Collagenase synthesis of rheumatoid arthritis synoviocytes: dose-dependent stimulation by substance P and capsaicin.

Abstract:

:The synthesis and release of collagenase in the presence of the neuropeptide substance P (SP) and capsaicin, were investigated in vitro using identical synoviocyte cultures from patients with rheumatoid arthritis (RA). On average 10(-12) M SP augmented statistically significantly the collagenase production by approximately a factor of five. An increase in the concentrations up to 10(-6) M SP resulted in a decreased collagenase synthesis, which, however, was still above the level of that of the untreated synoviocytes. Capsaicin, a homovanillic acid derivative that acts as a releaser of SP from primary afferent neurons, caused a strong stimulation of collagenase production and release at 10(-8) and 10(-6) M (about 7 times the amount of the control). With increasing concentrations up to 10(-3) M capsaicin this effect diminished continuously. The experiments clearly show that in RA synoviocytes in vitro SP and capsaicin in low concentrations act as potent inducers of the synthesis and release of collagenase.

journal_name

Scand J Rheumatol

authors

Partsch G,Matucci-Cerinic M,Marabini S,Jantsch S,Pignone A,Cagnoni M

doi

10.3109/03009749109165283

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

98-103

issue

2

eissn

0300-9742

issn

1502-7732

journal_volume

20

pub_type

杂志文章
  • Gammalinolenic acid treatment of fatigue associated with primary Sjögren's syndrome.

    abstract:OBJECTIVE:To evaluate the efficacy of the essential omega-6 fatty acid Gammalinolenic acid (GLA) on fatigue associated with primary Sjögren's syndrome. METHODS:Ninety patients with primary Sjögren's syndrome (with or without signs of autoimmunity) entered a 6-month double blind placebo-controlled randomised trial with...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1080/03009740252937577

    authors: Theander E,Horrobin DF,Jacobsson LT,Manthorpe R

    更新日期:2002-01-01 00:00:00

  • Osmium deposits detected by x-ray after synoviorthesis of the knee.

    abstract::A study of 113 knees of 72 patients treated with intra-articular injection of osmic acid for chronic exudative synovitis caused by various rheumatic diseases is reported. Certain cases presented abnormal radiological opacities, statistically more frequent after the injection of 200 mg than after 100 mg of osmic acid (...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:

    authors: Boussina I,Lagier R,Ott H,Fallet GH

    更新日期:1976-01-01 00:00:00

  • The distribution of YKL-40 in osteoarthritic and normal human articular cartilage.

    abstract::YKL-40, also called human cartilage glycoprotein-39, is a major secretory protein of human chondrocytes in cell culture. YKL-40 mRNA is expressed by cartilage from patients with rheumatoid arthritis, but is not detectable in normal human cartilage. The aim was to investigate the distribution of YKL-40 in osteoarthriti...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009749950154257

    authors: Volck B,Ostergaard K,Johansen JS,Garbarsch C,Price PA

    更新日期:1999-01-01 00:00:00

  • Xerostomia due to Sjögren's syndrome. Diagnostic criteria, treatment and outlines for a continuous dental care programme and an open trial with Sulfarlem.

    abstract::The initial evaluation of 25 patients suspected of suffering from Sjögren's syndrome (SS) disclosed that sialopenia and glandular atrophy without focal sialo-adenitis was the second most common cause, after SS itself, of patient complaints. This emphasizes the importance of conclusive diagnostic criteria to prevent ov...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章

    doi:10.3109/03009748809098766

    authors: Malmström MJ,Segerberg-Konttinen M,Tuominen TS,Hietanen JH,Wolf JE,Sane JI,Konttinen YT

    更新日期:1988-01-01 00:00:00

  • A five day course of high dose corticosteroids has no effect on the clearance of soluble aggregates of human immunoglobulin G in healthy volunteers.

    abstract::It is thought that glucocorticosteroids impair the clearance of immune complexes by the mononuclear phagocyte system (MPS). We studied the effect of a five day course of prednisone (1 mg/kg body weight per day) on MPS function in 10 healthy volunteers, using soluble radiolabeled aggregates of human immunoglobulin G as...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749209095084

    authors: Halma C,Daha MR,Evers-Schouten JH,Pauwels EK,van Es LA

    更新日期:1992-01-01 00:00:00

  • Pain and pain problems among subjects with systemic lupus erythematosus in Iceland.

    abstract::This population study includes the majority of all systemic lupus erythematosus (SLE) patients in Iceland (n = 65). The study lists various self-rated pain descriptions both from a 54-item pain questionnaire and from the somatisation section of the Diagnostic Interview Schedule (DIS). Results show SLE patients to have...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749309095104

    authors: Líndal E,Thorlacius S,Stefánsson JG,Steinsson K

    更新日期:1993-01-01 00:00:00

  • Association between the HLA-DRB1 gene and clinical features of systemic sclerosis in Korea.

    abstract:OBJECTIVE:To determine whether HLA-DR alleles are associated with the development and clinical features of systemic sclerosis (SSc) in Koreans. METHODS:Seventy-nine patients (74 women and five men; 45 diffuse types and 34 limited types; mean age at diagnosis 43.9 years) fulfilling the American College of Rheumatology ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009740510026751

    authors: Joung CI,Jun JB,Chung WT,Song GG,Choe JY,Chang HK,Yoo DH

    更新日期:2006-01-01 00:00:00

  • Clinical effectiveness and cost-effectiveness of foot orthoses for people with established rheumatoid arthritis: an exploratory clinical trial.

    abstract:OBJECTIVES:Foot orthoses are commonly prescribed as an intervention for people with rheumatoid arthritis (RA). Data relating to the cost-effectiveness of foot orthoses in people with RA are limited. The aim was to evaluate the clinical and cost-effectiveness of two types of foot orthoses in people with established RA. ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/03009742.2016.1196500

    authors: Rome K,Clark H,Gray J,McMeekin P,Plant M,Dixon J

    更新日期:2017-05-01 00:00:00

  • Involvement of the lateral atlanto-axial joints as first and late symptom of rheumatoid arthritis.

    abstract::Thirty cases of unilateral or bilateral atlanto-axial arthritis are described. They were found among 606 RA patients. According to the degree of involvement, the 30 cases were divided into four groups: A. 16 cases. B. 5 cases. C. 7 cases. D. 2 cases. In two patients the atlanto-axial arthritis was the primary lesion. ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009747009165372

    authors: Kerckhove HV

    更新日期:1987-01-01 00:00:00

  • Major salivary gland sonography in Sjögren's syndrome: diagnostic value of a novel ultrasonography score (0-12) for parenchymal inhomogeneity.

    abstract:OBJECTIVE:To validate ultrasonographic criteria for examination of the major salivary glands in the diagnosis of primary Sjögren's syndrome (SS). METHOD:A total of 209 consecutive patients with rheumatic diseases were selected according to the American-European Consensus Group (AECG) classification criteria for SS. On...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009740903270623

    authors: Milic VD,Petrovic RR,Boricic IV,Radunovic GL,Pejnovic NN,Soldatovic I,Damjanov NS

    更新日期:2010-03-01 00:00:00

  • Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in Korean patients with adult-onset Still's disease.

    abstract:OBJECTIVE:Interleukin-1 (IL-1) has been implicated in the pathogenesis of several rheumatic inflammatory diseases, including adult-onset Still's disease (AOSD) and systemic-onset juvenile idiopathic arthritis (SoJIA). Several clinical trials also suggest that anakinra, a human recombinant interleukin-1 receptor antagon...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009740701340081

    authors: Youm JY,Woo JH,Kim TH,Bae SC,Yoo DH

    更新日期:2007-09-01 00:00:00

  • Early rheumatoid arthritis in the USSR and in Finland.

    abstract::In 1974-76 patients with early rheumatoid arthritis (duration less than or equal to 6 months) were investigated at the Institute for Rheumatism, Moscow, and at the Rheumatism Foundation Hospital, Heinola, Finland. Of 200 patients in each centre, 142 sex- and age-matched patients were chosen and followed up for one yea...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:

    authors: Martio J,Kiviniemi P,von Essen R,Isomäki H,Akimova T,Ievleva L,Trofimova T,Mylov N

    更新日期:1980-01-01 00:00:00

  • Intra-articular glucocorticoid treatment of the rheumatoid wrist. An ultrasonographic study.

    abstract::Fifty consecutive patients with RA and clinical wrist synovitis were randomly allocated to either receive an injection of glucocorticoid into the radiocarpal joint or have the same amount of drug divided into the radiocarpal and midcarpal joints. Inferior radioulnar joint synovitis was treated with extra steroid injec...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章

    doi:10.1080/030097401753180336

    authors: Koski JM,Hermunen H

    更新日期:2001-01-01 00:00:00

  • Comparison of serum salicylate levels and gastro-intestinal blood loss between salsalate (Disalcid)and other forms of salicylates.

    abstract::In a first stage the effect of a single dose of 3 g of salsalate on serum salicylate level was compared with a single intake of 3 g of soluble or enteric-coated acetylsalicylates in 12 healthy subjects. Salsalate seems to resorb faster than the enteric-coated forms but more slowly than the soluble forms of acetylsalic...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章

    doi:10.3109/03009748109095292

    authors: Mielants H,Veys EM,Verbruggen G,Schelstraete

    更新日期:1981-01-01 00:00:00

  • Hyaluronan concentration and molecular mass in psoriatic arthritis: biomarkers of disease severity, resistance to treatment, and outcome.

    abstract::Objective: Low molecular mass hyaluronan causes inflammatory processes and can act as a pro-inflammatory cytokine in skin and other sites of activity in psoriatic arthritis (PsA). This study investigated whether the molecular mass distribution of hyaluronan (HA) in skin and the quantity of circulating HA are related t...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1080/03009742.2019.1577490

    authors: Hellman U,Engström-Laurent A,Larsson A,Lindqvist U

    更新日期:2019-07-01 00:00:00

  • Atlanto-axial subluxation in rheumatoid arthritis. A study of 104 hospital patients.

    abstract::Arthritic affection of the upper cervical spine is relatively common in rheumatoid arthritis (RA). Atlanto-axial subluxations are also reported to occur frequently, but it seems that neurological symptoms due to the subluxations seldom occur. We have studied 104 consecutive in-patients. In a group of 50 non-arthritics...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748409111302

    authors: Haaland K,Aadland HA,Haavik TK,Vallersnes FM

    更新日期:1984-01-01 00:00:00

  • Weight-bearing physical activity, calcium intake, systemic glucocorticoids, chronic inflammation, and body constitution as determinants of lumbar and femoral bone mineral in juvenile chronic arthritis.

    abstract::The associations between the lumbar and femoral bone mineral and several body constitutional, lifestyle, and disease related variables were studied in 111 children with juvenile chronic arthritis (JCA) by factor and multiple linear regression analyses. In addition to the measurement of bone mineral density (BMD), bone...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009749950155733

    authors: Kotaniemi A,Savolainen A,Kröger H,Kautiainen H,Isomäki H

    更新日期:1999-01-01 00:00:00

  • Elevated IL-6 levels in the synovial fluid of osteoarthritis patients stem from plasma cells.

    abstract:OBJECTIVE:To analyse the levels of interleukin-6 (IL-6) in the synovial fluids and sera of patients with osteoarthritis (OA) and to identify the IL-6-secreting cells. METHODS:Serum, synovial fluid, synovial tissue, and articular cartilage samples were collected from 49 OA patients with end-stage knee or hip OA who und...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009740701250785

    authors: Doss F,Menard J,Hauschild M,Kreutzer HJ,Mittlmeier T,Müller-Steinhardt M,Müller B

    更新日期:2007-03-01 00:00:00

  • Incidence and predictors of thoracic aortic damage in biopsy-proven giant cell arteritis.

    abstract::Objective: To describe the frequency and predisposing factors of aortic structural disease among patients with biopsy-proven giant cell arteritis (GCA). Method: A retrospective review identified all patients with biopsy-proven GCA from 1998 to 2013 with aortic imaging. Kaplan-Meier methods were used to estimate cumula...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009742.2020.1786855

    authors: Koster MJ,Crowson CS,Labarca C,Warrington KJ

    更新日期:2020-09-17 00:00:00

  • Nailfold capillary permeability in psoriatic arthritis.

    abstract::This study is the first report of the permeability status of nailfold capillaries in psoriatic arthritis (PA). "Traditional" nailfold capillary microscopy and intravital fluorescence videomicroscopy were carried out at the nailfold of 13 patients with PA. Twenty five healthy subjects served as controls for nailfold ca...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749209099229

    authors: Grassi W,Core P,Carlino G,Cervini C

    更新日期:1992-01-01 00:00:00

  • Clonal analysis of B cells in the synovial membrane of patients with rheumatoid arthritis.

    abstract:OBJECTIVE:To investigate the clonal characteristics of B cells in the synovial membranes of rheumatoid arthritis (RA) patients. METHODS:The clonality of B cells at separate sites of the synovial membrane and other tissues from RA patients were investigated by a reverse transcriptase-polymerase chain reaction with a VH...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009740310000346

    authors: Shiokawa S,Matsumato N,Nishimura J

    更新日期:2003-01-01 00:00:00

  • The safety profile of low-dose cladribine in refractory rheumatoid arthritis. A pilot trial.

    abstract::Cladribine (2-chlorodeoxyadenosine, 2-CdA) is a newer purine analog with specific toxicity to lymphocytes. As lymphocytes play a major role in rheumatoid arthritis (RA), we assessed the safety profile of low-dose 2-CdA in patients who were refractory to more than three disease-modifying drugs. Five patients were given...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章

    doi:10.3109/03009749709065702

    authors: Schirmer M,Mur E,Pfeiffer KP,Thaler J,Konwalinka G

    更新日期:1997-01-01 00:00:00

  • Antinuclear antibody screening in this new millennium: farewell to the microscope?

    abstract::ANA testing by immunofluorescence technique (F-ANA) is nowadays still performed in much the same way as 45 years ago when the test was introduced. Due to its low specificity the F-ANA test has a poor predictive value for systemic autoimmune diseases and in addition has proven difficult to standardise. In the meantime,...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/030097401300162860

    authors: Nossent H,Rekvig OP

    更新日期:2001-01-01 00:00:00

  • Hydroxyproline levels and collagenolytic activity in synovial fluids of patients with rheumatic diseases.

    abstract::Free, total, and peptide hydroxyproline levels were determined in synovial fluid obtained from the knee joints of 60 patients with theumatoid arthritis (RA), and 26 patients with degenerative joint disease. In addition, in 160 synovial fluid samples obtained from 121 patients including 50 with degenerative joint disea...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009747509095617

    authors: Wize J,Sopata I,Gietka J,Jakubowski S,Kruze D

    更新日期:1975-01-01 00:00:00

  • Serum levels of IL-33 and its receptor ST2 are elevated in patients with ankylosing spondylitis.

    abstract:OBJECTIVES:The aims of this study were to measure the levels of interleukin (IL)-33 and ST2 and T-helper (Th)2-associated cytokines (IL-13, IL-4, IL-5) in patients with ankylosing spondylitis (AS), and examine the correlation of serum cytokine levels with disease activity and laboratory parameters. METHOD:Serum IL-33,...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2012.735700

    authors: Li GX,Wang S,Duan ZH,Zeng Z,Pan FM

    更新日期:2013-01-01 00:00:00

  • The effect of fasting on plasma cyclic adenosine-3', 5'-monophosphate in rheumatoid arthritis.

    abstract::Cyclic adenosine-3', 5'-monophosphate (cAMP) may influence important mechanisms in the inflammatory process, and fasting has been claimed to be clinically beneficial in rheumatoid arthritis (RA). A study was therefore designed to measure the concentrations of plasma cAMP in RA patients not undergoing drug treatment du...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009748009112353

    authors: Trang LE,Lövgren O,Bendz R,Mjös O

    更新日期:1980-01-01 00:00:00

  • The coexistence of systemic lupus erythematosus and multiple sclerosis in a mother and daughter.

    abstract::The occurrence of both multiple sclerosis (MS) and systemic lupus erythematosus (SLE) has previously been described in several members within the same family and in twins of successive generations, but the finding of both diseases in one patient is a great rarity. We here report on a rare coexistence of MS and SLE bot...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.1080/03009740151095484

    authors: Hietaharju A,Peltola J,Seppä J,Luukkainen R,Dastidar P

    更新日期:2001-01-01 00:00:00

  • Longterm physical training in rheumatoid arthritis. A randomized trial with different training programs and blinded observers.

    abstract::The objective was to study the long-term effect (2 years) of different training programs in patients with rheumatoid arthritis. The method was a randomized trial with 75 patients participating. The measured variables included morning stiffness, a pain score, number of swollen joints, a health assessment score, a funct...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/03009749309099253

    authors: Hansen TM,Hansen G,Langgaard AM,Rasmussen JO

    更新日期:1993-01-01 00:00:00

  • Epstein-Barr virus early antigen diffuse (EBV-EA/D)-directed immunoglobulin A antibodies in systemic lupus erythematosus patients.

    abstract:OBJECTIVE:We sought to determine whether the serological response towards lytic cycle antigens of Epstein-Barr virus (EBV) is altered in systemic lupus erythematosus (SLE) patients. METHOD:We used enzyme-linked immunosorbent assay (ELISA) to investigate the prevalence of EBV early antigen diffuse (EBV-EA/D) antibodies...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009742.2012.665944

    authors: Draborg AH,Jørgensen JM,Müller H,Nielsen CT,Jacobsen S,Iversen LV,Theander E,Nielsen LP,Houen G,Duus K

    更新日期:2012-08-01 00:00:00

  • Dactylitis, a term for different digit diseases.

    abstract::Dorland's Illustrated Medical Dictionary gives the following definition of dactylitis (deltaalphachitauupsilonlambdaomicronsigma = digit): 'inflammation of a finger or toe'. Although any inflammatory process involving the fingers or toes may be called dactylitis, the term has entered in current use only in some well-d...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章,评审

    doi:10.1080/03009740600906677

    authors: Olivieri I,Scarano E,Padula A,Giasi V,Priolo F

    更新日期:2006-09-01 00:00:00