diet, experiments were performed on days 0-28 following bilateral femoral artery ligation. Calf blood pressure (C(BP)), exercise tolerance, flow reserve, agonist vasodilatation, angiography and capillary density were examined and modeled. RESULTS:C(BP) decreased markedly post-ligation and returned to 41 and 68% of baseline by days 7 and 28. Exercise tolerance was attenuated 40% and flow reserve 50-60% on day 7, with recovery by day 28. Ligation caused decreases in 5-hydroxytryptamine-induced dilatation, while adenosine and acetylcholine responses were unaffected. Hypercholesterolemia attenuated acetylcholine-elicited dilatation. There was marked loss of adenosine dilatation on days 7-14 in the ligation plus hypercholesterolemia group. Ligation caused a doubling in the number of medium-sized collateral arteries. Hypercholesterolemia, either alone or combined with ligation, greatly augmented small vessel density. Capillary density was unaltered by any treatment. CONCLUSIONS:The rabbit hindlimb shows a remarkable ability to recover its muscle function through vascular adaptation and remodeling 4 weeks following ligation, with or without hypercholesterolemia. Exercise tolerance, flow reserve and vascular reactivity were mainly restored 28 days post-ligation.
journal_name
J Vasc Resjournal_title
Journal of vascular researchauthors
Wafai R,Angus JA,Wright CEdoi
10.1159/000113600subject
Has Abstractpub_date
2008-01-01 00:00:00pages
279-94issue
4eissn
1018-1172issn
1423-0135pii
000113600journal_volume
45pub_type
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journal_title：Journal of vascular research
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更新日期：1998-03-01 00:00:00
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journal_title：Journal of vascular research
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更新日期：1998-05-01 00:00:00
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journal_title：Journal of vascular research
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更新日期：1993-05-01 00:00:00
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更新日期：2007-01-01 00:00:00
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更新日期：2017-01-01 00:00:00
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