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Pain analysis in patients with fibromyalgia. Effects of intravenous morphine, lidocaine, and ketamine.

Abstract：

:Pain intensity, muscle strength, static muscle endurance, pressure pain threshold, and pain tolerance at tender points and control points were assessed in 31 patients with fibromyalgia (FM), before and after intravenous administration of morphine (9 patients), lidocaine (11 patients), and ketamine (11 patients). The three different studies were double-blind and placebo-controlled. The patients were classified as placebo-responders, responders (decrease in pain intensity by > 50%) and non-responders. The morphine test did not show any significant changes. The lidocaine test showed a pain decrease during and after the infusion. The ketamine test showed a significant reduction in pain intensity during and after the test period. Tenderness at tender points decreased and endurance increased significantly, while muscle strength remained unchanged. The present results support the hypothesis that the NMDA receptors are involved in pain mechanisms in fibromyalgia. These findings also suggest that central sensitization is present in FM and that tender points represent secondary hyperalgesia.

journal_name

Scand J Rheumatol

journal_title

Scandinavian journal of rheumatology

authors

Sörensen J,Bengtsson A,Bäckman E,Henriksson KG,Bengtsson M

doi

10.3109/03009749509095181

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

360-5

issue

6

eissn

0300-9742

issn

1502-7732

journal_volume

24

pub_type

临床试验,杂志文章,随机对照试验

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