Abstract:
OBJECTIVES:To determine which variables at baseline are predictive for the development of rheumatoid arthritis (RA) from palindromic rheumatism (PR) in a Japanese population. METHODS:Anti-cyclic citrullinated peptide (anti-CCP) antibodies, joint involvement pattern, genotypes of HLA-DRB1, peptidylarginine deiminase (PADI4), and protein tyrosine phosphatase (PTPN22) were examined in 28 patients with PR at baseline, and their clinical outcome was prospectively evaluated. The same variables were also investigated in 38 healthy controls. RESULTS:Eleven out of 28 patients with PR developed RA. The prevalence of anti-CCP antibodies in the PR patients who developed RA was significantly higher compared to the patients who did not. Proximal interphalangeal (PIP) joint involvement at baseline was also predictive towards the development of RA. Compared with the controls, differences in the frequency of single-nucleotide polymorphism (SNP) on padi4_104 [T(RA susceptible)-->C(RA non-susceptible)] and the presence of an RA susceptible homozygote of the PADI4 haplotype were detected in patients with PR whereas we could not find any further difference in PR patients who developed RA compared to PR patients who do not develop RA in PADI4. None of the subjects possessed the PTPN22 SNP (1858C-->T). Cox regression analysis revealed that anti-CCP antibodies as well as PIP involvement are the most relevant variables for the development of RA from PR. None of the PR patients with either HLA-DRB1*SE alleles (or the HLA-DRB1*0405 allele) or anti-CCP antibodies developed RA. CONCLUSIONS:Anti-CCP antibodies, in relation to HLA-DRB1*SE carriership, and PIP involvement are predictive for the development of RA from PR in the Japanese population.
journal_name
Scand J Rheumatoljournal_title
Scandinavian journal of rheumatologyauthors
Tamai M,Kawakami A,Iwamoto N,Arima K,Aoyagi K,Eguchi Kdoi
10.3109/03009741003604534subject
Has Abstractpub_date
2010-08-01 00:00:00pages
287-91issue
4eissn
0300-9742issn
1502-7732journal_volume
39pub_type
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009742.2016.1153140
更新日期:2016-11-01 00:00:00
abstract::The relative value of nine spinal and thoracic mobility measurements was investigated in 73 male patients with ankylosing spondylitis (AS). The value of a test was obtained by the relative ranks of validity, reliability and sensitivity to change. Validity was determined as age-adjusted correlation of the test result w...
journal_title:Scandinavian journal of rheumatology
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doi:10.3109/03009749509099291
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journal_title:Scandinavian journal of rheumatology
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journal_title:Scandinavian journal of rheumatology
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doi:10.1080/03009742.2019.1704053
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abstract::Complement activation products, C9 and C3-containing circulating immune complexes (CIC), were evaluated in plasma and synovial fluid (SF) from patients with rheumatoid arthritis (RA) and osteoarthritis. C3 activation products and the fluid phase terminal complement complex were considerably elevated in SF from RA pati...
journal_title:Scandinavian journal of rheumatology
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doi:10.3109/03009749109103019
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.1080/03009742.2019.1606274
更新日期:2019-11-01 00:00:00
abstract::Objective: Predicting treatment response and disease progression in rheumatoid arthritis (RA) remains an elusive endeavour. Identifying subgroups of patients with similar progression is essential for understanding what hinders improvement. However, this cannot be achieved with response criteria based on current versus...
journal_title:Scandinavian journal of rheumatology
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journal_title:Scandinavian journal of rheumatology
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749109096822
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journal_title:Scandinavian journal of rheumatology
pub_type: 杂志文章
doi:10.3109/03009749009102534
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更新日期:2004-01-01 00:00:00
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doi:10.3109/03009749309095125
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更新日期:2015-05-01 00:00:00
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更新日期:1976-01-01 00:00:00
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更新日期:2010-01-01 00:00:00
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journal_title:Scandinavian journal of rheumatology
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更新日期:2002-01-01 00:00:00
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journal_title:Scandinavian journal of rheumatology
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更新日期:1980-01-01 00:00:00
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更新日期:1992-01-01 00:00:00
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journal_title:Scandinavian journal of rheumatology
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更新日期:2015-01-01 00:00:00
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更新日期:2019-03-01 00:00:00