Abstract：
:Conduit arteries of hypertensive rats are thicker and stiffer than those of normotensive controls. The possible role played by collagen type I and II subtypes in the mechanism of arterial stiffness remains unknown. The carotid and aortic arterial wall of rats of Japanese (Wistar-Kyoto and spontaneously hypertensive rats) and Lyon (normotensive and hypertensive rats) origin were studied. The stiffness of the carotid wall material (ultrasound), the histomorphometry of the aortic wall with the content in collagen I and III subtypes and their corresponding mRNA were analyzed. Independently of hypertension, the Japanese group differed from the Lyon group by a stiffer carotid wall material at any given value of wall stress; a lesser degree of aortic hypertrophy with a higher percentage of elastin, and a higher density of collagen III but not of collagen I. All other hemodynamic and histomorphometric parameters were affected by both the origin of the rats (Japanese vs. Lyon) and the presence of hypertension. Large artery stiffness in genetically hypertensive rats was not only influenced by hypertension itself, but also by differences in the contents of collagen subtypes which are also found in their corresponding normotensive controls.
journal_name
J Vasc Resjournal_title
Journal of vascular researchauthors
Chamiot Clerc P,Renaud JF,Blacher J,Legrand M,Samuel JL,Levy BI,Sassard J,Safar MEdoi
10.1159/000025637keywords:
subject
Has Abstractpub_date
1999-03-01 00:00:00pages
139-46issue
2eissn
1018-1172issn
1423-0135pii
25637journal_volume
36pub_type
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