Abstract：
:Pain intensity, muscle strength, static muscle endurance, pressure pain threshold, and pain tolerance at tender points and control points were assessed in 31 patients with fibromyalgia (FM), before and after intravenous administration of morphine (9 patients), lidocaine (11 patients), and ketamine (11 patients). The three different studies were double-blind and placebo-controlled. The patients were classified as placebo-responders, responders (decrease in pain intensity by > 50%) and non-responders. The morphine test did not show any significant changes. The lidocaine test showed a pain decrease during and after the infusion. The ketamine test showed a significant reduction in pain intensity during and after the test period. Tenderness at tender points decreased and endurance increased significantly, while muscle strength remained unchanged. The present results support the hypothesis that the NMDA receptors are involved in pain mechanisms in fibromyalgia. These findings also suggest that central sensitization is present in FM and that tender points represent secondary hyperalgesia.
journal_name
Scand J Rheumatoljournal_title
Scandinavian journal of rheumatologyauthors
Sörensen J,Bengtsson A,Bäckman E,Henriksson KG,Bengtsson Mdoi
10.3109/03009749509095181subject
Has Abstractpub_date
1995-01-01 00:00:00pages
360-5issue
6eissn
0300-9742issn
1502-7732journal_volume
24pub_type
临床试验,杂志文章,随机对照试验abstract：:Objectives: To study associations between different anthropometric measures and incident gout, and to find the best predictive measure. Method: We used the baseline investigation from the Malmö Diet and Cancer study, excluding cases of prevalent gout (n = 28 081). Cox regression for each anthropometric measurement was...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009742.2019.1583368
更新日期：2019-07-01 00:00:00
abstract：:Lysozyme (LZM) concentrations in synovial fluid were determined in patients with seropositive and seronegative rheumatoid arthritis (RA) and in patients whose arthritic exudates had been caused by Reiter's disease, a Yersinia enterocolitica infection, osteoarthritis, or trauma. Patients with rheumatoid disease had sig...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748509102021
更新日期：1985-01-01 00:00:00
abstract：OBJECTIVE:To study the frequence of deltoideal proximal insertion enthesitis (DPIE) in patients affected with spondyloarthritis (SpA) and to evaluate its clinical, sonographic and radiological characteristics. METHODS:A retrospective study of clinical, sonographic and radiological examinations of the shoulders of 100 ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVES:The reproducibility of clinical tests for skin extensibility and consistency, essential for differentiating between types of Ehlers-Danlos syndrome (EDS) and benign joint hypermobility syndrome (BJHS), is unknown. Paraclinical methods may provide objective differential diagnostic methods. METHODS:Six EDS, 1...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009740802520714
更新日期：2009-05-01 00:00:00
abstract：:To assess the role of crystal size in the biologic response, we quantitated the generation of reactive oxygen metabolites in human polymorphonuclear leukocytes (PMNs) or mononuclear leukocytes (MNs) with a chemiluminescence assay using 6 alpha-alumina preparations with average diameters of 0.6, 0.8, 3.2, 7.5, 28 and 6...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009749509099293
更新日期：1995-01-01 00:00:00
abstract：OBJECTIVE:To determine the expression of bcl-2, p53, and caspase 3, and measure the Ki-67 proliferation index as well as DNA content and DNA fragmentation in a case of diffuse pigmented villonodular synovitis (PVNS) of the knee with aggressive clinical behaviour. METHODS:Expression of p53, Bcl-2 and Ki-67 was investig...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009740410009823
更新日期：2005-01-01 00:00:00
abstract：:Thirty-four patients with Sjögren's syndrome were retrospectively examined in order to evaluate longitudinal alterations in objective ocular disease parameters and their possible relation to systemic bromhexine treatment. Twenty-three patients (68%) were initially found to respond to peroral bromhexine treatment and w...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748909099928
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVES:Rheumatoid arthritis (RA) is a systemic, inflammatory disease. Renal involvement worsens the course of RA and increases mortality. It is suggested that chronic inflammatory processes may contribute to renal impairment. The aim of this study was to investigate the impact of chronic inflammation and RA activit...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009742.2011.571219
更新日期：2011-01-01 00:00:00
abstract：:A patient with familial Pelger-Huet (PH) anomaly, which accompanied tuberculosis, and acute polyarthritis is described. Investigations surrounding this case suggests that the immunological abnormalities may be associated with the PH anomaly and the tuberculosis, and that the complications may be related to the develop...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009749509095172
更新日期：1995-01-01 00:00:00
abstract：:Objective: The aim of this study was to review the literature to identify studies reporting repair of erosions in rheumatoid arthritis (RA).Method: A systematic literature search for publications on the repair of erosions was performed in PubMed and Embase, limited to human adults and published in English. Titles, abs...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009742.2019.1606274
更新日期：2019-11-01 00:00:00
abstract：:Assessment of health-related quality of life (HRQoL) is relevant for the patients and is important in both clinical research and daily clinical practice. Generic and disease-specific instruments for assessment of HRQoL are reviewed. Changes in HRQoL provide important information on randomized controlled clinical trial...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章,评审
doi：10.1080/03009740500327727
更新日期：2005-09-01 00:00:00
abstract：:Soluble interleukin 2 receptor (sIL2R) may be used as an index of immune perturbation. We report on the correlation between the serum levels of sIL2R, as assessed with a sandwich-ELISA, and disease activity in 61 patients with Systemic Lupus Erythematosus (SLE) and in 15 with systemic idiopathic vasculitis (SIV). The ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009749309095125
更新日期：1993-01-01 00:00:00
abstract：:Using the fluorescence polarization of 1.6-diphenyl-1, 3, 5-hexatriene, the membrane fluidity of lymphocytes obtained from rheumatoid arthritis patients was measured during 12 months of auranofin treatment. Significant differences in fluorescence polarization values were observed following auranofin treatment. The cor...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748909102104
更新日期：1989-01-01 00:00:00
abstract：OBJECTIVES:Sarcoidosis is a chronic granulomatous disease. Pyrin has anti-inflammatory activity in the regulation of inflammasomes and is encoded by the Mediterranean fever (MEFV) gene. MEFV gene mutations trigger the inflammatory cascade and cause familial Mediterranean fever (FMF). A relationship between various rheu...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009742.2015.1092580
更新日期：2016-01-01 00:00:00
abstract：:Objectives: IgG4-related disease (IgG4-RD) may present as 'idiopathic' retroperitoneal fibrosis (IRPF). We aimed to determine the occurrence of IgG4-retroperitoneal fibrosis (IgG4-RPF) in a nationwide study on patients with newly diagnosed IRPF, and to compare histopathological, imaging, and clinical features in the I...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009742.2018.1551963
更新日期：2019-07-01 00:00:00
abstract：:We evaluated the efficacy and toxicity of cyclosporine A (CsA) in combination with methotrexate (MTX) or hydroxychloroquine (HCQ) in patients with refractory rheumatoid arthritis (RA). Fourteen patients with active RA who had failed to respond adequately to injectable MTX and 14 who had failed to respond to oral HCQ h...
journal_title：Scandinavian journal of rheumatology
pub_type： 临床试验,杂志文章
doi：10.3109/03009749609082662
更新日期：1996-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of low-dose oral methotrexate (MTX) as treatment for patients with Kawasaki disease (KD) resistant to intravenous immunoglobulin (IVIG). METHODS:The subjects were four patients with KD, aged 8 months to 8 years old, who showed persistent disease after treatment with high-dose IVIG (2 g...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009740510026328
更新日期：2005-03-01 00:00:00
abstract：:The clinical outcome and tolerability following treatment with samarium-153 particulate hydroxyapatite was evaluated in patients with persistent rheumatoid knee synovitis. The clinical review of 18 patients treated with intra-articular samarium-153 particulate hydroxyapatite combined with triamcinolone hexacetonide wh...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009749609065647
更新日期：1996-01-01 00:00:00
abstract：:Corneal chrysiasis is a common consequence of parenteral chrysotherapy in patients affected by rheumatoid arthritis. Concerning the factors and conditions that could be determinant for the gold accumulation in the cornea, there are contradictory opinions. Total or weekly gold dose and its accumulation quota, and the f...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748509165501
更新日期：1985-01-01 00:00:00
abstract：:Shoulder muscle performance was tested in 8 working ankylosing spondylitis (AS) patients and compared with 10 healthy male referents. The AS patients were all in a non-active state and had no shoulder symptoms. Electromyographic fatigue development in the descending part of the trapezius muscle was significantly faste...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748709165269
更新日期：1987-01-01 00:00:00
abstract：OBJECTIVE:To report mortality and disability due to rheumatoid arthritis (RA) in the Nordic region (Denmark, Finland, Greenland, Iceland, Norway, and Sweden) using data from the Global Burden of Disease Study (GBD) 2015. METHOD:Using the results of GBD 2015, we present rates and trends in prevalence, mortality, years ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009742.2017.1314002
更新日期：2018-03-01 00:00:00
abstract：:The variation between four radiologists in the evaluation of hand, wrist, and foot radiographs of rheumatoid arthritis was examined. The recognition of individual radiologic changes varied considerably as judged by the findings of the different observers. Erosion and joint space narrowing were interpreted more uniform...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009747909105347
更新日期：1979-01-01 00:00:00
abstract：:The effect of indomethacin and naproxen on collagen metabolism was studied in arthritic animals after an injection of [3H]-proline, both the specific and total radioactivity of [3H]-hydroxyproline being determined in skin collagen fractions and in urine. It was found that collagen synthesis and conversion of soluble t...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748109095291
更新日期：1981-01-01 00:00:00
abstract：:Nine patients suffering from chronic rheumatoid arthritis were each given single doses of 1 g acetylsalicylic acid, in the form of each of the preparations studied: an enteric-coated tablet, a microcrystalline tablet, and a capsule containing enterosoluble granules. Absorption from each preparation was good in all pat...
journal_title：Scandinavian journal of rheumatology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3109/03009748309098554
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:To estimate the prevalence of spondyloarthropathies (SpA) in an adult population in Marche, a region located in central Italy. METHODS:A cross-sectional population-based study was conducted on a target adult population of 20 882. Questionnaires were sent to a random sample of 3664 individuals aged 18 years a...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009740600904243
更新日期：2007-01-01 00:00:00
abstract：OBJECTIVES:The human urate transporter 1 (URAT1, encoded by SLC22A12) was recently identified as the major absorptive urate transporter protein in the kidney responsible for regulating blood urate levels. The present study was designed to investigate the rs893006 polymorphism (GG, GT, and TT) in SLC22A12 in a total of ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009740802572483
更新日期：2009-01-01 00:00:00
abstract：:Reports of the rheumatic manifestations of Campylobacter jejuni and C. fetus infections in adults are reviewed in order to determine the most common presentations and which individuals are at risk for rheumatic disease. Relevant English-language articles were identified through a Medline search and from bibliographies...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章,评审
doi：10.3109/03009749409103055
更新日期：1994-01-01 00:00:00
abstract：:Cytokines are signalling glycoproteins mediating acute inflammation, chronic inflammation, and connective tissue destruction. The present study was designed to characterize the profile of cytokine message in normal human articular cartilage and from patients with rheumatoid arthritis (RA) and osteoarthritis (OA), by m...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/030097498441191
更新日期：1998-01-01 00:00:00
abstract：:A vast accumulation of clinical experience and controlled studies justifies the use of gold compounds in selected cases of rheumatoid arthritis. The striking therapeutical efficacy observed in some patients has stimulated active research to clarify the pharmacokinetics and mechanisms of action of gold compounds. Based...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009747709095455
更新日期：1977-01-01 00:00:00
abstract：:Cogan's syndrome (CS) is a rare multisystemic disease characterized by vestibuloauditory dysfunction, inflammatory eye disease and vasculitis. Aortic aneurysms due to aortitis are under-recognized in CS, and are potentially fatal, with two of eight reported cases dying from aneurysm/arterial rupture. The presence of a...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009740600907923
更新日期：2007-01-01 00:00:00
