Comparison of serum salicylate levels and gastro-intestinal blood loss between salsalate (Disalcid)and other forms of salicylates.

Abstract:

:In a first stage the effect of a single dose of 3 g of salsalate on serum salicylate level was compared with a single intake of 3 g of soluble or enteric-coated acetylsalicylates in 12 healthy subjects. Salsalate seems to resorb faster than the enteric-coated forms but more slowly than the soluble forms of acetylsalicylate. However, in comparison with these latter forms, salsalate activity is more protracted. In the second part of the study, 42 patients were admitted to a trial in which 3 to 5 g of salsalate was given daily and in which serum salicylate levels and blood loss in stools were measured using the method of labelling red blood cells with Cr51. The ideal dosage to obtain a serum salicylate level of 20 mg/100 ml seems to lie between 3 and 4 g of salsalate a day. Salsalate caused abnormal gastro-intestinal blood loss in only 2 of the 42 patients studied, which is significantly fewer compared with the soluble, intravenous or enteric-coated forms of acetylsalicylates.

journal_name

Scand J Rheumatol

authors

Mielants H,Veys EM,Verbruggen G,Schelstraete

doi

10.3109/03009748109095292

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

169-73

issue

3

eissn

0300-9742

issn

1502-7732

journal_volume

10

pub_type

临床试验,杂志文章
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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章,多中心研究

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    pub_type: 临床试验,杂志文章

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章,随机对照试验

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    更新日期:1995-01-01 00:00:00

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

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    更新日期:1992-01-01 00:00:00

  • Symptomatology and diagnosis in connective tissue disease. II. Evaluations and follow-up examinations in consequence of a speckled antinuclear immunofluorescence pattern.

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    pub_type: 杂志文章

    doi:10.3109/03009747809095661

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    更新日期:1978-01-01 00:00:00

  • Prevalence of spondyloarthropathies in an Italian population sample: a regional community-based study.

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    pub_type: 杂志文章

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    authors: De Angelis R,Salaffi F,Grassi W

    更新日期:2007-01-01 00:00:00

  • Cationic myeloma M-components frequently show cross-reacting anti-DNA, Anti-F(ab')2 and anti-nucleosome specificities.

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009749709115823

    authors: Williams RC Jr,Malone CC,Silvestris F

    更新日期:1997-01-01 00:00:00

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    pub_type: 杂志文章

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    authors: Hammarström L,Heigl Z,Smith CI

    更新日期:1986-01-01 00:00:00

  • A radiological survey of the hips and knees in female specialist teachers of physical education.

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009747909114633

    authors: Eastmond CJ,Hudson A,Wright V

    更新日期:1979-01-01 00:00:00

  • Interobserver variation in the evaluation of radiologic changes of rheumatoid arthritis.

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    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章

    doi:10.3109/03009747909105347

    authors: Larsen A,Edgren J,Harju E,Laasonen L,Reitamo T

    更新日期:1979-01-01 00:00:00

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    更新日期:2003-01-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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