A comparison of the content of iron in normal and rheumatoid striated muscle.

Abstract:

:An investigation has been carried out on the presence of iron in striated muscle from normal individuals and from patients with rheumatoid disease. The methods used for the estimation of iron required a neutron activation analysis of total iron and extraction of hemoglobin in cyanide buffer. The results disclosed that there was a higher deposition of iron in rheumatoid muscle as compared with normals. Iron has a destructive effect on lysosomes and mast cells, the effect of which is an inflammatory reaction which may in part cause "metabolic myopathy" in rheumatoid disease. It is tentatively suggested that this "metabolic myopathy" may cause muscular pain and weakness in rheumatoid disease.

journal_name

Scand J Rheumatol

authors

Goldie IF,Bjönness T,Tiselius P,Plantin LO,Sato T

doi

10.3109/03009747609099906

keywords:

subject

Has Abstract

pub_date

1976-01-01 00:00:00

pages

205-8

issue

4

eissn

0300-9742

issn

1502-7732

journal_volume

5

pub_type

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