Gammalinolenic acid treatment of fatigue associated with primary Sjögren's syndrome.

Abstract:

OBJECTIVE:To evaluate the efficacy of the essential omega-6 fatty acid Gammalinolenic acid (GLA) on fatigue associated with primary Sjögren's syndrome. METHODS:Ninety patients with primary Sjögren's syndrome (with or without signs of autoimmunity) entered a 6-month double blind placebo-controlled randomised trial with high dose GLA (extracted from Evening Primrose Oil) or corn oil. The primary outcome parameter was fatigue; secondary endpoints were eye dryness, mouth dryness, muscle and joint pain. RESULTS:No statistically significant improvement was found in fatigue assessed by Visual Analogue Scale (VAS) or in the time needed for sleeping/resting during a 24-hour period. No differences were found between the treatment and placebo group. The same applies to the secondary endpoints: no differences in VAS for eye and mouth dryness or pain, no significant changes in Schirmer-1-test, van Bijsterveld score, unstimulated whole sialometry (UWS), or use of artificial tears or analgesics. Only mild side effects were observed. CONCLUSION:According to our study results GLA (Evening Primrose oil) treatment for fatigue in primary Sjögren's syndrome is ineffective.

journal_name

Scand J Rheumatol

authors

Theander E,Horrobin DF,Jacobsson LT,Manthorpe R

doi

10.1080/03009740252937577

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

72-9

issue

2

eissn

0300-9742

issn

1502-7732

journal_volume

31

pub_type

临床试验,杂志文章,随机对照试验
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