Abstract：
:Objective: Vasculopathy in systemic sclerosis (SSc) is characterized by the obliteration of arterioles and a reduced capillary density in various tissues. In SSc, atrophic alterations of the choroid have been suggested based on morphological data acquired by optical coherence tomography (OCT). In this study, we aimed to assess the choroid in eyes of patients with SSc from a microcirculatory, dynamic point of view by adding optical coherence tomography angiography (OCTA) to the diagnostic spectrum.Method: SSc patients were enrolled, and age- and gender-matched healthy subjects were used as controls. In addition to basic ophthalmological and rheumatological examinations, individuals underwent enhanced-depth imaging OCT and OCTA. Subfoveal thicknesses of the choroid as well as all three choroidal vascular sublayers were measured and submacular perfusion values were evaluated.Results: In total, 12 patients with SSc and 12 matched controls were included. The median age of participants was 64 years. Submacular perfusion was significantly lower in the choriocapillaris (Δ = 0.72%; p = 0.045), Sattler's layer (Δ = 2.87%; p = 0.001), and Haller's layer (Δ = 2.69%; p = 0.018) of SSc patients compared to controls. Subfoveal thicknesses of Sattler's layer (Δ = 15 µm; p = 0.026) and Haller's layer (Δ = 41 µm; p = 0.045) were also significantly smaller in the SSc group.Conclusion: Choroidal microcirculation is impaired in SSc, even in patients without ophthalmological symptoms. Choroidal OCT and OCTA may offer additional biomarkers for SSc activity.
journal_name
Scand J Rheumatoljournal_title
Scandinavian journal of rheumatologyauthors
Ranjbar M,Rothe M,Klapa S,Lange T,Prasuhn M,Grisanti S,Riemekasten G,Humrich JYdoi
10.1080/03009742.2019.1641616subject
Has Abstractpub_date
2020-03-01 00:00:00pages
141-145issue
2eissn
0300-9742issn
1502-7732journal_volume
49pub_type
杂志文章abstract：:The effect of indomethacin and naproxen on collagen metabolism was studied in arthritic animals after an injection of [3H]-proline, both the specific and total radioactivity of [3H]-hydroxyproline being determined in skin collagen fractions and in urine. It was found that collagen synthesis and conversion of soluble t...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748109095291
更新日期：1981-01-01 00:00:00
abstract：OBJECTIVE:The objective was to prospectively evaluate the short as well as the long-term effects of intensive physiotherapy in a stable, sunny and warm climate on physical function and health related quality of life in patients with rheumatoid arthritis (RA) and spondylarthropathies (SpA). METHODS:Ninety-three Swedish...
journal_title：Scandinavian journal of rheumatology
pub_type： 临床试验,杂志文章
doi：10.1080/03009740310000120
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVES:Juvenile idiopathic arthritis (JIA) frequently causes temporomandibular joint (TMJ) inflammation. The aim of this study was to evaluate the presence of orofacial pain and temporomandibular dysfunction in patients with JIA and controls. METHODS. Forty-one patients with JIA and 41 age- and sex-matched healthy ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009742.2012.675585
更新日期：2012-10-01 00:00:00
abstract：:Objective: Predicting treatment response and disease progression in rheumatoid arthritis (RA) remains an elusive endeavour. Identifying subgroups of patients with similar progression is essential for understanding what hinders improvement. However, this cannot be achieved with response criteria based on current versus...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009742.2020.1774646
更新日期：2021-01-01 00:00:00
abstract：:Synovectomy of 20 wrist joints in 15 patients with juvenile chronic arthritis (JCA) was performed and results were evaluated 3 (0.5-5) years after surgery. The surgical procedure consisted of synovectomy of the radiocarpal joint, around the ulnar head and in all intercarpal joints. Resection of the ulnar head was not ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009749009102534
更新日期：1990-01-01 00:00:00
abstract：:The IgG subclass distribution of anti-RNP antibodies was determined in sera from 34 patients. The antibodies were mainly of the complement-fixing IgG1 subclass with minor contributions of IgG3 and IgG4 antibodies. Selected sera contained IgG2 (non-complement fixing) anti-RNP antibodies and may possibly identify a subg...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748609092672
更新日期：1986-01-01 00:00:00
abstract：:The chronic inflammatory response to abrasion particles from total hip replacement (THR) is believed to cause osteolysis and to contribute to prosthetic loosening. The expression of interleukin-11(IL-11) and its major cellular sources in the interface and pseudocapsular tissues obtained from total hip revisions perfor...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009749850154393
更新日期：1998-01-01 00:00:00
abstract：:Lysozyme (LZM) concentrations in synovial fluid were determined in patients with seropositive and seronegative rheumatoid arthritis (RA) and in patients whose arthritic exudates had been caused by Reiter's disease, a Yersinia enterocolitica infection, osteoarthritis, or trauma. Patients with rheumatoid disease had sig...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748509102021
更新日期：1985-01-01 00:00:00
abstract：:Antibodies to three major antigens of the non-histone or saline-extractable nuclear antigen (ENA) complex were sought by counterimmunoelectrophoresis (CEP) in three groups of sera which gave different patterns in the immunofluorescence test for antinuclear antibodies (ANA). Precipitins, mainly anti RNP and anti SS-B, ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748409111300
更新日期：1984-01-01 00:00:00
abstract：:We studied HLA antigens in 105 unrelated American Caucasian patients with rheumatoid arthritis (RA), 70 of them with familial disease. HLA-DR4 was observed in 71% of familial RA, 63% of non-familial RA, and 27% of normal controls, confirming the already well-established association between HLA-DR4 and both familial an...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748709165415
更新日期：1987-01-01 00:00:00
abstract：:In this retrospective analysis of the DMARD CPH 82 in 44 Icelandic patients with severe refractory arthritis, clinical tolerance was good and serious side effects absent, although the majority were using the drug in combination with other DMARDS. Side effects leading to discontinuation were seen in 16% and the three y...
journal_title：Scandinavian journal of rheumatology
pub_type： 临床试验,杂志文章
doi：10.1080/030097400447723
更新日期：2000-01-01 00:00:00
abstract：:Dorland's Illustrated Medical Dictionary gives the following definition of dactylitis (deltaalphachitauupsilonlambdaomicronsigma = digit): 'inflammation of a finger or toe'. Although any inflammatory process involving the fingers or toes may be called dactylitis, the term has entered in current use only in some well-d...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章,评审
doi：10.1080/03009740600906677
更新日期：2006-09-01 00:00:00
abstract：:We have recently shown that synoviocytes and extracellular matrices exhibit distinct patterns of carbohydrate expression. Their biological relevance is however not known. The purpose of the present study was to find out whether human synovial tissue would also show a specific receptor pattern for complex sugar molecul...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009749109096796
更新日期：1991-01-01 00:00:00
abstract：OBJECTIVES:To compare prognosis parameters and arterial site involvement in Takayasu arteritis (TA) patients with disease onset at age ≤ 18 and ≥ 21 years. METHODS:Sixty-two TA patients [American College of Rheumatology (ACR) and European League Against Rheumatism/Paediatric Rheumatology European Society (EULAR/PreS) ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009741003742730
更新日期：2010-11-01 00:00:00
abstract：:Nine patients with active classical rheumatoid arthritis (ARA criteria) were studied with reference to circadian variation of immunological and clinical parameters. Complement-mediated solubilization (CMS) of immune complexes (IC) and the level of circulating IC were found to be inversely related with low CMS and incr...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748609102075
更新日期：1986-01-01 00:00:00
abstract：:Cytokines are signalling glycoproteins mediating acute inflammation, chronic inflammation, and connective tissue destruction. The present study was designed to characterize the profile of cytokine message in normal human articular cartilage and from patients with rheumatoid arthritis (RA) and osteoarthritis (OA), by m...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/030097498441191
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVE:To compare bone mass (BMD) in women with fibromyalgia (FM) with healthy females, and to evaluate whether self-reported pain and lack of functional capacity correlate to reduced BMD in FM patients. METHODS:Thirty-one FM patients (20 pre- and 11 postmenopausal) and fourty-one healthy women (30 pre- and 10 post...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009740310002470
更新日期：2003-01-01 00:00:00
abstract：:Using the fluorescence polarization of 1.6-diphenyl-1, 3, 5-hexatriene, the membrane fluidity of lymphocytes obtained from rheumatoid arthritis patients was measured during 12 months of auranofin treatment. Significant differences in fluorescence polarization values were observed following auranofin treatment. The cor...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748909102104
更新日期：1989-01-01 00:00:00
abstract：:The coexistence of cryoglobulinemia and C4 deficiency was found in one family. Twelve subjects were examined, most of them being asymptomatic. Cryoglobulins were found in 9 members and its type was defined in 6 of them, 3 having mixed IgM-IgG and 3 having monoclonal IgM cryoglobulins. The concentration of the third co...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748409100379
更新日期：1984-01-01 00:00:00
abstract：:Objective: The aim of this study was to review the literature to identify studies reporting repair of erosions in rheumatoid arthritis (RA).Method: A systematic literature search for publications on the repair of erosions was performed in PubMed and Embase, limited to human adults and published in English. Titles, abs...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009742.2019.1606274
更新日期：2019-11-01 00:00:00
abstract：:Churg-Strauss syndrome (CSS) is a rare disorder characterized by the histopathological triad of systemic necrotizing vasculitis, extravascular granuloma, and eosinophilic infiltrate, occurring in individuals with asthma or a history of allergy. We report a case of CSS with rare presentation of diffuse pulmonary hemorr...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/030097498440877
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVES:To (i) examine the association between fatigue, psychosocial work characteristics (job control, support, participation in decision making, psychological job demands), and physical work requirements on the one hand and work ability of employees with rheumatoid arthritis (RA) on the other, and (ii) determine t...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009740510018615
更新日期：2005-07-01 00:00:00
abstract：:The prognostically important signs and symptoms in the early stage of rheumatoid arthritis were studied in 136 patients selected and treated in Moscow and in 139 patients in Heinola, Finland. The follow-up time was 3 years. The outcome was poor in patients with early signs of radiological destruction in the joints, wi...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748409102665
更新日期：1984-01-01 00:00:00
abstract：:ANA testing by immunofluorescence technique (F-ANA) is nowadays still performed in much the same way as 45 years ago when the test was introduced. Due to its low specificity the F-ANA test has a poor predictive value for systemic autoimmune diseases and in addition has proven difficult to standardise. In the meantime,...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/030097401300162860
更新日期：2001-01-01 00:00:00
abstract：:Psychological and emotional status was assessed in 36 patients with systemic lupus erythematosus (SLE) with the General Health Questionnaire-30 (GHQ-30) and Minnesota Multiphasic Personality Inventory (MMPI) questionnaires. The two tests were found to measure different aspects of psychological functioning. More than 5...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/030097498442226
更新日期：1998-01-01 00:00:00
abstract：:This study is the first report of the permeability status of nailfold capillaries in psoriatic arthritis (PA). "Traditional" nailfold capillary microscopy and intravital fluorescence videomicroscopy were carried out at the nailfold of 13 patients with PA. Twenty five healthy subjects served as controls for nailfold ca...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009749209099229
更新日期：1992-01-01 00:00:00
abstract：:Oxygen consumption was investigated during phagocytosis by leukocytes in patients suffering from rheumatoid arthritis, juvenile rheumatoid arthritis, dermatomyositis, systemic lupus erythematosus and scleroderma. Compared with the situation in normal persons, the mean oxygen consumption in the total patient group was ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009747709095439
更新日期：1977-01-01 00:00:00
abstract：:Several different sets of diagnostic criteria of rheumatoid arthritis in children are in practical use. The criteria most widely applied are discussed here, especially with regard to clinical studies. Reasons are presented for the selection of criteria used in the present controlled clinical studies on rheumatic child...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.3109/03009748209098189
更新日期：1982-01-01 00:00:00
abstract：OBJECTIVES:This study examined differences in reactions to disability between early and established rheumatoid arthritis (RA) patients, and whether these reactions were related to age, physical functioning, acceptance of illness, or self-efficacy. METHODS:Thirty-four patients with early RA (< 2 years since diagnosis) ...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章
doi：10.1080/03009740310004685
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVES:To provide a thorough description of team rehabilitation care and compare the structure, process, and outcomes in two specialized arthritis rehabilitation settings. METHODS:Patients with inflammatory arthritis scheduled for inpatient rehabilitation in seven specialized rehabilitation centres and three rheum...
journal_title：Scandinavian journal of rheumatology
pub_type： 杂志文章,多中心研究
doi：10.3109/03009742.2011.601757
更新日期：2012-02-01 00:00:00
