Abstract:
:Proper development of the vascular system as one of the earliest and most critical steps during vertebrate embryogenesis is ensured by the exact spatial and temporal control of gene expression in cells forming the vessel network. Whereas the regulation of vascular system development is well elucidated on the level of ligand-receptor signaling, the processes on the transcriptional level are much less understood. As the signaling mechanisms in embryogenesis and pathological conditions are similar, the study of embryonic blood vessel development is of great interest for the treatment of cardiovascular diseases and cancer. This review discusses two transcription factors, HOXA9 and VEZF1, which are relevant for endothelial biology but are excluded in the bulk of transcription factor references discussing endothelial biology. To our knowledge, there is no comprehensive overview of these two transcription factors available to date. Here, we summarize the current knowledge of human HOXA9 and VEZF1 biology and function, we detail their target genes and roles in endothelial biology and propose that HOXA9 and VEZF1 also deserve consideration as relevant transcriptional regulators of endothelial biology. Due to their broad role in multiple aspects of endothelial biology, they might potentially become interesting targets for therapeutic manipulation of pathological blood vessel growth.
journal_name
J Vasc Resjournal_title
Journal of vascular researchauthors
Bruderer M,Alini M,Stoddart MJdoi
10.1159/000353287subject
Has Abstractpub_date
2013-01-01 00:00:00pages
265-78issue
4eissn
1018-1172issn
1423-0135pii
000353287journal_volume
50pub_type
杂志文章,评审abstract:BACKGROUND:Extracellular matrix deposition is the main factor inducing stenotic lesions in arterial grafts. Lysyl oxidases (LOX) play a key role in stabilizing collagen and elastin. OBJECTIVE:To examine the repair response to arterial allografts in terms of LOX expression and collagen/elastin deposition using LOX inhi...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000317399
更新日期:2011-01-01 00:00:00
abstract::Studies on the possible causal relationship between the Ca2+ channel current density in the vascular muscle cell (VMC) and increases in blood pressure were extended by a comparison of stroke-prone spontaneously hypertensive rats (SP-SHR) with N/nih outbred normotensive rats. Maximal amplitudes of both L-type and T-typ...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000159064
更新日期:1994-11-01 00:00:00
abstract::The circadian clock is rhythmically expressed in blood vessels, but the interaction between the circadian clock and disturbed blood flow remains unclear. We examined the relationships between BMAL1 and CLOCK and 2 regulators of endothelial function, AKT1 and endothelial nitric oxide synthase (eNOS), in vascular region...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000452410
更新日期:2016-01-01 00:00:00
abstract:UNLABELLED:Diabetic patients have an increased risk of restenosis and late stent thrombosis after angioplasty, i.e. complications that are related to a defective re-endothelialization. Exendin-4, a stable glucagon-like peptide (GLP)-1 receptor agonist, has been suggested to influence the formation of intimal hyperplasi...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000381097
更新日期:2015-01-01 00:00:00
abstract::Dietary flavonoids are thought to protect against cardiovascular disease. We have studied the effects of bioactive isoflavone metabolites on hyperlipidemia, endothelial dysfunction and the development of atherosclerotic lesions in apolipoprotein E-deficient (apoE(0)) mice fed a Western high-fat diet. Supplementation w...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000071891
更新日期:2003-05-01 00:00:00
abstract::The contribution of ATP-sensitive potassium channel (KATP channel) blockade in the vasoconstriction produced by vasopressin was studied. All experiments were performed using rat thoracic aorta cut in 4-mm rings, denuded from their endothelium and mounted into 20-ml organ baths. Glibenclamide (0.01-10 microM), a KATP c...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000159088
更新日期:1995-03-01 00:00:00
abstract:INTRODUCTION:This study aimed to investigate whether epigallocatechin-3-gallate (EGCG) shows antioxidant activity against angiotensin II (Ang II)-induced human umbilical vein endothelial cell (HUVEC) apoptosis. MATERIALS AND METHODS:The viability of HUVECs was revealed by MTT and LDH assay. The cell apoptosis was dete...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000479873
更新日期:2017-01-01 00:00:00
abstract::This study was designed to establish the in vitro pharmacological responses of rat middle cerebral arteries (MCA), and also their susceptibility to overnight cold storage at 4 degrees C. MCAs were harvested from rats and pharmacological responses were studied using a Mulvany myograph. Responses to prostaglandin F2 alp...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000159097
更新日期:1995-07-01 00:00:00
abstract::Previous studies have demonstrated endothelial and smooth muscle hyperplasia occur during arterial luminal expansion associated with elevation of arterial wall shear rates. The current study investigated whether remodeling induced by elevated wall shear would ultimately result in a vessel with intimal and medial cell ...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000025592
更新日期:1998-07-01 00:00:00
abstract::Previous studies demonstrated that maintenance of steady-state myogenic tone requires Ca(2+)-dependent myosin phosphorylation. The present studies furthered these observations by examining temporal relationships among Ca(2+), myosin phosphorylation and vessel diameter during acute increases in intraluminal pressure an...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000054089
更新日期:2000-11-01 00:00:00
abstract::Thrombospondin-1 (TSP1) is a potent natural inhibitor of angiogenesis. Although TSP1 has been reported to induce endothelial cell apoptosis in vitro and to downregulate neovascularization in vivo, the molecular mechanisms that link these two processes have yet to be established. Here we report that TSP1 mediates endot...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000025733
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Transfer of molecular signals from veins to adjacent arteries is an established mechanism of vascular communication in the uterine circulation, which ultimately depends on venous permeability. This study tests the hypotheses that: (1) uterine veins are permeable to intravenous solutes, using a 3-kDa dextran ...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000082976
更新日期:2005-01-01 00:00:00
abstract::Chemokines play an important role in the process of leukocyte recruitment and activation at sites of inflammation. Until recently, the actions of chemokines and the expression of their receptors have only been described on different leukocyte populations. However, increasing evidence has suggested that non-haematopoie...
journal_title:Journal of vascular research
pub_type: 杂志文章,评审
doi:10.1159/000025707
更新日期:2000-01-01 00:00:00
abstract:AIMS:Percutaneous coronary intervention is routinely performed to treat occlusive coronary artery disease. Coronary perforation is a potential complication and can be treated with a stent graft. Current stent grafts are associated with high restenosis rates. We tested the safety and feasibility of biodegradable stent g...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000505454
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND/AIMS:Endoplasmic reticulum (ER) stress has emerged as a potential mechanism contributing to diabetes and its comorbidities. However, the importance of ER stress in diabetic vascular dysfunction is unclear. The purpose of this study was to examine the effects of the ER stress inhibitor, tauroursodeoxycholic a...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000479967
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:It is well known that inflammation plays key roles in the development of atherosclerosis and that the transplantation of bone marrow mononuclear cells (BMMNCs) can suppress inflammation in rodent models of ischemic diseases. Here, we explored whether transplantation of autologous BMMNCs could prevent the prog...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000449201
更新日期:2016-01-01 00:00:00
abstract::The proliferation of vascular smooth muscle cells (VSMC) plays a significant part in both the developing atherosclerotic lesion and in restenosis. Heparin has been widely reported to inhibit the growth of VSMC in culture and intimal VSMC in some animal models of vascular hyperplasia. Clinical trials with heparin, howe...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000025616
更新日期:1998-11-01 00:00:00
abstract::In segments of rabbit basilar artery (BA) platelet-activating factor (PAF) initiated a concentration-dependent transitory contraction which was unaffected by indomethacin or nordihydroguaiaretic acid (NDGA). N omega-nitro-L-arginine (NLA) did not change the magnitude of PAF-induced contraction, but in the presence of ...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000159077
更新日期:1995-01-01 00:00:00
abstract::It has been well established that wall shear stress is an important determinant of endothelial cell function and gene expression as well as of its structure. There is increasing evidence that low wall shear stress, as present in artery bifurcations opposite to the flow divider where atherosclerotic lesions preferentia...
journal_title:Journal of vascular research
pub_type: 杂志文章,评审
doi:10.1159/000091648
更新日期:2006-01-01 00:00:00
abstract::During the early stage of angiogenesis, neovascular sprouts are composed primarily of endothelial cells. As they mature, microvessels acquire a coating of mural cells, which are critical for the development and maintenance of a functional vasculature. Though growth factor regulation of mural cell recruitment has been ...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000070711
更新日期:2003-03-01 00:00:00
abstract::The purpose of the present study was to develop a rapid, reproducible method of nonviral gene transfer to the intact vasculature. Male Sprague-Dawley rats were anesthetized, a midline abdominal incision was made and segmental branches of the superior mesenteric artery were dissected free of surrounding mesentery. A sp...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000025753
更新日期:2000-09-01 00:00:00
abstract:UNLABELLED:Nitric oxide (NO) and cyclooxygenase (COX) derived prostaglandins (PGs) are involved in vascular homeostasis. Contradictory results have been obtained in previous studies on the putative 'cross-talk' between these two pathways. Our aim was to evaluate the interaction between NO and PG release in human microv...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000074550
更新日期:2003-09-01 00:00:00
abstract::Protein localization in endothelial cells is tightly regulated to create distinct signaling domains within their tight spatial restrictions including luminal membranes, abluminal membranes, and interendothelial junctions, as well as caveolae and calcium signaling domains. Protein localization in endothelial cells is a...
journal_title:Journal of vascular research
pub_type: 杂志文章,评审
doi:10.1159/000512618
更新日期:2021-01-27 00:00:00
abstract:OBJECTIVES:Hyperuricemia provokes endothelial dysfunction (ECD). Decreased endothelial nitric oxide synthase (eNOS) activity is an important source of ECD. Cationic amino acid transporter-1 (CAT-1) is the specific arginine transporter for eNOS. We hypothesize that hyperuricemia inhibits arginine uptake. METHODS:Experi...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000320356
更新日期:2011-01-01 00:00:00
abstract::A radioligand binding assay and autoradiographic localisation of P2X-purinoceptors were carried out in several different blood vessels from rat, guinea-pig and rabbit by using [3H]alpha,beta-methylene ATP ([3H]alpha,beta-MeATP) as the radioligand. The radioligand binding assay on rabbit ear artery showed that the bind...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000158980
更新日期:1993-03-01 00:00:00
abstract::Neointima formation participates in the pathophysiology of atherosclerosis and restenosis. Proliferation and migration of vascular smooth muscle cells (VSMC) are initial responses to vascular injury. The aim of the present study was to assess the effect of gliotoxin, an inhibitor of nuclear factor (NF)-kappaB, on migr...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000176043
更新日期:2009-01-01 00:00:00
abstract::Regulation of [Ca2+]i and modulation of the [Ca2+]i sensitivity of myosin phosphorylation in smooth muscles may involve phosphorylation of one or more proteins on tyrosine residues. We tested this hypothesis by measuring tyrosine phosphorylation of proteins extracted from swine carotid artery and separated by SDS gel ...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000159196
更新日期:1997-01-01 00:00:00
abstract::Most virus-infected cells release interferon-beta (IFN-beta) as a powerful inducer of antiviral defense. Endothelial cells tightly regulate local immune cell recruitment by expression of adhesion molecules and chemokines. Here, we studied the transcriptional regulation of IFN-beta-induced chemokine expression in prima...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000097977
更新日期:2007-01-01 00:00:00
abstract::Conduit arteries of hypertensive rats are thicker and stiffer than those of normotensive controls. The possible role played by collagen type I and II subtypes in the mechanism of arterial stiffness remains unknown. The carotid and aortic arterial wall of rats of Japanese (Wistar-Kyoto and spontaneously hypertensive ra...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000025637
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVES:Extracellular nucleotide release at the site of arterial injury mediates the proliferation and migration of vascular smooth muscle cells. Our aim was to investigate the role of the P2Y2 nucleotide receptor (P2Y2R) in neointimal hyperplasia. Approach and Results: Vascular injury was induced by the implantatio...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000449059
更新日期:2016-01-01 00:00:00