Interleukin-18 is associated with the presence of interstitial lung disease in rheumatoid arthritis: a cross-sectional study.


OBJECTIVE:Serum interleukin-18 (IL-18) levels are increased in patients with interstitial lung disease (ILD). In addition, IL-18 levels are increased in patients with rheumatoid arthritis (RA) and are associated with arthritis activity. We determined whether increased IL-18 levels are associated with ILD in RA. METHOD:RA patients were enrolled using an RA cohort database. Plasma IL-18 levels were measured by enzyme-linked immunosorbent assay. ILD was determined by a pulmonologist and a radiologist based on chest radiography and computed tomography findings. IL-18 levels for RA with ILD and RA without ILD were compared. Associations between ILD and various markers including IL-18 and confounding factors (e.g. smoking history) were investigated by logistic regression analysis. Diagnostic values of IL-18 for the presence of ILD were investigated using receiver operating characteristics curve analysis. RESULTS:ILD was complicated in 8.2% (n = 26) of the study population (N = 312). Plasma IL-18 levels were higher for RA patients with ILD than for RA patients without ILD (721.0 ± 481.4 vs 436.8 ± 438.9 pg/mL, p < 0.001). IL-18, Krebs von den Lungen-6, and anti-cyclic citrullinated peptide antibody titre and glucocorticoid doses were independently associated with the presence of ILD during multivariate logistic regression analysis. Sensitivity and specificity of IL-18 levels for the detection of ILD in RA patients were 65.3% and 76.3%, respectively (area under the curve = 0.73). CONCLUSION:Plasma IL-18 levels were higher for RA patients with ILD than for those without ILD. Increased IL-18 levels were associated with the presence of ILD.


Scand J Rheumatol


Matsuo T,Hashimoto M,Ito I,Kubo T,Uozumi R,Furu M,Ito H,Fujii T,Tanaka M,Terao C,Kono H,Mori M,Hamaguchi M,Yamamoto W,Ohmura K,Morita S,Mimori T




Has Abstract


2019-03-01 00:00:00












  • Incidence and survival rate in cases of biopsy-proven temporal arteritis.

    abstract::In the population of the city of Tampere, Finland, 66 patients with histologically verified temporal arteritis were identified during the 20-year period from 1969 to 89. The cases were followed up to March 31st in 1991. The annual age- and sex-adjusted incidence of temporal arteritis per 100,000 population aged 50 or ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Rajala SA,Ahvenainen JE,Mattila KJ,Saarni MI

    更新日期:1993-01-01 00:00:00

  • Magnetic resonance imaging of the hand joints in patients with inflammatory bowel disease and arthralgia: a pilot study.

    abstract:OBJECTIVES:To assess whether subclinical inflammatory changes are present on magnetic resonance imaging (MRI) in patients with inflammatory bowel disease (IBD) and arthralgia. METHOD:In this pilot study, painful hand joints [metacarpophalangeal (MCP), proximal interphalangeal (PIP), and/or distal interphalangeal (DIP)...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Brakenhoff LK,Stomp W,van Gaalen FA,Hommes DW,Bloem JL,van der Heijde DM,Fidder HH,Reijnierse M

    更新日期:2014-01-01 00:00:00

  • Home parenteral nutrition is beneficial in systemic sclerosis patients with gastrointestinal dysfunction.

    abstract:OBJECTIVES:To assess 12-month changes in nutritional status and quality of life (QoL) in systemic sclerosis (SSc) patients requiring home parenteral nutrition (HPN). METHOD:We conducted a retrospective, single-centre database analysis of SSc patients regarding a 12-month period of HPN at an interdisciplinary Universit...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Stanga Z,Aeberhard C,Schärer P,Kocher A,Adler S,Villiger PM

    更新日期:2016-01-01 00:00:00

  • Enhanced propensity of T lymphocytes in patients with systemic lupus erythematosus to apoptosis in the presence of tumour necrosis factor alpha.

    abstract:OBJECTIVE:To determine the effect of inflammation through exposure to tumour necrosis factor (TNF)alpha on T lymphocytes in patients with systemic lupus erythematosus (SLE). METHODS:We studied the effect of TNFalpha on T-lymphocyte apoptosis in patients with SLE, rheumatoid arthritis (RA), and in healthy controls. Apo...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Habib HM,Taher TE,Isenberg DA,Mageed RA

    更新日期:2009-03-01 00:00:00

  • Glycosaminoglycan polysulphate treatment in experimental osteoarthritis in rabbits.

    abstract::The effect of glycosaminoglycan polysulphate as medication for osteoarthritis was studied in an experimental model of osteoarthritis induced by periodic immobilization of rabbit knees. In a pilot experiment with 5 weeks of continuous immobilization there were indistinct differences between treated and control groups. ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Vanharanta H

    更新日期:1983-01-01 00:00:00

  • Enhanced breakdown of bovine articular cartilage proteoglycans by conditioned synovial medium. The effect of serum and dextran sulphate.

    abstract::Medium from cultured bovine synovial membrane when applied to articular cartilage from the same animal enhanced proteoglycan breakdown, as measured by the release of [35S]sulphate from prelabelled cartilage, principally by activating chondrocytes to secrete or activate their own enzymes. This effect persisted whether ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Jones IL,Klämfeldt A,McGuire MB

    更新日期:1982-01-01 00:00:00

  • Anti-CD20 therapy of treatment-resistant Wegener's granulomatosis: favourable but temporary response.

    abstract::Rituximab is a genetically engineered chimeric monoclonal immunoglobulin (Ig)G1 antibody. It binds the CD20 trans-membrane surface antigen expressed by mature B cells but not by antibody secreting plasma cells, and removes the cells by activating complement, inducing cell-mediated lysis, and by apoptosis. Mainly used ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Omdal R,Wildhagen K,Hansen T,Gunnarsson R,Kristoffersen G

    更新日期:2005-05-01 00:00:00

  • Disease activity trajectories in rheumatoid arthritis: a tool for prediction of outcome.

    abstract::Objective: Predicting treatment response and disease progression in rheumatoid arthritis (RA) remains an elusive endeavour. Identifying subgroups of patients with similar progression is essential for understanding what hinders improvement. However, this cannot be achieved with response criteria based on current versus...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Leu Agelii M,Andersson M,Jones BL,Sjöwall C,Kastbom A,Hafström I,Forslind K,Gjertsson I

    更新日期:2021-01-01 00:00:00

  • Weight-bearing physical activity, calcium intake, systemic glucocorticoids, chronic inflammation, and body constitution as determinants of lumbar and femoral bone mineral in juvenile chronic arthritis.

    abstract::The associations between the lumbar and femoral bone mineral and several body constitutional, lifestyle, and disease related variables were studied in 111 children with juvenile chronic arthritis (JCA) by factor and multiple linear regression analyses. In addition to the measurement of bone mineral density (BMD), bone...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Kotaniemi A,Savolainen A,Kröger H,Kautiainen H,Isomäki H

    更新日期:1999-01-01 00:00:00

  • Incidence of thromboembolic events in patients with primary Sjögren's syndrome.

    abstract::Primary Sjögren's syndrome (pSS) is a connective tissue disease with symptoms and serological findings often overlapping with systemic lupus erythematosus (SLE) (1). Thromboembolic events are common in SLE but not in pSS (2)(3). However, case reports have described pSS patients who developed fulminant multiorgan disea...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Haga HJ,Jacobsen EM,Peen E

    更新日期:2008-03-01 00:00:00

  • In vivo interactions of platelets and leucocytes with the endothelium in murine antigen-induced arthritis: the role of P-selectin.

    abstract:OBJECTIVE:Platelets are thought to participate in the pathogenesis of chronic inflammatory diseases such as rheumatoid arthritis (RA). We showed recently an in vivo increase in platelet-endothelial cell interactions in mice with antigen-induced arthritis (AiA). The underlying mechanisms are not yet clear. The aim of th...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Schmitt-Sody M,Metz P,Klose A,Gottschalk O,Zysk S,Hausdorf J,Veihelmann A,Jansson V

    更新日期:2007-07-01 00:00:00

  • Renal function is mostly preserved in patients with systemic sclerosis.

    abstract:OBJECTIVE:Chronic renal disease other than scleroderma renal crisis (SRC) is not well documented in systemic sclerosis (SSc). We examined the occurrence of decreased glomerular filtration rate (GFR) in a large consecutive SSc cohort and analysed whether it was related to SSc or could be related to other causes. METHOD...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Scheja A,Bartosik I,Wuttge DM,Hesselstrand R

    更新日期:2009-01-01 00:00:00

  • Radiographic assessment in relation to clinical and biochemical variables in rheumatoid arthritis.

    abstract::Radiographs of hands and feet were obtained from 125 consecutive patients with rheumatoid arthritis (RA) and the degree of destruction was assessed numerically on a 200-point scale using Larsen's standard radiographs as reference. The method is shown to possess a satisfactory degree of reproducibility. In 96 of these ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Wollheim FA,Pettersson H,Saxne T,Sjöblom KG

    更新日期:1988-01-01 00:00:00

  • Detection of cytokine mRNA in human, articular cartilage from patients with rheumatoid arthritis and osteoarthritis by reverse transcriptase-polymerase chain reaction.

    abstract::Cytokines are signalling glycoproteins mediating acute inflammation, chronic inflammation, and connective tissue destruction. The present study was designed to characterize the profile of cytokine message in normal human articular cartilage and from patients with rheumatoid arthritis (RA) and osteoarthritis (OA), by m...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Leistad L,Ostensen M,Faxvaag A

    更新日期:1998-01-01 00:00:00

  • Rheumatoid arthritis: what does it cost and what factors are driving those costs? Results of a survey in a community-derived population in Malmö, Sweden.

    abstract:OBJECTIVE:We sought to investigate the cost of living with rheumatoid arthritis (RA) and evaluate the influence of both demographics and specific disease characteristics on these costs. METHODS:We used a population-based questionnaire to survey 895 patients living in the city of Malmö, Sweden, during 2002. Data were o...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Jacobsson LT,Lindroth Y,Marsal L,Juran E,Bergström U,Kobelt G

    更新日期:2007-05-01 00:00:00

  • Parthenolide inhibits pro-inflammatory cytokine production and exhibits protective effects on progression of collagen-induced arthritis in a rat model.

    abstract:OBJECTIVES:Progressive destruction of synovial joint cartilage and bone occurs in pathological conditions such as rheumatoid arthritis (RA) because of the overproduction of pro-inflammatory cytokines and activation of nuclear factor kappa B (NF-κB). Through the screening of NF-κB inhibitors by a luciferase reporter gen...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Liu Q,Zhao J,Tan R,Zhou H,Lin Z,Zheng M,Romas E,Xu J,Sims NA

    更新日期:2015-05-01 00:00:00

  • Culture of joint specimens in bacterial arthritis. Impact of blood culture bottle utilization.

    abstract::The advantage of inoculating blood culture bottles (BCB) with a bulk volume of joint fluid was studied by analyzing results for 155 positive specimens cultured in parallel in BCB and on conventional solid media. The specimens came from both natural and artificial joints of 89 patients treated in 1975-1994. One third o...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: von Essen R

    更新日期:1997-01-01 00:00:00

  • Exogenous expression of IL-1Ra and TGF-β1 promotes in vivo repair in experimental rabbit osteoarthritis.

    abstract:OBJECTIVES:Potential gene therapy application of single and co-expression of interleukin 1 (IL-1) receptor antagonist (IL-1Ra) and transforming growth factor-β1 (TGF-β1) to alter disease progression was investigated in an in-vivo rabbit model of osteoarthritis (OA). METHOD:Sixteen young adult rabbits were randomly and...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Zhang P,Zhong ZH,Yu HT,Liu B

    更新日期:2015-01-01 00:00:00

  • Trabecular bone score value is associated with new bone formation independently of fat metaplasia on spinal magnetic resonance imaging in patients with ankylosing spondylitis.

    abstract:OBJECTIVE:To evaluate the association between trabecular bone score (TBS) and new bone formation in ankylosing spondylitis (AS) patients, and to investigate whether TBS is independently associated with new bone formation. METHOD:Sixty-eight patients with AS underwent spinal magnetic resonance imaging (MRI) and dual-en...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Kang KY,Jung JY,Lee SK,Min HK,Hong YS,Park SH,Ju JH

    更新日期:2020-07-01 00:00:00

  • Pulmonary hypertension in rheumatoid arthritis.

    abstract::Using Doppler echocardiography (DE), we measured pulmonary arterial systolic pressure (PASP) in rheumatoid arthritis (RA) patients without coexisting cardiopulmonary diseases. Accepting the normal upper limit of PASP as 30 mmHg, we found elevated PASP in 11 out of 40 (27.5%) RA patients, values being mostly 30-40 mmHg...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Keser G,Capar I,Aksu K,Inal V,Danaoğlu Z,Savas R,Oksel F,Tunc E,Kabasakal Y,Kitapcioglu G,Doganavsargil E

    更新日期:2004-01-01 00:00:00

  • Radiographic measurements of severe temporomandibular joint destruction at cervical radiography. Designed for evaluation in rheumatoid arthritis.

    abstract::Radiological examinations of the temporomandibular joints are not so often performed in patients with rheumatoid arthritis (RA). However, greater abnormalities of the mandibular head and neck may be evaluated at cervical radiography. With a new method, where the perpendicular distance from the palato-occipital line to...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Redlund-Johnell I

    更新日期:1987-01-01 00:00:00

  • More evidence of distinctive features of mixed connective tissue disease.

    abstract::A comparison of clinical, immunological and HLA-D region antigen features was made between 22 patients with mixed connective tissue disease (MCTD) and 118 patients with systemic lupus erythematosus (SLE), scleroderma or primary Sjögren's syndrome. The MCTD patients had hypergammaglobulinemia more often than did those ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Hämeenkorpi R,Ruuska P,Forsberg S,Tiilikainen R,Mäkitalo R,Hakala M

    更新日期:1993-01-01 00:00:00

  • Gold compounds in rheumatoid arthritis. Report of a symposium.

    abstract::A vast accumulation of clinical experience and controlled studies justifies the use of gold compounds in selected cases of rheumatoid arthritis. The striking therapeutical efficacy observed in some patients has stimulated active research to clarify the pharmacokinetics and mechanisms of action of gold compounds. Based...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Gottlieb NL,Bjelle A

    更新日期:1977-01-01 00:00:00

  • The influence of antirheumatic drugs on the occurrence of peptic ulcers. A controlled study of patients with chronic rheumatic diseases.

    abstract::46 patients who had an ulcer (verified by X-ray pictures) during treatment at the Rheumatism Foundation Hospital were compared with two patient groups of the same size. The first control group consisted of randomly selected patients who had been examined in the same way for the same indications but where the X-ray pic...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章


    authors: Martio J

    更新日期:1980-01-01 00:00:00

  • Prevalence of interstitial lung involvement in patients with connective tissue diseases assessed with high-resolution computed tomography.

    abstract:OBJECTIVES:To assess the prevalence of interstitial lung disease (ILD) in patients with different forms of connective tissue disease (CTD) using non-invasive procedures including high-resolution computed tomography (HRCT) and to evaluate the relationship between the imaging and functional status of the patients. METHO...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 临床试验,杂志文章


    authors: Afeltra A,Zennaro D,Garzia P,Gigante A,Vadacca M,Ruggiero A,Dardes N,Navajas MF,Zobel BB,Amoroso A

    更新日期:2006-09-01 00:00:00

  • Churg-Strauss syndrome presenting with pulmonary capillaritis and diffuse alveolar hemorrhage.

    abstract::Churg-Strauss syndrome (CSS) is a rare disorder characterized by the histopathological triad of systemic necrotizing vasculitis, extravascular granuloma, and eosinophilic infiltrate, occurring in individuals with asthma or a history of allergy. We report a case of CSS with rare presentation of diffuse pulmonary hemorr...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Lai RS,Lin SL,Lai NS,Lee PC

    更新日期:1998-01-01 00:00:00

  • Achilles tendinitis in Vibrio vulnificus sepsis: a rare presentation.

    abstract::Vibrio vulnificus infection commonly presents as sepsis or wound infection. A case of alcoholic liver cirrhosis developed acute left heel pain and swelling 2 days after ingesting raw fish. Two sets of blood cultures indicated V. vulnificus. HLA-B27 was negative. Ultrasonography revealed left Achilles tendinitis. Fluid...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Yang CH,Shie SS,Yu KH,Jan Wu YJ

    更新日期:2008-05-01 00:00:00

  • Effects of a PEGylated soluble TNF receptor type 1 (PEG sTNF-RI) on cytokine expression in adjuvant arthritis.

    abstract:OBJECTIVE:To investigate the effects of TNF blocking therapy on synovial immune activity in rat adjuvant arthritis (AA) by measuring mRNA expression of key macrophage and T cell cytokines during PEG sTNF-RI treatment (10mg/kg) on days 8, 10 and 12. METHODS:Paw volume was assessed every 3-4 days. Ankles were removed fo...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Bush KA,Walker JS,Frazier J,Kirkham BW

    更新日期:2002-01-01 00:00:00

  • Differences associated with age at onset in early systemic sclerosis patients: a report from the EULAR Scleroderma Trials and Research Group (EUSTAR) database.

    abstract:OBJECTIVE:The aim of this study was to analyse differences in clinical presentation in patients with early (< 3 years' duration) systemic sclerosis (SSc), comparing three age groups according to disease subsets. METHOD:Cross-sectional analysis of the prospective EULAR Scleroderma Trials and Research database (EUSTAR) ...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章,多中心研究


    authors: Carreira PE,Carmona L,Joven BE,Loza E,Andréu JL,Riemekasten G,Vettori S,Balbir-Gurman A,Airò P,Walker U,Damjanov N,Matucci-Cerinic M,Ananieva LP,Rednic S,Czirják L,Distler O,Farge D,Hesselstrand R,Corrado A,Caramasc

    更新日期:2019-01-01 00:00:00

  • The effect of daily administration of naproxen on the prothrombin complex activity in patients under long-term therapy with phenprocoumon.

    abstract::Out of a total of 150 patients attending an out-patient clinic for anticoagulant therapy, 12 had disorders which normally would indicate a prolonged use of an antirheumatic drug. To 6 of these patients, naproxen (1/4 g twice daily) was given while anticoagulant treatment with phenprocoumon was continued in an unchange...

    journal_title:Scandinavian journal of rheumatology

    pub_type: 杂志文章


    authors: Petersen PB,Husted S,Mortensen A,Andreasen F

    更新日期:1979-01-01 00:00:00